Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P54675

- PI3K3_DICDI

UniProt

P54675 - PI3K3_DICDI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Phosphatidylinositol 3-kinase 3

Gene

pikC

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

GO - Molecular functioni

  1. 1-phosphatidylinositol-3-kinase activity Source: dictyBase
  2. 1-phosphatidylinositol-4-phosphate 3-kinase activity Source: RefGenome
  3. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. cellular component movement Source: dictyBase
  2. phosphatidylinositol-3-phosphate biosynthetic process Source: GOC
  3. phosphatidylinositol-mediated signaling Source: InterPro
  4. response to bacterium Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.137. 1939.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 3-kinase 3 (EC:2.7.1.137)
Short name:
PI3-kinase
Short name:
PI3K
Short name:
PtdIns-3-kinase
Gene namesi
Name:pikC
Synonyms:pik3
ORF Names:DDB_G0275011
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0275011. pikC.

Subcellular locationi

GO - Cellular componenti

  1. phosphatidylinositol 3-kinase complex Source: RefGenome
  2. plasma membrane Source: RefGenome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16971697Phosphatidylinositol 3-kinase 3PRO_0000088824Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0185203.

Structurei

3D structure databases

ProteinModelPortaliP54675.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini737 – 82387PI3K-RBDPROSITE-ProRule annotationAdd
BLAST
Domaini888 – 1036149C2 PI3K-typePROSITE-ProRule annotationAdd
BLAST
Domaini1060 – 1238179PIK helicalPROSITE-ProRule annotationAdd
BLAST
Domaini1333 – 1596264PI3K/PI4KPROSITE-ProRule annotationAdd
BLAST
Repeati1622 – 162651
Repeati1627 – 163152
Repeati1632 – 163653
Repeati1642 – 164654
Repeati1647 – 165155

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1622 – 1651305 X 5 AA approximate repeatsAdd
BLAST
Regioni1659 – 1672147 X 2 AA tandem repeats of K-EAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi170 – 19627Poly-AsnAdd
BLAST
Compositional biasi210 – 22213Poly-AsnAdd
BLAST
Compositional biasi312 – 33827Poly-AsnAdd
BLAST
Compositional biasi351 – 36616Poly-AsnAdd
BLAST
Compositional biasi457 – 49034Poly-AsnAdd
BLAST
Compositional biasi495 – 5028Poly-Asn
Compositional biasi596 – 6005Poly-Ser
Compositional biasi832 – 84918Poly-GlnAdd
BLAST
Compositional biasi1681 – 16877Poly-Asn

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation
Contains 1 C2 PI3K-type domain.PROSITE-ProRule annotation
Contains 1 PI3K-RBD domain.PROSITE-ProRule annotation
Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation
Contains 1 PIK helical domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5032.
InParanoidiP54675.
KOiK00922.
OMAiLIHESIG.
PhylomeDBiP54675.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view]
SMARTiSM00142. PI3K_C2. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54675-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRQIVTGVIH QTTQSQQIPN VINSNQIQFS NEPMVVGSIE DFDIDSEVPP
60 70 80 90 100
LAINLQRSIN NNNNNNNNNN NNNNNNNNNN NNNNNNNTQP CTTVFLDRDS
110 120 130 140 150
CVNVKATIDL LKEQLEFTIK DLIDFKENYD KLESTEQFKQ WSNLIKNIKE
160 170 180 190 200
NSLNNSNIYL TIPTTQNLIN NNNNNNNNNN NNNNNNNNNN NNNNNNVIIP
210 220 230 240 250
SASTENKEEN DNNNSNNNNN INLSPDSSIT KDINITENKI TEIKTTETKE
260 270 280 290 300
TSTGTSPLEK SPSKGFIISP KKPEEENEIE GETINNIAIT NYTQGPSMLT
310 320 330 340 350
LMKKKLENIK KNNNNNNNNG NGNNNSNNNN SNSNNNNNGI SPSSSPPSHL
360 370 380 390 400
NGNNNNNNSN NTNSNNTTNA TTNSVGFSIT MTNSNSLSVS KRMNKFKSWT
410 420 430 440 450
SSKPTSSSIG FASSPQNNGK PLNISGSSRF FTSRQDSKID LLKSPSSSPP
460 470 480 490 500
TQSDIFNENN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN EELINNNNNN
510 520 530 540 550
NNDENYKIEE TEESLKELLE KEKLENEERE KILKERNEID NLKKKNHLSK
560 570 580 590 600
GYFMRACNAS NDDGLEEEDI PLQDEHWETN VIVLLPCRHH VKVPGSSSSS
610 620 630 640 650
IDSIRQLAWA SGKMQGHLNL EKDEKFFTLR WCNKDVVFDQ DTPLGHLIQY
660 670 680 690 700
NLNYNNPTQK PTNIKLELVL EDELCKERLV DLQSLEINNG RPSIWKSHID
710 720 730 740 750
DVLSFNRKLR ELAMLAKPQS NVPAARLTPY PPPKTIPEFF VIRVHLFKNQ
760 770 780 790 800
TKSLRCANNH TAFSLMTILS EKLKNTTPFD PTQYRFLITG INQYVDPNVP
810 820 830 840 850
LLSVEYIVEK IKRKGEIDLT MVELLSLGLI IQQQQQQQQQ QQQQQQQQQI
860 870 880 890 900
ENIDDENILK LNNGILNVLS KIEKPIREKD NCISSLTVTE NLQVRLLHAH
910 920 930 940 950
EIFASKASEI IGTDSPSIQL FIEAAVYFGG ELLATQSSKL VSFQDTVVWN
960 970 980 990 1000
EWVNIPLAVS NIPNGARMCL GLNARYRGDI FNIGWVGHRL FDSKGILNTF
1010 1020 1030 1040 1050
APFSLLLWPG KINPIGTCVD NLESKDQAII IAFEFKDYVV PKTIHYEDDL
1060 1070 1080 1090 1100
IELISKDENG NELPVVTMEE MDRVEQIILQ DPLYSLNKEE RLLIWKSRYF
1110 1120 1130 1140 1150
CHTKPQALSK LLQSVEWTNY KQVGEAFQLL KIWPTLSAVD ALELLDPKFA
1160 1170 1180 1190 1200
DCVEIREYAV KCLDQMSDYE LEIYMLQLVQ AIKHDVFHNS VLSLFLIGRV
1210 1220 1230 1240 1250
WQNMQVLGHP FFWHLRADID NQEVCERFRV LSSGFLRYAP TQLMESFKRE
1260 1270 1280 1290 1300
ITTLRILENL AKRVKEVPYE KRKQYVENNL REEQSFPTEL FVPFDPSIRI
1310 1320 1330 1340 1350
LNIIPEKCKS MDSAKVPLWV TFKNADPFAP PLQMIAKTGD DLRQDILTLQ
1360 1370 1380 1390 1400
LLRLMDHMWK SQDLDLHMTI YRCIATGMGT GLIEVVPNSE TAARIQAGAG
1410 1420 1430 1440 1450
GVSGAFKQTP IANWLKNHNQ TENSYQKAVS KFTLSCAGYC VATYVLGIGD
1460 1470 1480 1490 1500
RHNDNIMVDI HGHLFHIDFG HFLGNFKTFA GFQREKAPFV LTPDFVYVIG
1510 1520 1530 1540 1550
GKDSPNFAFF VDICCKAFNI IRSNAHVFIN MFELMLSTGI PELRSENDIV
1560 1570 1580 1590 1600
YLRDKFRLDL TDAEASEYFK KLIHESIGTL TTTINFAIHI MAHRKNLVSG
1610 1620 1630 1640 1650
NSAPKIGSAS SLNLNKNKPS SQSKLDLSRS DLSRSDSSRS DSSRLDLSRS
1660 1670 1680 1690
DKKNNKDNKE KEKEKEKEKE KENNDNNDKD NNNNSNNDTE KENSIDK
Length:1,697
Mass (Da):192,942
Last modified:December 4, 2007 - v2
Checksum:iC5442DC2C3202E32
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1159 – 11591A → T in AAA85723. (PubMed:7565716)Curated
Sequence conflicti1175 – 11751M → L in AAA85723. (PubMed:7565716)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000013 Genomic DNA. Translation: EAL69786.1.
U23478 mRNA. Translation: AAA85723.1.
PIRiT18274.
RefSeqiXP_643820.1. XM_638728.1.

Genome annotation databases

EnsemblProtistsiDDB0185203; DDB0185203; DDB_G0275011.
GeneIDi8619867.
KEGGiddi:DDB_G0275011.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000013 Genomic DNA. Translation: EAL69786.1 .
U23478 mRNA. Translation: AAA85723.1 .
PIRi T18274.
RefSeqi XP_643820.1. XM_638728.1.

3D structure databases

ProteinModelPortali P54675.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0185203.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0185203 ; DDB0185203 ; DDB_G0275011 .
GeneIDi 8619867.
KEGGi ddi:DDB_G0275011.

Organism-specific databases

dictyBasei DDB_G0275011. pikC.

Phylogenomic databases

eggNOGi COG5032.
InParanoidi P54675.
KOi K00922.
OMAi LIHESIG.
PhylomeDBi P54675.

Enzyme and pathway databases

BRENDAi 2.7.1.137. 1939.

Family and domain databases

Gene3Di 1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 1 hit.
InterProi IPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
PANTHERi PTHR10048. PTHR10048. 1 hit.
Pfami PF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view ]
SMARTi SM00142. PI3K_C2. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  3. "A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian p110 and yeast Vps34p PI 3-kinase homologs during growth and development."
    Zhou K., Takegawa K., Emr S.D., Firtel R.A.
    Mol. Cell. Biol. 15:5645-5656(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 113-1697.
    Strain: AX3.

Entry informationi

Entry nameiPI3K3_DICDI
AccessioniPrimary (citable) accession number: P54675
Secondary accession number(s): Q553Z1, Q869X9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 4, 2007
Last modified: October 29, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3