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Protein

Branched-chain-amino-acid aminotransferase, cytosolic

Gene

Bcat1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.

Catalytic activityi

L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.
L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate.
L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate.

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processAmino-acid biosynthesis, Branched-chain amino acid biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-RNO-70895 Branched-chain amino acid catabolism
SABIO-RKiP54690

Names & Taxonomyi

Protein namesi
Recommended name:
Branched-chain-amino-acid aminotransferase, cytosolic (EC:2.6.1.42)
Short name:
BCAT(c)
Gene namesi
Name:Bcat1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi2195 Bcat1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4678

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001032941 – 411Branched-chain-amino-acid aminotransferase, cytosolicAdd BLAST411

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei247N6-(pyridoxal phosphate)lysineBy similarity1

Post-translational modificationi

The N-terminus is blocked.

Proteomic databases

PaxDbiP54690
PRIDEiP54690

PTM databases

iPTMnetiP54690
PhosphoSitePlusiP54690
SwissPalmiP54690

Expressioni

Tissue specificityi

Brain, low expression in ovary and placenta, but not found in liver, kidney, and skeletal muscle.

Gene expression databases

BgeeiENSRNOG00000015514
ExpressionAtlasiP54690 baseline and differential
GenevisibleiP54690 RN

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

  • identical protein binding Source: RGD

Protein-protein interaction databases

BioGridi248224, 1 interactor
STRINGi10116.ENSRNOP00000021193

Chemistry databases

BindingDBiP54690

Structurei

3D structure databases

ProteinModelPortaliP54690
SMRiP54690
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi26 – 31Poly-Glu6

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0975 Eukaryota
COG0115 LUCA
GeneTreeiENSGT00390000009532
HOGENOMiHOG000276704
HOVERGENiHBG050678
InParanoidiP54690
KOiK00826
OMAiTICTDHM
OrthoDBiEOG091G07KO
PhylomeDBiP54690
TreeFamiTF300882

Family and domain databases

CDDicd01557 BCAT_beta_family, 1 hit
InterProiView protein in InterPro
IPR001544 Aminotrans_IV
IPR018300 Aminotrans_IV_CS
IPR036038 Aminotransferase-like
IPR005786 B_amino_transII
IPR033939 BCAT_family
PfamiView protein in Pfam
PF01063 Aminotran_4, 1 hit
PIRSFiPIRSF006468 BCAT1, 1 hit
SUPFAMiSSF56752 SSF56752, 1 hit
TIGRFAMsiTIGR01123 ilvE_II, 1 hit
PROSITEiView protein in PROSITE
PS00770 AA_TRANSFER_CLASS_4, 1 hit

Sequencei

Sequence statusi: Complete.

P54690-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYLSRATAT LARQDCSNGC SASYAEEEEL EASTESYDEE GGSEASTQTF
60 70 80 90 100
RAKDLIITKA DVLKKKPDPS SLVFGASFTD HMLMVEWTSK YGWDKPHIKP
110 120 130 140 150
FENLSIHPAA SVLHYAVELF EGLKAFRGVD NKIRLFRPDL NMKRMCRSAV
160 170 180 190 200
RTTLPEFDKE ELLQCVLQLI QLDREWVPYS TSASLYIRPT FIGIEPSLGV
210 220 230 240 250
KKPSKALLFV ILSPVGSYFS NGTFSPVSLW ANPKFVRSWK GGTGDFKMGC
260 270 280 290 300
NYGSSLLAQC EAAENGCHQV LWLYGKENRI TEVGTMNLFL YWINKDGEEE
310 320 330 340 350
LATPPLDGVI LPGVTRQSIL ELGEEWGEFK VCERHITMDD LSTALEENRV
360 370 380 390 400
KEMFGSGTAC VVCPVASILY KGQMLHIPTM ENGHKLSSRI MAKLTDIQYG
410
RIKSEWTLEL P
Length:411
Mass (Da):46,046
Last modified:October 1, 1996 - v1
Checksum:i98030737376F1DB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35774 mRNA Translation: AAC52385.1
BC087710 mRNA Translation: AAH87710.1
RefSeqiNP_058949.1, NM_017253.2
UniGeneiRn.8273

Genome annotation databases

EnsembliENSRNOT00000021193; ENSRNOP00000021193; ENSRNOG00000015514
GeneIDi29592
KEGGirno:29592
UCSCiRGD:2195 rat

Similar proteinsi

Entry informationi

Entry nameiBCAT1_RAT
AccessioniPrimary (citable) accession number: P54690
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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