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Protein

Cell division control protein 2 homolog 3

Gene

CRK3

Organism
Trypanosoma brucei brucei
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Probably involved in the control of the cell cycle.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Phosphorylation at Thr-33 or Tyr-34 inactivates the enzyme.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei52ATPPROSITE-ProRule annotation1
Active sitei145Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 37ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • mitotic cell cycle Source: GeneDB
  • protein phosphorylation Source: GeneDB

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22 6520

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 2 homolog 3 (EC:2.7.11.22)
Gene namesi
Name:CRK3
OrganismiTrypanosoma brucei brucei
Taxonomic identifieri5702 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000857091 – 311Cell division control protein 2 homolog 3Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33PhosphothreonineBy similarity1
Modified residuei34PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP54666

Interactioni

Subunit structurei

Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin.By similarity

Structurei

3D structure databases

ProteinModelPortaliP54666
SMRiP54666
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 306Protein kinasePROSITE-ProRule annotationAdd BLAST284

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

P54666-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMLGALTGR QLSSGLKDQF DRYNRMDILG EGTYGVVYRA VDRATGQIVA
60 70 80 90 100
LKKVRLDRTD EGIPQTALRE VSILQEIHHP NIVNLLDVIC ADGKLYLIFE
110 120 130 140 150
YVDHDLKKAL EKRGGAFTGT TLKKIIYQLL EGLSFCHRHR IVHRDLKPAN
160 170 180 190 200
ILVTTDNSVK IADFGLARAF QIPMHTYTHE VVTLWYRAPE ILLGEKHYTP
210 220 230 240 250
AVDMWSIGCI FAELARGKVL FRGDSEIGQL FEIFQVLGTP MDAEGSWLGV
260 270 280 290 300
SSLPDYRDVF PKWSGKPLTQ VLPTLDGDAV DLLSQMLRYN PAERISAKAA
310
LQHPWFSDAM F
Length:311
Mass (Da):35,047
Last modified:October 1, 1996 - v1
Checksum:i168D97820100E016
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74617 Genomic DNA Translation: CAA52688.1
PIRiS36619

Genome annotation databases

GeneDBiTb927.10.4990:pep

Similar proteinsi

Entry informationi

Entry nameiCC2H3_TRYBB
AccessioniPrimary (citable) accession number: P54666
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

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