Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Osteocalcin-related protein

Gene

Bglap-rs1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. biomineral tissue development Source: UniProtKB-KW
  2. regulation of bone mineralization Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Biomineralization

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Osteocalcin-related protein
Alternative name(s):
Nephrocalcin
OC-X
Gene namesi
Name:Bglap-rs1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:88155. Bglap-rs1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323CuratedAdd
BLAST
Propeptidei24 – 4926CuratedPRO_0000011090Add
BLAST
Chaini50 – 9546Osteocalcin-related proteinPRO_0000011091Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi68 ↔ 74PROSITE-ProRule annotation

Post-translational modificationi

Gamma-carboxyglutamic acid residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium (By similarity).By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acid

Proteomic databases

PaxDbiP54615.

Expressioni

Tissue specificityi

Expressed in kidney but not in bone.

Gene expression databases

BgeeiP54615.
GenevestigatoriP54615.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103167.

Structurei

3D structure databases

ProteinModelPortaliP54615.
SMRiP54615. Positions 62-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 9247GlaPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG72046.
GeneTreeiENSGT00410000026290.
HOGENOMiHOG000115820.
HOVERGENiHBG003085.
InParanoidiP54615.
OrthoDBiEOG7VDXRQ.
PhylomeDBiP54615.
TreeFamiTF330920.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PfamiPF00594. Gla. 1 hit.
[Graphical view]
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54615-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTLSLLTLL ALAALCLSDL TDATPTGPES DKAFMSKQEG NKVVNRLRRY
60 70 80 90
LGASVPSPDP LEPTRELCEL DPACDELSNQ YGLKTAYRRI YGITI
Length:95
Mass (Da):10,459
Last modified:October 1, 1996 - v1
Checksum:i231968AA8B55848E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24430 Genomic DNA. Translation: AAA39855.1.
S67456 Genomic DNA. Translation: AAB29146.1.
U11541 Unassigned DNA. Translation: AAB60445.1.
CCDSiCCDS17472.1.
PIRiI61188.
RefSeqiNP_112736.3. NM_031368.5.
UniGeneiMm.482191.

Genome annotation databases

EnsembliENSMUST00000075523; ENSMUSP00000074965; ENSMUSG00000074489.
ENSMUST00000107542; ENSMUSP00000103166; ENSMUSG00000074489.
ENSMUST00000107543; ENSMUSP00000103167; ENSMUSG00000074489.
GeneIDi12095.
KEGGimmu:12095.
UCSCiuc008puv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24430 Genomic DNA. Translation: AAA39855.1.
S67456 Genomic DNA. Translation: AAB29146.1.
U11541 Unassigned DNA. Translation: AAB60445.1.
CCDSiCCDS17472.1.
PIRiI61188.
RefSeqiNP_112736.3. NM_031368.5.
UniGeneiMm.482191.

3D structure databases

ProteinModelPortaliP54615.
SMRiP54615. Positions 62-92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103167.

Proteomic databases

PaxDbiP54615.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075523; ENSMUSP00000074965; ENSMUSG00000074489.
ENSMUST00000107542; ENSMUSP00000103166; ENSMUSG00000074489.
ENSMUST00000107543; ENSMUSP00000103167; ENSMUSG00000074489.
GeneIDi12095.
KEGGimmu:12095.
UCSCiuc008puv.2. mouse.

Organism-specific databases

CTDi12095.
MGIiMGI:88155. Bglap-rs1.

Phylogenomic databases

eggNOGiNOG72046.
GeneTreeiENSGT00410000026290.
HOGENOMiHOG000115820.
HOVERGENiHBG003085.
InParanoidiP54615.
OrthoDBiEOG7VDXRQ.
PhylomeDBiP54615.
TreeFamiTF330920.

Miscellaneous databases

NextBioi280411.
PROiP54615.
SOURCEiSearch...

Gene expression databases

BgeeiP54615.
GenevestigatoriP54615.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PfamiPF00594. Gla. 1 hit.
[Graphical view]
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression."
    Desbois C., Hogue D.A., Karsenty G.
    J. Biol. Chem. 269:1183-1190(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Multiple copies of the bone-specific osteocalcin gene in mouse and rat."
    Rahman S., Oberdorf A., Montecino M., Tanhauser S.M., Lian J.B., Stein G.S., Laipis P.J., Stein J.L.
    Endocrinology 133:3050-3053(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Yotov W.V., St Arnaud R.
    Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/SvJ.
    Tissue: Liver.

Entry informationi

Entry nameiOSTR_MOUSE
AccessioniPrimary (citable) accession number: P54615
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 29, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.