Reviewed, UniProtKB/Swiss-Prot P54666 (CC2H3_TRYBB)

Names and origin

Protein names

Recommended name:
    Cell division control protein 2 homolog 3
    EC=2.7.11.22

Gene names

Name:

CRK3

Organism

Trypanosoma brucei brucei

Taxonomic identifier

5702 [NCBI]

Taxonomic lineage

Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Trypanosoma

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Probably involved in the control of the cell cycle.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Enzyme regulation	Phosphorylation at Thr-33 or Tyr-34 inactivates the enzyme.
Subunit structure	Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cyclin-dependent protein kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Cell division control protein 2 homolog 3		PRO_0000085709
Regions
	Domain	23 – 306	284	Protein kinase
	Nucleotide binding	29 – 37	9	ATP By similarity
Sites
	Active site	145	1	Proton acceptor By similarity
	Binding site	52	1	ATP By similarity
Amino acid modifications
	Modified residue	33	1	Phosphothreonine By similarity
	Modified residue	34	1	Phosphotyrosine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P54666-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 168D97820100E016	FASTA	311	35,047
	10 20 30 40 50 60 MTMLGALTGR QLSSGLKDQF DRYNRMDILG EGTYGVVYRA VDRATGQIVA LKKVRLDRTD 70 80 90 100 110 120 EGIPQTALRE VSILQEIHHP NIVNLLDVIC ADGKLYLIFE YVDHDLKKAL EKRGGAFTGT 130 140 150 160 170 180 TLKKIIYQLL EGLSFCHRHR IVHRDLKPAN ILVTTDNSVK IADFGLARAF QIPMHTYTHE 190 200 210 220 230 240 VVTLWYRAPE ILLGEKHYTP AVDMWSIGCI FAELARGKVL FRGDSEIGQL FEIFQVLGTP 250 260 270 280 290 300 MDAEGSWLGV SSLPDYRDVF PKWSGKPLTQ VLPTLDGDAV DLLSQMLRYN PAERISAKAA 310 LQHPWFSDAM F

References

[1]	"A family of trypanosome cdc2-related protein kinases." Mottram J., Smith G. Gene 162:147-152(1995) [PubMed: 7557404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ISTAT.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X74617 Genomic DNA. Translation: CAA52688.1.
PIR	S36619.
3D structure databases
HSSP	HSSP built from PDB template 1H26 based on UniProtKB P24941.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.11.22. 74165.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CC2H3_TRYBB

Accession

Primary (citable) accession number: P54666

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	June 16, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)