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Protein

Protein screw

Gene

scw

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the signal that specifies dorsal cell fates in the embryo. Acts together with dpp.1 Publication

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • growth factor activity Source: UniProtKB-KW
  • protein heterodimerization activity Source: UniProtKB
  • transforming growth factor beta receptor binding Source: FlyBase

GO - Biological processi

  • amnioserosa formation Source: FlyBase
  • BMP signaling pathway Source: GO_Central
  • cell development Source: GO_Central
  • cell fate specification Source: FlyBase
  • digestive tract mesoderm development Source: FlyBase
  • dorsal/ventral pattern formation Source: FlyBase
  • gonad development Source: FlyBase
  • negative regulation of gene expression Source: FlyBase
  • positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
  • regulation of apoptotic process Source: GO_Central
  • regulation of MAPK cascade Source: GO_Central
  • SMAD protein signal transduction Source: GO_Central
  • transforming growth factor beta receptor signaling pathway Source: FlyBase
  • zygotic determination of anterior/posterior axis, embryo Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein, Growth factor
Biological processDifferentiation

Enzyme and pathway databases

SignaLinkiP54631.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein screw
Gene namesi
Name:scw
ORF Names:CG31695
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0005590. scw.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: FlyBase

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
PropeptideiPRO_000003367217 – 277Sequence analysisAdd BLAST261
ChainiPRO_0000033673278 – 400Protein screwAdd BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi165N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi189N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi201N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi300 ↔ 365By similarity
Glycosylationi304N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi329 ↔ 397By similarity
Disulfide bondi333 ↔ 399By similarity
Glycosylationi342N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi364InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP54631.
PRIDEiP54631.

Expressioni

Tissue specificityi

Ubiquitously expressed during early stages of embryogenesis, but the effect on development appears graded and is restricted to the dorsal side of the embryo.1 Publication

Developmental stagei

Expressed both maternally and zygotically. Highest embryonic expression is found during syncytial blastoderm (nuclear cycles 11-12). Expression declines rapidly at cellular blastoderm stage 5 and is not detected during the rest of embryonic development.1 Publication

Gene expression databases

BgeeiFBgn0005590.
ExpressionAtlasiP54631. differential.
GenevisibleiP54631. DM.

Interactioni

Subunit structurei

Heterodimers of scw/dpp are the active subunit, dpp/dpp homodimers elicit a basal response and scw/scw homodimers alone are ineffective in specifying a dorsal pattern.

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • growth factor activity Source: UniProtKB-KW
  • protein heterodimerization activity Source: UniProtKB
  • transforming growth factor beta receptor binding Source: FlyBase

Protein-protein interaction databases

BioGridi70052. 4 interactors.
DIPiDIP-59820N.
STRINGi7227.FBpp0080802.

Structurei

3D structure databases

ProteinModelPortaliP54631.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi283 – 297Pro-richAdd BLAST15

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
InParanoidiP54631.
OMAiCERLNFT.
OrthoDBiEOG091G0C2J.
PhylomeDBiP54631.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiView protein in InterPro
IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_propeptide.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiView protein in Pfam
PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
SMARTiView protein in SMART
SM00204. TGFB. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiView protein in PROSITE
PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54631-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNVFFLTSL FYAASATTYV TTNNHIEMPI YQKRPLSEQM EMIDILDLGD
60 70 80 90 100
RPRRQAEPNL HNSASKFLLE VYNEISEDQE PKEVLHQRHK RSLDDDILIS
110 120 130 140 150
NEDRQEIASC NSILTFSSRL KPEQLDNELD MHITFNTNDV PVDLSLVQAM
160 170 180 190 200
LRIYKQPSLV DRRANFTVSV YRKLDNRQDF SYRILGSVNT TSSQRGWLEF
210 220 230 240 250
NLTDTLRYWL HNKGLQRRNE LRISIGDSQL STFAAGLVTP QASRTSLEPF
260 270 280 290 300
IVGYFNGPEL LVKIQKLRFK RDLEKRRAGG GSPPPPPPPP VDLYRPPQSC
310 320 330 340 350
ERLNFTVDFK ELHMHNWVIA PKKFEAYFCG GGCNFPLGTK MNATNHAIVQ
360 370 380 390 400
TLMHLKQPHL PKPCCVPTVL GAITILRYLN EDIIDLTKYQ KAVAKECGCH
Length:400
Mass (Da):45,891
Last modified:November 2, 2001 - v2
Checksum:i2B42B7D28B9B8336
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6F → L in AAA56872 (PubMed:7958918).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17573 mRNA. Translation: AAA56872.1.
AE014134 Genomic DNA. Translation: AAN11056.2.
AY051793 mRNA. Translation: AAK93217.1.
RefSeqiNP_001286088.1. NM_001299159.1.
NP_524863.3. NM_080124.5.
UniGeneiDm.14123.

Genome annotation databases

EnsemblMetazoaiFBtr0081261; FBpp0080802; FBgn0005590.
FBtr0343860; FBpp0310402; FBgn0005590.
GeneIDi46000.
KEGGidme:Dmel_CG31695.
UCSCiCG31695-RA. d. melanogaster.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSCW_DROME
AccessioniPrimary (citable) accession number: P54631
Secondary accession number(s): Q8INV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 2, 2001
Last modified: June 7, 2017
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families