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P54628 (TRYT_DROER) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length262 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Subcellular location

Secretedextracellular space.

Sequence similarities

Belongs to the peptidase S1 family.

Contains 1 peptidase S1 domain.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
Protease
Serine protease
   PTMDisulfide bond
Zymogen
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Probable
Propeptide20 – 3415Activation peptide
PRO_0000028277
Chain35 – 262228Trypsin theta
PRO_0000028278

Regions

Domain35 – 260226Peptidase S1

Sites

Active site761Charge relay system By similarity
Active site1211Charge relay system By similarity
Active site2161Charge relay system By similarity
Site2101Required for specificity By similarity

Amino acid modifications

Disulfide bond61 ↔ 77 By similarity
Disulfide bond186 ↔ 203 By similarity
Disulfide bond212 ↔ 236 By similarity

Sequences

Sequence LengthMass (Da)Tools
P54628 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: EF3BCABD1143F25D

FASTA26228,210
        10         20         30         40         50         60 
MHGLVVLLVC LAVGSAFAGT IGVSNADPFE REGRIVGGED TTIRAHPYQV SLQNKKGSHF 

        70         80         90        100        110        120 
CGGSLINEDT VVTAAHCLVG KKIAKVFVRL GSTLYNEGGI VVAVRALTYN ADYSSKTMEN 

       130        140        150        160        170        180 
DVGILKLAEK VKETDDIRYI ELATETPPTG TTAVVTGWGS KCYFWCMTLP KTLQAVYVNI 

       190        200        210        220        230        240 
VDWKTCASDE YKYGEVIYDT MVCAYEKKKD ACQGDSGGPL AIGNTLVGIV SWGYACASNL 

       250        260 
LPGVYSDVPA LRKWILNASQ TL 

« Hide

References

[1]"Concerted evolution within a trypsin gene cluster in Drosophila."
Wang S., Magoulas C., Hickey D.A.
Mol. Biol. Evol. 16:1117-1124(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U40653 Genomic DNA. Translation: AAA83238.1.

3D structure databases

ProteinModelPortalP54628.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS01.114.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

FlyBaseFBgn0015082. Dere\thetaTry.

Phylogenomic databases

OrthoDBEOG7MKW6Q.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRYT_DROER
AccessionPrimary (citable) accession number: P54628
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 13, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase