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Protein

Osteocalcin-related protein

Gene

Bglap3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds strongly to apatite and calcium.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi62 – 621Calcium 3By similarity
Metal bindingi66 – 661Calcium 2By similarity
Metal bindingi69 – 691Calcium 1By similarity
Metal bindingi69 – 691Calcium 2By similarity
Metal bindingi75 – 751Calcium 1By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Biomineralization

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-159740. Gamma-carboxylation of protein precursors.
R-MMU-159763. Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus.
R-MMU-159782. Removal of aminoterminal propeptides from gamma-carboxylated proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Osteocalcin-related protein1 Publication
Alternative name(s):
Gamma-carboxyglutamic acid-containing protein 3Curated
Nephrocalcin1 Publication
OC-XImported
Gene namesi
Name:Bglap3Imported
Synonyms:Bglap-rs1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:88155. Bglap3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Propeptidei24 – 4926CuratedPRO_0000011090Add
BLAST
Chaini50 – 9546Osteocalcin-related proteinPRO_0000011091Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei66 – 6614-carboxyglutamatePROSITE-ProRule annotation
Disulfide bondi68 ↔ 74PROSITE-ProRule annotation
Modified residuei69 – 6914-carboxyglutamatePROSITE-ProRule annotation

Post-translational modificationi

Gamma-carboxyglutamic acid residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acid

Proteomic databases

PaxDbiP54615.

Expressioni

Tissue specificityi

Expressed in kidney and lung, but not in bone.1 Publication

Gene expression databases

BgeeiENSMUSG00000074489.
GenevisibleiP54615. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074965.

Structurei

3D structure databases

ProteinModelPortaliP54615.
SMRiP54615. Positions 62-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 9247GlaPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J11Z. Eukaryota.
ENOG410ZS6W. LUCA.
GeneTreeiENSGT00410000026290.
HOGENOMiHOG000115820.
HOVERGENiHBG003085.
InParanoidiP54615.
OrthoDBiEOG091G13UG.
PhylomeDBiP54615.
TreeFamiTF330920.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54615-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTLSLLTLL ALAALCLSDL TDATPTGPES DKAFMSKQEG NKVVNRLRRY
60 70 80 90
LGASVPSPDP LEPTRELCEL DPACDELSNQ YGLKTAYRRI YGITI
Length:95
Mass (Da):10,459
Last modified:October 1, 1996 - v1
Checksum:i231968AA8B55848E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261T → S in AAH31815 (PubMed:15489334).Curated
Sequence conflicti26 – 261T → S in AAH55868 (PubMed:15489334).Curated
Sequence conflicti26 – 261T → S in AAI00688 (PubMed:15489334).Curated
Sequence conflicti26 – 261T → S in AAI01949 (PubMed:15489334).Curated
Sequence conflicti26 – 261T → S in AAI41239 (PubMed:15489334).Curated
Sequence conflicti26 – 261T → S in AAI45566 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24430 Genomic DNA. Translation: AAA39855.1.
S67456 Genomic DNA. Translation: AAB29146.1.
U11541 Unassigned DNA. Translation: AAB60445.1.
BC031815 mRNA. Translation: AAH31815.1.
BC055868 mRNA. Translation: AAH55868.1.
BC100687 mRNA. Translation: AAI00688.1.
BC101948 mRNA. Translation: AAI01949.1.
BC141238 mRNA. Translation: AAI41239.1.
BC145565 mRNA. Translation: AAI45566.1.
CCDSiCCDS17472.1.
PIRiI61188.
RefSeqiNP_001292377.1. NM_001305448.1.
NP_001292378.1. NM_001305449.1.
NP_001292379.1. NM_001305450.1.
NP_112736.3. NM_031368.5.
UniGeneiMm.482191.

Genome annotation databases

EnsembliENSMUST00000075523; ENSMUSP00000074965; ENSMUSG00000074489.
ENSMUST00000107542; ENSMUSP00000103166; ENSMUSG00000074489.
ENSMUST00000107543; ENSMUSP00000103167; ENSMUSG00000074489.
GeneIDi12095.
KEGGimmu:12095.
UCSCiuc008puv.3. mouse.
uc012cru.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24430 Genomic DNA. Translation: AAA39855.1.
S67456 Genomic DNA. Translation: AAB29146.1.
U11541 Unassigned DNA. Translation: AAB60445.1.
BC031815 mRNA. Translation: AAH31815.1.
BC055868 mRNA. Translation: AAH55868.1.
BC100687 mRNA. Translation: AAI00688.1.
BC101948 mRNA. Translation: AAI01949.1.
BC141238 mRNA. Translation: AAI41239.1.
BC145565 mRNA. Translation: AAI45566.1.
CCDSiCCDS17472.1.
PIRiI61188.
RefSeqiNP_001292377.1. NM_001305448.1.
NP_001292378.1. NM_001305449.1.
NP_001292379.1. NM_001305450.1.
NP_112736.3. NM_031368.5.
UniGeneiMm.482191.

3D structure databases

ProteinModelPortaliP54615.
SMRiP54615. Positions 62-92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074965.

Proteomic databases

PaxDbiP54615.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075523; ENSMUSP00000074965; ENSMUSG00000074489.
ENSMUST00000107542; ENSMUSP00000103166; ENSMUSG00000074489.
ENSMUST00000107543; ENSMUSP00000103167; ENSMUSG00000074489.
GeneIDi12095.
KEGGimmu:12095.
UCSCiuc008puv.3. mouse.
uc012cru.2. mouse.

Organism-specific databases

CTDi12095.
MGIiMGI:88155. Bglap3.

Phylogenomic databases

eggNOGiENOG410J11Z. Eukaryota.
ENOG410ZS6W. LUCA.
GeneTreeiENSGT00410000026290.
HOGENOMiHOG000115820.
HOVERGENiHBG003085.
InParanoidiP54615.
OrthoDBiEOG091G13UG.
PhylomeDBiP54615.
TreeFamiTF330920.

Enzyme and pathway databases

ReactomeiR-MMU-159740. Gamma-carboxylation of protein precursors.
R-MMU-159763. Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus.
R-MMU-159782. Removal of aminoterminal propeptides from gamma-carboxylated proteins.

Miscellaneous databases

PROiP54615.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000074489.
GenevisibleiP54615. MM.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOSTR_MOUSE
AccessioniPrimary (citable) accession number: P54615
Secondary accession number(s): Q78H72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.