UniProtKB - P54697 (MYOJ_DICDI)
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Protein
Myosin-J heavy chain
Gene
myoJ
Organism
Dictyostelium discoideum (Slime mold)
Status
Functioni
Processive motor protein that can move over long distances along F-actin without disassociating; processiveness depends on high physiological Mg2+ concentrations. Presents a high actin affinity in the presence of ADP, fast ATP hydrolysis, and a high steady-state ATPase activity in the presence of actin that is rate limited by ADP release. Physiological decrease of free Mg2+ ions leads to an increased rate of ADP release and shortening of the fraction of time it spends in the strong acting binding states.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 174 – 181 | ATPSequence analysis | 8 |
GO - Molecular functioni
- actin-dependent ATPase activity Source: dictyBase
- actin filament binding Source: dictyBase
- ADP binding Source: dictyBase
- ATP binding Source: dictyBase
- calmodulin binding Source: UniProtKB-KW
- microfilament motor activity Source: dictyBase
- microtubule binding Source: InterPro
- microtubule motor activity Source: InterPro
GO - Biological processi
- actin-myosin filament sliding Source: dictyBase
- establishment of contractile vacuole localization Source: dictyBase
- microtubule-based movement Source: InterPro
Keywordsi
Molecular function | Actin-binding, Calmodulin-binding, Motor protein, Myosin |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Myosin-J heavy chainAlternative name(s): Myosin-5b |
Gene namesi | Name:myoJ Synonyms:myo5B ORF Names:DDB_G0272112 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Mycetozoa › Dictyostelids › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0272112. myoJ. |
Subcellular locationi
- Contractile vacuole 1 Publication
GO - Cellular componenti
- actomyosin Source: dictyBase
- contractile vacuole Source: dictyBase
- myosin complex Source: UniProtKB-KW
Keywords - Cellular componenti
VacuolePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000123372 | 1 – 2245 | Myosin-J heavy chainAdd BLAST | 2245 |
Proteomic databases
PaxDbi | P54697. |
Interactioni
Subunit structurei
Homodimer that associates with six light chains.
GO - Molecular functioni
- actin filament binding Source: dictyBase
- calmodulin binding Source: UniProtKB-KW
- microtubule binding Source: InterPro
Protein-protein interaction databases
STRINGi | 44689.DDB0185050. |
Chemistry databases
BindingDBi | P54697. |
Structurei
3D structure databases
ProteinModelPortali | P54697. |
SMRi | P54697. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 77 | Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST | 53 | |
Domaini | 81 – 821 | Myosin motorPROSITE-ProRule annotationAdd BLAST | 741 | |
Domaini | 824 – 851 | IQ 1PROSITE-ProRule annotationAdd BLAST | 28 | |
Domaini | 872 – 901 | IQ 2PROSITE-ProRule annotationAdd BLAST | 30 | |
Domaini | 943 – 972 | IQ 3PROSITE-ProRule annotationAdd BLAST | 30 | |
Domaini | 1969 – 2188 | DilutePROSITE-ProRule annotationAdd BLAST | 220 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 669 – 749 | Actin-bindingAdd BLAST | 81 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 973 – 1812 | Sequence analysisAdd BLAST | 840 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG0160. Eukaryota. COG5022. LUCA. |
InParanoidi | P54697. |
OMAi | RPMNPPK. |
PhylomeDBi | P54697. |
Family and domain databases
Gene3Di | 2.30.30.360. 1 hit. 3.40.850.10. 4 hits. |
InterProi | View protein in InterPro IPR002710. Dilute_dom. IPR000048. IQ_motif_EF-hand-BS. IPR036961. Kinesin_motor_dom_sf. IPR001609. Myosin_head_motor_dom. IPR004009. Myosin_N. IPR008989. Myosin_S1_N. IPR027417. P-loop_NTPase. |
Pfami | View protein in Pfam PF01843. DIL. 1 hit. PF00612. IQ. 3 hits. PF00063. Myosin_head. 1 hit. PF02736. Myosin_N. 1 hit. |
PRINTSi | PR00193. MYOSINHEAVY. |
SMARTi | View protein in SMART SM01132. DIL. 1 hit. SM00015. IQ. 3 hits. SM00242. MYSc. 1 hit. |
SUPFAMi | SSF52540. SSF52540. 2 hits. |
PROSITEi | View protein in PROSITE PS51126. DILUTE. 1 hit. PS50096. IQ. 3 hits. PS51456. MYOSIN_MOTOR. 1 hit. PS51844. SH3_LIKE. 1 hit. |
i Sequence
Sequence statusi: Complete.
P54697-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTTSTIENGA SSPIIVSSST PKLYQEGAGV WIPDQELGWI GADVIEHSET
60 70 80 90 100
SADQVLVRTE DDREVKIPLS KVFQKNPDIL EGVDDLSFLS HLHEPAILHN
110 120 130 140 150
LHHRYNLNQI YTYIGKILIA INPYTSLPLY GKEMISAYYG KQLGTLAPHV
160 170 180 190 200
YAVAEDAFKD MRYDGTSQSI LVSGESGAGK TETTKFLLQY FAAMGNMIKE
210 220 230 240 250
STSSSSINGI NTSSDGIPVT PPPSPMKKSP VDKSVEERVL ESTPLLEAFG
260 270 280 290 300
NAKTLRNDNS SRFGKFIEIH FNEMGSIIGA KILTYLLEKS RIVRQVYNER
310 320 330 340 350
NYHIFYQLLS GASEELKEKL NLKTIEEYSY LNKSGCFEIE GVSDEEHFNK
360 370 380 390 400
TCHAMQVAGI TLVEQENVFR ILSAILLIGN FEFENIAGSN DDSCQLIDRD
410 420 430 440 450
PLEKVSVLLG CAQPDELLNS MLTRKVVTGK ESYISHNTKE RAENARDSLS
460 470 480 490 500
MFLYGMMFDW LVVKINSSMS ISTQQKSKSF IGVLDIYGFE SFEVNGFEQF
510 520 530 540 550
CINYANEKLQ QLFNQHVFKE EQQEYIKEKI DWSYIDFNDN QDTLDLIEKK
560 570 580 590 600
PICILTLLDE ETMFPKATPQ TLATKLYSKM TSHSKFEKPR FSSTAFTINH
610 620 630 640 650
YAGKVTYETD QFLDKNKDFI IPEQISILQR SNFSFIKVLM SHSDKFTQSP
660 670 680 690 700
GGHPQGNGGP TSSNTKGTSG SSSMKFLSVG SQFSTSLATL MKTISTTTPH
710 720 730 740 750
YVRCIKPNPE KLPQTFNKQD VIHQLRCGGV MESVRICCAG FPTRRLLSEF
760 770 780 790 800
YQRYKILYVK DINTGSGGGK KGSNNNKIKD PKILVQNLLT GIELSDDKYK
810 820 830 840 850
IGLTKVFLRA GQLASLEDMR LEQLDRSATV IQKRWKGYLY RKRYKQLRDA
860 870 880 890 900
SLIIQTKLRS VHAKQQLSAL QRTHSAILIQ KVWRAHRDRV QYQKIRDASL
910 920 930 940 950
QLQTVMRRHL FSEQVHRERC ENAAIILQTK IRQILSKREV DKKLRGIILI
960 970 980 990 1000
QARWRMKLAK RVYIQLRAEA RSLRTVQEQK NKLQEKLEEL QWRLTSEAKR
1010 1020 1030 1040 1050
KQQLEDQKVK SDTTISELSS NNDHLELQLS EIQLKYQELD KSNQSSQLQL
1060 1070 1080 1090 1100
SECLSKLEEQ TQQLDHSSKL NKKLEKDLSD QHDSIEKLQS QFNETEQQLQ
1110 1120 1130 1140 1150
QFKQQSEELS SKLSKTTQQL DFNKQEFDRL SQERDTDNTN NQLEIQQLKK
1160 1170 1180 1190 1200
ANSTLEEDYF SLSGIRDNLE RQVLELRDEN QLIKERLDSL GQQSSQFQSG
1210 1220 1230 1240 1250
AALEKQQLEQ LVQEQSEQLI KLSSEKLGSE EEAKKQINQL ELELTDHKSK
1260 1270 1280 1290 1300
LQIQLQLTEQ SNEKIKKLKG KLEEYQDEKK QLQQELERIK QSKQSVEDEK
1310 1320 1330 1340 1350
NSLITQLTTV KFESTQVSTN VSHQKEKITT LKSTIEELNK SIGKLQAEQK
1360 1370 1380 1390 1400
NKDDEIRKIQ FELNDQKQQF TRQTKEFSDL QSQQSIDRQK SEITIHSLER
1410 1420 1430 1440 1450
TNETLKSDFE RVQQSLKQQE RDCQQYKDTI NRLENEVKQL TQLKERFENE
1460 1470 1480 1490 1500
FFVAKEQNSN QTQESVYLKE VTTQMQQNQS RIERELEEKK QHITRIDDER
1510 1520 1530 1540 1550
DELKKQLTQL QQQHEQSSTQ LLLAQNELER LRKKELKYKE RGHETSKQQD
1560 1570 1580 1590 1600
QFNMEIQSLR ITNNDQLKSL QDYEQEKKKL KDKLSSSKQE AQQQRESIIK
1610 1620 1630 1640 1650
MDAELSAIKQ HSQWVENSFT DMKQRNQELI ESSALYKQQL LQQTSTIDST
1660 1670 1680 1690 1700
IKEKENEISK LQQQLETSNQ QLHQLKEELN SMKQSNQLES TEQSKQLNQL
1710 1720 1730 1740 1750
IQENQQLKSV TNEISKQLDD AVFENQKINN TIKEQEIKSK RMSVELQQHI
1760 1770 1780 1790 1800
DEGKQQEIQQ LQSTIAQLKQ QQQSETDRLE KEIQQMKRER ETQMKLVEST
1810 1820 1830 1840 1850
KLNYHMLEDR MELYRNVMEI IDYKETEWEK LARLAGCKEL DTKLLSDFLL
1860 1870 1880 1890 1900
SCKLEHTSLG SQMWFHQIDY WCPYERDSSK GIFYGIIRSI VDFTIKNFDD
1910 1920 1930 1940 1950
VDLLSYLLAC CSLTLFLYKK NLVKHLNGAN SIMPIIPTLG DLEELNERLS
1960 1970 1980 1990 2000
HQSLTTSGKF SGGGGGGGID FIDQLQQSTG ITFGLIFKAT TLKLSPLVDG
2010 2020 2030 2040 2050
AILNENYNKK LTSISASSFG SGSFGLGSNG VGSVLSIELI TTYLSSIITI
2060 2070 2080 2090 2100
FQHRMVHFTL SQRFFNQVFC WIGALIMKGF MLRQTFCTET FATFVKTKID
2110 2120 2130 2140 2150
FLTRWADDIG NVWVGDVANA FQQVREVINV LNIKDKEKII DDKIRKQYCP
2160 2170 2180 2190 2200
TLNSNQLKQV LSLFSPGEFG GKRVSAKVIA SICPPNKSSA GQSFVQDENK
2210 2220 2230 2240
LNTIPIDSLH YLEIQDIKTL SLPLSIRQTI ETEIINLKQQ IACKK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 191 | F → L in AAA85186 (PubMed:8636147).Curated | 1 | |
Sequence conflicti | 284 | T → A in AAA85186 (PubMed:8636147).Curated | 1 | |
Sequence conflicti | 291 | R → G in AAA85186 (PubMed:8636147).Curated | 1 | |
Sequence conflicti | 332 – 347 | NKSGC…SDEEH → IEWMFELKVYRMKS in AAA79858 (PubMed:8884597).CuratedAdd BLAST | 16 | |
Sequence conflicti | 550 | K → N in AAA85186 (PubMed:8636147).Curated | 1 | |
Sequence conflicti | 865 – 866 | QQ → HH in AAA85186 (PubMed:8636147).Curated | 2 | |
Sequence conflicti | 1041 | K → N in AAA85186 (PubMed:8636147).Curated | 1 | |
Sequence conflicti | 1389 | Q → P in AAA85186 (PubMed:8636147).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U42409 Genomic DNA. Translation: AAA85186.1. AAFI02000008 Genomic DNA. Translation: EAL71208.1. L35322 Genomic DNA. Translation: AAA79858.1. |
PIRi | T18278. |
RefSeqi | XP_645195.1. XM_640103.1. |
Genome annotation databases
EnsemblProtistsi | EAL71208; EAL71208; DDB_G0272112. |
GeneIDi | 8618367. |
KEGGi | ddi:DDB_G0272112. |
Entry informationi
Entry namei | MYOJ_DICDI | |
Accessioni | P54697Primary (citable) accession number: P54697 Secondary accession number(s): Q559Y9, Q86A36 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | December 4, 2007 | |
Last modified: | March 28, 2018 | |
This is version 111 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |