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P54676 (PI3K4_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphatidylinositol 3-kinase VPS34-like

Short name=PI3-kinase
Short name=PI3K
Short name=PtdIns-3-kinase
EC=2.7.1.137
Gene names
Name:pikE
Synonyms:pik5
ORF Names:DDB_G0289601
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length816 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

Sequence similarities

Belongs to the PI3/PI4-kinase family.

Contains 1 C2 PI3K-type domain.

Contains 1 PI3K/PI4K domain.

Contains 1 PIK helical domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 816816Phosphatidylinositol 3-kinase VPS34-like
PRO_0000088825

Regions

Domain39 – 186148C2 PI3K-type
Domain275 – 460186PIK helical
Domain559 – 816258PI3K/PI4K

Experimental info

Sequence conflict41S → T in AAA85726. Ref.1
Sequence conflict131R → S in AAA85726. Ref.1
Sequence conflict44 – 463EKK → DDP in AAA85726. Ref.1
Sequence conflict289 – 2902LT → NS in AAA85726. Ref.1
Sequence conflict3821K → P in AAA85726. Ref.1
Sequence conflict5651G → N in AAA85726. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P54676 [UniParc].

Last modified December 4, 2007. Version 2.
Checksum: DC6637F485FD6975

FASTA81694,748
        10         20         30         40         50         60 
MKVSKDFKFY YSRDIPIKYK IKLCTLEGKR NKENAPETVD KWIEKKYLKY SSLYRDTTID 

        70         80         90        100        110        120 
LYITCTLYSD GKQLSTSEHT SYNPFSVSNK WDETIIFPLK HQDLPFDTMI VITIWDIYSP 

       130        140        150        160        170        180 
MKKVPIGGTS FNIFGMNKIE RKGKHKLLIW QDREGDGEKE TTTPGQIQGK DEQYRLEKLK 

       190        200        210        220        230        240 
KKYDRKLINH CQWLDKFSLN EIERLSRASE SLNKNQIYLT IELPEFELPI LFKQQNCPLY 

       250        260        270        280        290        300 
IPLSQTQKKS LVLINDIEMD EHPSEQKYHR LNLYDHKDLK PNSTELKGLT DILKQPPNTK 

       310        320        330        340        350        360 
VTSKEALLIW RFRYYLTNNK KALTKFLRCV EWSESHQKNE ALSIMPKWDP IDIADSLELL 

       370        380        390        400        410        420 
SSAFTHKNTI MVRRYAVEIL KKADDEELLY YLLQLVQATK YEQFDGNPSD SPLISFLFER 

       430        440        450        460        470        480 
SNKNFILGSH FYWYLTVDSV LKSSIFCSHY KTLQELYFRQ LDHTDAQRVN AQNKFISRLS 

       490        500        510        520        530        540 
LLSVELKAMN ITREKKIEKL RIMLAEGEYK DLSDFQPIRL PVNPDIEIIG IVPEKSNIYK 

       550        560        570        580        590        600 
SAKSPLGLKL RTTKGEEYGV IFKTGDDLRQ DQLIIQLISL MDRLLKKENL DLKLTPYKVL 

       610        620        630        640        650        660 
ATAEEDGIVE MVNPSEAMAS VLSKYDGDIL KFFKTHNPDA DSPYGIAPEV MDTFVKSCAG 

       670        680        690        700        710        720 
YCVITYILGI GDRHLDNLLL TPNGKLFHID FGYILGKDPK ILPPPMKLCK EMVLGMGGEN 

       730        740        750        760        770        780 
SKHYEKFKQL CCEAYNILRK SSHLILNLFA LMVDASIPSI SDDKEKSILK VQEKLQLELT 

       790        800        810 
DQEASNSLLQ LLNDSVTALF PVIIEMAHKW LQYWKA 

« Hide

References

« Hide 'large scale' references
[1]"A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian p110 and yeast Vps34p PI 3-kinase homologs during growth and development."
Zhou K., Takegawa K., Emr S.D., Firtel R.A.
Mol. Cell. Biol. 15:5645-5656(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: AX3.
[2]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U23480 Genomic DNA. Translation: AAA85726.1.
AAFI02000147 Genomic DNA. Translation: EAL62618.1.
PIRA59003.
RefSeqXP_636122.1. XM_631030.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0219939.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0219939; DDB0219939; DDB_G0289601.
GeneID8627225.
KEGGddi:DDB_G0289601.

Organism-specific databases

dictyBaseDDB_G0289601. pikE.

Phylogenomic databases

eggNOGCOG5032.
OMAYLMVEFP.
PhylomeDBP54676.

Enzyme and pathway databases

BRENDA2.7.1.137. 1939.

Family and domain databases

Gene3D1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 1 hit.
InterProIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR008290. PI3K_Vps34.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
[Graphical view]
PANTHERPTHR10048. PTHR10048. 1 hit.
PfamPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view]
PIRSFPIRSF000587. PI3K_Vps34. 1 hit.
SMARTSM00239. C2. 1 hit.
SM00142. PI3K_C2. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP54676.

Entry information

Entry namePI3K4_DICDI
AccessionPrimary (citable) accession number: P54676
Secondary accession number(s): Q54HA2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 4, 2007
Last modified: July 9, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase