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P54707

- AT12A_HUMAN

UniProt

P54707 - AT12A_HUMAN

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Protein

Potassium-transporting ATPase alpha chain 2

Gene

ATP12A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane. Responsible for potassium absorption in various tissues.

Catalytic activityi

ATP + H2O + H+(In) + K+(Out) = ADP + phosphate + H+(Out) + K+(In).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei391 – 39114-aspartylphosphate intermediateBy similarity
Metal bindingi732 – 7321MagnesiumBy similarity
Metal bindingi736 – 7361MagnesiumBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hydrogen:potassium-exchanging ATPase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. ATP biosynthetic process Source: InterPro
  2. ion transmembrane transport Source: Reactome
  3. potassium ion homeostasis Source: Ensembl
  4. regulation of pH Source: Ensembl
  5. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

BRENDAi3.6.3.10. 2681.
ReactomeiREACT_25149. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium-transporting ATPase alpha chain 2 (EC:3.6.3.10)
Alternative name(s):
Non-gastric H(+)/K(+) ATPase subunit alpha
Proton pump
Gene namesi
Name:ATP12A
Synonyms:ATP1AL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:13816. ATP12A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 102102CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei103 – 12321HelicalSequence AnalysisAdd
BLAST
Topological domaini124 – 14623LumenalSequence AnalysisAdd
BLAST
Transmembranei147 – 16721HelicalSequence AnalysisAdd
BLAST
Topological domaini168 – 303136CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei304 – 32320HelicalSequence AnalysisAdd
BLAST
Topological domaini324 – 33512LumenalSequence AnalysisAdd
BLAST
Transmembranei336 – 35318HelicalSequence AnalysisAdd
BLAST
Topological domaini354 – 787434CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei788 – 80720HelicalSequence AnalysisAdd
BLAST
Topological domaini808 – 81710LumenalSequence Analysis
Transmembranei818 – 83821HelicalSequence AnalysisAdd
BLAST
Topological domaini839 – 85820CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei859 – 88123HelicalSequence AnalysisAdd
BLAST
Topological domaini882 – 93352LumenalSequence AnalysisAdd
BLAST
Transmembranei934 – 95320HelicalSequence AnalysisAdd
BLAST
Topological domaini954 – 96714CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei968 – 98619HelicalSequence AnalysisAdd
BLAST
Topological domaini987 – 100115LumenalSequence AnalysisAdd
BLAST
Transmembranei1002 – 102221HelicalSequence AnalysisAdd
BLAST
Topological domaini1023 – 103917CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: Ensembl
  2. hydrogen:potassium-exchanging ATPase complex Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25104.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10391039Potassium-transporting ATPase alpha chain 2PRO_0000046260Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei958 – 9581Phosphoserine; by PKABy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP54707.
PaxDbiP54707.
PRIDEiP54707.

PTM databases

PhosphoSiteiP54707.

Expressioni

Tissue specificityi

Found in skin and kidney. Detected in prostate basal cells (at protein level). Expression is increased in benign prostate hyperplasia and tumor tissues (at protein level).2 Publications

Gene expression databases

BgeeiP54707.
CleanExiHS_ATP12A.
GenevestigatoriP54707.

Organism-specific databases

HPAiHPA039526.

Interactioni

Subunit structurei

Composed of two subunits: alpha (catalytic) and beta.

Protein-protein interaction databases

BioGridi106969. 31 interactions.
IntActiP54707. 4 interactions.
MINTiMINT-4656898.
STRINGi9606.ENSP00000371372.

Structurei

3D structure databases

ProteinModelPortaliP54707.
SMRiP54707. Positions 48-1039.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0474.
GeneTreeiENSGT00760000119003.
HOGENOMiHOG000265622.
HOVERGENiHBG004298.
InParanoidiP54707.
KOiK01544.
OMAiNLRVEWE.
OrthoDBiEOG7327N0.
PhylomeDBiP54707.
TreeFamiTF312838.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P54707-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHQKTPEIYS VELSGTKDIV KTDKGDGKEK YRGLKNNCLE LKKKNHKEEF
60 70 80 90 100
QKELHLDDHK LSNRELEEKY GTDIIMGLSS TRAAELLARD GPNSLTPPKQ
110 120 130 140 150
TPEIVKFLKQ MVGGFSILLW VGAFLCWIAY GIQYSSDKSA SLNNVYLGCV
160 170 180 190 200
LGLVVILTGI FAYYQEAKST NIMSSFNKMI PQQALVIRDS EKKTIPSEQL
210 220 230 240 250
VVGDIVEVKG GDQIPADIRV LSSQGCRVDN SSLTGESEPQ PRSSEFTHEN
260 270 280 290 300
PLETKNICFY STTCLEGTVT GMVINTGDRT IIGHIASLAS GVGNEKTPIA
310 320 330 340 350
IEIEHFVHIV AGVAVSIGIL FFIIAVSLKY QVLDSIIFLI GIIVANVPEG
360 370 380 390 400
LLATVTVTLS LTAKRMAKKN CLVKNLEAVE TLGSTSIICS DKTGTLTQNR
410 420 430 440 450
MTVAHLWFDN QIFVADTSED HSNQVFDQSS RTWASLSKII TLCNRAEFKP
460 470 480 490 500
GQENVPIMKK AVIGDASETA LLKFSEVILG DVMEIRKRNR KVAEIPFNST
510 520 530 540 550
NKFQLSIHEM DDPHGKRFLM VMKGAPERIL EKCSTIMING EEHPLDKSTA
560 570 580 590 600
KTFHTAYMEL GGLGERVLGF CHLYLPADEF PETYSFDIDA MNFPTSNLCF
610 620 630 640 650
VGLLSMIDPP RSTVPDAVTK CRSAGIKVIM VTGDHPITAK AIAKSVGIIS
660 670 680 690 700
ANSETVEDIA HRLNIAVEQV NKRDAKAAVV TGMELKDMSS EQLDEILANY
710 720 730 740 750
QEIVFARTSP QQKLIIVEGC QRQDAVVAVT GDGVNDSPAL KKADIGIAMG
760 770 780 790 800
IAGSDAAKNA ADMVLLDDNF ASIVTGVEEG RLIFDNLKKT IAYSLTKNIA
810 820 830 840 850
ELCPFLIYII VGLPLPIGTI TILFIDLGTD IIPSIALAYE KAESDIMNRK
860 870 880 890 900
PRHKNKDRLV NQPLAVYSYL HIGLMQALGA FLVYFTVYAQ EGFLPRTLIN
910 920 930 940 950
LRVEWEKDYV NDLKDSYGQE WTRYQREYLE WTGYTAFFVG ILVQQIADLI
960 970 980 990 1000
IRKTRRNSIF QQGLFRNKVI WVGITSQIII GLILSYGLGS VTALSFTMLR
1010 1020 1030
AQYWFVAVPH AILIWVYDEV RKLFIRLYPG SWWDKNMYY
Length:1,039
Mass (Da):115,511
Last modified:July 22, 2008 - v3
Checksum:iC906897E11FA406C
GO
Isoform 2 (identifier: P54707-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     266-266: E → EASTSPV

Note: No experimental confirmation available.

Show »
Length:1,045
Mass (Da):116,053
Checksum:i15088FC158FB580A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31Q → QLFQ in AAC37589. (PubMed:8838794)Curated
Sequence conflicti145 – 1451V → VRLWGVQV in CAA49477. (PubMed:1847115)Curated
Sequence conflicti225 – 2273Missing in CAA49477. (PubMed:1847115)Curated
Sequence conflicti266 – 2661E → V in CAA49477. (PubMed:1847115)Curated
Sequence conflicti382 – 3821L → P in AAA35576. (PubMed:3036582)Curated
Sequence conflicti724 – 7274DAVV → VGGQ in CAA49478. (PubMed:1847115)Curated
Sequence conflicti772 – 7732SI → LH in CAA49478. (PubMed:1847115)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti863 – 8631P → L.
Corresponds to variant rs2289909 [ dbSNP | Ensembl ].
VAR_020186

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei266 – 2661E → EASTSPV in isoform 2. 1 PublicationVSP_034640

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02076 mRNA. Translation: AAB37755.1.
L42563
, L42558, L42559, L42565, L42566, L42567, L42560, L42561, L42568, L42562, L42569 Genomic DNA. Translation: AAC37589.2.
AK292968 mRNA. Translation: BAF85657.1.
AL157364 Genomic DNA. Translation: CAH72440.1.
CH471075 Genomic DNA. Translation: EAX08346.1.
CH471075 Genomic DNA. Translation: EAX08345.1.
BC031609 mRNA. Translation: AAH31609.1.
X69823 Genomic DNA. Translation: CAA49477.1.
X69824 Genomic DNA. Translation: CAA49478.1.
M16797 mRNA. Translation: AAA51802.1.
M27574 Genomic DNA. Translation: AAA35576.1.
CCDSiCCDS31948.1. [P54707-1]
CCDS53858.1. [P54707-2]
PIRiA26641.
D27795.
E27397.
I38401.
S13028.
S31504.
RefSeqiNP_001172014.1. NM_001185085.1. [P54707-2]
NP_001667.4. NM_001676.5. [P54707-1]
UniGeneiHs.147111.

Genome annotation databases

EnsembliENST00000218548; ENSP00000218548; ENSG00000075673. [P54707-2]
ENST00000381946; ENSP00000371372; ENSG00000075673. [P54707-1]
GeneIDi479.
KEGGihsa:479.
UCSCiuc001upp.3. human. [P54707-1]
uc010aaa.3. human. [P54707-2]

Polymorphism databases

DMDMi212287925.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02076 mRNA. Translation: AAB37755.1 .
L42563
, L42558 , L42559 , L42565 , L42566 , L42567 , L42560 , L42561 , L42568 , L42562 , L42569 Genomic DNA. Translation: AAC37589.2 .
AK292968 mRNA. Translation: BAF85657.1 .
AL157364 Genomic DNA. Translation: CAH72440.1 .
CH471075 Genomic DNA. Translation: EAX08346.1 .
CH471075 Genomic DNA. Translation: EAX08345.1 .
BC031609 mRNA. Translation: AAH31609.1 .
X69823 Genomic DNA. Translation: CAA49477.1 .
X69824 Genomic DNA. Translation: CAA49478.1 .
M16797 mRNA. Translation: AAA51802.1 .
M27574 Genomic DNA. Translation: AAA35576.1 .
CCDSi CCDS31948.1. [P54707-1 ]
CCDS53858.1. [P54707-2 ]
PIRi A26641.
D27795.
E27397.
I38401.
S13028.
S31504.
RefSeqi NP_001172014.1. NM_001185085.1. [P54707-2 ]
NP_001667.4. NM_001676.5. [P54707-1 ]
UniGenei Hs.147111.

3D structure databases

ProteinModelPortali P54707.
SMRi P54707. Positions 48-1039.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106969. 31 interactions.
IntActi P54707. 4 interactions.
MINTi MINT-4656898.
STRINGi 9606.ENSP00000371372.

Chemistry

BindingDBi P54707.
ChEMBLi CHEMBL2933.

PTM databases

PhosphoSitei P54707.

Polymorphism databases

DMDMi 212287925.

Proteomic databases

MaxQBi P54707.
PaxDbi P54707.
PRIDEi P54707.

Protocols and materials databases

DNASUi 479.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000218548 ; ENSP00000218548 ; ENSG00000075673 . [P54707-2 ]
ENST00000381946 ; ENSP00000371372 ; ENSG00000075673 . [P54707-1 ]
GeneIDi 479.
KEGGi hsa:479.
UCSCi uc001upp.3. human. [P54707-1 ]
uc010aaa.3. human. [P54707-2 ]

Organism-specific databases

CTDi 479.
GeneCardsi GC13P025254.
HGNCi HGNC:13816. ATP12A.
HPAi HPA039526.
MIMi 182360. gene.
neXtProti NX_P54707.
PharmGKBi PA25104.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0474.
GeneTreei ENSGT00760000119003.
HOGENOMi HOG000265622.
HOVERGENi HBG004298.
InParanoidi P54707.
KOi K01544.
OMAi NLRVEWE.
OrthoDBi EOG7327N0.
PhylomeDBi P54707.
TreeFami TF312838.

Enzyme and pathway databases

BRENDAi 3.6.3.10. 2681.
Reactomei REACT_25149. Ion transport by P-type ATPases.

Miscellaneous databases

ChiTaRSi ATP12A. human.
GeneWikii ATP12A.
GenomeRNAii 479.
NextBioi 1985.
PROi P54707.
SOURCEi Search...

Gene expression databases

Bgeei P54707.
CleanExi HS_ATP12A.
Genevestigatori P54707.

Family and domain databases

Gene3Di 1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SMARTi SM00831. Cation_ATPase_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the entire cDNA encoded by ATP1AL1 --a member of the human Na,K/H,K-ATPase gene family."
    Grishin A.V., Sverdlov V.E., Kostina M.B., Modyanov N.N.
    FEBS Lett. 349:144-150(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Kidney and Skin.
  2. "Genomic organization of the human ATP1AL1 gene encoding a ouabain-sensitive H,K-ATPase."
    Sverdlov V.E., Kostina M.B., Modyanov N.N.
    Genomics 32:317-327(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Trachea.
  4. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  7. "The family of human Na,K-ATPase genes. ATP1AL1 gene is transcriptionally competent and probably encodes the related ion transport ATPase."
    Modyanov N.N., Petrukhin K.E., Sverdlov V.E., Grishin A.V., Orlova M.Y., Kostina M.B., Makarevich O.I., Broude N.E., Monastyrskaya G.S., Sverdlov E.D.
    FEBS Lett. 278:91-94(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 77-348 AND 681-780.
  8. "Multiple genes encode the human Na+,K+-ATPase catalytic subunit."
    Shull M.M., Lingrel J.B.
    Proc. Natl. Acad. Sci. U.S.A. 84:4039-4043(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 183-253.
  9. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 357-412.
  10. "Ouabain-sensitive H,K-ATPase: tissue-specific expression of the mammalian genes encoding the catalytic alpha subunit."
    Pestov N.B., Romanova L.G., Korneenko T.V., Egorov M.V., Kostina M.B., Sverdlov V.E., Askari A., Shakhparonov M.I., Modyanov N.N.
    FEBS Lett. 440:320-324(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  11. "Expression of the non-gastric H+/K+ ATPase ATP12A in normal and pathological human prostate tissue."
    Streif D., Iglseder E., Hauser-Kronberger C., Fink K.G., Jakab M., Ritter M.
    Cell. Physiol. Biochem. 28:1287-1294(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiAT12A_HUMAN
AccessioniPrimary (citable) accession number: P54707
Secondary accession number(s): Q13816
, Q13817, Q16734, Q5W035, Q8N5U2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 22, 2008
Last modified: November 26, 2014
This is version 153 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3