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P54664 (CC2H1_TRYCO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cell division control protein 2 homolog 1

EC=2.7.11.22
Gene names
Name:CRK1
Synonyms:CRK
OrganismTrypanosoma congolense
Taxonomic identifier5692 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaNannomonas

Protein attributes

Sequence length301 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Probably involved in the control of the cell cycle.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation

Phosphorylation at Ser-15 or Tyr-16 inactivates the enzyme, while phosphorylation at Thr-160 activates it By similarity.

Subunit structure

Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 301301Cell division control protein 2 homolog 1
PRO_0000085707

Regions

Domain5 – 297293Protein kinase
Nucleotide binding11 – 199ATP By similarity

Sites

Active site1271Proton acceptor By similarity
Binding site341ATP By similarity

Amino acid modifications

Modified residue151Phosphoserine By similarity
Modified residue161Phosphotyrosine By similarity
Modified residue1601Phosphothreonine; by CAK By similarity

Sequences

Sequence LengthMass (Da)Tools
P54664 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 4D31FFA7B952F256

FASTA30134,468
        10         20         30         40         50         60 
MGSRYQRLEK IGEGSYGVVY RARDITTDVI VALKRIRLES VEEGVPCTAI REISILKELR 

        70         80         90        100        110        120 
HENIVRLLDV CHSENRLNLV FEYMEMDLKK YMDRASGNLD PATIQEFMRS LLKGVRFCHE 

       130        140        150        160        170        180 
RNVLHRDLKP PNLLISREKE LKLADFGLGR AFGIPVKKYT HEVVTLWYRS PDVLLGSTQY 

       190        200        210        220        230        240 
GTPVDIWSVG CIFAEMAIGA PLFAGKNDAD QLLRIFRFLG TPSSQVWPSM NLYPNSTNML 

       250        260        270        280        290        300 
SKPEFQQNLI ATCDEQFQTH PAYAKLGPQG IDLLRRLLRY EPGERLTAAQ ALEHPYFSVE 


F 

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References

[1]Ricard B., Mottram J.C., Muthiani A., Omolo E., Pandit P., Gobright E., Murphy N.B.
Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: IL3000.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z30312 Genomic DNA. Translation: CAA82956.1.
PIRS42101.

3D structure databases

ProteinModelPortalP54664.
SMRP54664. Positions 3-298.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCC2H1_TRYCO
AccessionPrimary (citable) accession number: P54664
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families