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P54615 (OSTR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Osteocalcin-related protein
Alternative name(s):
Nephrocalcin
OC-X
Gene names
Name:Bglap-rs1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length95 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.

Subcellular location

Secreted.

Tissue specificity

Expressed in kidney but not in bone.

Post-translational modification

Gamma-carboxyglutamic acid residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium By similarity.

Sequence similarities

Belongs to the osteocalcin/matrix Gla protein family.

Contains 1 Gla (gamma-carboxy-glutamate) domain.

Ontologies

Keywords
   Biological processBiomineralization
   Cellular componentSecreted
   DomainSignal
   LigandCalcium
   PTMCleavage on pair of basic residues
Disulfide bond
Gamma-carboxyglutamic acid
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbiomineral tissue development

Inferred from electronic annotation. Source: UniProtKB-KW

regulation of bone mineralization

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Probable
Propeptide24 – 4926 Probable
PRO_0000011090
Chain50 – 9546Osteocalcin-related protein
PRO_0000011091

Regions

Domain46 – 9247Gla

Amino acid modifications

Disulfide bond68 ↔ 74 By similarity

Sequences

Sequence LengthMass (Da)Tools
P54615 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 231968AA8B55848E

FASTA9510,459
        10         20         30         40         50         60 
MRTLSLLTLL ALAALCLSDL TDATPTGPES DKAFMSKQEG NKVVNRLRRY LGASVPSPDP 

        70         80         90 
LEPTRELCEL DPACDELSNQ YGLKTAYRRI YGITI 

« Hide

References

[1]"The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression."
Desbois C., Hogue D.A., Karsenty G.
J. Biol. Chem. 269:1183-1190(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Multiple copies of the bone-specific osteocalcin gene in mouse and rat."
Rahman S., Oberdorf A., Montecino M., Tanhauser S.M., Lian J.B., Stein G.S., Laipis P.J., Stein J.L.
Endocrinology 133:3050-3053(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]Yotov W.V., St Arnaud R.
Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 129/SvJ.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L24430 Genomic DNA. Translation: AAA39855.1.
S67456 Genomic DNA. Translation: AAB29146.1.
U11541 Unassigned DNA. Translation: AAB60445.1.
CCDSCCDS17472.1.
PIRI61188.
RefSeqNP_112736.3. NM_031368.4.
XP_006501001.1. XM_006500938.1.
UniGeneMm.482191.

3D structure databases

ProteinModelPortalP54615.
SMRP54615. Positions 62-92.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000103167.

Proteomic databases

PaxDbP54615.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000075523; ENSMUSP00000074965; ENSMUSG00000074489.
ENSMUST00000107542; ENSMUSP00000103166; ENSMUSG00000074489.
ENSMUST00000107543; ENSMUSP00000103167; ENSMUSG00000074489.
GeneID12095.
KEGGmmu:12095.
UCSCuc008puv.2. mouse.

Organism-specific databases

CTD12095.
MGIMGI:88155. Bglap-rs1.

Phylogenomic databases

eggNOGNOG72046.
GeneTreeENSGT00410000026290.
HOGENOMHOG000115820.
HOVERGENHBG003085.
InParanoidP54615.
OMALIERCIN.
OrthoDBEOG7VDXRQ.
PhylomeDBP54615.
TreeFamTF330920.

Gene expression databases

BgeeP54615.
GenevestigatorP54615.

Family and domain databases

InterProIPR000294. GLA_domain.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PfamPF00594. Gla. 1 hit.
[Graphical view]
PRINTSPR00002. GLABONE.
SMARTSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMSSF57630. SSF57630. 1 hit.
PROSITEPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio280411.
PROP54615.
SOURCESearch...

Entry information

Entry nameOSTR_MOUSE
AccessionPrimary (citable) accession number: P54615
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot