Reviewed,
UniProtKB/Swiss-Prot P54570 (ADPP_BACSU)
Last modified
June 16, 2009.
Version 68.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: ADP-ribose pyrophosphatase EC=3.6.1.13 Alternative name(s): ADP-ribose diphosphatase Adenosine diphosphoribose pyrophosphatase Short name=ADPR-PPase ADP-ribose phosphohydrolase Short name=ASPPase | ||||||
| Gene names |
| ||||||
| Organism | Bacillus subtilis [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 1423 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus |
Protein attributes
| Sequence length | 185 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Acts on ADP-mannose and ADP-glucose as well as ADP-ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process By similarity. |
| Catalytic activity | ADP-ribose + H2O = AMP + D-ribose 5-phosphate. |
| Cofactor | Binds 3 magnesium ions per subunit By similarity. |
| Sequence similarities | Belongs to the Nudix hydrolase family. NudF subfamily. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Magnesium Metal-binding |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Molecular function | ADP-ribose diphosphatase activity Inferred from electronic annotation. Source: EC magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 185 | 185 | ADP-ribose pyrophosphatase | PRO_0000057041 | |||||
Regions | |||||||||
| Motif | 77 – 98 | 22 | Nudix box | ||||||
Sites | |||||||||
| Active site | 140 | 1 | Proton acceptor By similarity | ||||||
| Metal binding | 92 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 92 | 1 | Magnesium 2 By similarity | ||||||
| Metal binding | 96 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 96 | 1 | Magnesium 3 By similarity | ||||||
| Metal binding | 142 | 1 | Magnesium 1 By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the Bacillus subtilis genome containing the skin element and many sporulation genes." Mizuno M., Masuda S., Takemaru K., Hosono S., Sato T., Takeuchi M., Kobayashi Y. Microbiology 142:3103-3111(1996) [PubMed: 8969508] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168 / JH642. |
| [2] | "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.  Danchin A.Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168. |
| [3] | "Studies on the ADP-ribose pyrophosphatase subfamily of the nudix hydrolases and tentative identification of trgB, a gene associated with tellurite resistance." Dunn C.A., O'Handley S.F., Frick D.N., Bessman M.J. J. Biol. Chem. 274:32318-32324(1999) [PubMed: 10542272] [Abstract] Cited for: CHARACTERIZATION. |
Cross-references
Sequence databases | |
|---|---|
| D84432 Genomic DNA. Translation: BAA12639.1. AL009126 Genomic DNA. Translation: CAB14293.1. | |
| PIR | A69967. |
| RefSeq | NP_390242.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 938719. |
| GenomeReviews | Gene locus BSU23610 in contig AL009126_GR. |
| KEGG | bsu:BSU23610. |
| NMPDR | fig|224308.1.peg.2366. |
Organism-specific databases | |
| SubtiList | BG11762. nudF. [Micado] |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P54570. |
| OMA | P54570. NEGQRIV. |
Enzyme and pathway databases | |
| BioCyc | BSUB224308:BSU2360-MON. |
| BRENDA | 3.6.1.13. 150. |
Family and domain databases | |
| InterPro | IPR004385. NDP_pyrophos. IPR000086. NUDIX_hydrolase_core. [Graphical view] |
| Gene3D | G3DSA:3.90.79.10. NUDIX_hydrolase. 1 hit. |
| Pfam | PF00293. NUDIX. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00052. NDP_pyrophos. 1 hit. |
| PROSITE | PS00893. NUDIX. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ADPP_BACSU | ||||||||
| Accession | Primary (citable) accession number: P54570 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Bacillus subtilis Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList |
| SIMILARITY comments Index of protein domains and families |
