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P54675

- PI3K3_DICDI

UniProt

P54675 - PI3K3_DICDI

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Protein

Phosphatidylinositol 3-kinase 3

Gene
pikC, pik3, DDB_G0275011
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

GO - Molecular functioni

  1. 1-phosphatidylinositol-3-kinase activity Source: dictyBase
  2. 1-phosphatidylinositol-4-phosphate 3-kinase activity Source: RefGenome
  3. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. cellular component movement Source: dictyBase
  2. phosphatidylinositol-3-phosphate biosynthetic process Source: GOC
  3. phosphatidylinositol-mediated signaling Source: InterPro
  4. response to bacterium Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.137. 1939.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 3-kinase 3 (EC:2.7.1.137)
Short name:
PI3-kinase
Short name:
PI3K
Short name:
PtdIns-3-kinase
Gene namesi
Name:pikC
Synonyms:pik3
ORF Names:DDB_G0275011
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0275011. pikC.

Subcellular locationi

GO - Cellular componenti

  1. phosphatidylinositol 3-kinase complex Source: RefGenome
  2. plasma membrane Source: RefGenome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16971697Phosphatidylinositol 3-kinase 3PRO_0000088824Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0185203.

Structurei

3D structure databases

ProteinModelPortaliP54675.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini737 – 82387PI3K-RBDAdd
BLAST
Domaini888 – 1036149C2 PI3K-typeAdd
BLAST
Domaini1060 – 1238179PIK helicalAdd
BLAST
Domaini1333 – 1596264PI3K/PI4KAdd
BLAST
Repeati1622 – 162651
Repeati1627 – 163152
Repeati1632 – 163653
Repeati1642 – 164654
Repeati1647 – 165155

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1622 – 1651305 X 5 AA approximate repeatsAdd
BLAST
Regioni1659 – 1672147 X 2 AA tandem repeats of K-EAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi170 – 19627Poly-AsnAdd
BLAST
Compositional biasi210 – 22213Poly-AsnAdd
BLAST
Compositional biasi312 – 33827Poly-AsnAdd
BLAST
Compositional biasi351 – 36616Poly-AsnAdd
BLAST
Compositional biasi457 – 49034Poly-AsnAdd
BLAST
Compositional biasi495 – 5028Poly-Asn
Compositional biasi596 – 6005Poly-Ser
Compositional biasi832 – 84918Poly-GlnAdd
BLAST
Compositional biasi1681 – 16877Poly-Asn

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.
Contains 1 PI3K-RBD domain.
Contains 1 PI3K/PI4K domain.
Contains 1 PIK helical domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5032.
KOiK00922.
OMAiLIHESIG.
PhylomeDBiP54675.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view]
SMARTiSM00142. PI3K_C2. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54675-1 [UniParc]FASTAAdd to Basket

« Hide

MRQIVTGVIH QTTQSQQIPN VINSNQIQFS NEPMVVGSIE DFDIDSEVPP     50
LAINLQRSIN NNNNNNNNNN NNNNNNNNNN NNNNNNNTQP CTTVFLDRDS 100
CVNVKATIDL LKEQLEFTIK DLIDFKENYD KLESTEQFKQ WSNLIKNIKE 150
NSLNNSNIYL TIPTTQNLIN NNNNNNNNNN NNNNNNNNNN NNNNNNVIIP 200
SASTENKEEN DNNNSNNNNN INLSPDSSIT KDINITENKI TEIKTTETKE 250
TSTGTSPLEK SPSKGFIISP KKPEEENEIE GETINNIAIT NYTQGPSMLT 300
LMKKKLENIK KNNNNNNNNG NGNNNSNNNN SNSNNNNNGI SPSSSPPSHL 350
NGNNNNNNSN NTNSNNTTNA TTNSVGFSIT MTNSNSLSVS KRMNKFKSWT 400
SSKPTSSSIG FASSPQNNGK PLNISGSSRF FTSRQDSKID LLKSPSSSPP 450
TQSDIFNENN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN EELINNNNNN 500
NNDENYKIEE TEESLKELLE KEKLENEERE KILKERNEID NLKKKNHLSK 550
GYFMRACNAS NDDGLEEEDI PLQDEHWETN VIVLLPCRHH VKVPGSSSSS 600
IDSIRQLAWA SGKMQGHLNL EKDEKFFTLR WCNKDVVFDQ DTPLGHLIQY 650
NLNYNNPTQK PTNIKLELVL EDELCKERLV DLQSLEINNG RPSIWKSHID 700
DVLSFNRKLR ELAMLAKPQS NVPAARLTPY PPPKTIPEFF VIRVHLFKNQ 750
TKSLRCANNH TAFSLMTILS EKLKNTTPFD PTQYRFLITG INQYVDPNVP 800
LLSVEYIVEK IKRKGEIDLT MVELLSLGLI IQQQQQQQQQ QQQQQQQQQI 850
ENIDDENILK LNNGILNVLS KIEKPIREKD NCISSLTVTE NLQVRLLHAH 900
EIFASKASEI IGTDSPSIQL FIEAAVYFGG ELLATQSSKL VSFQDTVVWN 950
EWVNIPLAVS NIPNGARMCL GLNARYRGDI FNIGWVGHRL FDSKGILNTF 1000
APFSLLLWPG KINPIGTCVD NLESKDQAII IAFEFKDYVV PKTIHYEDDL 1050
IELISKDENG NELPVVTMEE MDRVEQIILQ DPLYSLNKEE RLLIWKSRYF 1100
CHTKPQALSK LLQSVEWTNY KQVGEAFQLL KIWPTLSAVD ALELLDPKFA 1150
DCVEIREYAV KCLDQMSDYE LEIYMLQLVQ AIKHDVFHNS VLSLFLIGRV 1200
WQNMQVLGHP FFWHLRADID NQEVCERFRV LSSGFLRYAP TQLMESFKRE 1250
ITTLRILENL AKRVKEVPYE KRKQYVENNL REEQSFPTEL FVPFDPSIRI 1300
LNIIPEKCKS MDSAKVPLWV TFKNADPFAP PLQMIAKTGD DLRQDILTLQ 1350
LLRLMDHMWK SQDLDLHMTI YRCIATGMGT GLIEVVPNSE TAARIQAGAG 1400
GVSGAFKQTP IANWLKNHNQ TENSYQKAVS KFTLSCAGYC VATYVLGIGD 1450
RHNDNIMVDI HGHLFHIDFG HFLGNFKTFA GFQREKAPFV LTPDFVYVIG 1500
GKDSPNFAFF VDICCKAFNI IRSNAHVFIN MFELMLSTGI PELRSENDIV 1550
YLRDKFRLDL TDAEASEYFK KLIHESIGTL TTTINFAIHI MAHRKNLVSG 1600
NSAPKIGSAS SLNLNKNKPS SQSKLDLSRS DLSRSDSSRS DSSRLDLSRS 1650
DKKNNKDNKE KEKEKEKEKE KENNDNNDKD NNNNSNNDTE KENSIDK 1697
Length:1,697
Mass (Da):192,942
Last modified:December 4, 2007 - v2
Checksum:iC5442DC2C3202E32
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1159 – 11591A → T in AAA85723. 1 Publication
Sequence conflicti1175 – 11751M → L in AAA85723. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000013 Genomic DNA. Translation: EAL69786.1.
U23478 mRNA. Translation: AAA85723.1.
PIRiT18274.
RefSeqiXP_643820.1. XM_638728.1.

Genome annotation databases

EnsemblProtistsiDDB0185203; DDB0185203; DDB_G0275011.
GeneIDi8619867.
KEGGiddi:DDB_G0275011.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000013 Genomic DNA. Translation: EAL69786.1 .
U23478 mRNA. Translation: AAA85723.1 .
PIRi T18274.
RefSeqi XP_643820.1. XM_638728.1.

3D structure databases

ProteinModelPortali P54675.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0185203.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0185203 ; DDB0185203 ; DDB_G0275011 .
GeneIDi 8619867.
KEGGi ddi:DDB_G0275011.

Organism-specific databases

dictyBasei DDB_G0275011. pikC.

Phylogenomic databases

eggNOGi COG5032.
KOi K00922.
OMAi LIHESIG.
PhylomeDBi P54675.

Enzyme and pathway databases

BRENDAi 2.7.1.137. 1939.

Family and domain databases

Gene3Di 1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 1 hit.
InterProi IPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
PANTHERi PTHR10048. PTHR10048. 1 hit.
Pfami PF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view ]
SMARTi SM00142. PI3K_C2. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  3. "A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian p110 and yeast Vps34p PI 3-kinase homologs during growth and development."
    Zhou K., Takegawa K., Emr S.D., Firtel R.A.
    Mol. Cell. Biol. 15:5645-5656(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 113-1697.
    Strain: AX3.

Entry informationi

Entry nameiPI3K3_DICDI
AccessioniPrimary (citable) accession number: P54675
Secondary accession number(s): Q553Z1, Q869X9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 4, 2007
Last modified: September 3, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3