P54636 (VP2_LORDV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein VP2

Alternative name(s):
Minor capsid protein

Gene names

ORF Names:

ORF3

Organism

Lordsdale virus (strain GII/Human/United Kingdom/Lordsdale/1993) (Human enteric calicivirus) (Hu/NV/LD/1993/UK) [Complete proteome]

Taxonomic identifier

82658 [NCBI]

Taxonomic lineage

Viruses › ssRNA viruses › ssRNA positive-strand viruses, no DNA stage › Caliciviridae › Norovirus › Norwalk virus › Norovirus genogroup II

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Minor structural protein present in one or two copies per virion. Stabilizes capsid protein VP1 by protecting it from disassembly and degradation. May play a role in RNA genome packaging By similarity.
Subcellular location	Virion. Host cytoplasm By similarity.
Miscellaneous	Translated by a ribosomal termination-reinitiation process from the bicistronic mRNA encoding for VP1 and VP2.
Sequence similarities	Belongs to the norovirus VP2 family.

Ontologies

Keywords
Cellular component	Host cytoplasm Virion
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	host cell cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell virion Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 268	268	Protein VP2		PRO_0000100130

Sequences

	Sequence		Length	Mass (Da)
	P54636 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: FE6F19E4D7D1587E	FASTA	268	28,458
	10 20 30 40 50 60 MAGAFFAGLA SDVLGSGLGS LINAGAGAIN QKVEFENNRK LQQASFQFSS TLQQASFQHD 70 80 90 100 110 120 KEMLQAQIEA TQKLQQDLMK VKQAVLLEGG FSTADAARGA INAPMTKALD WSGTRYWAPD 130 140 150 160 170 180 ARVTTYNAGH FSTPQSLGAL TGRTNSRVSA PARSSPSALS NAPTATSLHS NQTVSTRLGS 190 200 210 220 230 240 SAGSGTGVSS LSSAARTRSW VEDQNRNLSP FMRGALNTSF VTPPSSRSSS QSTVSTVPKE 250 260 ILDSWTGAFN TRRQPLFAHI RKRGESRV

References

[1]

"Human enteric Caliciviridae: the complete genome sequence and expression of virus-like particles from a genetic group II small round structured virus." Dingle K.E., Lambden P.R., Caul E.O., Clarke I.N. J. Gen. Virol. 76:2349-2355(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X86557 Genomic RNA. Translation: CAA60256.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR004278. RNA_pol/capsid. [Graphical view]
Pfam	PF03035. RNA_capsid. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VP2_LORDV

Accession

Primary (citable) accession number: P54636

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program