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P54615

- OSTR_MOUSE

UniProt

P54615 - OSTR_MOUSE

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Protein

Osteocalcin-related protein

Gene

Bglap-rs1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. biomineral tissue development Source: UniProtKB-KW
  2. regulation of bone mineralization Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Biomineralization

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Osteocalcin-related protein
Alternative name(s):
Nephrocalcin
OC-X
Gene namesi
Name:Bglap-rs1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:88155. Bglap-rs1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323CuratedAdd
BLAST
Propeptidei24 – 4926CuratedPRO_0000011090Add
BLAST
Chaini50 – 9546Osteocalcin-related proteinPRO_0000011091Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi68 ↔ 74PROSITE-ProRule annotation

Post-translational modificationi

Gamma-carboxyglutamic acid residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium (By similarity).By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acid

Proteomic databases

PaxDbiP54615.

Expressioni

Tissue specificityi

Expressed in kidney but not in bone.

Gene expression databases

BgeeiP54615.
GenevestigatoriP54615.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103167.

Structurei

3D structure databases

ProteinModelPortaliP54615.
SMRiP54615. Positions 62-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 9247GlaPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG72046.
GeneTreeiENSGT00410000026290.
HOGENOMiHOG000115820.
HOVERGENiHBG003085.
InParanoidiP54615.
OMAiLIERCIN.
OrthoDBiEOG7VDXRQ.
PhylomeDBiP54615.
TreeFamiTF330920.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PfamiPF00594. Gla. 1 hit.
[Graphical view]
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54615-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRTLSLLTLL ALAALCLSDL TDATPTGPES DKAFMSKQEG NKVVNRLRRY
60 70 80 90
LGASVPSPDP LEPTRELCEL DPACDELSNQ YGLKTAYRRI YGITI
Length:95
Mass (Da):10,459
Last modified:October 1, 1996 - v1
Checksum:i231968AA8B55848E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L24430 Genomic DNA. Translation: AAA39855.1.
S67456 Genomic DNA. Translation: AAB29146.1.
U11541 Unassigned DNA. Translation: AAB60445.1.
CCDSiCCDS17472.1.
PIRiI61188.
RefSeqiNP_112736.3. NM_031368.4.
XP_006501001.1. XM_006500938.1.
UniGeneiMm.482191.

Genome annotation databases

EnsembliENSMUST00000075523; ENSMUSP00000074965; ENSMUSG00000074489.
ENSMUST00000107542; ENSMUSP00000103166; ENSMUSG00000074489.
ENSMUST00000107543; ENSMUSP00000103167; ENSMUSG00000074489.
GeneIDi12095.
KEGGimmu:12095.
UCSCiuc008puv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L24430 Genomic DNA. Translation: AAA39855.1 .
S67456 Genomic DNA. Translation: AAB29146.1 .
U11541 Unassigned DNA. Translation: AAB60445.1 .
CCDSi CCDS17472.1.
PIRi I61188.
RefSeqi NP_112736.3. NM_031368.4.
XP_006501001.1. XM_006500938.1.
UniGenei Mm.482191.

3D structure databases

ProteinModelPortali P54615.
SMRi P54615. Positions 62-92.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000103167.

Proteomic databases

PaxDbi P54615.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000075523 ; ENSMUSP00000074965 ; ENSMUSG00000074489 .
ENSMUST00000107542 ; ENSMUSP00000103166 ; ENSMUSG00000074489 .
ENSMUST00000107543 ; ENSMUSP00000103167 ; ENSMUSG00000074489 .
GeneIDi 12095.
KEGGi mmu:12095.
UCSCi uc008puv.2. mouse.

Organism-specific databases

CTDi 12095.
MGIi MGI:88155. Bglap-rs1.

Phylogenomic databases

eggNOGi NOG72046.
GeneTreei ENSGT00410000026290.
HOGENOMi HOG000115820.
HOVERGENi HBG003085.
InParanoidi P54615.
OMAi LIERCIN.
OrthoDBi EOG7VDXRQ.
PhylomeDBi P54615.
TreeFami TF330920.

Miscellaneous databases

NextBioi 280411.
PROi P54615.
SOURCEi Search...

Gene expression databases

Bgeei P54615.
Genevestigatori P54615.

Family and domain databases

InterProi IPR000294. GLA_domain.
IPR002384. Osteocalcin/MGP.
[Graphical view ]
Pfami PF00594. Gla. 1 hit.
[Graphical view ]
PRINTSi PR00002. GLABONE.
SMARTi SM00069. GLA. 1 hit.
[Graphical view ]
SUPFAMi SSF57630. SSF57630. 1 hit.
PROSITEi PS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression."
    Desbois C., Hogue D.A., Karsenty G.
    J. Biol. Chem. 269:1183-1190(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Multiple copies of the bone-specific osteocalcin gene in mouse and rat."
    Rahman S., Oberdorf A., Montecino M., Tanhauser S.M., Lian J.B., Stein G.S., Laipis P.J., Stein J.L.
    Endocrinology 133:3050-3053(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Yotov W.V., St Arnaud R.
    Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/SvJ.
    Tissue: Liver.

Entry informationi

Entry nameiOSTR_MOUSE
AccessioniPrimary (citable) accession number: P54615
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3