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Reviewed, UniProtKB/Swiss-Prot P54677 (PI4K_DICDI)

Last modified February 9, 2010. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Phosphatidylinositol 4-kinase
      Short name=PtdIns-4-kinase
      Short name=PI4-kinase
    EC=2.7.1.67
Alternative name(s):
    PI4K-alpha
Gene names
Name: pikD
Synonyms: pik4
ORF Names: DDB_G0288485
OrganismDictyostelium discoideum (Slime mold) [Complete proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length1180 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate.

Catalytic activity

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.

Sequence similarities

Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

Contains 1 PI3K/PI4K domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11801180Phosphatidylinositol 4-kinase
PRO_0000088826

Regions

Domain919 – 1178260PI3K/PI4K
Compositional bias21 – 277Poly-Asn
Compositional bias38 – 436Poly-Asn
Compositional bias62 – 698Poly-Ser
Compositional bias70 – 745Poly-Asn
Compositional bias233 – 2386Poly-Asp
Compositional bias271 – 28717Poly-Asn
Compositional bias290 – 2934Poly-Asn
Compositional bias314 – 3207Poly-Asn
Compositional bias364 – 40239Poly-Asn
Compositional bias528 – 5325Poly-Asp
Compositional bias542 – 55312Poly-Thr
Compositional bias581 – 5888Poly-Gly
Compositional bias777 – 7837Poly-Thr
Compositional bias838 – 8414Poly-Gln
Compositional bias848 – 85912Poly-Thr
Compositional bias862 – 87211Poly-Thr

Experimental info

Sequence conflict1381T → N in AAA85725. Ref.2
Sequence conflict1491H → L in AAA85725. Ref.2
Sequence conflict252 – 2532ND → KC in AAA85725. Ref.2
Sequence conflict3261D → N in AAA85725. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P54677-1 [UniParc].

Last modified September 2, 2008. Version 3.
Checksum: 1AB9290C91445F32

FASTA1,180132,681
        10         20         30         40         50         60 
MNKISDTIII TSTSNEDEVD NNNNNNNLKE IDRSPRVNNN NNNILTNVNN NKNNTITSSG 

        70         80         90        100        110        120 
GSDSSSSSSN NNNNKIKKSK KHKEKEHMDS IVKLYSGKFD SWMVICHLFK YRDNPGIVDF 

       130        140        150        160        170        180 
LCNKMYNLED KDIDFYITQL CILLINQPHD QKASFSSLAR FILDRCASSF RFAIKAYWIF 

       190        200        210        220        230        240 
QAFEEDGEKN LFSIEGSVYL HSPSTSPKDV PMYSNDQIVP IDLDKIYNQS QYDDDDFDLS 

       250        260        270        280        290        300 
DDDGGFEIIK KNDHHYENDH HIENDPKKDI NSNNNNNNNI NNNNSNNDDN NNNEILPNEN 

       310        320        330        340        350        360 
SDNSINDENN QYGNSNNNNN ISGENDNIKI DINSQNKSDS NIETLNSTLC EETKTSPIKD 

       370        380        390        400        410        420 
DMENNNNNNN NNNNNNNNNN NNNNINNNNI NNNNINNNNN INYGHINGSL STLDGIGQPY 

       430        440        450        460        470        480 
ISQPNDPIEN ITQILKRNRI IYKKVEEKKE LATRLREFCE MSVITCSRPL ITRPRTSSLP 

       490        500        510        520        530        540 
SPLISYNSGK IGGNYHKILS PSSVDSTSLI SEDDKIIEKE EEDNVVEDDD DDEVNSEDFI 

       550        560        570        580        590        600 
PTATTTATTT TTTIPNHLSK TTSGVGINSN SSTPININSA GAGAGGGGEI NHIGYDDISY 

       610        620        630        640        650        660 
LDKCKTPPAE SKLSDHDFEF ELSKSHRCDY LNDILSFIQK LAHISKILLP IPIDLRQAKL 

       670        680        690        700        710        720 
KHEISLLNIN LPLGLYVPLW QSSNHHCVVR IPPEEVKILN SRERVPFLLV LEVIESEHEA 

       730        740        750        760        770        780 
LSSNIFEVVS SYLQYTTGNS ALKKDDIKRK YYSEKFKKSF LNSSINSTIS NSSDSCTTET 

       790        800        810        820        830        840 
TTTSPVATSP TLPINIPHSK LINDGSNSIS KSLPVTPTQS TVLNNLISTS TAISPPSQQQ 

       850        860        870        880        890        900 
QLPSPSNTTT TTTTTTTNTN NTTTTTTTTT TTLSTSPTNE KILNENKQNS SPFGESWQEK 

       910        920        930        940        950        960 
IERYKKISPF GDYPNWRLYS VIVKTGDDCR QEQMAVQLIS KFDEIWKETR LPLYLRPYSI 

       970        980        990       1000       1010       1020 
LVTSSGGGII ETIPDTMSLH NLKKSTPGFT TLLNYFKSTY GDPSGLRFRT AQSNFIESMA 

      1030       1040       1050       1060       1070       1080 
AYSIVTYILQ IKDRHNGNIL IDKEGHIVHI DFGFILSNSP GNISFESAPF KLTQELVDVM 

      1090       1100       1110       1120       1130       1140 
GGIQSGQFQY FKVLCVRGLI EARKQVDKII SLIEIMMSGP KMSCFVGGKE VIEQLKARFF 

      1150       1160       1170       1180 
LDVNERECST LVENLISYSI DHFKTRYYDK YQSWLNGIYQ 

« Hide

References

« Hide 'large scale' references
[1]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed: 15875012] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
[2]"A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian p110 and yeast Vps34p PI 3-kinase homologs during growth and development."
Zhou K., Takegawa K., Emr S.D., Firtel R.A.
Mol. Cell. Biol. 15:5645-5656(1995) [PubMed: 7565716] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 88-1180.
Strain: AX3.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000112 Genomic DNA. Translation: EAL63191.2.
U23479 Genomic DNA. Translation: AAA85725.1.
PIRT18275.
RefSeqXP_636702.2.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGP54677.

Genome annotation databases

GeneID8626659.
KEGGddi:DDB_0191346.

Organism-specific databases

dictyBaseDDB_G0288485. pikD.

Phylogenomic databases

eggNOGKOG0903.

Enzyme and pathway databases

BRENDA2.7.1.67. 424.

Family and domain databases

InterProIPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat.
IPR018936. PI3/4_kinase_CS.
IPR015433. PI_Kinase.
[Graphical view]
Gene3DG3DSA:1.10.1070.11. PI3/4_kinase_cat. 1 hit.
PANTHERPTHR10048. PI_Kinase. 1 hit.
PfamPF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
SMARTSM00146. PI3Kc. 1 hit.
[Graphical view]
PROSITEPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePI4K_DICDI
AccessionPrimary (citable) accession number: P54677
Secondary accession number(s): Q54IV1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 2, 2008
Last modified: February 9, 2010
This is version 54 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents