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Protein

Fimbrin

Gene

fimA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to actin.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi20 – 311PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi56 – 672PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • actin filament binding Source: dictyBase
  • calcium ion binding Source: dictyBase

GO - Biological processi

  • actin crosslink formation Source: GO_Central
  • actin filament bundle assembly Source: dictyBase
  • actin filament network formation Source: GO_Central
  • sexual reproduction Source: dictyBase

Keywordsi

Molecular functionActin-binding
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fimbrin
Gene namesi
Name:fimA
ORF Names:DDB_G0277855
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0277855 fimA

Subcellular locationi

GO - Cellular componenti

  • actin filament Source: GO_Central
  • actin filament bundle Source: GO_Central
  • cell leading edge Source: dictyBase
  • lamellipodium Source: dictyBase
  • phagocytic cup Source: dictyBase
  • phagocytic vesicle Source: dictyBase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000737521 – 610FimbrinAdd BLAST610

Proteomic databases

PaxDbiP54680
PRIDEiP54680

Interactioni

GO - Molecular functioni

  • actin filament binding Source: dictyBase

Protein-protein interaction databases

STRINGi44689.DDB0214994

Structurei

3D structure databases

ProteinModelPortaliP54680
SMRiP54680
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 42EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini43 – 78EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini116 – 232Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST117
Domaini260 – 365Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST106
Domaini379 – 488Calponin-homology (CH) 3PROSITE-ProRule annotationAdd BLAST110
Domaini501 – 608Calponin-homology (CH) 4PROSITE-ProRule annotationAdd BLAST108

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni102 – 365Actin-binding 1Add BLAST264
Regioni366 – 608Actin-binding 2Add BLAST243

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0046 Eukaryota
COG5069 LUCA
InParanoidiP54680
KOiK17276
OMAiMFDECKD
PhylomeDBiP54680

Family and domain databases

CDDicd00014 CH, 3 hits
cd00051 EFh, 1 hit
Gene3Di1.10.418.10, 4 hits
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF00307 CH, 4 hits
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00033 CH, 4 hits
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
SSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 2 hits
PS00020 ACTININ_2, 2 hits
PS50021 CH, 4 hits
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits

Sequencei

Sequence statusi: Complete.

P54680-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNFSESEIS EFKASFNQFD ENGDGQISAL ELQKILTKCG EKVTGVEVRD
60 70 80 90 100
MIKEVDTDGN GSIDFKEFLQ VMQKARQHSA NASPAFASAV KKVGAVNTIG
110 120 130 140 150
GYSGSTASGV QHSYSDEEKV AYIDWINNCL AKDVDLKSRL PIPEDGDKFF
160 170 180 190 200
AACNDGLLLC KLINDAVPDT IDERVLNKKN LNAFRINENQ VLCINSAKAI
210 220 230 240 250
GCNVVNIGAG DLVEGRAHLI MGLTWQIIKI GLFARINLTN HPELYRLLHD
260 270 280 290 300
GETIEDLLKL PVEEILLRWF NYHLAAAGSQ RRVKNFSGDI KDSECYTILL
310 320 330 340 350
KQIAPKDAGV ETSALNISNL DQRAVKVLEN ADKLGCKKFL KPKDIVTGFQ
360 370 380 390 400
KLNLAFVANL FNTHPALEPV EDVVIIEETR EEKTFRNWMN SLGVDPFVNN
410 420 430 440 450
LYEGTYDGLI LIQLFDKIYP GLVDHKKVNY PPYKAMGAEM KKIENCNYAI
460 470 480 490 500
QLGKDCKYSL VGIDGKNVYD KNKTLTLSIL WQLMRGHVIS ILTALSGSGK
510 520 530 540 550
PIADADIVNW TNSKLSAAGK KQISGFKDST ISTGIPILDV IEAVRPGSVD
560 570 580 590 600
PALVATSGSA EDNLLNAKLA VSTARKVGAV VFALPEDIVE VKPKMVLTLF
610
ASLWQVEMTK
Length:610
Mass (Da):67,092
Last modified:December 4, 2007 - v2
Checksum:iA497D1F987AFD904
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti510 – 511WT → VA in AAA75489 (Ref. 1) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36202 mRNA Translation: AAA75489.1
AAFI02000023 Genomic DNA Translation: EAL68100.1
RefSeqiXP_642085.1, XM_636993.1

Genome annotation databases

EnsemblProtistsiEAL68100; EAL68100; DDB_G0277855
GeneIDi8621298
KEGGiddi:DDB_G0277855

Similar proteinsi

Entry informationi

Entry nameiFIMB_DICDI
AccessioniPrimary (citable) accession number: P54680
Secondary accession number(s): Q54YW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 4, 2007
Last modified: May 23, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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