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Protein

Bifunctional riboflavin kinase/FMN adenylyltransferase

Gene

ribC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.By similarity

Catalytic activityi

ATP + riboflavin = ADP + FMN.By similarity
ATP + FMN = diphosphate + FAD.By similarity

Pathwayi: FAD biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes FAD from FMN.By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional riboflavin kinase/FMN adenylyltransferase (ribC)
This subpathway is part of the pathway FAD biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes FAD from FMN, the pathway FAD biosynthesis and in Cofactor biosynthesis.

Pathwayi: FMN biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes FMN from riboflavin (ATP route).By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional riboflavin kinase/FMN adenylyltransferase (ribC)
This subpathway is part of the pathway FMN biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes FMN from riboflavin (ATP route), the pathway FMN biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Multifunctional enzyme, Nucleotidyltransferase, Transferase
LigandATP-binding, FAD, Flavoprotein, FMN, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU16670-MONOMER
MetaCyc:MONOMER-14605
BRENDAi2.7.1.26 658
2.7.7.2 658
UniPathwayiUPA00276; UER00406
UPA00277; UER00407

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional riboflavin kinase/FMN adenylyltransferaseBy similarity
Alternative name(s):
Riboflavin biosynthesis protein RibFBy similarity
Including the following 2 domains:
Riboflavin kinaseBy similarity (EC:2.7.1.26By similarity)
Alternative name(s):
FlavokinaseBy similarity
FMN adenylyltransferaseBy similarity (EC:2.7.7.2By similarity)
Alternative name(s):
FAD pyrophosphorylaseBy similarity
FAD synthaseBy similarity
Gene namesi
Name:ribC
Ordered Locus Names:BSU16670
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001941331 – 316Bifunctional riboflavin kinase/FMN adenylyltransferaseAdd BLAST316

Proteomic databases

PaxDbiP54575
PRIDEiP54575

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100009181

Structurei

3D structure databases

ProteinModelPortaliP54575
SMRiP54575
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RibF family.Curated

Phylogenomic databases

eggNOGiENOG4105DTN Bacteria
COG0196 LUCA
HOGENOMiHOG000006844
InParanoidiP54575
KOiK11753
OMAiHRGHQAI
PhylomeDBiP54575

Family and domain databases

Gene3Di2.40.30.30, 1 hit
3.40.50.620, 1 hit
InterProiView protein in InterPro
IPR004821 Cyt_trans-like
IPR015864 FAD_synthase
IPR023468 Riboflavin_kinase
IPR002606 Riboflavin_kinase_bac
IPR015865 Riboflavin_kinase_bac/euk
IPR023465 Riboflavin_kinase_dom_sf
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR22749 PTHR22749, 1 hit
PfamiView protein in Pfam
PF06574 FAD_syn, 1 hit
PF01687 Flavokinase, 1 hit
PIRSFiPIRSF004491 FAD_Synth, 1 hit
SMARTiView protein in SMART
SM00904 Flavokinase, 1 hit
SUPFAMiSSF82114 SSF82114, 1 hit
TIGRFAMsiTIGR00125 cyt_tran_rel, 1 hit
TIGR00083 ribF, 1 hit

Sequencei

Sequence statusi: Complete.

P54575-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTIHITHPH HLIKEEQAKS VMALGYFDGV HLGHQKVIGT AKQIAEEKGL
60 70 80 90 100
TLAVMTFHPH PSHVLGRDKE PKDLITPLED KINQIEQLGT EVLYVVKFNE
110 120 130 140 150
VFASLSPKQF IDQYIIGLNV QHAVAGFDFT YGKYGKGTMK TMPDDLDGKA
160 170 180 190 200
GCTMVEKLTE QDKKISSSYI RTALQNGDVE LANVLLGQPY FIKGIVIHGD
210 220 230 240 250
KRGRTIGFPT ANVGLNNSYI VPPTGVYAVK AEVNGEVYNG VCNIGYKPTF
260 270 280 290 300
YEKRPEQPSI EVNLFDFNQE VYGAAIKIEW YKRIRSERKF NGIKELTEQI
310
EKDKQEAIRY FSNLRK
Length:316
Mass (Da):35,662
Last modified:August 29, 2003 - v2
Checksum:i0B8F11D356B7D7B9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti199G → N in CAA64624 (PubMed:9454067).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95312 Genomic DNA Translation: CAA64624.1
Z80835 Genomic DNA Translation: CAB02559.1
AL009126 Genomic DNA Translation: CAB13540.1
PIRiD69692
RefSeqiNP_389549.1, NC_000964.3
WP_003245551.1, NZ_JNCM01000035.1

Genome annotation databases

EnsemblBacteriaiCAB13540; CAB13540; BSU16670
GeneIDi938110
KEGGibsu:BSU16670
PATRICifig|224308.179.peg.1808

Similar proteinsi

Entry informationi

Entry nameiRIBC_BACSU
AccessioniPrimary (citable) accession number: P54575
Secondary accession number(s): P70987
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: August 29, 2003
Last modified: May 23, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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