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P54630

- TRYZ_DROER

UniProt

P54630 - TRYZ_DROER

Protein

Trypsin zeta

Gene

zetaTry

Organism
Drosophila erecta (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei88 – 881Charge relay systemBy similarity
    Active sitei135 – 1351Charge relay systemBy similarity
    Sitei229 – 2291Required for specificityBy similarity
    Active sitei235 – 2351Charge relay systemBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS01.116.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trypsin zeta (EC:3.4.21.4)
    Gene namesi
    Name:zetaTry
    OrganismiDrosophila erecta (Fruit fly)
    Taxonomic identifieri7220 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

    Organism-specific databases

    FlyBaseiFBgn0015083. Dere\zetaTry.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323CuratedAdd
    BLAST
    Propeptidei24 – 3916Activation peptidePRO_0000028285Add
    BLAST
    Chaini40 – 281242Trypsin zetaPRO_0000028286Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi73 ↔ 89PROSITE-ProRule annotation
    Disulfide bondi199 ↔ 219PROSITE-ProRule annotation
    Disulfide bondi231 ↔ 255PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Zymogen

    Structurei

    3D structure databases

    ProteinModelPortaliP54630.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini40 – 279240Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    OrthoDBiEOG75B84T.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P54630-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSSSWLGCL LAVLLSALAL SQGLPLLEDL DENSFPDGRI VGGYVTDIAQ    50
    VPYQITLRYK AISSPENPFR HRCGGSIVNE TTILTAAHCV IGTVASQFKV 100
    VAGTNFQTGT DGVITNVKRV IMHEGYNSGA AYNNDIAVLF VDPPLPLNNF 150
    TIKAIKLATE PPLDGAPSKI SGWGSTYPGG YSSNQLLAVD VPIVGNDLCD 200
    LDYENFIDET YHITSAMLCA GKRGVGGADA CQGDSGGPLV VRDELHGVVS 250
    WGNSCALPNY PGVYANVAFL RPWIDAVRAG L 281
    Length:281
    Mass (Da):29,736
    Last modified:October 1, 1996 - v1
    Checksum:iA1E0BC1812AAD468
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U40653 Genomic DNA. Translation: AAA83236.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U40653 Genomic DNA. Translation: AAA83236.1 .

    3D structure databases

    ProteinModelPortali P54630.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S01.116.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    FlyBasei FBgn0015083. Dere\zetaTry.

    Phylogenomic databases

    OrthoDBi EOG75B84T.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Concerted evolution within a trypsin gene cluster in Drosophila."
      Wang S., Magoulas C., Hickey D.A.
      Mol. Biol. Evol. 16:1117-1124(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiTRYZ_DROER
    AccessioniPrimary (citable) accession number: P54630
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3