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Protein

Tyrosine-protein phosphatase 3

Gene

ptpC

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Seems to dephosphorylate a protein of 130 kDa (p130).

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei650Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

  • phosphatase activity Source: dictyBase
  • protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  • calcium-mediated signaling Source: dictyBase
  • dephosphorylation Source: dictyBase
  • intracellular signal transduction Source: dictyBase
  • negative regulation of STAT cascade Source: dictyBase
  • protein localization to nucleus Source: dictyBase
  • response to 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one Source: dictyBase
  • response to osmotic stress Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiR-DDI-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase 3 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine-phosphate phosphohydrolase 3
Gene namesi
Name:ptpC
Synonyms:ptp3
ORF Names:DDB_G0282145
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0282145. ptpC.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: dictyBase
  • endosome Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000948881 – 990Tyrosine-protein phosphatase 3Add BLAST990

Proteomic databases

PaxDbiP54637.
PRIDEiP54637.

Expressioni

Tissue specificityi

In the anterior-like and prestalk cell types.

Developmental stagei

Expressed at moderate levels during growth and development.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0214986.

Structurei

3D structure databases

ProteinModelPortaliP54637.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini422 – 715Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST294

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi64 – 71Poly-Asn8
Compositional biasi109 – 118Poly-Asn10
Compositional biasi137 – 191Poly-AsnAdd BLAST55
Compositional biasi250 – 258Poly-Ser9
Compositional biasi259 – 266Poly-Thr8
Compositional biasi287 – 290Poly-Asn4
Compositional biasi367 – 372Poly-Ser6
Compositional biasi788 – 791Poly-Gln4
Compositional biasi835 – 840Poly-Gln6
Compositional biasi884 – 893Poly-Gln10
Compositional biasi907 – 915Poly-Asn9
Compositional biasi944 – 964Poly-AsnAdd BLAST21

Sequence similaritiesi

Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0789. Eukaryota.
COG5599. LUCA.
InParanoidiP54637.
OMAiSININMA.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54637-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISSSMSYRH STNSVYTLNP HLNIPISTST TIPPTSFYAN NTPEMIQSQS
60 70 80 90 100
ENTNTNNINN SSSNINNNNN NTPDSMSMST SLSSSPSVSF NHLDLNSINN
110 120 130 140 150
KINNNTTTNN NNNNNNNNDD KFDTNALKLS NTMIIKNNNN NNNNNNNNNN
160 170 180 190 200
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNSNS NIEINVPSIQ
210 220 230 240 250
FDNEPAMEVD SVAPLNVPSN HTRTTLAMHN TKSLSTSNIG LLNILPNQQS
260 270 280 290 300
SSSSSLSSTT TTTTTTSSSL LMPQSLFNNS TYNNHHNNNN SSNAGIVGGL
310 320 330 340 350
NGSTSSLPTQ AQVQLQQMQQ QMQQHQQHQY KKANLSSLST VVDNNLNNNP
360 370 380 390 400
MNTSTSSPAQ PNASPFSFSS SSLFSNSSLS NSGSGSASTT STSTSSSNSM
410 420 430 440 450
SSSPPPSLKT SFSQLDEDRE KMRLEFEMIK KPEMASKKSH KHHQRHYSHN
460 470 480 490 500
DLDNRKHDEE KFFSALQPNN YGKNRYHDVL PNESTRVRLT PIESGDGDYI
510 520 530 540 550
NANYINGEVP NSYRYYIACQ APLPSTIKDF WRMVWEERSS VIVCLTKLEE
560 570 580 590 600
NGKKKADVYY PETSQAQEYG SFWIHLHKKV MFKDIGVSSL HLYKKGEEFP
610 620 630 640 650
REVVLLHYTQ WPDCGAPPSS SHIRTLSVMV NTFKARGSAK NTNGPVIVHC
660 670 680 690 700
SAGIGRSGTF ISININMAKI ERFGNDPSQM NISIKDSVLE LRRQRRGMVQ
710 720 730 740 750
TLDQYIFIFK VINDVLTDMG IRSLSSPSKR RSCEMIKSTP MPRLDISIPP
760 770 780 790 800
PLTFTPKDFQ SSISPSTDMI ASLSIITQMT QTLKFPPQQQ QDNPFSKSSI
810 820 830 840 850
KISPSPLNST NISIPKNQQF QHPFQIQPQL DLNLQQQQQQ SSQQLNDNPP
860 870 880 890 900
LNMSSNSIKF PPVTSLSSCH LFEDSKNNDN NNKQQQQQQQ QQQKNNQQCS
910 920 930 940 950
GFSHFLNNNN NNDNNGSSGG GFNGSFLFNS NNSGSSSTNS ECSNNNKNNN
960 970 980 990
NNSNNNNNNN NNKNSDNNGT KDKDENDSCE SPRVTPIKCF
Length:990
Mass (Da):110,110
Last modified:December 4, 2007 - v2
Checksum:i123EAF31B9ED0AF4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti187Missing in AAC47041 (PubMed:8628311).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38197 mRNA. Translation: AAC47041.1.
AAFI02000045 Genomic DNA. Translation: EAL66352.1.
RefSeqiXP_640326.1. XM_635234.1.

Genome annotation databases

EnsemblProtistsiEAL66352; EAL66352; DDB_G0282145.
GeneIDi8623427.
KEGGiddi:DDB_G0282145.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38197 mRNA. Translation: AAC47041.1.
AAFI02000045 Genomic DNA. Translation: EAL66352.1.
RefSeqiXP_640326.1. XM_635234.1.

3D structure databases

ProteinModelPortaliP54637.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0214986.

Proteomic databases

PaxDbiP54637.
PRIDEiP54637.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL66352; EAL66352; DDB_G0282145.
GeneIDi8623427.
KEGGiddi:DDB_G0282145.

Organism-specific databases

dictyBaseiDDB_G0282145. ptpC.

Phylogenomic databases

eggNOGiKOG0789. Eukaryota.
COG5599. LUCA.
InParanoidiP54637.
OMAiSININMA.

Enzyme and pathway databases

ReactomeiR-DDI-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiP54637.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTP3_DICDI
AccessioniPrimary (citable) accession number: P54637
Secondary accession number(s): Q54SY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 4, 2007
Last modified: November 30, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.