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P54676

- PI3K4_DICDI

UniProt

P54676 - PI3K4_DICDI

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Protein
Phosphatidylinositol 3-kinase VPS34-like
Gene
pikE, pik5, DDB_G0289601
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

GO - Molecular functioni

  1. 1-phosphatidylinositol-3-kinase activity Source: RefGenome
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. phosphatidylinositol-3-phosphate biosynthetic process Source: GOC
  2. phosphatidylinositol-mediated signaling Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.137. 1939.
ReactomeiREACT_207952. Synthesis of PIPs at the early endosome membrane.
REACT_209866. Synthesis of PIPs at the Golgi membrane.
REACT_210188. Synthesis of PIPs at the late endosome membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 3-kinase VPS34-like (EC:2.7.1.137)
Short name:
PI3-kinase
Short name:
PI3K
Short name:
PtdIns-3-kinase
Gene namesi
Name:pikE
Synonyms:pik5
ORF Names:DDB_G0289601
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0289601. pikE.

Subcellular locationi

GO - Cellular componenti

  1. phosphatidylinositol 3-kinase complex Source: RefGenome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 816816Phosphatidylinositol 3-kinase VPS34-like
PRO_0000088825Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0219939.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 186148C2 PI3K-type
Add
BLAST
Domaini275 – 460186PIK helical
Add
BLAST
Domaini559 – 816258PI3K/PI4K
Add
BLAST

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.
Contains 1 PI3K/PI4K domain.
Contains 1 PIK helical domain.

Phylogenomic databases

eggNOGiCOG5032.
KOiK00914.
OMAiYLMVEFP.
PhylomeDBiP54676.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR008290. PI3K_Vps34.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view]
PIRSFiPIRSF000587. PI3K_Vps34. 1 hit.
SMARTiSM00239. C2. 1 hit.
SM00142. PI3K_C2. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54676-1 [UniParc]FASTAAdd to Basket

« Hide

MKVSKDFKFY YSRDIPIKYK IKLCTLEGKR NKENAPETVD KWIEKKYLKY    50
SSLYRDTTID LYITCTLYSD GKQLSTSEHT SYNPFSVSNK WDETIIFPLK 100
HQDLPFDTMI VITIWDIYSP MKKVPIGGTS FNIFGMNKIE RKGKHKLLIW 150
QDREGDGEKE TTTPGQIQGK DEQYRLEKLK KKYDRKLINH CQWLDKFSLN 200
EIERLSRASE SLNKNQIYLT IELPEFELPI LFKQQNCPLY IPLSQTQKKS 250
LVLINDIEMD EHPSEQKYHR LNLYDHKDLK PNSTELKGLT DILKQPPNTK 300
VTSKEALLIW RFRYYLTNNK KALTKFLRCV EWSESHQKNE ALSIMPKWDP 350
IDIADSLELL SSAFTHKNTI MVRRYAVEIL KKADDEELLY YLLQLVQATK 400
YEQFDGNPSD SPLISFLFER SNKNFILGSH FYWYLTVDSV LKSSIFCSHY 450
KTLQELYFRQ LDHTDAQRVN AQNKFISRLS LLSVELKAMN ITREKKIEKL 500
RIMLAEGEYK DLSDFQPIRL PVNPDIEIIG IVPEKSNIYK SAKSPLGLKL 550
RTTKGEEYGV IFKTGDDLRQ DQLIIQLISL MDRLLKKENL DLKLTPYKVL 600
ATAEEDGIVE MVNPSEAMAS VLSKYDGDIL KFFKTHNPDA DSPYGIAPEV 650
MDTFVKSCAG YCVITYILGI GDRHLDNLLL TPNGKLFHID FGYILGKDPK 700
ILPPPMKLCK EMVLGMGGEN SKHYEKFKQL CCEAYNILRK SSHLILNLFA 750
LMVDASIPSI SDDKEKSILK VQEKLQLELT DQEASNSLLQ LLNDSVTALF 800
PVIIEMAHKW LQYWKA 816
Length:816
Mass (Da):94,748
Last modified:December 4, 2007 - v2
Checksum:iDC6637F485FD6975
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41S → T in AAA85726. 1 Publication
Sequence conflicti13 – 131R → S in AAA85726. 1 Publication
Sequence conflicti44 – 463EKK → DDP in AAA85726. 1 Publication
Sequence conflicti289 – 2902LT → NS in AAA85726. 1 Publication
Sequence conflicti382 – 3821K → P in AAA85726. 1 Publication
Sequence conflicti565 – 5651G → N in AAA85726. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U23480 Genomic DNA. Translation: AAA85726.1.
AAFI02000147 Genomic DNA. Translation: EAL62618.1.
PIRiA59003.
RefSeqiXP_636122.1. XM_631030.1.

Genome annotation databases

EnsemblProtistsiDDB0219939; DDB0219939; DDB_G0289601.
GeneIDi8627225.
KEGGiddi:DDB_G0289601.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U23480 Genomic DNA. Translation: AAA85726.1 .
AAFI02000147 Genomic DNA. Translation: EAL62618.1 .
PIRi A59003.
RefSeqi XP_636122.1. XM_631030.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0219939.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0219939 ; DDB0219939 ; DDB_G0289601 .
GeneIDi 8627225.
KEGGi ddi:DDB_G0289601.

Organism-specific databases

dictyBasei DDB_G0289601. pikE.

Phylogenomic databases

eggNOGi COG5032.
KOi K00914.
OMAi YLMVEFP.
PhylomeDBi P54676.

Enzyme and pathway databases

BRENDAi 2.7.1.137. 1939.
Reactomei REACT_207952. Synthesis of PIPs at the early endosome membrane.
REACT_209866. Synthesis of PIPs at the Golgi membrane.
REACT_210188. Synthesis of PIPs at the late endosome membrane.

Miscellaneous databases

PROi P54676.

Family and domain databases

Gene3Di 1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 1 hit.
InterProi IPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR008290. PI3K_Vps34.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
[Graphical view ]
PANTHERi PTHR10048. PTHR10048. 1 hit.
Pfami PF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view ]
PIRSFi PIRSF000587. PI3K_Vps34. 1 hit.
SMARTi SM00239. C2. 1 hit.
SM00142. PI3K_C2. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian p110 and yeast Vps34p PI 3-kinase homologs during growth and development."
    Zhou K., Takegawa K., Emr S.D., Firtel R.A.
    Mol. Cell. Biol. 15:5645-5656(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: AX3.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiPI3K4_DICDI
AccessioniPrimary (citable) accession number: P54676
Secondary accession number(s): Q54HA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 4, 2007
Last modified: September 3, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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