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P54637 (PTP3_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein phosphatase 3

EC=3.1.3.48
Alternative name(s):
Protein-tyrosine-phosphate phosphohydrolase 3
Gene names
Name:ptpC
Synonyms:ptp3
ORF Names:DDB_G0282145
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length990 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Seems to dephosphorylate a protein of 130 kDa (p130).

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Cytoplasm.

Tissue specificity

In the anterior-like and prestalk cell types.

Developmental stage

Expressed at moderate levels during growth and development.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 990990Tyrosine-protein phosphatase 3
PRO_0000094888

Regions

Domain422 – 715294Tyrosine-protein phosphatase
Compositional bias64 – 718Poly-Asn
Compositional bias109 – 11810Poly-Asn
Compositional bias137 – 19155Poly-Asn
Compositional bias250 – 2589Poly-Ser
Compositional bias259 – 2668Poly-Thr
Compositional bias287 – 2904Poly-Asn
Compositional bias367 – 3726Poly-Ser
Compositional bias788 – 7914Poly-Gln
Compositional bias835 – 8406Poly-Gln
Compositional bias884 – 89310Poly-Gln
Compositional bias907 – 9159Poly-Asn
Compositional bias944 – 96421Poly-Asn

Sites

Active site6501Phosphocysteine intermediate By similarity

Experimental info

Sequence conflict1871Missing in AAC47041. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P54637 [UniParc].

Last modified December 4, 2007. Version 2.
Checksum: 123EAF31B9ED0AF4

FASTA990110,110
        10         20         30         40         50         60 
MISSSMSYRH STNSVYTLNP HLNIPISTST TIPPTSFYAN NTPEMIQSQS ENTNTNNINN 

        70         80         90        100        110        120 
SSSNINNNNN NTPDSMSMST SLSSSPSVSF NHLDLNSINN KINNNTTTNN NNNNNNNNDD 

       130        140        150        160        170        180 
KFDTNALKLS NTMIIKNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 

       190        200        210        220        230        240 
NNNNNNNSNS NIEINVPSIQ FDNEPAMEVD SVAPLNVPSN HTRTTLAMHN TKSLSTSNIG 

       250        260        270        280        290        300 
LLNILPNQQS SSSSSLSSTT TTTTTTSSSL LMPQSLFNNS TYNNHHNNNN SSNAGIVGGL 

       310        320        330        340        350        360 
NGSTSSLPTQ AQVQLQQMQQ QMQQHQQHQY KKANLSSLST VVDNNLNNNP MNTSTSSPAQ 

       370        380        390        400        410        420 
PNASPFSFSS SSLFSNSSLS NSGSGSASTT STSTSSSNSM SSSPPPSLKT SFSQLDEDRE 

       430        440        450        460        470        480 
KMRLEFEMIK KPEMASKKSH KHHQRHYSHN DLDNRKHDEE KFFSALQPNN YGKNRYHDVL 

       490        500        510        520        530        540 
PNESTRVRLT PIESGDGDYI NANYINGEVP NSYRYYIACQ APLPSTIKDF WRMVWEERSS 

       550        560        570        580        590        600 
VIVCLTKLEE NGKKKADVYY PETSQAQEYG SFWIHLHKKV MFKDIGVSSL HLYKKGEEFP 

       610        620        630        640        650        660 
REVVLLHYTQ WPDCGAPPSS SHIRTLSVMV NTFKARGSAK NTNGPVIVHC SAGIGRSGTF 

       670        680        690        700        710        720 
ISININMAKI ERFGNDPSQM NISIKDSVLE LRRQRRGMVQ TLDQYIFIFK VINDVLTDMG 

       730        740        750        760        770        780 
IRSLSSPSKR RSCEMIKSTP MPRLDISIPP PLTFTPKDFQ SSISPSTDMI ASLSIITQMT 

       790        800        810        820        830        840 
QTLKFPPQQQ QDNPFSKSSI KISPSPLNST NISIPKNQQF QHPFQIQPQL DLNLQQQQQQ 

       850        860        870        880        890        900 
SSQQLNDNPP LNMSSNSIKF PPVTSLSSCH LFEDSKNNDN NNKQQQQQQQ QQQKNNQQCS 

       910        920        930        940        950        960 
GFSHFLNNNN NNDNNGSSGG GFNGSFLFNS NNSGSSSTNS ECSNNNKNNN NNSNNNNNNN 

       970        980        990 
NNKNSDNNGT KDKDENDSCE SPRVTPIKCF 

« Hide

References

« Hide 'large scale' references
[1]"Multiple roles of the novel protein tyrosine phosphatase PTP3 during Dictyostelium growth and development."
Gamper M., Howard P.K., Hunter T., Firtel R.A.
Mol. Cell. Biol. 16:2431-2444(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: AX3.
[2]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U38197 mRNA. Translation: AAC47041.1.
AAFI02000045 Genomic DNA. Translation: EAL66352.1.

3D structure databases

ProteinModelPortalP54637.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0214986.

Proteomic databases

PRIDEP54637.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0214986; DDB0214986; DDB_G0282145.
KEGGddi:DDB_G0282145.

Organism-specific databases

dictyBaseDDB_G0282145. ptpC.

Phylogenomic databases

eggNOGCOG5599.
OMASININMA.

Family and domain databases

InterProIPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSPR00700. PRTYPHPHTASE.
SMARTSM00194. PTPc. 1 hit.
[Graphical view]
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePTP3_DICDI
AccessionPrimary (citable) accession number: P54637
Secondary accession number(s): Q54SY3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 4, 2007
Last modified: April 16, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase