UniProtKB - P54709 (AT1B3_HUMAN)
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Protein
Sodium/potassium-transporting ATPase subunit beta-3
Gene
ATP1B3
Organism
Homo sapiens (Human)
Status
Functioni
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The exact function of the beta-3 subunit is not known.
GO - Molecular functioni
- ATPase activator activity Source: BHF-UCL
- ATPase binding Source: BHF-UCL
- sodium:potassium-exchanging ATPase activity Source: BHF-UCL
GO - Biological processi
- cellular potassium ion homeostasis Source: BHF-UCL
- cellular sodium ion homeostasis Source: BHF-UCL
- ion transmembrane transport Source: Reactome
- leukocyte migration Source: Reactome
- membrane repolarization Source: BHF-UCL
- positive regulation of ATPase activity Source: BHF-UCL
- positive regulation of potassium ion import Source: BHF-UCL
- positive regulation of potassium ion transmembrane transporter activity Source: BHF-UCL
- positive regulation of sodium ion export across plasma membrane Source: BHF-UCL
- potassium ion import Source: BHF-UCL
- protein localization to plasma membrane Source: BHF-UCL
- protein stabilization Source: BHF-UCL
- regulation of cardiac conduction Source: Reactome
- sodium ion export across plasma membrane Source: BHF-UCL
Keywordsi
Biological process | Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport |
Ligand | Potassium, Sodium |
Enzyme and pathway databases
Reactomei | R-HSA-210991. Basigin interactions. R-HSA-5578775. Ion homeostasis. R-HSA-936837. Ion transport by P-type ATPases. |
Protein family/group databases
TCDBi | 3.A.3.1.1. the p-type atpase (p-atpase) superfamily. |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium/potassium-transporting ATPase subunit beta-3Alternative name(s): Sodium/potassium-dependent ATPase subunit beta-3 Short name: ATPB-3 CD_antigen: CD298 |
Gene namesi | Name:ATP1B3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000069849.10. |
HGNCi | HGNC:806. ATP1B3. |
MIMi | 601867. gene. |
neXtProti | NX_P54709. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 35 | CytoplasmicSequence analysisAdd BLAST | 35 | |
Transmembranei | 36 – 56 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 57 – 279 | ExtracellularSequence analysisAdd BLAST | 223 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000069849. |
PharmGKBi | PA68. |
Chemistry databases
ChEMBLi | CHEMBL2095186. |
DrugBanki | DB09479. Rubidium chloride Rb-82. |
Polymorphism and mutation databases
BioMutai | ATP1B3. |
DMDMi | 1703470. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000219108 | 1 – 279 | Sodium/potassium-transporting ATPase subunit beta-3Add BLAST | 279 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 124 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 128 ↔ 144 | By similarity | ||
Disulfide bondi | 154 ↔ 170 | By similarity | ||
Disulfide bondi | 191 ↔ 250 | By similarity | ||
Glycosylationi | 240 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | P54709. |
MaxQBi | P54709. |
PaxDbi | P54709. |
PeptideAtlasi | P54709. |
PRIDEi | P54709. |
TopDownProteomicsi | P54709-1. [P54709-1] |
PTM databases
iPTMneti | P54709. |
PhosphoSitePlusi | P54709. |
SwissPalmi | P54709. |
Expressioni
Gene expression databases
Bgeei | ENSG00000069849. |
CleanExi | HS_ATP1B3. |
ExpressionAtlasi | P54709. baseline and differential. |
Genevisiblei | P54709. HS. |
Organism-specific databases
HPAi | CAB020697. HPA048963. |
Interactioni
Subunit structurei
The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.Curated
GO - Molecular functioni
- ATPase binding Source: BHF-UCL
Protein-protein interaction databases
BioGridi | 106973. 107 interactors. |
DIPi | DIP-50717N. |
IntActi | P54709. 12 interactors. |
STRINGi | 9606.ENSP00000286371. |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 186 – 279 | immunoglobulin-likeBy similarityAdd BLAST | 94 |
Domaini
The C-terminal lobe folds into an immunoglobulin-like domain and may mediate cell adhesion properties.By similarity
Sequence similaritiesi
Belongs to the X(+)/potassium ATPases subunit beta family.Curated
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3927. Eukaryota. ENOG411150A. LUCA. |
GeneTreei | ENSGT00550000074530. |
HOGENOMi | HOG000039248. |
HOVERGENi | HBG050603. |
InParanoidi | P54709. |
KOi | K01540. |
OMAi | LMISPKP. |
OrthoDBi | EOG091G0DJ4. |
PhylomeDBi | P54709. |
TreeFami | TF314618. |
Family and domain databases
InterProi | View protein in InterPro IPR000402. Na/K_ATPase_sub_beta. |
PANTHERi | PTHR11523. PTHR11523. 1 hit. |
Pfami | View protein in Pfam PF00287. Na_K-ATPase. 1 hit. |
TIGRFAMsi | TIGR01107. Na_K_ATPase_bet. 1 hit. |
PROSITEi | View protein in PROSITE PS00390. ATPASE_NA_K_BETA_1. 1 hit. |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: P54709-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MTKNEKKSLN QSLAEWKLFI YNPTTGEFLG RTAKSWGLIL LFYLVFYGFL
60 70 80 90 100
AALFSFTMWV MLQTLNDEVP KYRDQIPSPG LMVFPKPVTA LEYTFSRSDP
110 120 130 140 150
TSYAGYIEDL KKFLKPYTLE EQKNLTVCPD GALFEQKGPV YVACQFPISL
160 170 180 190 200
LQACSGMNDP DFGYSQGNPC ILVKMNRIIG LKPEGVPRID CVSKNEDIPN
210 220 230 240 250
VAVYPHNGMI DLKYFPYYGK KLHVGYLQPL VAVQVSFAPN NTGKEVTVEC
260 270
KIDGSANLKS QDDRDKFLGR VMFKITARA
Isoform 2 (identifier: P54709-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
1-36: MTKNEKKSLNQSLAEWKLFIYNPTTGEFLGRTAKSW → MLSEGDILFSSLLSSPSLFWPP
195-279: NEDIPNVAVY...RVMFKITARA → TNNVKDGMKIYQM
Note: No experimental confirmation available.
Show »Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056686 | 1 – 36 | MTKNE…TAKSW → MLSEGDILFSSLLSSPSLFW PP in isoform 2. 1 PublicationAdd BLAST | 36 | |
Alternative sequenceiVSP_056687 | 195 – 279 | NEDIP…ITARA → TNNVKDGMKIYQM in isoform 2. 1 PublicationAdd BLAST | 85 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U51478 mRNA. Translation: AAC50665.1. AF005896 AF005895 Genomic DNA. Translation: AAB61713.1. AK293697 mRNA. Translation: BAH11573.1. AC112504 Genomic DNA. No translation available. BC011835 mRNA. Translation: AAH11835.1. |
CCDSi | CCDS3121.1. [P54709-1] |
PIRi | G02485. |
RefSeqi | NP_001670.1. NM_001679.3. [P54709-1] |
UniGenei | Hs.477789. |
Genome annotation databases
Ensembli | ENST00000286371; ENSP00000286371; ENSG00000069849. [P54709-1] |
GeneIDi | 483. |
KEGGi | hsa:483. |
UCSCi | uc003eug.2. human. [P54709-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | AT1B3_HUMAN | |
Accessioni | P54709Primary (citable) accession number: P54709 Secondary accession number(s): B7Z1N7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | March 28, 2018 | |
This is version 161 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |