ID   PTP3_DICDI              Reviewed;         990 AA.
AC   P54637; Q54SY3;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 2.
DT   27-MAR-2024, entry version 122.
DE   RecName: Full=Tyrosine-protein phosphatase 3;
DE            EC=3.1.3.48;
DE   AltName: Full=Protein-tyrosine-phosphate phosphohydrolase 3;
GN   Name=ptpC; Synonyms=ptp3; ORFNames=DDB_G0282145;
OS   Dictyostelium discoideum (Social amoeba).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=AX3;
RX   PubMed=8628311; DOI=10.1128/mcb.16.5.2431;
RA   Gamper M., Howard P.K., Hunter T., Firtel R.A.;
RT   "Multiple roles of the novel protein tyrosine phosphatase PTP3 during
RT   Dictyostelium growth and development.";
RL   Mol. Cell. Biol. 16:2431-2444(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Seems to dephosphorylate a protein of 130 kDa (p130).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-
CC         ProRule:PRU10044};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- TISSUE SPECIFICITY: In the anterior-like and prestalk cell types.
CC   -!- DEVELOPMENTAL STAGE: Expressed at moderate levels during growth and
CC       development.
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC       receptor class subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U38197; AAC47041.1; -; mRNA.
DR   EMBL; AAFI02000045; EAL66352.1; -; Genomic_DNA.
DR   RefSeq; XP_640326.1; XM_635234.1.
DR   AlphaFoldDB; P54637; -.
DR   SMR; P54637; -.
DR   STRING; 44689.P54637; -.
DR   PaxDb; 44689-DDB0214986; -.
DR   EnsemblProtists; EAL66352; EAL66352; DDB_G0282145.
DR   GeneID; 8623427; -.
DR   KEGG; ddi:DDB_G0282145; -.
DR   dictyBase; DDB_G0282145; ptpC.
DR   eggNOG; KOG0789; Eukaryota.
DR   HOGENOM; CLU_301777_0_0_1; -.
DR   InParanoid; P54637; -.
DR   OMA; SHNDLDN; -.
DR   PRO; PR:P54637; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005829; C:cytosol; IDA:dictyBase.
DR   GO; GO:0005768; C:endosome; IDA:dictyBase.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IDA:dictyBase.
DR   GO; GO:0019722; P:calcium-mediated signaling; IMP:dictyBase.
DR   GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IMP:dictyBase.
DR   GO; GO:1904893; P:negative regulation of receptor signaling pathway via STAT; IMP:dictyBase.
DR   GO; GO:0034504; P:protein localization to nucleus; IMP:dictyBase.
DR   GO; GO:1903013; P:response to differentiation-inducing factor 1; IDA:dictyBase.
DR   GO; GO:0006970; P:response to osmotic stress; IMP:dictyBase.
DR   CDD; cd00047; PTPc; 1.
DR   Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR000242; PTP_cat.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   InterPro; IPR000387; Tyr_Pase_dom.
DR   PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR   PANTHER; PTHR19134:SF555; TYROSINE-PROTEIN PHOSPHATASE 3; 1.
DR   Pfam; PF00102; Y_phosphatase; 1.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM00194; PTPc; 1.
DR   SMART; SM00404; PTPc_motif; 1.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Hydrolase; Protein phosphatase; Reference proteome.
FT   CHAIN           1..990
FT                   /note="Tyrosine-protein phosphatase 3"
FT                   /id="PRO_0000094888"
FT   DOMAIN          422..715
FT                   /note="Tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"
FT   REGION          47..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          100..193
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          246..414
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          431..452
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          786..814
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          834..990
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        246..412
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        834..966
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        967..981
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        650
FT                   /note="Phosphocysteine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00160,
FT                   ECO:0000255|PROSITE-ProRule:PRU10044"
FT   CONFLICT        187
FT                   /note="Missing (in Ref. 1; AAC47041)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   990 AA;  110110 MW;  123EAF31B9ED0AF4 CRC64;
     MISSSMSYRH STNSVYTLNP HLNIPISTST TIPPTSFYAN NTPEMIQSQS ENTNTNNINN
     SSSNINNNNN NTPDSMSMST SLSSSPSVSF NHLDLNSINN KINNNTTTNN NNNNNNNNDD
     KFDTNALKLS NTMIIKNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
     NNNNNNNSNS NIEINVPSIQ FDNEPAMEVD SVAPLNVPSN HTRTTLAMHN TKSLSTSNIG
     LLNILPNQQS SSSSSLSSTT TTTTTTSSSL LMPQSLFNNS TYNNHHNNNN SSNAGIVGGL
     NGSTSSLPTQ AQVQLQQMQQ QMQQHQQHQY KKANLSSLST VVDNNLNNNP MNTSTSSPAQ
     PNASPFSFSS SSLFSNSSLS NSGSGSASTT STSTSSSNSM SSSPPPSLKT SFSQLDEDRE
     KMRLEFEMIK KPEMASKKSH KHHQRHYSHN DLDNRKHDEE KFFSALQPNN YGKNRYHDVL
     PNESTRVRLT PIESGDGDYI NANYINGEVP NSYRYYIACQ APLPSTIKDF WRMVWEERSS
     VIVCLTKLEE NGKKKADVYY PETSQAQEYG SFWIHLHKKV MFKDIGVSSL HLYKKGEEFP
     REVVLLHYTQ WPDCGAPPSS SHIRTLSVMV NTFKARGSAK NTNGPVIVHC SAGIGRSGTF
     ISININMAKI ERFGNDPSQM NISIKDSVLE LRRQRRGMVQ TLDQYIFIFK VINDVLTDMG
     IRSLSSPSKR RSCEMIKSTP MPRLDISIPP PLTFTPKDFQ SSISPSTDMI ASLSIITQMT
     QTLKFPPQQQ QDNPFSKSSI KISPSPLNST NISIPKNQQF QHPFQIQPQL DLNLQQQQQQ
     SSQQLNDNPP LNMSSNSIKF PPVTSLSSCH LFEDSKNNDN NNKQQQQQQQ QQQKNNQQCS
     GFSHFLNNNN NNDNNGSSGG GFNGSFLFNS NNSGSSSTNS ECSNNNKNNN NNSNNNNNNN
     NNKNSDNNGT KDKDENDSCE SPRVTPIKCF
//