Reviewed, UniProtKB/Swiss-Prot P54652 (HSP72_HUMAN)

Names and origin

Protein names

Recommended name:
Heat shock-related 70 kDa protein 2
Short name=Heat shock 70 kDa protein 2

Gene names

Name:

HSPA2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	639 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage.
Subunit structure	Interacts with ZNF541 By similarity.
Sequence similarities	Belongs to the heat shock protein 70 family.

Ontologies

Keywords
Biological process	Stress response
Coding sequence diversity	Polymorphism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chaperone
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	male meiosis Traceable author statement. Source: ProtInc response to unfolded protein Ref.1 Traceable author statement. Source: ProtInc spermatid development Traceable author statement. Source: ProtInc
Cellular component	cell surface Inferred from direct assay. Source: UniProtKB
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW unfolded protein binding Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 639

639

Heat shock-related 70 kDa protein 2

PRO_0000078258

Amino acid modifications

Modified residue

42

1

Phosphotyrosine Ref.7

Modified residue

108

1

Phosphotyrosine Ref.7

Natural variations

Natural variant

191

1

C → S

VAR_032706

Natural variant

496

1

K → E

VAR_032707

Experimental info

Sequence conflict

14

1

T → P in AAH36107. Ref.5

Sequence conflict

54

1

Missing in AAC50076. Ref.6

Sequence conflict

80

1

E → G in AAH36107. Ref.5

Sequence conflict

266

1

L → S in AAD11466. Ref.2

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

639

Helix Strand Turn

Details...

Beta strand

16 – 18

3

Beta strand

38 – 40

3

Beta strand

43 – 45

3

Helix

55 – 58

4

Turn

59 – 62

4

Helix

71 – 73

3

Helix

82 – 88

7

Beta strand

92 – 97

6

Beta strand

102 – 107

6

Beta strand

112 – 115

4

Helix

117 – 135

19

Beta strand

142 – 147

6

Helix

153 – 161

9

Beta strand

169 – 175

7

Helix

176 – 183

8

Beta strand

197 – 203

7

Beta strand

209 – 215

7

Beta strand

220 – 226

7

Helix

235 – 252

18

Helix

260 – 276

17

Turn

277 – 279

3

Beta strand

280 – 287

8

Beta strand

296 – 301

6

Helix

302 – 308

7

Helix

310 – 313

4

Helix

317 – 327

11

Beta strand

336 – 340

5

Helix

347 – 356

10

Turn

368 – 373

6

Helix

377 – 383

7

Sequences

	Sequence		Length	Mass (Da)
	P54652-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 3851755494E7B729	FASTA	639	70,021
	10 20 30 40 50 60 MSARGPAIGI DLGTTYSCVG VFQHGKVEII ANDQGNRTTP SYVAFTDTER LIGDAAKNQV 70 80 90 100 110 120 AMNPTNTIFD AKRLIGRKFE DATVQSDMKH WPFRVVSEGG KPKVQVEYKG ETKTFFPEEI 130 140 150 160 170 180 SSMVLTKMKE IAEAYLGGKV HSAVITVPAY FNDSQRQATK DAGTITGLNV LRIINEPTAA 190 200 210 220 230 240 AIAYGLDKKG CAGGEKNVLI FDLGGGTFDV SILTIEDGIF EVKSTAGDTH LGGEDFDNRM 250 260 270 280 290 300 VSHLAEEFKR KHKKDIGPNK RAVRRLRTAC ERAKRTLSSS TQASIEIDSL YEGVDFYTSI 310 320 330 340 350 360 TRARFEELNA DLFRGTLEPV EKALRDAKLD KGQIQEIVLV GGSTRIPKIQ KLLQDFFNGK 370 380 390 400 410 420 ELNKSINPDE AVAYGAAVQA AILIGDKSEN VQDLLLLDVT PLSLGIETAG GVMTPLIKRN 430 440 450 460 470 480 TTIPTKQTQT FTTYSDNQSS VLVQVYEGER AMTKDNNLLG KFDLTGIPPA PRGVPQIEVT 490 500 510 520 530 540 FDIDANGILN VTAADKSTGK ENKITITNDK GRLSKDDIDR MVQEAERYKS EDEANRDRVA 550 560 570 580 590 600 AKNALESYTY NIKQTVEDEK LRGKISEQDK NKILDKCQEV INWLDRNQMA EKDEYEHKQK 610 620 630 ELERVCNPII SKLYQGGPGG GSGGGGSGAS GGPTIEEVD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, sequencing, and mapping of the human chromosome 14 heat shock protein gene (HSPA2)." Bonnycastle L.L.C., Yu C.-E., Hunt C.R., Trask B.J., Clancy K.P., Weber J.L., Patterson D., Schellenberg G.D. Genomics 23:85-93(1994) [PubMed: 7829106] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	Goralski T.J., Krensky A.M. Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	NIEHS SNPs program Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-191 AND GLU-496.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Eye.
[6]	"A heat shock gene at 14q22: mapping and expression." Roux A.-F., Nguyen V.T.T., Squire J.A., Cox D.W. Hum. Mol. Genet. 3:1819-1822(1994) [PubMed: 7849706] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-126.
[7]	"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. , Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J. Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-42 AND TYR-108, MASS SPECTROMETRY. Tissue: Lung.
[8]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L26336 Genomic DNA. Translation: AAA52698.1.
U56725 mRNA. Translation: AAD11466.1.
BT009815 mRNA. Translation: AAP88817.1.
DQ489378 Genomic DNA. Translation: ABE96830.1.
BC001752 mRNA. Translation: AAH01752.1.
BC036107 mRNA. Translation: AAH36107.1.
U10149 Genomic DNA. Translation: AAC50076.1.

IPI

IPI00007702.

PIR

A55719.
I37564.

RefSeq

NP_068814.2.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3I33	X-ray	1.30	A	6-386	[»]

SMR

P54652. Positions 3-557, 545-620.

ModBase

Search...

Protein-protein interaction databases

IntAct

P54652. 8 interactions.

STRING

P54652.

PTM databases

PhosphoSite

P54652.

2-D gel databases

REPRODUCTION-2DPAGE

IPI00007702.

Proteomic databases

PeptideAtlas

P54652.

PRIDE

P54652.

Genome annotation databases

Ensembl

ENST00000247207; ENSP00000247207; ENSG00000126803; Homo sapiens. [Genome view]
ENST00000394709; ENSP00000378199; ENSG00000126803; Homo sapiens. [Genome view]

GeneID

3306.

KEGG

hsa:3306.

UCSC

uc001xhj.2. human.

Organism-specific databases

CTD

3306.

GeneCards

GC14P064072.

H-InvDB

HIX0011736.

HGNC

HGNC:5235. HSPA2.

HPA

HPA000798.

MIM

140560. gene.

PharmGKB

PA29501.

GenAtlas

Search...

Phylogenomic databases

eggNOG

maNOG09073.

HOGENOM

HBG334976.

HOVERGEN

HBG051845.

InParanoid

P54652.

OMA

LESYTYN.

OrthoDB

EOG9TQPV5.

PhylomeDB

P54652.

Gene expression databases

ArrayExpress

P54652.

Bgee

P54652.

CleanEx

HS_HSPA2.

Genevestigator

P54652.

GermOnline

ENSG00000126803. Homo sapiens.

Family and domain databases

InterPro

IPR018181. Heat_shock_70_CS.
IPR001023. Hsp70.
IPR013126. Hsp_70.
[Graphical view]

PANTHER

PTHR19375. Hsp70. 1 hit.

Pfam

PF00012. HSP70. 1 hit.
[Graphical view]

PRINTS

PR00301. HEATSHOCK70.

PROSITE

PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

13115.

SOURCE

Search...

Entry information

Entry name

HSP72_HUMAN

Accession

Primary (citable) accession number: P54652
Secondary accession number(s): Q15508, Q53XM3, Q9UE78

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	March 2, 2010
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.