ID OSTR_MOUSE Reviewed; 95 AA. AC P54615; Q78H72; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1996, sequence version 1. DT 24-JAN-2024, entry version 150. DE RecName: Full=Osteocalcin-related protein {ECO:0000303|PubMed:8288580}; DE AltName: Full=Gamma-carboxyglutamic acid-containing protein 3 {ECO:0000305}; DE AltName: Full=Nephrocalcin {ECO:0000303|PubMed:8288580}; DE AltName: Full=OC-X {ECO:0000312|MGI:MGI:88155}; DE Flags: Precursor; GN Name=Bglap3 {ECO:0000312|MGI:MGI:88155}; GN Synonyms=Bglap-rs1 {ECO:0000312|MGI:MGI:88155}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY. RX PubMed=8288580; DOI=10.1016/s0021-9258(17)42240-x; RA Desbois C., Hogue D.A., Karsenty G.; RT "The mouse osteocalcin gene cluster contains three genes with two separate RT spatial and temporal patterns of expression."; RL J. Biol. Chem. 269:1183-1190(1994). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=8243336; DOI=10.1210/endo.133.6.8243336; RA Rahman S., Oberdorf A., Montecino M., Tanhauser S.M., Lian J.B., RA Stein G.S., Laipis P.J., Stein J.L.; RT "Multiple copies of the bone-specific osteocalcin gene in mouse and rat."; RL Endocrinology 133:3050-3053(1993). RN [3] RP NUCLEOTIDE SEQUENCE. RC STRAIN=129/SvJ; TISSUE=Liver; RA Yotov W.V., St Arnaud R.; RL Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Salivary gland {ECO:0000312|EMBL:AAH31815.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Binds strongly to apatite and calcium. CC {ECO:0000250|UniProtKB:P02820}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. CC -!- TISSUE SPECIFICITY: Expressed in kidney and lung, but not in bone. CC {ECO:0000269|PubMed:8288580}. CC -!- PTM: Gamma-carboxyglutamic acid residues are formed by vitamin K CC dependent carboxylation. These residues are essential for the binding CC of calcium. {ECO:0000250|UniProtKB:P02820}. CC -!- SIMILARITY: Belongs to the osteocalcin/matrix Gla protein family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L24430; AAA39855.1; -; Genomic_DNA. DR EMBL; S67456; AAB29146.1; -; Genomic_DNA. DR EMBL; U11541; AAB60445.1; -; Unassigned_DNA. DR EMBL; BC031815; AAH31815.1; -; mRNA. DR EMBL; BC055868; AAH55868.1; -; mRNA. DR EMBL; BC100687; AAI00688.1; -; mRNA. DR EMBL; BC101948; AAI01949.1; -; mRNA. DR EMBL; BC141238; AAI41239.1; -; mRNA. DR EMBL; BC145565; AAI45566.1; -; mRNA. DR CCDS; CCDS17472.1; -. DR PIR; I61188; I61188. DR RefSeq; NP_001292377.1; NM_001305448.1. DR RefSeq; NP_001292378.1; NM_001305449.1. DR RefSeq; NP_001292379.1; NM_001305450.1. DR RefSeq; NP_112736.3; NM_031368.5. DR AlphaFoldDB; P54615; -. DR SMR; P54615; -. DR STRING; 10090.ENSMUSP00000103166; -. DR PaxDb; 10090-ENSMUSP00000074965; -. DR DNASU; 12095; -. DR Ensembl; ENSMUST00000075523.11; ENSMUSP00000074965.5; ENSMUSG00000074489.10. DR Ensembl; ENSMUST00000107542.2; ENSMUSP00000103166.2; ENSMUSG00000074489.10. DR Ensembl; ENSMUST00000107543.8; ENSMUSP00000103167.2; ENSMUSG00000074489.10. DR GeneID; 12095; -. DR KEGG; mmu:12095; -. DR UCSC; uc008puv.3; mouse. DR UCSC; uc012cru.2; mouse. DR AGR; MGI:88155; -. DR CTD; 12095; -. DR MGI; MGI:88155; Bglap3. DR VEuPathDB; HostDB:ENSMUSG00000074489; -. DR eggNOG; ENOG502S85I; Eukaryota. DR GeneTree; ENSGT00410000026290; -. DR HOGENOM; CLU_160110_0_0_1; -. DR InParanoid; P54615; -. DR OMA; MGFQDAY; -. DR OrthoDB; 4841862at2759; -. DR PhylomeDB; P54615; -. DR TreeFam; TF330920; -. DR BioGRID-ORCS; 12095; 0 hits in 56 CRISPR screens. DR ChiTaRS; Bglap3; mouse. DR PRO; PR:P54615; -. DR Proteomes; UP000000589; Chromosome 3. DR RNAct; P54615; Protein. DR Bgee; ENSMUSG00000074489; Expressed in esophagus and 75 other cell types or tissues. DR GO; GO:0042995; C:cell projection; ISO:MGI. DR GO; GO:0005737; C:cytoplasm; ISO:MGI. DR GO; GO:0030425; C:dendrite; ISO:MGI. DR GO; GO:0005576; C:extracellular region; IBA:GO_Central. DR GO; GO:0005615; C:extracellular space; ISO:MGI. DR GO; GO:0043204; C:perikaryon; ISO:MGI. DR GO; GO:0031982; C:vesicle; ISO:MGI. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0046848; F:hydroxyapatite binding; IBA:GO_Central. DR GO; GO:0008147; F:structural constituent of bone; ISO:MGI. DR GO; GO:0031214; P:biomineral tissue development; IEA:UniProtKB-KW. DR GO; GO:0060348; P:bone development; IBA:GO_Central. DR GO; GO:0016311; P:dephosphorylation; ISO:MGI. DR GO; GO:0001649; P:osteoblast differentiation; IBA:GO_Central. DR GO; GO:0030500; P:regulation of bone mineralization; IEA:InterPro. DR GO; GO:1900076; P:regulation of cellular response to insulin stimulus; IEA:InterPro. DR GO; GO:0032571; P:response to vitamin K; IEA:InterPro. DR InterPro; IPR035972; GLA-like_dom_SF. DR InterPro; IPR000294; GLA_domain. DR InterPro; IPR039176; Osteocalcin. DR InterPro; IPR002384; Osteocalcin/MGP. DR PANTHER; PTHR14235; OSTEOCALCIN; 1. DR PANTHER; PTHR14235:SF0; OSTEOCALCIN; 1. DR PRINTS; PR00002; GLABONE. DR SMART; SM00069; GLA; 1. DR SUPFAM; SSF57630; GLA-domain; 1. DR PROSITE; PS00011; GLA_1; 1. DR PROSITE; PS50998; GLA_2; 1. DR Genevisible; P54615; MM. PE 2: Evidence at transcript level; KW Biomineralization; Calcium; Cleavage on pair of basic residues; KW Disulfide bond; Gamma-carboxyglutamic acid; Metal-binding; KW Reference proteome; Secreted; Signal. FT SIGNAL 1..23 FT /evidence="ECO:0000255" FT PROPEP 24..49 FT /evidence="ECO:0000305" FT /id="PRO_0000011090" FT CHAIN 50..95 FT /note="Osteocalcin-related protein" FT /id="PRO_0000011091" FT DOMAIN 46..92 FT /note="Gla" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00463" FT BINDING 62 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="3" FT /evidence="ECO:0000250|UniProtKB:P02820" FT BINDING 66 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="2" FT /evidence="ECO:0000250|UniProtKB:P02820" FT BINDING 69 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="1" FT /evidence="ECO:0000250|UniProtKB:P02820" FT BINDING 69 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="2" FT /evidence="ECO:0000250|UniProtKB:P02820" FT BINDING 75 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="1" FT /evidence="ECO:0000250|UniProtKB:P02820" FT MOD_RES 66 FT /note="4-carboxyglutamate" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00463" FT MOD_RES 69 FT /note="4-carboxyglutamate" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00463" FT DISULFID 68..74 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00463" FT CONFLICT 26 FT /note="T -> S (in Ref. 4; FT AAH31815/AAH55868/AAI00688/AAI01949/AAI41239/AAI45566)" FT /evidence="ECO:0000305" SQ SEQUENCE 95 AA; 10459 MW; 231968AA8B55848E CRC64; MRTLSLLTLL ALAALCLSDL TDATPTGPES DKAFMSKQEG NKVVNRLRRY LGASVPSPDP LEPTRELCEL DPACDELSNQ YGLKTAYRRI YGITI //