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Protein

Fimbrin

Gene

fimA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to actin.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi20 – 311PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi56 – 672PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • actin filament binding Source: dictyBase
  • calcium ion binding Source: dictyBase

GO - Biological processi

  • actin crosslink formation Source: GO_Central
  • actin filament bundle assembly Source: dictyBase
  • actin filament network formation Source: GO_Central
  • sexual reproduction Source: dictyBase
Complete GO annotation...

Keywords - Ligandi

Actin-binding, Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fimbrin
Gene namesi
Name:fimA
ORF Names:DDB_G0277855
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0277855. fimA.

Subcellular locationi

GO - Cellular componenti

  • actin filament Source: GO_Central
  • actin filament bundle Source: GO_Central
  • cell leading edge Source: dictyBase
  • lamellipodium Source: dictyBase
  • phagocytic cup Source: dictyBase
  • phagocytic vesicle Source: dictyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000737521 – 610FimbrinAdd BLAST610

Proteomic databases

PaxDbiP54680.

Interactioni

GO - Molecular functioni

  • actin filament binding Source: dictyBase

Protein-protein interaction databases

STRINGi44689.DDB0214994.

Structurei

3D structure databases

ProteinModelPortaliP54680.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 42EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini43 – 78EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini102 – 365Actin-binding 1Add BLAST264
Domaini116 – 232CH 1PROSITE-ProRule annotationAdd BLAST117
Domaini260 – 365CH 2PROSITE-ProRule annotationAdd BLAST106
Domaini366 – 608Actin-binding 2Add BLAST243
Domaini379 – 488CH 3PROSITE-ProRule annotationAdd BLAST110
Domaini501 – 608CH 4PROSITE-ProRule annotationAdd BLAST108

Sequence similaritiesi

Contains 2 actin-binding domains.Curated
Contains 4 CH (calponin-homology) domains.PROSITE-ProRule annotation
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0046. Eukaryota.
COG5069. LUCA.
InParanoidiP54680.
KOiK17276.
OMAiPQDIVEG.
PhylomeDBiP54680.

Family and domain databases

CDDicd00014. CH. 3 hits.
cd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
1.10.418.10. 4 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF00307. CH. 4 hits.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 4 hits.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF47576. SSF47576. 1 hit.
PROSITEiPS00019. ACTININ_1. 2 hits.
PS00020. ACTININ_2. 2 hits.
PS50021. CH. 4 hits.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54680-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNFSESEIS EFKASFNQFD ENGDGQISAL ELQKILTKCG EKVTGVEVRD
60 70 80 90 100
MIKEVDTDGN GSIDFKEFLQ VMQKARQHSA NASPAFASAV KKVGAVNTIG
110 120 130 140 150
GYSGSTASGV QHSYSDEEKV AYIDWINNCL AKDVDLKSRL PIPEDGDKFF
160 170 180 190 200
AACNDGLLLC KLINDAVPDT IDERVLNKKN LNAFRINENQ VLCINSAKAI
210 220 230 240 250
GCNVVNIGAG DLVEGRAHLI MGLTWQIIKI GLFARINLTN HPELYRLLHD
260 270 280 290 300
GETIEDLLKL PVEEILLRWF NYHLAAAGSQ RRVKNFSGDI KDSECYTILL
310 320 330 340 350
KQIAPKDAGV ETSALNISNL DQRAVKVLEN ADKLGCKKFL KPKDIVTGFQ
360 370 380 390 400
KLNLAFVANL FNTHPALEPV EDVVIIEETR EEKTFRNWMN SLGVDPFVNN
410 420 430 440 450
LYEGTYDGLI LIQLFDKIYP GLVDHKKVNY PPYKAMGAEM KKIENCNYAI
460 470 480 490 500
QLGKDCKYSL VGIDGKNVYD KNKTLTLSIL WQLMRGHVIS ILTALSGSGK
510 520 530 540 550
PIADADIVNW TNSKLSAAGK KQISGFKDST ISTGIPILDV IEAVRPGSVD
560 570 580 590 600
PALVATSGSA EDNLLNAKLA VSTARKVGAV VFALPEDIVE VKPKMVLTLF
610
ASLWQVEMTK
Length:610
Mass (Da):67,092
Last modified:December 4, 2007 - v2
Checksum:iA497D1F987AFD904
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti510 – 511WT → VA in AAA75489 (Ref. 1) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36202 mRNA. Translation: AAA75489.1.
AAFI02000023 Genomic DNA. Translation: EAL68100.1.
RefSeqiXP_642085.1. XM_636993.1.

Genome annotation databases

EnsemblProtistsiEAL68100; EAL68100; DDB_G0277855.
GeneIDi8621298.
KEGGiddi:DDB_G0277855.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36202 mRNA. Translation: AAA75489.1.
AAFI02000023 Genomic DNA. Translation: EAL68100.1.
RefSeqiXP_642085.1. XM_636993.1.

3D structure databases

ProteinModelPortaliP54680.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0214994.

Proteomic databases

PaxDbiP54680.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL68100; EAL68100; DDB_G0277855.
GeneIDi8621298.
KEGGiddi:DDB_G0277855.

Organism-specific databases

dictyBaseiDDB_G0277855. fimA.

Phylogenomic databases

eggNOGiKOG0046. Eukaryota.
COG5069. LUCA.
InParanoidiP54680.
KOiK17276.
OMAiPQDIVEG.
PhylomeDBiP54680.

Miscellaneous databases

PROiP54680.

Family and domain databases

CDDicd00014. CH. 3 hits.
cd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
1.10.418.10. 4 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF00307. CH. 4 hits.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 4 hits.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF47576. SSF47576. 1 hit.
PROSITEiPS00019. ACTININ_1. 2 hits.
PS00020. ACTININ_2. 2 hits.
PS50021. CH. 4 hits.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFIMB_DICDI
AccessioniPrimary (citable) accession number: P54680
Secondary accession number(s): Q54YW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 4, 2007
Last modified: November 30, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.