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P54665 (CC2H2_TRYBB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cell division control protein 2 homolog 2

EC=2.7.11.22
Gene names
Name:CRK2
OrganismTrypanosoma brucei brucei
Taxonomic identifier5702 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Protein attributes

Sequence length345 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Probably involved in the control of the cell cycle.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation

Phosphorylation at Ser-56 or Tyr-57 inactivates the enzyme By similarity.

Subunit structure

Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 345345Cell division control protein 2 homolog 2
PRO_0000085708

Regions

Domain46 – 328283Protein kinase
Nucleotide binding52 – 609ATP By similarity

Sites

Active site1681Proton acceptor By similarity
Binding site751ATP By similarity

Amino acid modifications

Modified residue561Phosphoserine By similarity
Modified residue571Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
P54665 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 6E4E88D2571931B8

FASTA34539,238
        10         20         30         40         50         60 
MQVQVQEGQT ACDGSLRPLP SAGPASFVPR SLRPAPLRGT STPDRYSRIE KVGEGSYGIV 

        70         80         90        100        110        120 
YKCHDNFTGR TVAMKRIPLI VNDGGVPSTA VREVSLLREL NHPYVVRLLD VVLHEAKLLL 

       130        140        150        160        170        180 
IFEYMEQDLQ GMLKQRNTAF VGGKLRRIMF QLLLGLHECH SRRFVHRDIK PSNILIDRKE 

       190        200        210        220        230        240 
SVVKLADFGL GRAFRVPLQT YTTEVMTLWY RAPEVLLGDK QYLPAVDVWS MGCVFAELAR 

       250        260        270        280        290        300 
RRSLFAGDTA INQLFSIFQL LGTPTEATWR GVTSLPHHNV NFPRWTAKPL RTAVPALDDD 

       310        320        330        340 
GVDLLRRMLC YNPRERITAY EALQHSYFDE VREEEVEKLM RFNGA 

« Hide

References

[1]"A family of trypanosome cdc2-related protein kinases."
Mottram J., Smith G.
Gene 162:147-152(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ISTAT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X74598 Genomic DNA. Translation: CAA52676.1.
PIRS36607.

3D structure databases

ProteinModelPortalP54665.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA2.7.11.22. 6520.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCC2H2_TRYBB
AccessionPrimary (citable) accession number: P54665
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families