P54614 (2ABB_PIG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

Alternative name(s):
PP2A subunit B isoform B55-beta
PP2A subunit B isoform PR55-beta
PP2A subunit B isoform R2-beta
PP2A subunit B isoform beta

Gene names

Name:

PPP2R2B

Organism

Sus scrofa (Pig) [Reference proteome]

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	443 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Subunit structure	PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.
Subcellular location	Cytoplasm By similarity. Cytoplasm › cytoskeleton By similarity. Membrane By similarity.
Tissue specificity	Brain.
Sequence similarities	Belongs to the phosphatase 2A regulatory subunit B family. Contains 7 WD repeats.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Membrane
Domain	Repeat WD repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-SubCell protein phosphatase type 2A complex Inferred from electronic annotation. Source: InterPro
Molecular_function	protein phosphatase type 2A regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 443	443	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform		PRO_0000071424
Regions
	Repeat	22 – 61	40	WD 1
	Repeat	87 – 128	42	WD 2
	Repeat	171 – 209	39	WD 3
	Repeat	220 – 260	41	WD 4
	Repeat	279 – 317	39	WD 5
	Repeat	334 – 375	42	WD 6
	Repeat	410 – 442	33	WD 7

Sequences

	Sequence		Length	Mass (Da)
	P54614 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: F8562FC696719F41	FASTA	443	51,460
	10 20 30 40 50 60 MEEDIDTRKI NNSFLRDHSY ATEADIISAV EFNHTGELLA TGDKGGRVVI FQREQESKNQ 70 80 90 100 110 120 VHRRGEYNVY STFQSHEPEF DYLKSLEIEE KINKIRWLPQ QNAAYFLLST NDKTVKLWKV 130 140 150 160 170 180 SERDKRPEGY NLKDEEGRLR DPATITTLRV PVLRPMDLMV EATPRRVFAN AHTYHINSIS 190 200 210 220 230 240 VNSDYETYMS ADDLRINLWN FEITNQSFNI ADIKPANMEE LTEVITAAEF HPHHCNTFVY 250 260 270 280 290 300 SSSKGTIRLC DMRASACVTG TPNFLKEPED PSNRSFSLKL SSSISDVKFS QQWEDIMTRD 310 320 330 340 350 360 YLTVKVWDLN MENRPIETYQ VHNYLRSKLC SLYENDCIFD KFECVWNGSD SVIMTGSYNN 370 380 390 400 410 420 FFRMFDRNTK RDVTLEASRE NSKPRAILKP RKVCVGGKRR KDEISVDSLD FSKKILHTAW 430 440 HPSENIIAVA ATNNLYIFQD KVN

References

[1]	Mayer-Jaekel R.E. Thesis (1992), Friedrich Miescher Institut / Basel, Switzerland Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z34933 mRNA. Translation: CAA84405.1.
RefSeq	NP_999190.1. NM_214025.2.
UniGene	Ssc.103.
3D structure databases
ProteinModelPortal	P54614.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	397089.
KEGG	ssc:397089.
Organism-specific databases
CTD	5521.
Phylogenomic databases
HOVERGEN	HBG000012.
KO	K04354.
Family and domain databases
Gene3D	2.130.10.10. 3 hits.
InterPro	IPR000009. PP2A_PR55. IPR018067. PP2A_PR55_CS. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
PANTHER	PTHR11871. PTHR11871. 1 hit.
PIRSF	PIRSF037309. PP2A_PR55. 1 hit.
PRINTS	PR00600. PP2APR55.
SMART	SM00320. WD40. 5 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS01024. PR55_1. 1 hit. PS01025. PR55_2. 1 hit. PS00678. WD_REPEATS_1. 1 hit. PS50082. WD_REPEATS_2. False negative. PS50294. WD_REPEATS_REGION. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

2ABB_PIG

Accession

Primary (citable) accession number: P54614

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	March 6, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program