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P54630 (TRYZ_DROER) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length281 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Subcellular location

Secretedextracellular space.

Sequence similarities

Belongs to the peptidase S1 family.

Contains 1 peptidase S1 domain.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
Protease
Serine protease
   PTMDisulfide bond
Zymogen
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Probable
Propeptide24 – 3916Activation peptide
PRO_0000028285
Chain40 – 281242Trypsin zeta
PRO_0000028286

Regions

Domain40 – 279240Peptidase S1

Sites

Active site881Charge relay system By similarity
Active site1351Charge relay system By similarity
Active site2351Charge relay system By similarity
Site2291Required for specificity By similarity

Amino acid modifications

Disulfide bond73 ↔ 89 By similarity
Disulfide bond199 ↔ 219 By similarity
Disulfide bond231 ↔ 255 By similarity

Sequences

Sequence LengthMass (Da)Tools
P54630 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: A1E0BC1812AAD468

FASTA28129,736
        10         20         30         40         50         60 
MSSSSWLGCL LAVLLSALAL SQGLPLLEDL DENSFPDGRI VGGYVTDIAQ VPYQITLRYK 

        70         80         90        100        110        120 
AISSPENPFR HRCGGSIVNE TTILTAAHCV IGTVASQFKV VAGTNFQTGT DGVITNVKRV 

       130        140        150        160        170        180 
IMHEGYNSGA AYNNDIAVLF VDPPLPLNNF TIKAIKLATE PPLDGAPSKI SGWGSTYPGG 

       190        200        210        220        230        240 
YSSNQLLAVD VPIVGNDLCD LDYENFIDET YHITSAMLCA GKRGVGGADA CQGDSGGPLV 

       250        260        270        280 
VRDELHGVVS WGNSCALPNY PGVYANVAFL RPWIDAVRAG L 

« Hide

References

[1]"Concerted evolution within a trypsin gene cluster in Drosophila."
Wang S., Magoulas C., Hickey D.A.
Mol. Biol. Evol. 16:1117-1124(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U40653 Genomic DNA. Translation: AAA83236.1.

3D structure databases

ProteinModelPortalP54630.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS01.116.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

FlyBaseFBgn0015083. Dere\zetaTry.

Phylogenomic databases

OrthoDBEOG75B84T.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRYZ_DROER
AccessionPrimary (citable) accession number: P54630
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 13, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase