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Protein

Putative propionyl-CoA carboxylase beta chain

Gene

yqjD

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA.

Pathwayi: propanoyl-CoA degradation

This protein is involved in step 1 of the subpathway that synthesizes succinyl-CoA from propanoyl-CoA.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Putative propionyl-CoA carboxylase beta chain (yqjD)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway propanoyl-CoA degradation, which is itself part of Metabolic intermediate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes succinyl-CoA from propanoyl-CoA, the pathway propanoyl-CoA degradation and in Metabolic intermediate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU23920-MONOMER.
UniPathwayiUPA00945; UER00908.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative propionyl-CoA carboxylase beta chain (EC:6.4.1.3)
Short name:
PCCase
Alternative name(s):
Propanoyl-CoA:carbon dioxide ligase
Gene namesi
Name:yqjD
Ordered Locus Names:BSU23920
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001997971 – 507Putative propionyl-CoA carboxylase beta chainAdd BLAST507

Proteomic databases

PaxDbiP54541.

Interactioni

Subunit structurei

Probably a dodecamer composed of six biotin-containing alpha subunits and six beta subunits.By similarity

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100013121.

Structurei

3D structure databases

ProteinModelPortaliP54541.
SMRiP54541.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 254CoA carboxyltransferase N-terminalPROSITE-ProRule annotationAdd BLAST254
Domaini256 – 501CoA carboxyltransferase C-terminalPROSITE-ProRule annotationAdd BLAST246

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 501CarboxyltransferasePROSITE-ProRule annotationAdd BLAST501

Sequence similaritiesi

Belongs to the AccD/PCCB family.Curated

Phylogenomic databases

eggNOGiENOG4108HNZ. Bacteria.
COG4799. LUCA.
HOGENOMiHOG000218693.
InParanoidiP54541.
KOiK01966.
OMAiGKLWVRE.
PhylomeDBiP54541.

Family and domain databases

InterProiView protein in InterPro
IPR034733. AcCoA_carboxyl.
IPR000438. Acetyl_CoA_COase_Trfase_b_su.
IPR029045. ClpP/crotonase-like_dom_sf.
IPR011763. COA_CT_C.
IPR011762. COA_CT_N.
PfamiView protein in Pfam
PF01039. Carboxyl_trans. 1 hit.
PRINTSiPR01070. ACCCTRFRASEB.
SUPFAMiSSF52096. SSF52096. 2 hits.
PROSITEiView protein in PROSITE
PS50989. COA_CT_CTER. 1 hit.
PS50980. COA_CT_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

P54541-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEHMDHFYT KRKQAEEGGG REKLAQQRQK GKLTARERII FLLDQDSFIE
60 70 80 90 100
LHPFMESQVL TREQRMLGDG VVTGYGTIDG RSVYVFAQDF TVYGGALGET
110 120 130 140 150
HARKICALMD LAAKNKAPII GLNDSGGARI QEGVLSLDGY GHIFYRNVLY
160 170 180 190 200
SGVIPQISVI LGPCAGGAVY SPALTDFIFM AEQTGRMFIT GPKVIEKVTG
210 220 230 240 250
EQVDAESLGG AGIHNAVSGN AHFSGHTEKE VLTGVRKLLS YLPLNGRTTE
260 270 280 290 300
PKPEKEASRP LLNRLVPADT TKPYDVRKVI RELADPQSFF EIQPFFAKNI
310 320 330 340 350
VIGFARLGEK AIGIVASQPK HLAGSLTIDA ADKAARFIRF CDAFDIPLLT
360 370 380 390 400
VEDVPGFLPG IQQEHNGIIR HGAKLLFAYA EATVPKVTLI IRKAYGGAYV
410 420 430 440 450
AMNSKAIGAD LVFAWPNAEI AVMGPEGAAS ILYEKEIKAS ADPQKTKREK
460 470 480 490 500
TAEYKKQNAG PYKAAACGMV DDIILPEESR GRLIQAFHML THKTEERPKK

KHGNIPL
Length:507
Mass (Da):55,475
Last modified:May 26, 2009 - v2
Checksum:i1D428B7B8E7BFA25
GO

Sequence cautioni

The sequence BAA12610 differs from that shown. Reason: Frameshift at position 12.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84432 Genomic DNA. Translation: BAA12610.1. Frameshift.
AL009126 Genomic DNA. Translation: CAB14323.2.
PIRiD69963.
RefSeqiNP_390272.2. NC_000964.3.
WP_010886564.1. NZ_JNCM01000036.1.

Genome annotation databases

EnsemblBacteriaiCAB14323; CAB14323; BSU23920.
GeneIDi938685.
KEGGibsu:BSU23920.
PATRICifig|224308.43.peg.2495.

Similar proteinsi

Entry informationi

Entry nameiPCCB_BACSU
AccessioniPrimary (citable) accession number: P54541
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 26, 2009
Last modified: November 22, 2017
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families