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P54629 (TRYU_DROER) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Subcellular location

Secretedextracellular space.

Sequence similarities

Belongs to the peptidase S1 family.

Contains 1 peptidase S1 domain.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
Protease
Serine protease
   PTMDisulfide bond
Zymogen
Gene Ontology (GO)
   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Propeptide23 – 275Activation peptide
PRO_0000028281
Chain28 – 258231Trypsin eta
PRO_0000028282

Regions

Domain28 – 258231Peptidase S1

Sites

Active site741Charge relay system By similarity
Active site1201Charge relay system By similarity
Active site2151Charge relay system By similarity
Site2091Required for specificity By similarity

Amino acid modifications

Disulfide bond59 ↔ 75 By similarity
Disulfide bond185 ↔ 200 By similarity
Disulfide bond211 ↔ 235 By similarity

Sequences

Sequence LengthMass (Da)Tools
P54629 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 4D45051AF8F58145

FASTA25827,343
        10         20         30         40         50         60 
MNKVILRILA LLFLLGIGAV SAQPDGRIVG GADTTNYHTK YVVQLRRRSS PSSSYAQTCG 

        70         80         90        100        110        120 
GCILDAVTIA TAAHCVYNRE AENFLVVAGD DSRGGMSGVV VRVSKLIPHE LYNATIMDND 

       130        140        150        160        170        180 
IALVIVDPPL PLASSSTMEA IEIAAEQPAV GVQATISGWG YTKENGLSSD QLQQVNVPVV 

       190        200        210        220        230        240 
DSEKCQEAYY WRPISEGMLC AGLSEGGKDA CQGDSGGPLV VANKLAGIVS WGEGCARPNY 

       250 
PGVYANVAYF KDWIASRV 

« Hide

References

[1]"Concerted evolution within a trypsin gene cluster in Drosophila."
Wang S., Magoulas C., Hickey D.A.
Mol. Biol. Evol. 16:1117-1124(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U40653 Genomic DNA. Translation: AAA83237.1.

3D structure databases

ProteinModelPortalP54629.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS01.117.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

FlyBaseFBgn0015079. Dere\etaTry.

Phylogenomic databases

OrthoDBEOG75B84T.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRYU_DROER
AccessionPrimary (citable) accession number: P54629
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase