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Protein

Single-stranded DNA-binding protein, mitochondrial

Gene

mtSSB

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein binds preferentially and cooperatively to pyrimidine rich ss-DNA. Required for mitochondrial DNA replication.3 Publications

GO - Molecular functioni

  • single-stranded DNA binding Source: UniProtKB

GO - Biological processi

  • mitochondrial DNA replication Source: UniProtKB
  • mitochondrial genome maintenance Source: UniProtKB

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
Single-stranded DNA-binding protein, mitochondrial
Short name:
Dm mtSSB
Short name:
Mt-SSB
Short name:
MtSSB
Alternative name(s):
Protein low power
Gene namesi
Name:mtSSB
Synonyms:lopo
ORF Names:CG4337
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0010438 mtSSB

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 22Mitochondrion1 PublicationAdd BLAST22
ChainiPRO_000003326823 – 146Single-stranded DNA-binding protein, mitochondrialAdd BLAST124

Proteomic databases

PaxDbiP54622
PRIDEiP54622

Expressioni

Tissue specificityi

Uniformly distributed in the early embryo. High levels detected in the anterior and posterior midgut primordia of stage 12 embryos. In larvae, high levels were detected in proliferating tissues including the CNS and digestive tract. In adults, highly expressed in the CNS, digestive tract and ovary.3 Publications

Developmental stagei

Expressed both maternally and zygotically. Levels are high during embryogenesis and in the larvae but decrease in the pupae before increasing again in the adult.3 Publications

Gene expression databases

BgeeiFBgn0010438
GenevisibleiP54622 DM

Interactioni

Subunit structurei

Homotetramer.1 Publication

Protein-protein interaction databases

BioGridi67018, 18 interactors
DIPiDIP-22042N
IntActiP54622, 6 interactors
MINTiP54622
STRINGi7227.FBpp0099503

Structurei

3D structure databases

ProteinModelPortaliP54622
SMRiP54622
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 142SSBAdd BLAST105

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1653 Eukaryota
COG0629 LUCA
GeneTreeiENSGT00390000002796
InParanoidiP54622
KOiK03111
OMAiSLATHTN
OrthoDBiEOG091G1330
PhylomeDBiP54622

Family and domain databases

CDDicd04496 SSB_OBF, 1 hit
HAMAPiMF_00984 SSB, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR000424 Primosome_PriB/ssb
IPR011344 ssDNA-bd
PANTHERiPTHR10302 PTHR10302, 1 hit
PTHR10302:SF0 PTHR10302:SF0, 1 hit
PfamiView protein in Pfam
PF00436 SSB, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00621 ssb, 1 hit
PROSITEiView protein in PROSITE
PS50935 SSB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54622-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQHTRRMLNP LLTGLRNLPA RGATTTTAAA PAKVEKTVNT VTILGRVGAD
60 70 80 90 100
PQLRGSQEHP VVTFSVATHT NYKYENGDWA QRTDWHRVVV FKPNLRDTVL
110 120 130 140
EYLKKGQRTM VQGKITYGEI TDQQGNQKTS TSIIADDVLF FRDANN
Length:146
Mass (Da):16,368
Last modified:July 25, 2003 - v2
Checksum:iAD505175C0555D48
GO

Sequence cautioni

The sequence AAA20507 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAF16936 differs from that shown. Reason: Erroneous gene model prediction.Curated

Mass spectrometryi

Molecular mass is 13845±14 Da from positions 23 - 146. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181084 Genomic DNA Translation: AAF16936.1 Sequence problems.
AE014297 Genomic DNA Translation: AAF55287.2
BT016028 mRNA Translation: AAV36913.2
U00669 mRNA Translation: AAA20507.1 Different initiation.
RefSeqiNP_536744.2, NM_080496.4
UniGeneiDm.5334

Genome annotation databases

EnsemblMetazoaiFBtr0083277; FBpp0082729; FBgn0010438
GeneIDi41968
KEGGidme:Dmel_CG4337

Similar proteinsi

Entry informationi

Entry nameiSSBP_DROME
AccessioniPrimary (citable) accession number: P54622
Secondary accession number(s): Q5U164, Q9V3U4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 25, 2003
Last modified: May 23, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase

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