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P54664

- CC2H1_TRYCO

UniProt

P54664 - CC2H1_TRYCO

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Protein
Cell division control protein 2 homolog 1
Gene
CRK1, CRK
Organism
Trypanosoma congolense
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Probably involved in the control of the cell cycle.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Phosphorylation at Ser-15 or Tyr-16 inactivates the enzyme, while phosphorylation at Thr-160 activates it By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341ATP By similarity
Active sitei127 – 1271Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 199ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 2 homolog 1 (EC:2.7.11.22)
Gene namesi
Name:CRK1
Synonyms:CRK
OrganismiTrypanosoma congolense
Taxonomic identifieri5692 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaNannomonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301Cell division control protein 2 homolog 1
PRO_0000085707Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei15 – 151Phosphoserine By similarity
Modified residuei16 – 161Phosphotyrosine By similarity
Modified residuei160 – 1601Phosphothreonine; by CAK By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin By similarity.

Structurei

3D structure databases

ProteinModelPortaliP54664.
SMRiP54664. Positions 3-298.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 297293Protein kinase
Add
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54664-1 [UniParc]FASTAAdd to Basket

« Hide

MGSRYQRLEK IGEGSYGVVY RARDITTDVI VALKRIRLES VEEGVPCTAI    50
REISILKELR HENIVRLLDV CHSENRLNLV FEYMEMDLKK YMDRASGNLD 100
PATIQEFMRS LLKGVRFCHE RNVLHRDLKP PNLLISREKE LKLADFGLGR 150
AFGIPVKKYT HEVVTLWYRS PDVLLGSTQY GTPVDIWSVG CIFAEMAIGA 200
PLFAGKNDAD QLLRIFRFLG TPSSQVWPSM NLYPNSTNML SKPEFQQNLI 250
ATCDEQFQTH PAYAKLGPQG IDLLRRLLRY EPGERLTAAQ ALEHPYFSVE 300
F 301
Length:301
Mass (Da):34,468
Last modified:October 1, 1996 - v1
Checksum:i4D31FFA7B952F256
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z30312 Genomic DNA. Translation: CAA82956.1.
PIRiS42101.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z30312 Genomic DNA. Translation: CAA82956.1 .
PIRi S42101.

3D structure databases

ProteinModelPortali P54664.
SMRi P54664. Positions 3-298.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Ricard B., Mottram J.C., Muthiani A., Omolo E., Pandit P., Gobright E., Murphy N.B.
    Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: IL3000.

Entry informationi

Entry nameiCC2H1_TRYCO
AccessioniPrimary (citable) accession number: P54664
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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