Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cell division control protein 2 homolog 2

Gene

CRK2

Organism
Trypanosoma brucei brucei
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Probably involved in the control of the cell cycle.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Phosphorylation at Ser-56 or Tyr-57 inactivates the enzyme.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei75ATPPROSITE-ProRule annotation1
Active sitei168Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi52 – 60ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22 6520

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 2 homolog 2 (EC:2.7.11.22)
Gene namesi
Name:CRK2
OrganismiTrypanosoma brucei brucei
Taxonomic identifieri5702 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000857081 – 345Cell division control protein 2 homolog 2Add BLAST345

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei56PhosphoserineBy similarity1
Modified residuei57PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP54665

Interactioni

Subunit structurei

Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin.By similarity

Structurei

3D structure databases

ProteinModelPortaliP54665
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 328Protein kinasePROSITE-ProRule annotationAdd BLAST283

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

P54665-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVQVQEGQT ACDGSLRPLP SAGPASFVPR SLRPAPLRGT STPDRYSRIE
60 70 80 90 100
KVGEGSYGIV YKCHDNFTGR TVAMKRIPLI VNDGGVPSTA VREVSLLREL
110 120 130 140 150
NHPYVVRLLD VVLHEAKLLL IFEYMEQDLQ GMLKQRNTAF VGGKLRRIMF
160 170 180 190 200
QLLLGLHECH SRRFVHRDIK PSNILIDRKE SVVKLADFGL GRAFRVPLQT
210 220 230 240 250
YTTEVMTLWY RAPEVLLGDK QYLPAVDVWS MGCVFAELAR RRSLFAGDTA
260 270 280 290 300
INQLFSIFQL LGTPTEATWR GVTSLPHHNV NFPRWTAKPL RTAVPALDDD
310 320 330 340
GVDLLRRMLC YNPRERITAY EALQHSYFDE VREEEVEKLM RFNGA
Length:345
Mass (Da):39,238
Last modified:October 1, 1996 - v1
Checksum:i6E4E88D2571931B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74598 Genomic DNA Translation: CAA52676.1
PIRiS36607

Similar proteinsi

Entry informationi

Entry nameiCC2H2_TRYBB
AccessioniPrimary (citable) accession number: P54665
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 25, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)