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Protein

UBX domain-containing protein 4

Gene

UBX4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway.By similarity

GO - Molecular functioni

  1. protein complex binding Source: SGD

GO - Biological processi

  1. ER-associated ubiquitin-dependent protein catabolic process Source: SGD
  2. sporulation resulting in formation of a cellular spore Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BioCyciYEAST:G3O-32769-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UBX domain-containing protein 4
Gene namesi
Name:UBX4
Ordered Locus Names:YMR067C
ORF Names:YM9916.06C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome XIII

Organism-specific databases

CYGDiYMR067c.
EuPathDBiFungiDB:YMR067C.
SGDiS000004671. UBX4.

Subcellular locationi

  1. Nucleus 1 Publication
  2. Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. extrinsic component of membrane Source: SGD
  3. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416UBX domain-containing protein 4PRO_0000211001Add
BLAST

Proteomic databases

MaxQBiP54730.
PaxDbiP54730.
PeptideAtlasiP54730.

Expressioni

Gene expression databases

GenevestigatoriP54730.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CDC48P256945EBI-28127,EBI-4308

Protein-protein interaction databases

BioGridi35242. 67 interactions.
DIPiDIP-5070N.
IntActiP54730. 2 interactions.
MINTiMINT-491552.
STRINGi4932.YMR067C.

Structurei

3D structure databases

ProteinModelPortaliP54730.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini273 – 35078UBXPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 UBX domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG317887.
HOGENOMiHOG000154766.
InParanoidiP54730.
OMAiPKWMKLS.
OrthoDBiEOG77Q567.

Family and domain databases

InterProiIPR021569. TUG/UBX4.
IPR029071. Ubiquitin-rel_dom.
IPR001012. UBX_dom.
[Graphical view]
PfamiPF11470. TUG-UBL1. 1 hit.
PF00789. UBX. 1 hit.
[Graphical view]
SMARTiSM00166. UBX. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 2 hits.
PROSITEiPS50033. UBX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54730-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPMVTVKYNF QLFKCKVSLN STLNDVLHQS IQFFQLHTSS NDWSLIHLDK
60 70 80 90 100
PVPLDLPWRL LNLPTGVNLE LSKSSNFPVA NKTNREDIPF NTIKIRFQIP
110 120 130 140 150
GRDSVVKEMP SDQPIAPILR QMSGAAGDDF KIQVFSKIIE FKTIKDENLT
160 170 180 190 200
LENLGIQEPS SVRLIFNNTS HSEGISANSA IHPKQTPPTM TNPETVASLP
210 220 230 240 250
PHELHKPSVF LPSDEPLAVI KDQIEDEEDY ELTVEQAKKY QKMLSSKAGT
260 270 280 290 300
LGGPILTKRL REQSANNLPK KNKAISECLL RVKFPDRSHI QIAFKPNEDM
310 320 330 340 350
RTVYNVVSQF LIDENMPFTL NQSHPFKPLA KDDKKLLDDL EFGSKTMLLF
360 370 380 390 400
ETNSNSNGPL IKAHLLEDAQ KITHETRTTP SVNTINKSNP QGPSDNATSI
410
KKTLNRVPKW MKLSKK
Length:416
Mass (Da):46,965
Last modified:October 1, 1996 - v1
Checksum:i615E5F8EC1DCDD31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48952 Genomic DNA. Translation: CAA88792.1.
BK006946 Genomic DNA. Translation: DAA09965.1.
PIRiS52827.
RefSeqiNP_013783.1. NM_001182565.1.

Genome annotation databases

EnsemblFungiiYMR067C; YMR067C; YMR067C.
GeneIDi855089.
KEGGisce:YMR067C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48952 Genomic DNA. Translation: CAA88792.1.
BK006946 Genomic DNA. Translation: DAA09965.1.
PIRiS52827.
RefSeqiNP_013783.1. NM_001182565.1.

3D structure databases

ProteinModelPortaliP54730.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35242. 67 interactions.
DIPiDIP-5070N.
IntActiP54730. 2 interactions.
MINTiMINT-491552.
STRINGi4932.YMR067C.

Proteomic databases

MaxQBiP54730.
PaxDbiP54730.
PeptideAtlasiP54730.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR067C; YMR067C; YMR067C.
GeneIDi855089.
KEGGisce:YMR067C.

Organism-specific databases

CYGDiYMR067c.
EuPathDBiFungiDB:YMR067C.
SGDiS000004671. UBX4.

Phylogenomic databases

eggNOGiNOG317887.
HOGENOMiHOG000154766.
InParanoidiP54730.
OMAiPKWMKLS.
OrthoDBiEOG77Q567.

Enzyme and pathway databases

BioCyciYEAST:G3O-32769-MONOMER.

Miscellaneous databases

NextBioi978390.
PROiP54730.

Gene expression databases

GenevestigatoriP54730.

Family and domain databases

InterProiIPR021569. TUG/UBX4.
IPR029071. Ubiquitin-rel_dom.
IPR001012. UBX_dom.
[Graphical view]
PfamiPF11470. TUG-UBL1. 1 hit.
PF00789. UBX. 1 hit.
[Graphical view]
SMARTiSM00166. UBX. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 2 hits.
PROSITEiPS50033. UBX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation."
    Schuberth C., Richly H., Rumpf S., Buchberger A.
    EMBO Rep. 5:818-824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CDC48.

Entry informationi

Entry nameiUBX4_YEAST
AccessioniPrimary (citable) accession number: P54730
Secondary accession number(s): D6VZP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 29, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3570 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.