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Protein

Exodeoxyribonuclease 7 large subunit

Gene

xseA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.UniRule annotation

Catalytic activityi

Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

BioCyciBSUB:BSU24300-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Exodeoxyribonuclease 7 large subunitUniRule annotation (EC:3.1.11.6UniRule annotation)
Alternative name(s):
Exodeoxyribonuclease VII large subunitUniRule annotation
Short name:
Exonuclease VII large subunitUniRule annotation
Gene namesi
Name:xseAUniRule annotation
Synonyms:yqiB
Ordered Locus Names:BSU24300
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001978281 – 448Exodeoxyribonuclease 7 large subunitAdd BLAST448

Proteomic databases

PaxDbiP54521.
PRIDEiP54521.

Interactioni

Subunit structurei

Heterooligomer composed of large and small subunits.UniRule annotation

Protein-protein interaction databases

IntActiP54521. 36 interactors.
STRINGi224308.Bsubs1_010100013331.

Structurei

3D structure databases

ProteinModelPortaliP54521.
SMRiP54521.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the XseA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DVS. Bacteria.
COG1570. LUCA.
HOGENOMiHOG000229265.
InParanoidiP54521.
KOiK03601.
OMAiENAQVRC.
PhylomeDBiP54521.

Family and domain databases

CDDicd04489. ExoVII_LU_OBF. 1 hit.
HAMAPiMF_00378. Exonuc_7_L. 1 hit.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 1 hit.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.

Sequencei

Sequence statusi: Complete.

P54521-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEAAYVTVS ALTKYIKRKF DVDPHLENIW IKGELSNVKI HTRGHIYFTL
60 70 80 90 100
KDENARMQSV MFARQSERLP FKPENGMKVL VRGGISVYEP SGNYQLYAKE
110 120 130 140 150
MQPDGVGALY LAYEELKKKL AGEGLFDDRY KKQIPAFPAT IGVVTSPTGA
160 170 180 190 200
AVRDVITTLK RRYPLVKVIV LPALVQGENA SRSIVTRIEE ANEKEICDVL
210 220 230 240 250
IVGRGGGSIE ELWAFNEEIV ARAIFASNIP IISAVGHETD FTISDFVADI
260 270 280 290 300
RAATPTGAAE IAVPHTTDLI ERTKTAEVRM TRAMQQHLGQ KKERIQTLQS
310 320 330 340 350
SYAFRFPKRL YAQKEQQFDL AYQQFQAQLT ALLDRKSRQL ERETYRLEAL
360 370 380 390 400
HPHEQLKQAR TRYQEQTNQL RKNMNIQMKQ LHSQFQTVLG KLNALSPLQV
410 420 430 440
MERGYSLAYK EDKLIKSVSQ IEEQDRLEIK LKDGVLTCEV LEKRGEEK
Length:448
Mass (Da):51,048
Last modified:July 7, 2009 - v2
Checksum:i060863CB5AD1D7DC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52 – 55DENA → ERKG in BAA12573 (PubMed:8969508).Curated4
Sequence conflicti291 – 293KKE → EKG in BAA12573 (PubMed:8969508).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84432 Genomic DNA. Translation: BAA12573.1.
AL009126 Genomic DNA. Translation: CAB14361.2.
PIRiG69960.
RefSeqiNP_390310.2. NC_000964.3.
WP_003246103.1. NZ_JNCM01000036.1.

Genome annotation databases

EnsemblBacteriaiCAB14361; CAB14361; BSU24300.
GeneIDi938650.
KEGGibsu:BSU24300.
PATRICi18976694. VBIBacSub10457_2537.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84432 Genomic DNA. Translation: BAA12573.1.
AL009126 Genomic DNA. Translation: CAB14361.2.
PIRiG69960.
RefSeqiNP_390310.2. NC_000964.3.
WP_003246103.1. NZ_JNCM01000036.1.

3D structure databases

ProteinModelPortaliP54521.
SMRiP54521.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP54521. 36 interactors.
STRINGi224308.Bsubs1_010100013331.

Proteomic databases

PaxDbiP54521.
PRIDEiP54521.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB14361; CAB14361; BSU24300.
GeneIDi938650.
KEGGibsu:BSU24300.
PATRICi18976694. VBIBacSub10457_2537.

Phylogenomic databases

eggNOGiENOG4105DVS. Bacteria.
COG1570. LUCA.
HOGENOMiHOG000229265.
InParanoidiP54521.
KOiK03601.
OMAiENAQVRC.
PhylomeDBiP54521.

Enzyme and pathway databases

BioCyciBSUB:BSU24300-MONOMER.

Family and domain databases

CDDicd04489. ExoVII_LU_OBF. 1 hit.
HAMAPiMF_00378. Exonuc_7_L. 1 hit.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 1 hit.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEX7L_BACSU
AccessioniPrimary (citable) accession number: P54521
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 7, 2009
Last modified: November 2, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.