Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cyclin-dependent kinase 7

Gene

cdk7

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic part of CAK which activates cyclin-associated CDK1/CDK2/CDK4 by threonine phosphorylation, thereby allowing MPF activation.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei130Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, Cell division, Meiosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22 1939
ReactomeiR-DDI-113418 Formation of the Early Elongation Complex
R-DDI-5696395 Formation of Incision Complex in GG-NER
R-DDI-674695 RNA Polymerase II Pre-transcription Events
R-DDI-6781823 Formation of TC-NER Pre-Incision Complex
R-DDI-6782135 Dual incision in TC-NER
R-DDI-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-DDI-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-DDI-6807505 RNA polymerase II transcribes snRNA genes
R-DDI-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-DDI-72086 mRNA Capping
R-DDI-73776 RNA Polymerase II Promoter Escape
R-DDI-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-DDI-75953 RNA Polymerase II Transcription Initiation
R-DDI-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-DDI-77075 RNA Pol II CTD phosphorylation and interaction with CE

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 7 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
CDK-activating kinase
Short name:
CAK
Cell division protein kinase 7
MO15 homolog
Gene namesi
Name:cdk7
Synonyms:cdcC, cdcD, mo15
ORF Names:DDB_G0285417
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0285417 cdk7

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000857961 – 360Cyclin-dependent kinase 7Add BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei157PhosphoserineBy similarity1
Modified residuei163PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP54685
PRIDEiP54685

Expressioni

Developmental stagei

Only expressed during vegetative cell growth.

Interactioni

Subunit structurei

Probably associates with cyclin H and mat1 to form a multimeric active enzyme.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0191429

Structurei

3D structure databases

ProteinModelPortaliP54685
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 288Protein kinasePROSITE-ProRule annotationAdd BLAST285

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi326 – 342Poly-GlnAdd BLAST17

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0659 Eukaryota
ENOG410XQDH LUCA
InParanoidiP54685
KOiK02202
OMAiADIKAWM
PhylomeDBiP54685

Family and domain databases

InterProiView protein in InterPro
IPR037770 CDK7
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR24056:SF0 PTHR24056:SF0, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

P54685-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKYNIEALI GEGTYGVVSR ATVKATGQIV AIKKIRKILI QNQTDDGINF
60 70 80 90 100
SAIREIKILQ ELKHDNVVNL LDIFAHKSNV YLVFELMQWD LQEVIEDKSI
110 120 130 140 150
ILKPADIKSY MKMLLQGIEA CHRNWVLHRD LKPNNLLMSI NGDLKLADFG
160 170 180 190 200
LARQYGSPNK VFSPQAVTIF YRAPELLFGA KSYGPSVDIW SIGCIFAELM
210 220 230 240 250
LRTPYLPGTG EIDQLRKICS ALGTPNESNW PGVTCLPNYI KFTDHPATPF
260 270 280 290 300
KQLFTAASDE AIDLISKMLL FNPSNRISAA DALNHPYFTS GVKHTNPADL
310 320 330 340 350
PVPFAKKASL LQQRQVLAQV QQQLLQKQQQ QQQQQQQQIQ SQPEPIQVDN
360
VEQTQQAQQV
Length:360
Mass (Da):40,567
Last modified:December 4, 2007 - v2
Checksum:iF6FE0441F21D6B37
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti360V → VKK in AAB35208 (PubMed:7662315).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S79590 mRNA Translation: AAB35208.2
AAFI02000079 Genomic DNA Translation: EAL64546.1
RefSeqiXP_638229.1, XM_633137.1

Genome annotation databases

EnsemblProtistsiEAL64546; EAL64546; DDB_G0285417
GeneIDi8625277
KEGGiddi:DDB_G0285417

Similar proteinsi

Entry informationi

Entry nameiCDK7_DICDI
AccessioniPrimary (citable) accession number: P54685
Secondary accession number(s): Q54MR4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 4, 2007
Last modified: March 28, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health