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P54666 (CC2H3_TRYBB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cell division control protein 2 homolog 3

EC=2.7.11.22
Gene names
Name:CRK3
OrganismTrypanosoma brucei brucei
Taxonomic identifier5702 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Probably involved in the control of the cell cycle.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation

Phosphorylation at Thr-33 or Tyr-34 inactivates the enzyme.

Subunit structure

Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Cell division control protein 2 homolog 3
PRO_0000085709

Regions

Domain23 – 306284Protein kinase
Nucleotide binding29 – 379ATP By similarity

Sites

Active site1451Proton acceptor By similarity
Binding site521ATP By similarity

Amino acid modifications

Modified residue331Phosphothreonine By similarity
Modified residue341Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
P54666 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 168D97820100E016

FASTA31135,047
        10         20         30         40         50         60 
MTMLGALTGR QLSSGLKDQF DRYNRMDILG EGTYGVVYRA VDRATGQIVA LKKVRLDRTD 

        70         80         90        100        110        120 
EGIPQTALRE VSILQEIHHP NIVNLLDVIC ADGKLYLIFE YVDHDLKKAL EKRGGAFTGT 

       130        140        150        160        170        180 
TLKKIIYQLL EGLSFCHRHR IVHRDLKPAN ILVTTDNSVK IADFGLARAF QIPMHTYTHE 

       190        200        210        220        230        240 
VVTLWYRAPE ILLGEKHYTP AVDMWSIGCI FAELARGKVL FRGDSEIGQL FEIFQVLGTP 

       250        260        270        280        290        300 
MDAEGSWLGV SSLPDYRDVF PKWSGKPLTQ VLPTLDGDAV DLLSQMLRYN PAERISAKAA 

       310 
LQHPWFSDAM F 

« Hide

References

[1]"A family of trypanosome cdc2-related protein kinases."
Mottram J., Smith G.
Gene 162:147-152(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ISTAT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X74617 Genomic DNA. Translation: CAA52688.1.
PIRS36619.

3D structure databases

ProteinModelPortalP54666.
SMRP54666. Positions 31-308.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA2.7.11.22. 6520.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCC2H3_TRYBB
AccessionPrimary (citable) accession number: P54666
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families