Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P54615

- OSTR_MOUSE

UniProt

P54615 - OSTR_MOUSE

Protein

Osteocalcin-related protein

Gene

Bglap-rs1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. biomineral tissue development Source: UniProtKB-KW
    2. regulation of bone mineralization Source: InterPro

    Keywords - Biological processi

    Biomineralization

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Osteocalcin-related protein
    Alternative name(s):
    Nephrocalcin
    OC-X
    Gene namesi
    Name:Bglap-rs1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:88155. Bglap-rs1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323CuratedAdd
    BLAST
    Propeptidei24 – 4926CuratedPRO_0000011090Add
    BLAST
    Chaini50 – 9546Osteocalcin-related proteinPRO_0000011091Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi68 ↔ 74PROSITE-ProRule annotation

    Post-translational modificationi

    Gamma-carboxyglutamic acid residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium By similarity.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acid

    Proteomic databases

    PaxDbiP54615.

    Expressioni

    Tissue specificityi

    Expressed in kidney but not in bone.

    Gene expression databases

    BgeeiP54615.
    GenevestigatoriP54615.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000103167.

    Structurei

    3D structure databases

    ProteinModelPortaliP54615.
    SMRiP54615. Positions 62-92.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 9247GlaPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG72046.
    GeneTreeiENSGT00410000026290.
    HOGENOMiHOG000115820.
    HOVERGENiHBG003085.
    InParanoidiP54615.
    OMAiLIERCIN.
    OrthoDBiEOG7VDXRQ.
    PhylomeDBiP54615.
    TreeFamiTF330920.

    Family and domain databases

    InterProiIPR000294. GLA_domain.
    IPR002384. Osteocalcin/MGP.
    [Graphical view]
    PfamiPF00594. Gla. 1 hit.
    [Graphical view]
    PRINTSiPR00002. GLABONE.
    SMARTiSM00069. GLA. 1 hit.
    [Graphical view]
    SUPFAMiSSF57630. SSF57630. 1 hit.
    PROSITEiPS00011. GLA_1. 1 hit.
    PS50998. GLA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P54615-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRTLSLLTLL ALAALCLSDL TDATPTGPES DKAFMSKQEG NKVVNRLRRY   50
    LGASVPSPDP LEPTRELCEL DPACDELSNQ YGLKTAYRRI YGITI 95
    Length:95
    Mass (Da):10,459
    Last modified:October 1, 1996 - v1
    Checksum:i231968AA8B55848E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L24430 Genomic DNA. Translation: AAA39855.1.
    S67456 Genomic DNA. Translation: AAB29146.1.
    U11541 Unassigned DNA. Translation: AAB60445.1.
    CCDSiCCDS17472.1.
    PIRiI61188.
    RefSeqiNP_112736.3. NM_031368.4.
    XP_006501001.1. XM_006500938.1.
    UniGeneiMm.482191.

    Genome annotation databases

    EnsembliENSMUST00000075523; ENSMUSP00000074965; ENSMUSG00000074489.
    ENSMUST00000107542; ENSMUSP00000103166; ENSMUSG00000074489.
    ENSMUST00000107543; ENSMUSP00000103167; ENSMUSG00000074489.
    GeneIDi12095.
    KEGGimmu:12095.
    UCSCiuc008puv.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L24430 Genomic DNA. Translation: AAA39855.1 .
    S67456 Genomic DNA. Translation: AAB29146.1 .
    U11541 Unassigned DNA. Translation: AAB60445.1 .
    CCDSi CCDS17472.1.
    PIRi I61188.
    RefSeqi NP_112736.3. NM_031368.4.
    XP_006501001.1. XM_006500938.1.
    UniGenei Mm.482191.

    3D structure databases

    ProteinModelPortali P54615.
    SMRi P54615. Positions 62-92.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000103167.

    Proteomic databases

    PaxDbi P54615.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000075523 ; ENSMUSP00000074965 ; ENSMUSG00000074489 .
    ENSMUST00000107542 ; ENSMUSP00000103166 ; ENSMUSG00000074489 .
    ENSMUST00000107543 ; ENSMUSP00000103167 ; ENSMUSG00000074489 .
    GeneIDi 12095.
    KEGGi mmu:12095.
    UCSCi uc008puv.2. mouse.

    Organism-specific databases

    CTDi 12095.
    MGIi MGI:88155. Bglap-rs1.

    Phylogenomic databases

    eggNOGi NOG72046.
    GeneTreei ENSGT00410000026290.
    HOGENOMi HOG000115820.
    HOVERGENi HBG003085.
    InParanoidi P54615.
    OMAi LIERCIN.
    OrthoDBi EOG7VDXRQ.
    PhylomeDBi P54615.
    TreeFami TF330920.

    Miscellaneous databases

    NextBioi 280411.
    PROi P54615.
    SOURCEi Search...

    Gene expression databases

    Bgeei P54615.
    Genevestigatori P54615.

    Family and domain databases

    InterProi IPR000294. GLA_domain.
    IPR002384. Osteocalcin/MGP.
    [Graphical view ]
    Pfami PF00594. Gla. 1 hit.
    [Graphical view ]
    PRINTSi PR00002. GLABONE.
    SMARTi SM00069. GLA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57630. SSF57630. 1 hit.
    PROSITEi PS00011. GLA_1. 1 hit.
    PS50998. GLA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression."
      Desbois C., Hogue D.A., Karsenty G.
      J. Biol. Chem. 269:1183-1190(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Multiple copies of the bone-specific osteocalcin gene in mouse and rat."
      Rahman S., Oberdorf A., Montecino M., Tanhauser S.M., Lian J.B., Stein G.S., Laipis P.J., Stein J.L.
      Endocrinology 133:3050-3053(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Yotov W.V., St Arnaud R.
      Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129/SvJ.
      Tissue: Liver.

    Entry informationi

    Entry nameiOSTR_MOUSE
    AccessioniPrimary (citable) accession number: P54615
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3