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Protein

Osteocalcin-related protein

Gene

Bglap3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds strongly to apatite and calcium.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi62 – 621Calcium 3By similarity
Metal bindingi66 – 661Calcium 2By similarity
Metal bindingi69 – 691Calcium 1By similarity
Metal bindingi69 – 691Calcium 2By similarity
Metal bindingi75 – 751Calcium 1By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Biomineralization

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-159740. Gamma-carboxylation of protein precursors.
R-MMU-159763. Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus.
R-MMU-159782. Removal of aminoterminal propeptides from gamma-carboxylated proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Osteocalcin-related protein1 Publication
Alternative name(s):
Gamma-carboxyglutamic acid-containing protein 3Curated
Nephrocalcin1 Publication
OC-XImported
Gene namesi
Name:Bglap3Imported
Synonyms:Bglap-rs1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:88155. Bglap3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Propeptidei24 – 4926CuratedPRO_0000011090Add
BLAST
Chaini50 – 9546Osteocalcin-related proteinPRO_0000011091Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei66 – 6614-carboxyglutamatePROSITE-ProRule annotation
Disulfide bondi68 ↔ 74PROSITE-ProRule annotation
Modified residuei69 – 6914-carboxyglutamatePROSITE-ProRule annotation

Post-translational modificationi

Gamma-carboxyglutamic acid residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acid

Proteomic databases

PaxDbiP54615.

Expressioni

Tissue specificityi

Expressed in kidney and lung, but not in bone.1 Publication

Gene expression databases

BgeeiP54615.
GenevisibleiP54615. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074965.

Structurei

3D structure databases

ProteinModelPortaliP54615.
SMRiP54615. Positions 62-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 9247GlaPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J11Z. Eukaryota.
ENOG410ZS6W. LUCA.
GeneTreeiENSGT00410000026290.
HOGENOMiHOG000115820.
HOVERGENiHBG003085.
InParanoidiP54615.
OrthoDBiEOG7VDXRQ.
PhylomeDBiP54615.
TreeFamiTF330920.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54615-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTLSLLTLL ALAALCLSDL TDATPTGPES DKAFMSKQEG NKVVNRLRRY
60 70 80 90
LGASVPSPDP LEPTRELCEL DPACDELSNQ YGLKTAYRRI YGITI
Length:95
Mass (Da):10,459
Last modified:October 1, 1996 - v1
Checksum:i231968AA8B55848E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261T → S in AAH31815 (PubMed:15489334).Curated
Sequence conflicti26 – 261T → S in AAH55868 (PubMed:15489334).Curated
Sequence conflicti26 – 261T → S in AAI00688 (PubMed:15489334).Curated
Sequence conflicti26 – 261T → S in AAI01949 (PubMed:15489334).Curated
Sequence conflicti26 – 261T → S in AAI41239 (PubMed:15489334).Curated
Sequence conflicti26 – 261T → S in AAI45566 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24430 Genomic DNA. Translation: AAA39855.1.
S67456 Genomic DNA. Translation: AAB29146.1.
U11541 Unassigned DNA. Translation: AAB60445.1.
BC031815 mRNA. Translation: AAH31815.1.
BC055868 mRNA. Translation: AAH55868.1.
BC100687 mRNA. Translation: AAI00688.1.
BC101948 mRNA. Translation: AAI01949.1.
BC141238 mRNA. Translation: AAI41239.1.
BC145565 mRNA. Translation: AAI45566.1.
CCDSiCCDS17472.1.
PIRiI61188.
RefSeqiNP_001292377.1. NM_001305448.1.
NP_001292378.1. NM_001305449.1.
NP_001292379.1. NM_001305450.1.
NP_112736.3. NM_031368.5.
UniGeneiMm.482191.

Genome annotation databases

EnsembliENSMUST00000075523; ENSMUSP00000074965; ENSMUSG00000074489.
ENSMUST00000107542; ENSMUSP00000103166; ENSMUSG00000074489.
ENSMUST00000107543; ENSMUSP00000103167; ENSMUSG00000074489.
GeneIDi12095.
KEGGimmu:12095.
UCSCiuc008puv.3. mouse.
uc012cru.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24430 Genomic DNA. Translation: AAA39855.1.
S67456 Genomic DNA. Translation: AAB29146.1.
U11541 Unassigned DNA. Translation: AAB60445.1.
BC031815 mRNA. Translation: AAH31815.1.
BC055868 mRNA. Translation: AAH55868.1.
BC100687 mRNA. Translation: AAI00688.1.
BC101948 mRNA. Translation: AAI01949.1.
BC141238 mRNA. Translation: AAI41239.1.
BC145565 mRNA. Translation: AAI45566.1.
CCDSiCCDS17472.1.
PIRiI61188.
RefSeqiNP_001292377.1. NM_001305448.1.
NP_001292378.1. NM_001305449.1.
NP_001292379.1. NM_001305450.1.
NP_112736.3. NM_031368.5.
UniGeneiMm.482191.

3D structure databases

ProteinModelPortaliP54615.
SMRiP54615. Positions 62-92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074965.

Proteomic databases

PaxDbiP54615.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075523; ENSMUSP00000074965; ENSMUSG00000074489.
ENSMUST00000107542; ENSMUSP00000103166; ENSMUSG00000074489.
ENSMUST00000107543; ENSMUSP00000103167; ENSMUSG00000074489.
GeneIDi12095.
KEGGimmu:12095.
UCSCiuc008puv.3. mouse.
uc012cru.2. mouse.

Organism-specific databases

CTDi12095.
MGIiMGI:88155. Bglap3.

Phylogenomic databases

eggNOGiENOG410J11Z. Eukaryota.
ENOG410ZS6W. LUCA.
GeneTreeiENSGT00410000026290.
HOGENOMiHOG000115820.
HOVERGENiHBG003085.
InParanoidiP54615.
OrthoDBiEOG7VDXRQ.
PhylomeDBiP54615.
TreeFamiTF330920.

Enzyme and pathway databases

ReactomeiR-MMU-159740. Gamma-carboxylation of protein precursors.
R-MMU-159763. Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus.
R-MMU-159782. Removal of aminoterminal propeptides from gamma-carboxylated proteins.

Miscellaneous databases

PROiP54615.
SOURCEiSearch...

Gene expression databases

BgeeiP54615.
GenevisibleiP54615. MM.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression."
    Desbois C., Hogue D.A., Karsenty G.
    J. Biol. Chem. 269:1183-1190(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
  2. "Multiple copies of the bone-specific osteocalcin gene in mouse and rat."
    Rahman S., Oberdorf A., Montecino M., Tanhauser S.M., Lian J.B., Stein G.S., Laipis P.J., Stein J.L.
    Endocrinology 133:3050-3053(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Yotov W.V., St Arnaud R.
    Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/SvJ.
    Tissue: Liver.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Salivary glandImported.

Entry informationi

Entry nameiOSTR_MOUSE
AccessioniPrimary (citable) accession number: P54615
Secondary accession number(s): Q78H72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 8, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.