P54663 (DEGS_BREBE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sensor protein degS
EC=2.7.13.3

Gene names

Name:

degS

Organism

Brevibacillus brevis (Bacillus brevis)

Taxonomic identifier

1393 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Paenibacillaceae › Brevibacillus

Protein attributes

Sequence length	386 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU.
Catalytic activity	ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.
Sequence similarities	Contains 1 histidine kinase domain.

Ontologies

Keywords
Biological process	Two-component regulatory system
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	peptidyl-histidine phosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein dimerization activity Inferred from electronic annotation. Source: InterPro two-component sensor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 386	386	Sensor protein degS		PRO_0000074755
Regions
	Domain	188 – 384	197	Histidine kinase
Amino acid modifications
	Modified residue	194	1	Phosphohistidine; by autocatalysis By similarity

Sequences

	Sequence		Length	Mass (Da)
	P54663 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: EE209CB8F663A17E	FASTA	386	44,837
	10 20 30 40 50 60 MPFKGLVVQV ADPQTLDKII DKTLDTVGKS REQIFEISEQ SRNEYVSLEQ ELQEVRMKVA 70 80 90 100 110 120 EIIDQSDRAE VHARFARNRL AEVSKQFHRY SNEEIRKVYE QANELQVKLA LLQQEEQQLR 130 140 150 160 170 180 DRRDAIERRL LNLKDTIERA EELVGQMTVV YNFLTGDLRQ VGEALEDARE KQAFGLQIIQ 190 200 210 220 230 240 AQEEERRKLS REIHDGPAQM MANVLLRSEL VERIYHDKGI DEALKEIRDL RKMVKSSLAE 250 260 270 280 290 300 VRRIIYDLRR MALDDLGLIP TLKKYVKTFE EHTGIFVDFK HIGKGERFPE HVEIALFRLV 310 320 330 340 350 360 QEALQNTRKH AKASHVHVKI EEQKTKFTVV IKDNGKGFDQ TEKKEGSFGL VGMKERVNML 370 380 KGQLVIRTKP NDGTTIIISI PITTEE

References

[1]	"Cloning and sequencing the degS-degU operon from an alkalophilic Bacillus brevis." Louw M.E., Reid S.J., James M.D., Watson T.G. Appl. Microbiol. Biotechnol. 42:78-84(1994) [PubMed: 7765823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Alk36.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L15444 Genomic DNA. Translation: AAC41438.1.
PIR	I39834.
3D structure databases
ProteinModelPortal	P54663.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR003594. ATPase-like_ATP-bd. IPR008595. DegS. IPR011712. Sig_transdc_His_kin_sub3_dim/P. IPR005467. Sig_transdc_His_kinase_core. IPR016381. Sig_transdc_His_kinase_DegS. [Graphical view]
Gene3D	G3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit.
Pfam	PF05384. DegS. 1 hit. PF02518. HATPase_c. 1 hit. PF07730. HisKA_3. 1 hit. [Graphical view]
PIRSF	PIRSF003169. STHK_DegS. 1 hit.
SMART	SM00387. HATPase_c. 1 hit. [Graphical view]
SUPFAM	SSF55874. ATP_bd_ATPase. 1 hit.
PROSITE	PS50109. HIS_KIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DEGS_BREBE

Accession

Primary (citable) accession number: P54663

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	January 11, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program