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P54709 (AT1B3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium/potassium-transporting ATPase subunit beta-3
Alternative name(s):
Sodium/potassium-dependent ATPase subunit beta-3
Short name=ATPB-3
CD_antigen=CD298
Gene names
Name:ATP1B3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length279 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The exact function of the beta-3 subunit is not known.

Subunit structure

Composed of three subunits: alpha (catalytic), beta and gamma.

Subcellular location

Cell membrane; Single-pass type II membrane protein. Melanosome. Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Ref.5

Domain

The C-terminal lobe folds into an immunoglobulin-like domain and may mediate cell adhesion properties By similarity.

Sequence similarities

Belongs to the X(+)/potassium ATPases subunit beta family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 279279Sodium/potassium-transporting ATPase subunit beta-3
PRO_0000219108

Regions

Topological domain1 – 3535Cytoplasmic Potential
Transmembrane36 – 5621Helical; Signal-anchor for type II membrane protein; Potential
Topological domain57 – 279223Extracellular Potential
Region186 – 27994immunoglobulin-like By similarity

Amino acid modifications

Glycosylation1241N-linked (GlcNAc...) Potential
Glycosylation2401N-linked (GlcNAc...) Ref.4
Disulfide bond128 ↔ 144 By similarity
Disulfide bond154 ↔ 170 By similarity
Disulfide bond191 ↔ 250 By similarity

Sequences

Sequence LengthMass (Da)Tools
P54709 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: D92ECB4F0F6EBFE5

FASTA27931,513
        10         20         30         40         50         60 
MTKNEKKSLN QSLAEWKLFI YNPTTGEFLG RTAKSWGLIL LFYLVFYGFL AALFSFTMWV 

        70         80         90        100        110        120 
MLQTLNDEVP KYRDQIPSPG LMVFPKPVTA LEYTFSRSDP TSYAGYIEDL KKFLKPYTLE 

       130        140        150        160        170        180 
EQKNLTVCPD GALFEQKGPV YVACQFPISL LQACSGMNDP DFGYSQGNPC ILVKMNRIIG 

       190        200        210        220        230        240 
LKPEGVPRID CVSKNEDIPN VAVYPHNGMI DLKYFPYYGK KLHVGYLQPL VAVQVSFAPN 

       250        260        270 
NTGKEVTVEC KIDGSANLKS QDDRDKFLGR VMFKITARA 

« Hide

References

« Hide 'large scale' references
[1]"Identification of the mammalian Na,K-ATPase 3 subunit."
Malik N., Canfield V.A., Beckers M.C., Gros P., Levenson R.
J. Biol. Chem. 271:22754-22758(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[2]"Structural organization and chromosomal localization of the human Na,K- ATPase beta 3 subunit gene and pseudogene."
Malik N., Canfield V., Sanchez-Watts G., Watts A.G., Scherer S., Beatty B.G., Gros P., Levenson R.
Mamm. Genome 9:136-143(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[4]"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
Zhang H., Li X.-J., Martin D.B., Aebersold R.
Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT ASN-240.
[5]"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."
Chi A., Valencia J.C., Hu Z.-Z., Watabe H., Yamaguchi H., Mangini N.J., Huang H., Canfield V.A., Cheng K.C., Yang F., Abe R., Yamagishi S., Shabanowitz J., Hearing V.J., Wu C., Appella E., Hunt D.F.
J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
Tissue: Melanoma.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U51478 mRNA. Translation: AAC50665.1.
AF005896 expand/collapse EMBL AC list , AF005890, AF005891, AF005892, AF005893, AF005894, AF005895 Genomic DNA. Translation: AAB61713.1.
BC011835 mRNA. Translation: AAH11835.1.
PIRG02485.
RefSeqNP_001670.1. NM_001679.2.
UniGeneHs.477789.

3D structure databases

ProteinModelPortalP54709.
SMRP54709. Positions 1-279.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid106973. 8 interactions.
IntActP54709. 4 interactions.
MINTMINT-5001083.
STRING9606.ENSP00000286371.

Chemistry

BindingDBP54709.
ChEMBLCHEMBL2095186.

Protein family/group databases

TCDB3.A.3.1.1. the p-type atpase (p-atpase) superfamily.

PTM databases

PhosphoSiteP54709.

Polymorphism databases

DMDM1703470.

Proteomic databases

PaxDbP54709.
PRIDEP54709.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000286371; ENSP00000286371; ENSG00000069849.
GeneID483.
KEGGhsa:483.
UCSCuc003eug.1. human.

Organism-specific databases

CTD483.
GeneCardsGC03P141594.
HGNCHGNC:806. ATP1B3.
HPACAB020697.
MIM601867. gene.
neXtProtNX_P54709.
PharmGKBPA68.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG263581.
HOGENOMHOG000039248.
HOVERGENHBG050603.
InParanoidP54709.
KOK01540.
OMAYDLEEQK.
PhylomeDBP54709.
TreeFamTF314618.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.
REACT_604. Hemostasis.

Gene expression databases

ArrayExpressP54709.
BgeeP54709.
CleanExHS_ATP1B3.
GenevestigatorP54709.

Family and domain databases

InterProIPR000402. Na/K_ATPase_sub_beta.
[Graphical view]
PANTHERPTHR11523. PTHR11523. 1 hit.
PfamPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEPS00390. ATPASE_NA_K_BETA_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiATP1B3.
GenomeRNAi483.
NextBio2005.
PROP54709.
SOURCESearch...

Entry information

Entry nameAT1B3_HUMAN
AccessionPrimary (citable) accession number: P54709
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries