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P54625

- TRYB_DROER

UniProt

P54625 - TRYB_DROER

Protein

Trypsin beta

Gene

betaTry

Organism
Drosophila erecta (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei71 – 711Charge relay systemBy similarity
    Active sitei116 – 1161Charge relay systemBy similarity
    Sitei204 – 2041Required for specificityBy similarity
    Active sitei210 – 2101Charge relay systemBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS01.110.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trypsin beta (EC:3.4.21.4)
    Gene namesi
    Name:betaTry
    ORF Names:GG20194
    OrganismiDrosophila erecta (Fruit fly)
    Taxonomic identifieri7220 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000008711: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0015077. Dere\betaTry.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222CuratedAdd
    BLAST
    Propeptidei23 – 308Activation peptidePRO_0000028263
    Chaini31 – 253223Trypsin betaPRO_0000028264Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi56 ↔ 72PROSITE-ProRule annotation
    Disulfide bondi180 ↔ 197PROSITE-ProRule annotation
    Disulfide bondi206 ↔ 230PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Zymogen

    Structurei

    3D structure databases

    ProteinModelPortaliP54625.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini31 – 253223Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    OrthoDBiEOG7MKW6Q.
    PhylomeDBiP54625.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P54625-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKFVILLSA VACALGGTIP EGLLPQLDGR IVGGTATTIS SFPWQISLQR    50
    SGSHSCGGSI YTDRVIVTAA HCLQSVSASS LQIRAGSSYW SSGGVTVKVS 100
    SFKNHEGYNP NTMVNDIAVI RLSSSLGFSS TIKSISLASS NPANGAAASV 150
    SGWGTQSSGS SSIPSQLQYV NVNIVSQSKC ASSAYGYGSE IRNTMICAAA 200
    SGKDACQGDS GGPLVSGGVL VGVVSWGYGC AYSNYPGVYA SVADLRSWVI 250
    NNA 253
    Length:253
    Mass (Da):25,814
    Last modified:October 1, 1996 - v1
    Checksum:i073832534B59655E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U40653 Genomic DNA. Translation: AAA83241.1.
    CH954179 Genomic DNA. Translation: EDV56479.1.
    RefSeqiXP_001976079.1. XM_001976043.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0140248; FBpp0138740; FBgn0015077.
    GeneIDi6547181.
    KEGGider:Dere_GG20194.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U40653 Genomic DNA. Translation: AAA83241.1 .
    CH954179 Genomic DNA. Translation: EDV56479.1 .
    RefSeqi XP_001976079.1. XM_001976043.1.

    3D structure databases

    ProteinModelPortali P54625.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S01.110.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0140248 ; FBpp0138740 ; FBgn0015077 .
    GeneIDi 6547181.
    KEGGi der:Dere_GG20194.

    Organism-specific databases

    FlyBasei FBgn0015077. Dere\betaTry.

    Phylogenomic databases

    OrthoDBi EOG7MKW6Q.
    PhylomeDBi P54625.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Concerted evolution within a trypsin gene cluster in Drosophila."
      Wang S., Magoulas C., Hickey D.A.
      Mol. Biol. Evol. 16:1117-1124(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 14021-0224.01.

    Entry informationi

    Entry nameiTRYB_DROER
    AccessioniPrimary (citable) accession number: P54625
    Secondary accession number(s): B3NSH7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3