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P54628

- TRYT_DROER

UniProt

P54628 - TRYT_DROER

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Protein

Trypsin theta

Gene
thetaTry
Organism
Drosophila erecta (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei76 – 761Charge relay system By similarity
Active sitei121 – 1211Charge relay system By similarity
Sitei210 – 2101Required for specificity By similarity
Active sitei216 – 2161Charge relay system By similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.114.

Names & Taxonomyi

Protein namesi
Recommended name:
Trypsin theta (EC:3.4.21.4)
Gene namesi
Name:thetaTry
OrganismiDrosophila erecta (Fruit fly)
Taxonomic identifieri7220 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0015082. Dere\thetaTry.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 InferredAdd
BLAST
Propeptidei20 – 3415Activation peptidePRO_0000028277Add
BLAST
Chaini35 – 262228Trypsin thetaPRO_0000028278Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi61 ↔ 77 By similarity
Disulfide bondi186 ↔ 203 By similarity
Disulfide bondi212 ↔ 236 By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Structurei

3D structure databases

ProteinModelPortaliP54628.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 260226Peptidase S1Add
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.

Keywords - Domaini

Signal

Phylogenomic databases

OrthoDBiEOG7MKW6Q.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54628-1 [UniParc]FASTAAdd to Basket

« Hide

MHGLVVLLVC LAVGSAFAGT IGVSNADPFE REGRIVGGED TTIRAHPYQV    50
SLQNKKGSHF CGGSLINEDT VVTAAHCLVG KKIAKVFVRL GSTLYNEGGI 100
VVAVRALTYN ADYSSKTMEN DVGILKLAEK VKETDDIRYI ELATETPPTG 150
TTAVVTGWGS KCYFWCMTLP KTLQAVYVNI VDWKTCASDE YKYGEVIYDT 200
MVCAYEKKKD ACQGDSGGPL AIGNTLVGIV SWGYACASNL LPGVYSDVPA 250
LRKWILNASQ TL 262
Length:262
Mass (Da):28,210
Last modified:October 1, 1996 - v1
Checksum:iEF3BCABD1143F25D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U40653 Genomic DNA. Translation: AAA83238.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U40653 Genomic DNA. Translation: AAA83238.1 .

3D structure databases

ProteinModelPortali P54628.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S01.114.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

FlyBasei FBgn0015082. Dere\thetaTry.

Phylogenomic databases

OrthoDBi EOG7MKW6Q.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Concerted evolution within a trypsin gene cluster in Drosophila."
    Wang S., Magoulas C., Hickey D.A.
    Mol. Biol. Evol. 16:1117-1124(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiTRYT_DROER
AccessioniPrimary (citable) accession number: P54628
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi