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P54730 (UBX4_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UBX domain-containing protein 4
Gene names
Name:UBX4
Ordered Locus Names:YMR067C
ORF Names:YM9916.06C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length416 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway By similarity.

Subcellular location

Nucleus. Cytoplasm Ref.3.

Miscellaneous

Present with 3570 molecules/cell in log phase SD medium.

Sequence similarities

Contains 1 UBX domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CDC48P256945EBI-28127,EBI-4308

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 416416UBX domain-containing protein 4
PRO_0000211001

Regions

Domain273 – 35078UBX

Sequences

Sequence LengthMass (Da)Tools
P54730 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 615E5F8EC1DCDD31

FASTA41646,965
        10         20         30         40         50         60 
MPMVTVKYNF QLFKCKVSLN STLNDVLHQS IQFFQLHTSS NDWSLIHLDK PVPLDLPWRL 

        70         80         90        100        110        120 
LNLPTGVNLE LSKSSNFPVA NKTNREDIPF NTIKIRFQIP GRDSVVKEMP SDQPIAPILR 

       130        140        150        160        170        180 
QMSGAAGDDF KIQVFSKIIE FKTIKDENLT LENLGIQEPS SVRLIFNNTS HSEGISANSA 

       190        200        210        220        230        240 
IHPKQTPPTM TNPETVASLP PHELHKPSVF LPSDEPLAVI KDQIEDEEDY ELTVEQAKKY 

       250        260        270        280        290        300 
QKMLSSKAGT LGGPILTKRL REQSANNLPK KNKAISECLL RVKFPDRSHI QIAFKPNEDM 

       310        320        330        340        350        360 
RTVYNVVSQF LIDENMPFTL NQSHPFKPLA KDDKKLLDDL EFGSKTMLLF ETNSNSNGPL 

       370        380        390        400        410 
IKAHLLEDAQ KITHETRTTP SVNTINKSNP QGPSDNATSI KKTLNRVPKW MKLSKK 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII."
Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. expand/collapse author list , Skelton J., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation."
Schuberth C., Richly H., Rumpf S., Buchberger A.
EMBO Rep. 5:818-824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CDC48.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z48952 Genomic DNA. Translation: CAA88792.1.
BK006946 Genomic DNA. Translation: DAA09965.1.
PIRS52827.
RefSeqNP_013783.1. NM_001182565.1.

3D structure databases

ProteinModelPortalP54730.
SMRP54730. Positions 2-78, 89-164.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35242. 65 interactions.
DIPDIP-5070N.
IntActP54730. 2 interactions.
MINTMINT-491552.
STRING4932.YMR067C.

Proteomic databases

MaxQBP54730.
PaxDbP54730.
PeptideAtlasP54730.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYMR067C; YMR067C; YMR067C.
GeneID855089.
KEGGsce:YMR067C.

Organism-specific databases

CYGDYMR067c.
SGDS000004671. UBX4.

Phylogenomic databases

eggNOGNOG317887.
HOGENOMHOG000154766.
OMAISECLLR.
OrthoDBEOG77Q567.

Enzyme and pathway databases

BioCycYEAST:G3O-32769-MONOMER.

Gene expression databases

GenevestigatorP54730.

Family and domain databases

InterProIPR021569. TUG/UBX4.
IPR029071. Ubiquitin-rel_dom.
IPR001012. UBX_dom.
[Graphical view]
PfamPF11470. TUG-UBL1. 1 hit.
PF00789. UBX. 1 hit.
[Graphical view]
SMARTSM00166. UBX. 1 hit.
[Graphical view]
SUPFAMSSF54236. SSF54236. 2 hits.
PROSITEPS50033. UBX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio978390.

Entry information

Entry nameUBX4_YEAST
AccessionPrimary (citable) accession number: P54730
Secondary accession number(s): D6VZP1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families