Reviewed, UniProtKB/Swiss-Prot P54664 (CC2H1_TRYCO)

Names and origin

Protein names

Recommended name:
    Cell division control protein 2 homolog 1
    EC=2.7.11.22

Gene names

Name:	CRK1
Synonyms:	CRK

Organism

Trypanosoma congolense

Taxonomic identifier

5692 [NCBI]

Taxonomic lineage

Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Trypanosoma › Nannomonas

Protein attributes

Sequence length	301 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Probably involved in the control of the cell cycle.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Enzyme regulation	Phosphorylation at Ser-15 or Tyr-16 inactivates the enzyme, while phosphorylation at Thr-160 activates it By similarity.
Subunit structure	Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cyclin-dependent protein kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 301	301	Cell division control protein 2 homolog 1		PRO_0000085707
Regions
	Domain	5 – 297	293	Protein kinase
	Nucleotide binding	11 – 19	9	ATP By similarity
Sites
	Active site	127	1	Proton acceptor By similarity
	Binding site	34	1	ATP By similarity
Amino acid modifications
	Modified residue	15	1	Phosphoserine By similarity
	Modified residue	16	1	Phosphotyrosine By similarity
	Modified residue	160	1	Phosphothreonine; by CAK By similarity

Sequences

	Sequence		Length	Mass (Da)
	P54664-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 4D31FFA7B952F256	FASTA	301	34,468
	10 20 30 40 50 60 MGSRYQRLEK IGEGSYGVVY RARDITTDVI VALKRIRLES VEEGVPCTAI REISILKELR 70 80 90 100 110 120 HENIVRLLDV CHSENRLNLV FEYMEMDLKK YMDRASGNLD PATIQEFMRS LLKGVRFCHE 130 140 150 160 170 180 RNVLHRDLKP PNLLISREKE LKLADFGLGR AFGIPVKKYT HEVVTLWYRS PDVLLGSTQY 190 200 210 220 230 240 GTPVDIWSVG CIFAEMAIGA PLFAGKNDAD QLLRIFRFLG TPSSQVWPSM NLYPNSTNML 250 260 270 280 290 300 SKPEFQQNLI ATCDEQFQTH PAYAKLGPQG IDLLRRLLRY EPGERLTAAQ ALEHPYFSVE F

References

[1]	Ricard B., Mottram J.C., Muthiani A., Omolo E., Pandit P., Gobright E., Murphy N.B. Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: IL3000.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z30312 Genomic DNA. Translation: CAA82956.1.
PIR	S42101.
3D structure databases
SMR	P54664. Positions 3-298.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.11.22. 95989.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_prot_kinase-like_dom. IPR008271. Ser/Thr_prot_kinase_AS. IPR002290. Ser/Thr_prot_kinase_dom. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CC2H1_TRYCO

Accession

Primary (citable) accession number: P54664

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	January 19, 2010
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)