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P54624

- TRYA_DROER

UniProt

P54624 - TRYA_DROER

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Protein
Trypsin alpha
Gene
alphaTry
Organism
Drosophila erecta (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei71 – 711Charge relay system By similarity
Active sitei116 – 1161Charge relay system By similarity
Sitei204 – 2041Required for specificity By similarity
Active sitei210 – 2101Charge relay system By similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS01.110.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trypsin alpha (EC:3.4.21.4)
    Gene namesi
    Name:alphaTry
    OrganismiDrosophila erecta (Fruit fly)
    Taxonomic identifieri7220 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

    Organism-specific databases

    FlyBaseiFBgn0015076. Dere\alphaTry.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222 Inferred
    Add
    BLAST
    Propeptidei23 – 308Activation peptide
    PRO_0000028259
    Chaini31 – 256226Trypsin alpha
    PRO_0000028260Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi56 ↔ 72 By similarity
    Disulfide bondi180 ↔ 197 By similarity
    Disulfide bondi206 ↔ 230 By similarity

    Keywords - PTMi

    Disulfide bond, Zymogen

    Structurei

    3D structure databases

    ProteinModelPortaliP54624.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini31 – 254224Peptidase S1
    Add
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.

    Keywords - Domaini

    Signal

    Phylogenomic databases

    OrthoDBiEOG7MKW6Q.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P54624-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKIVILLSA VVCALGGTVP EGLLPQLDGR IVGGSATTIS SFPWQISLQR    50
    SGSHSCGGSV YSANIIVTAA HCLQSVSASS LQVRAGSTYW SSGGVVAKVA 100
    AFRNHEGYNA NTMVNDIAVI RLSSSLSFSS SIKAIALATY NPANGAAAAV 150
    SGWGTQSSGS NSIPSQLQYV NVNIVSQSKC ASSAYGYGSE IRNTMICAAA 200
    SGKDACQGDS GGPLVSGGVL VGVVSWGYGC AYSNYPGVYA DVAVLRSWVI 250
    STANSI 256
    Length:256
    Mass (Da):25,991
    Last modified:October 1, 1996 - v1
    Checksum:i32C4B5BED84BCC2D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U40653 Genomic DNA. Translation: AAA83239.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U40653 Genomic DNA. Translation: AAA83239.1 .

    3D structure databases

    ProteinModelPortali P54624.
    ModBasei Search...

    Protein family/group databases

    MEROPSi S01.110.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    FlyBasei FBgn0015076. Dere\alphaTry.

    Phylogenomic databases

    OrthoDBi EOG7MKW6Q.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Concerted evolution within a trypsin gene cluster in Drosophila."
      Wang S., Magoulas C., Hickey D.A.
      Mol. Biol. Evol. 16:1117-1124(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiTRYA_DROER
    AccessioniPrimary (citable) accession number: P54624
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: July 9, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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