P54665 (CC2H2_TRYBB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cell division control protein 2 homolog 2
EC=2.7.11.22

Gene names

Name:

CRK2

Organism

Trypanosoma brucei brucei

Taxonomic identifier

5702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Trypanosoma › Trypanozoon › Trypanosoma brucei

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Probably involved in the control of the cell cycle.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Enzyme regulation	Phosphorylation at Ser-56 or Tyr-57 inactivates the enzyme By similarity.
Subunit structure	Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: GOC
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cyclin-dependent protein serine/threonine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 345	345	Cell division control protein 2 homolog 2		PRO_0000085708
Regions
	Domain	46 – 328	283	Protein kinase
	Nucleotide binding	52 – 60	9	ATP By similarity
Sites
	Active site	168	1	Proton acceptor By similarity
	Binding site	75	1	ATP By similarity
Amino acid modifications
	Modified residue	56	1	Phosphoserine By similarity
	Modified residue	57	1	Phosphotyrosine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P54665 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 6E4E88D2571931B8	FASTA	345	39,238
	10 20 30 40 50 60 MQVQVQEGQT ACDGSLRPLP SAGPASFVPR SLRPAPLRGT STPDRYSRIE KVGEGSYGIV 70 80 90 100 110 120 YKCHDNFTGR TVAMKRIPLI VNDGGVPSTA VREVSLLREL NHPYVVRLLD VVLHEAKLLL 130 140 150 160 170 180 IFEYMEQDLQ GMLKQRNTAF VGGKLRRIMF QLLLGLHECH SRRFVHRDIK PSNILIDRKE 190 200 210 220 230 240 SVVKLADFGL GRAFRVPLQT YTTEVMTLWY RAPEVLLGDK QYLPAVDVWS MGCVFAELAR 250 260 270 280 290 300 RRSLFAGDTA INQLFSIFQL LGTPTEATWR GVTSLPHHNV NFPRWTAKPL RTAVPALDDD 310 320 330 340 GVDLLRRMLC YNPRERITAY EALQHSYFDE VREEEVEKLM RFNGA

References

[1]	"A family of trypanosome cdc2-related protein kinases." Mottram J., Smith G. Gene 162:147-152(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ISTAT.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X74598 Genomic DNA. Translation: CAA52676.1.
PIR	S36607.
3D structure databases
ProteinModelPortal	P54665.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
BRENDA	2.7.11.22. 6520.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CC2H2_TRYBB

Accession

Primary (citable) accession number: P54665

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)