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P54707

- AT12A_HUMAN

UniProt

P54707 - AT12A_HUMAN

Protein

Potassium-transporting ATPase alpha chain 2

Gene

ATP12A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 151 (01 Oct 2014)
      Sequence version 3 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane. Responsible for potassium absorption in various tissues.

    Catalytic activityi

    ATP + H2O + H+(In) + K+(Out) = ADP + phosphate + H+(Out) + K+(In).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei391 – 39114-aspartylphosphate intermediateBy similarity
    Metal bindingi732 – 7321MagnesiumBy similarity
    Metal bindingi736 – 7361MagnesiumBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. hydrogen:potassium-exchanging ATPase activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. ATP biosynthetic process Source: InterPro
    2. ion transmembrane transport Source: Reactome
    3. potassium ion homeostasis Source: Ensembl
    4. regulation of pH Source: Ensembl
    5. transmembrane transport Source: Reactome

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Hydrogen ion transport, Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium

    Enzyme and pathway databases

    BRENDAi3.6.3.10. 2681.
    ReactomeiREACT_25149. Ion transport by P-type ATPases.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium-transporting ATPase alpha chain 2 (EC:3.6.3.10)
    Alternative name(s):
    Non-gastric H(+)/K(+) ATPase subunit alpha
    Proton pump
    Gene namesi
    Name:ATP12A
    Synonyms:ATP1AL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:13816. ATP12A.

    Subcellular locationi

    GO - Cellular componenti

    1. basolateral plasma membrane Source: Ensembl
    2. hydrogen:potassium-exchanging ATPase complex Source: ProtInc
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25104.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10391039Potassium-transporting ATPase alpha chain 2PRO_0000046260Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei958 – 9581Phosphoserine; by PKABy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP54707.
    PaxDbiP54707.
    PRIDEiP54707.

    PTM databases

    PhosphoSiteiP54707.

    Expressioni

    Tissue specificityi

    Found in skin and kidney. Detected in prostate basal cells (at protein level). Expression is increased in benign prostate hyperplasia and tumor tissues (at protein level).2 Publications

    Gene expression databases

    BgeeiP54707.
    CleanExiHS_ATP12A.
    GenevestigatoriP54707.

    Organism-specific databases

    HPAiHPA039526.

    Interactioni

    Subunit structurei

    Composed of two subunits: alpha (catalytic) and beta.

    Protein-protein interaction databases

    BioGridi106969. 5 interactions.
    IntActiP54707. 4 interactions.
    MINTiMINT-4656898.
    STRINGi9606.ENSP00000371372.

    Structurei

    3D structure databases

    ProteinModelPortaliP54707.
    SMRiP54707. Positions 48-1039.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 102102CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini124 – 14623LumenalSequence AnalysisAdd
    BLAST
    Topological domaini168 – 303136CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini324 – 33512LumenalSequence AnalysisAdd
    BLAST
    Topological domaini354 – 787434CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini808 – 81710LumenalSequence Analysis
    Topological domaini839 – 85820CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini882 – 93352LumenalSequence AnalysisAdd
    BLAST
    Topological domaini954 – 96714CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini987 – 100115LumenalSequence AnalysisAdd
    BLAST
    Topological domaini1023 – 103917CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei103 – 12321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei147 – 16721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei304 – 32320HelicalSequence AnalysisAdd
    BLAST
    Transmembranei336 – 35318HelicalSequence AnalysisAdd
    BLAST
    Transmembranei788 – 80720HelicalSequence AnalysisAdd
    BLAST
    Transmembranei818 – 83821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei859 – 88123HelicalSequence AnalysisAdd
    BLAST
    Transmembranei934 – 95320HelicalSequence AnalysisAdd
    BLAST
    Transmembranei968 – 98619HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1002 – 102221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0474.
    HOGENOMiHOG000265622.
    HOVERGENiHBG004298.
    KOiK01544.
    OMAiNLRVEWE.
    OrthoDBiEOG7327N0.
    PhylomeDBiP54707.
    TreeFamiTF312838.

    Family and domain databases

    Gene3Di1.20.1110.10. 2 hits.
    2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR005775. ATPase_P-typ_Na/K_IIC.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PfamiPF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view]
    PRINTSiPR00119. CATATPASE.
    SMARTiSM00831. Cation_ATPase_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 1 hit.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P54707-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MHQKTPEIYS VELSGTKDIV KTDKGDGKEK YRGLKNNCLE LKKKNHKEEF     50
    QKELHLDDHK LSNRELEEKY GTDIIMGLSS TRAAELLARD GPNSLTPPKQ 100
    TPEIVKFLKQ MVGGFSILLW VGAFLCWIAY GIQYSSDKSA SLNNVYLGCV 150
    LGLVVILTGI FAYYQEAKST NIMSSFNKMI PQQALVIRDS EKKTIPSEQL 200
    VVGDIVEVKG GDQIPADIRV LSSQGCRVDN SSLTGESEPQ PRSSEFTHEN 250
    PLETKNICFY STTCLEGTVT GMVINTGDRT IIGHIASLAS GVGNEKTPIA 300
    IEIEHFVHIV AGVAVSIGIL FFIIAVSLKY QVLDSIIFLI GIIVANVPEG 350
    LLATVTVTLS LTAKRMAKKN CLVKNLEAVE TLGSTSIICS DKTGTLTQNR 400
    MTVAHLWFDN QIFVADTSED HSNQVFDQSS RTWASLSKII TLCNRAEFKP 450
    GQENVPIMKK AVIGDASETA LLKFSEVILG DVMEIRKRNR KVAEIPFNST 500
    NKFQLSIHEM DDPHGKRFLM VMKGAPERIL EKCSTIMING EEHPLDKSTA 550
    KTFHTAYMEL GGLGERVLGF CHLYLPADEF PETYSFDIDA MNFPTSNLCF 600
    VGLLSMIDPP RSTVPDAVTK CRSAGIKVIM VTGDHPITAK AIAKSVGIIS 650
    ANSETVEDIA HRLNIAVEQV NKRDAKAAVV TGMELKDMSS EQLDEILANY 700
    QEIVFARTSP QQKLIIVEGC QRQDAVVAVT GDGVNDSPAL KKADIGIAMG 750
    IAGSDAAKNA ADMVLLDDNF ASIVTGVEEG RLIFDNLKKT IAYSLTKNIA 800
    ELCPFLIYII VGLPLPIGTI TILFIDLGTD IIPSIALAYE KAESDIMNRK 850
    PRHKNKDRLV NQPLAVYSYL HIGLMQALGA FLVYFTVYAQ EGFLPRTLIN 900
    LRVEWEKDYV NDLKDSYGQE WTRYQREYLE WTGYTAFFVG ILVQQIADLI 950
    IRKTRRNSIF QQGLFRNKVI WVGITSQIII GLILSYGLGS VTALSFTMLR 1000
    AQYWFVAVPH AILIWVYDEV RKLFIRLYPG SWWDKNMYY 1039
    Length:1,039
    Mass (Da):115,511
    Last modified:July 22, 2008 - v3
    Checksum:iC906897E11FA406C
    GO
    Isoform 2 (identifier: P54707-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         266-266: E → EASTSPV

    Note: No experimental confirmation available.

    Show »
    Length:1,045
    Mass (Da):116,053
    Checksum:i15088FC158FB580A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 31Q → QLFQ in AAC37589. (PubMed:8838794)Curated
    Sequence conflicti145 – 1451V → VRLWGVQV in CAA49477. (PubMed:1847115)Curated
    Sequence conflicti225 – 2273Missing in CAA49477. (PubMed:1847115)Curated
    Sequence conflicti266 – 2661E → V in CAA49477. (PubMed:1847115)Curated
    Sequence conflicti382 – 3821L → P in AAA35576. (PubMed:3036582)Curated
    Sequence conflicti724 – 7274DAVV → VGGQ in CAA49478. (PubMed:1847115)Curated
    Sequence conflicti772 – 7732SI → LH in CAA49478. (PubMed:1847115)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti863 – 8631P → L.
    Corresponds to variant rs2289909 [ dbSNP | Ensembl ].
    VAR_020186

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei266 – 2661E → EASTSPV in isoform 2. 1 PublicationVSP_034640

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U02076 mRNA. Translation: AAB37755.1.
    L42563
    , L42558, L42559, L42565, L42566, L42567, L42560, L42561, L42568, L42562, L42569 Genomic DNA. Translation: AAC37589.2.
    AK292968 mRNA. Translation: BAF85657.1.
    AL157364 Genomic DNA. Translation: CAH72440.1.
    CH471075 Genomic DNA. Translation: EAX08346.1.
    CH471075 Genomic DNA. Translation: EAX08345.1.
    BC031609 mRNA. Translation: AAH31609.1.
    X69823 Genomic DNA. Translation: CAA49477.1.
    X69824 Genomic DNA. Translation: CAA49478.1.
    M16797 mRNA. Translation: AAA51802.1.
    M27574 Genomic DNA. Translation: AAA35576.1.
    CCDSiCCDS31948.1. [P54707-1]
    CCDS53858.1. [P54707-2]
    PIRiA26641.
    D27795.
    E27397.
    I38401.
    S13028.
    S31504.
    RefSeqiNP_001172014.1. NM_001185085.1. [P54707-2]
    NP_001667.4. NM_001676.5. [P54707-1]
    UniGeneiHs.147111.

    Genome annotation databases

    EnsembliENST00000218548; ENSP00000218548; ENSG00000075673. [P54707-2]
    ENST00000381946; ENSP00000371372; ENSG00000075673. [P54707-1]
    GeneIDi479.
    KEGGihsa:479.
    UCSCiuc001upp.3. human. [P54707-1]
    uc010aaa.3. human. [P54707-2]

    Polymorphism databases

    DMDMi212287925.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U02076 mRNA. Translation: AAB37755.1 .
    L42563
    , L42558 , L42559 , L42565 , L42566 , L42567 , L42560 , L42561 , L42568 , L42562 , L42569 Genomic DNA. Translation: AAC37589.2 .
    AK292968 mRNA. Translation: BAF85657.1 .
    AL157364 Genomic DNA. Translation: CAH72440.1 .
    CH471075 Genomic DNA. Translation: EAX08346.1 .
    CH471075 Genomic DNA. Translation: EAX08345.1 .
    BC031609 mRNA. Translation: AAH31609.1 .
    X69823 Genomic DNA. Translation: CAA49477.1 .
    X69824 Genomic DNA. Translation: CAA49478.1 .
    M16797 mRNA. Translation: AAA51802.1 .
    M27574 Genomic DNA. Translation: AAA35576.1 .
    CCDSi CCDS31948.1. [P54707-1 ]
    CCDS53858.1. [P54707-2 ]
    PIRi A26641.
    D27795.
    E27397.
    I38401.
    S13028.
    S31504.
    RefSeqi NP_001172014.1. NM_001185085.1. [P54707-2 ]
    NP_001667.4. NM_001676.5. [P54707-1 ]
    UniGenei Hs.147111.

    3D structure databases

    ProteinModelPortali P54707.
    SMRi P54707. Positions 48-1039.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106969. 5 interactions.
    IntActi P54707. 4 interactions.
    MINTi MINT-4656898.
    STRINGi 9606.ENSP00000371372.

    Chemistry

    BindingDBi P54707.
    ChEMBLi CHEMBL2933.

    PTM databases

    PhosphoSitei P54707.

    Polymorphism databases

    DMDMi 212287925.

    Proteomic databases

    MaxQBi P54707.
    PaxDbi P54707.
    PRIDEi P54707.

    Protocols and materials databases

    DNASUi 479.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000218548 ; ENSP00000218548 ; ENSG00000075673 . [P54707-2 ]
    ENST00000381946 ; ENSP00000371372 ; ENSG00000075673 . [P54707-1 ]
    GeneIDi 479.
    KEGGi hsa:479.
    UCSCi uc001upp.3. human. [P54707-1 ]
    uc010aaa.3. human. [P54707-2 ]

    Organism-specific databases

    CTDi 479.
    GeneCardsi GC13P025254.
    HGNCi HGNC:13816. ATP12A.
    HPAi HPA039526.
    MIMi 182360. gene.
    neXtProti NX_P54707.
    PharmGKBi PA25104.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0474.
    HOGENOMi HOG000265622.
    HOVERGENi HBG004298.
    KOi K01544.
    OMAi NLRVEWE.
    OrthoDBi EOG7327N0.
    PhylomeDBi P54707.
    TreeFami TF312838.

    Enzyme and pathway databases

    BRENDAi 3.6.3.10. 2681.
    Reactomei REACT_25149. Ion transport by P-type ATPases.

    Miscellaneous databases

    GeneWikii ATP12A.
    GenomeRNAii 479.
    NextBioi 1985.
    PROi P54707.
    SOURCEi Search...

    Gene expression databases

    Bgeei P54707.
    CleanExi HS_ATP12A.
    Genevestigatori P54707.

    Family and domain databases

    Gene3Di 1.20.1110.10. 2 hits.
    2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR005775. ATPase_P-typ_Na/K_IIC.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    Pfami PF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view ]
    PRINTSi PR00119. CATATPASE.
    SMARTi SM00831. Cation_ATPase_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 1 hit.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of the entire cDNA encoded by ATP1AL1 --a member of the human Na,K/H,K-ATPase gene family."
      Grishin A.V., Sverdlov V.E., Kostina M.B., Modyanov N.N.
      FEBS Lett. 349:144-150(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Kidney and Skin.
    2. "Genomic organization of the human ATP1AL1 gene encoding a ouabain-sensitive H,K-ATPase."
      Sverdlov V.E., Kostina M.B., Modyanov N.N.
      Genomics 32:317-327(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Trachea.
    4. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    7. "The family of human Na,K-ATPase genes. ATP1AL1 gene is transcriptionally competent and probably encodes the related ion transport ATPase."
      Modyanov N.N., Petrukhin K.E., Sverdlov V.E., Grishin A.V., Orlova M.Y., Kostina M.B., Makarevich O.I., Broude N.E., Monastyrskaya G.S., Sverdlov E.D.
      FEBS Lett. 278:91-94(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 77-348 AND 681-780.
    8. "Multiple genes encode the human Na+,K+-ATPase catalytic subunit."
      Shull M.M., Lingrel J.B.
      Proc. Natl. Acad. Sci. U.S.A. 84:4039-4043(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 183-253.
    9. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 357-412.
    10. "Ouabain-sensitive H,K-ATPase: tissue-specific expression of the mammalian genes encoding the catalytic alpha subunit."
      Pestov N.B., Romanova L.G., Korneenko T.V., Egorov M.V., Kostina M.B., Sverdlov V.E., Askari A., Shakhparonov M.I., Modyanov N.N.
      FEBS Lett. 440:320-324(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    11. "Expression of the non-gastric H+/K+ ATPase ATP12A in normal and pathological human prostate tissue."
      Streif D., Iglseder E., Hauser-Kronberger C., Fink K.G., Jakab M., Ritter M.
      Cell. Physiol. Biochem. 28:1287-1294(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiAT12A_HUMAN
    AccessioniPrimary (citable) accession number: P54707
    Secondary accession number(s): Q13816
    , Q13817, Q16734, Q5W035, Q8N5U2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 151 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3