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P54512 (MNTR_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcriptional regulator MntR
Alternative name(s):
Manganese transport regulator
Gene names
Name:mntR
Synonyms:yqhN
Ordered Locus Names:BSU24520
OrganismBacillus subtilis (strain 168) [Reference proteome] [HAMAP]
Taxonomic identifier224308 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length142 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Central regulator of manganese homeostasis. In the presence of manganese, it mediates repression of the manganese transporter MntH; under low manganese conditions, it activates the transcription of the mntABCD operon. HAMAP-Rule MF_00732

Subunit structure

Homodimer Probable.

Subcellular location

Cytoplasm Probable HAMAP-Rule MF_00732.

Domain

It contains an N-terminal DNA-binding domain and a metal-binding domain. HAMAP-Rule MF_00732

Sequence similarities

Contains 1 HTH dtxR-type DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 142142Transcriptional regulator MntR HAMAP-Rule MF_00732
PRO_0000201118

Regions

Domain1 – 6363HTH dtxR-type

Experimental info

Sequence conflict811E → D in BAA12551. Ref.1

Secondary structure

...................... 142
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P54512 [UniParc].

Last modified July 7, 2009. Version 2.
Checksum: 653BD8E0F4AB9F2C

FASTA14216,759
        10         20         30         40         50         60 
MTTPSMEDYI EQIYMLIEEK GYARVSDIAE ALAVHPSSVT KMVQKLDKDE YLIYEKYRGL 

        70         80         90        100        110        120 
VLTSKGKKIG KRLVYRHELL EQFLRIIGVD EEKIYNDVEG IEHHLSWNSI DRIGDLVQYF 

       130        140 
EEDDARKKDL KSIQKKTEHH NQ 

« Hide

References

« Hide 'large scale' references
[1]"Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the Bacillus subtilis genome containing the skin element and many sporulation genes."
Mizuno M., Masuda S., Takemaru K., Hosono S., Sato T., Takeuchi M., Kobayashi Y.
Microbiology 142:3103-3111(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168 / JH642.
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[3]"From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later."
Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.
Microbiology 155:1758-1775(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION TO 81.
[4]"Manganese homeostasis in Bacillus subtilis is regulated by MntR, a bifunctional regulator related to the diphtheria toxin repressor family of proteins."
Que Q., Helmann J.D.
Mol. Microbiol. 35:1454-1468(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
Strain: 168.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D84432 Genomic DNA. Translation: BAA12551.1.
AL009126 Genomic DNA. Translation: CAB14383.2.
PIRE69959.
RefSeqNP_390332.2. NC_000964.3.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1ON1X-ray1.75A/B1-142[»]
1ON2X-ray1.61A/B1-142[»]
2EV0X-ray1.65A/B1-142[»]
2EV5X-ray2.00A/B1-142[»]
2EV6X-ray1.70A/B1-142[»]
2F5CX-ray2.40A1-142[»]
2F5DX-ray1.90A/B1-142[»]
2F5EX-ray2.20A/B1-142[»]
2F5FX-ray2.40A/B1-142[»]
2HYFX-ray2.80A/B/C/D1-142[»]
2HYGX-ray2.80D1-142[»]
3R60X-ray1.80A/B2-142[»]
3R61X-ray1.90A/B2-142[»]
4HV5X-ray1.90A/B2-142[»]
4HV6X-ray2.30A/B2-142[»]
4HX4X-ray1.65A/B2-142[»]
4HX7X-ray1.90A/B2-142[»]
4HX8X-ray2.00A/B2-142[»]
ProteinModelPortalP54512.
SMRP54512. Positions 4-140.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224308.BSU24520.

Proteomic databases

PaxDbP54512.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB14383; CAB14383; BSU24520.
GeneID938554.
KEGGbsu:BSU24520.
PATRIC18976738. VBIBacSub10457_2559.

Organism-specific databases

GenoListBSU24520. [Micado]

Phylogenomic databases

eggNOGCOG1321.
HOGENOMHOG000040349.
OrthoDBEOG6M9F3P.
PhylomeDBP54512.

Enzyme and pathway databases

BioCycBSUB:BSU24520-MONOMER.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
1.10.60.10. 1 hit.
HAMAPMF_00732. HTH_MntR.
InterProIPR001367. Fe_dep_repressor.
IPR022689. Fe_dep_repressor_HTH_DtxR.
IPR022687. Fe_dep_repressor_HTH_DtxR_N.
IPR022897. Tscrpt_reg_MntR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF02742. Fe_dep_repr_C. 1 hit.
PF01325. Fe_dep_repress. 1 hit.
[Graphical view]
SMARTSM00529. HTH_DTXR. 1 hit.
[Graphical view]
SUPFAMSSF47979. SSF47979. 1 hit.
PROSITEPS50944. HTH_DTXR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP54512.

Entry information

Entry nameMNTR_BACSU
AccessionPrimary (citable) accession number: P54512
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 7, 2009
Last modified: July 9, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList