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P54637

- PTP3_DICDI

UniProt

P54637 - PTP3_DICDI

Protein

Tyrosine-protein phosphatase 3

Gene

ptpC

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 2 (04 Dec 2007)
      Previous versions | rss
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    Functioni

    Seems to dephosphorylate a protein of 130 kDa (p130).

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei650 – 6501Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. phosphatase activity Source: dictyBase
    2. protein binding Source: dictyBase
    3. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. dephosphorylation Source: dictyBase
    2. intracellular signal transduction Source: dictyBase
    3. protein localization to nucleus Source: dictyBase
    4. response to 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one Source: dictyBase
    5. response to osmotic stress Source: dictyBase
    6. serine phosphorylation of STAT protein Source: dictyBase

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase 3 (EC:3.1.3.48)
    Alternative name(s):
    Protein-tyrosine-phosphate phosphohydrolase 3
    Gene namesi
    Name:ptpC
    Synonyms:ptp3
    ORF Names:DDB_G0282145
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0282145. ptpC.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 990990Tyrosine-protein phosphatase 3PRO_0000094888Add
    BLAST

    Proteomic databases

    PRIDEiP54637.

    Expressioni

    Tissue specificityi

    In the anterior-like and prestalk cell types.

    Developmental stagei

    Expressed at moderate levels during growth and development.

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDB_0214986.

    Structurei

    3D structure databases

    ProteinModelPortaliP54637.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini422 – 715294Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi64 – 718Poly-Asn
    Compositional biasi109 – 11810Poly-Asn
    Compositional biasi137 – 19155Poly-AsnAdd
    BLAST
    Compositional biasi250 – 2589Poly-Ser
    Compositional biasi259 – 2668Poly-Thr
    Compositional biasi287 – 2904Poly-Asn
    Compositional biasi367 – 3726Poly-Ser
    Compositional biasi788 – 7914Poly-Gln
    Compositional biasi835 – 8406Poly-Gln
    Compositional biasi884 – 89310Poly-Gln
    Compositional biasi907 – 9159Poly-Asn
    Compositional biasi944 – 96421Poly-AsnAdd
    BLAST

    Sequence similaritiesi

    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5599.
    OMAiSININMA.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PRINTSiPR00700. PRTYPHPHTASE.
    SMARTiSM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P54637-1 [UniParc]FASTAAdd to Basket

    « Hide

    MISSSMSYRH STNSVYTLNP HLNIPISTST TIPPTSFYAN NTPEMIQSQS    50
    ENTNTNNINN SSSNINNNNN NTPDSMSMST SLSSSPSVSF NHLDLNSINN 100
    KINNNTTTNN NNNNNNNNDD KFDTNALKLS NTMIIKNNNN NNNNNNNNNN 150
    NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNSNS NIEINVPSIQ 200
    FDNEPAMEVD SVAPLNVPSN HTRTTLAMHN TKSLSTSNIG LLNILPNQQS 250
    SSSSSLSSTT TTTTTTSSSL LMPQSLFNNS TYNNHHNNNN SSNAGIVGGL 300
    NGSTSSLPTQ AQVQLQQMQQ QMQQHQQHQY KKANLSSLST VVDNNLNNNP 350
    MNTSTSSPAQ PNASPFSFSS SSLFSNSSLS NSGSGSASTT STSTSSSNSM 400
    SSSPPPSLKT SFSQLDEDRE KMRLEFEMIK KPEMASKKSH KHHQRHYSHN 450
    DLDNRKHDEE KFFSALQPNN YGKNRYHDVL PNESTRVRLT PIESGDGDYI 500
    NANYINGEVP NSYRYYIACQ APLPSTIKDF WRMVWEERSS VIVCLTKLEE 550
    NGKKKADVYY PETSQAQEYG SFWIHLHKKV MFKDIGVSSL HLYKKGEEFP 600
    REVVLLHYTQ WPDCGAPPSS SHIRTLSVMV NTFKARGSAK NTNGPVIVHC 650
    SAGIGRSGTF ISININMAKI ERFGNDPSQM NISIKDSVLE LRRQRRGMVQ 700
    TLDQYIFIFK VINDVLTDMG IRSLSSPSKR RSCEMIKSTP MPRLDISIPP 750
    PLTFTPKDFQ SSISPSTDMI ASLSIITQMT QTLKFPPQQQ QDNPFSKSSI 800
    KISPSPLNST NISIPKNQQF QHPFQIQPQL DLNLQQQQQQ SSQQLNDNPP 850
    LNMSSNSIKF PPVTSLSSCH LFEDSKNNDN NNKQQQQQQQ QQQKNNQQCS 900
    GFSHFLNNNN NNDNNGSSGG GFNGSFLFNS NNSGSSSTNS ECSNNNKNNN 950
    NNSNNNNNNN NNKNSDNNGT KDKDENDSCE SPRVTPIKCF 990
    Length:990
    Mass (Da):110,110
    Last modified:December 4, 2007 - v2
    Checksum:i123EAF31B9ED0AF4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti187 – 1871Missing in AAC47041. (PubMed:8628311)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U38197 mRNA. Translation: AAC47041.1.
    AAFI02000045 Genomic DNA. Translation: EAL66352.1.
    RefSeqiXP_640326.1. XM_635234.1.

    Genome annotation databases

    EnsemblProtistsiDDB0214986; DDB0214986; DDB_G0282145.
    GeneIDi8623427.
    KEGGiddi:DDB_G0282145.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U38197 mRNA. Translation: AAC47041.1 .
    AAFI02000045 Genomic DNA. Translation: EAL66352.1 .
    RefSeqi XP_640326.1. XM_635234.1.

    3D structure databases

    ProteinModelPortali P54637.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0214986.

    Proteomic databases

    PRIDEi P54637.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0214986 ; DDB0214986 ; DDB_G0282145 .
    GeneIDi 8623427.
    KEGGi ddi:DDB_G0282145.

    Organism-specific databases

    dictyBasei DDB_G0282145. ptpC.

    Phylogenomic databases

    eggNOGi COG5599.
    OMAi SININMA.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PRINTSi PR00700. PRTYPHPHTASE.
    SMARTi SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Multiple roles of the novel protein tyrosine phosphatase PTP3 during Dictyostelium growth and development."
      Gamper M., Howard P.K., Hunter T., Firtel R.A.
      Mol. Cell. Biol. 16:2431-2444(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: AX3.
    2. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiPTP3_DICDI
    AccessioniPrimary (citable) accession number: P54637
    Secondary accession number(s): Q54SY3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3