Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P54625

- TRYB_DROER

UniProt

P54625 - TRYB_DROER

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Trypsin beta

Gene

betaTry

Organism
Drosophila erecta (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei71 – 711Charge relay systemBy similarity
Active sitei116 – 1161Charge relay systemBy similarity
Sitei204 – 2041Required for specificityBy similarity
Active sitei210 – 2101Charge relay systemBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.110.

Names & Taxonomyi

Protein namesi
Recommended name:
Trypsin beta (EC:3.4.21.4)
Gene namesi
Name:betaTry
ORF Names:GG20194
OrganismiDrosophila erecta (Fruit fly)
Taxonomic identifieri7220 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000008711: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0015077. Dere\betaTry.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222CuratedAdd
BLAST
Propeptidei23 – 308Activation peptidePRO_0000028263
Chaini31 – 253223Trypsin betaPRO_0000028264Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi56 ↔ 72PROSITE-ProRule annotation
Disulfide bondi180 ↔ 197PROSITE-ProRule annotation
Disulfide bondi206 ↔ 230PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Structurei

3D structure databases

ProteinModelPortaliP54625.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 253223Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

KOiK01312.
OrthoDBiEOG7MKW6Q.
PhylomeDBiP54625.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54625-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKFVILLSA VACALGGTIP EGLLPQLDGR IVGGTATTIS SFPWQISLQR
60 70 80 90 100
SGSHSCGGSI YTDRVIVTAA HCLQSVSASS LQIRAGSSYW SSGGVTVKVS
110 120 130 140 150
SFKNHEGYNP NTMVNDIAVI RLSSSLGFSS TIKSISLASS NPANGAAASV
160 170 180 190 200
SGWGTQSSGS SSIPSQLQYV NVNIVSQSKC ASSAYGYGSE IRNTMICAAA
210 220 230 240 250
SGKDACQGDS GGPLVSGGVL VGVVSWGYGC AYSNYPGVYA SVADLRSWVI

NNA
Length:253
Mass (Da):25,814
Last modified:October 1, 1996 - v1
Checksum:i073832534B59655E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U40653 Genomic DNA. Translation: AAA83241.1.
CH954179 Genomic DNA. Translation: EDV56479.1.
RefSeqiXP_001976079.1. XM_001976043.1.

Genome annotation databases

EnsemblMetazoaiFBtr0140248; FBpp0138740; FBgn0015077.
GeneIDi6547181.
KEGGider:Dere_GG20194.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U40653 Genomic DNA. Translation: AAA83241.1 .
CH954179 Genomic DNA. Translation: EDV56479.1 .
RefSeqi XP_001976079.1. XM_001976043.1.

3D structure databases

ProteinModelPortali P54625.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S01.110.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0140248 ; FBpp0138740 ; FBgn0015077 .
GeneIDi 6547181.
KEGGi der:Dere_GG20194.

Organism-specific databases

FlyBasei FBgn0015077. Dere\betaTry.

Phylogenomic databases

KOi K01312.
OrthoDBi EOG7MKW6Q.
PhylomeDBi P54625.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Concerted evolution within a trypsin gene cluster in Drosophila."
    Wang S., Magoulas C., Hickey D.A.
    Mol. Biol. Evol. 16:1117-1124(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 14021-0224.01.

Entry informationi

Entry nameiTRYB_DROER
AccessioniPrimary (citable) accession number: P54625
Secondary accession number(s): B3NSH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3