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Protein

Transcriptional regulator MntR

Gene

mntR

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Central regulator of manganese homeostasis. In the presence of manganese, it mediates repression of the manganese transporter MntH; under low manganese conditions, it activates the transcription of the mntABCD operon.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandManganese

Enzyme and pathway databases

BioCyciBSUB:BSU24520-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulator MntR
Alternative name(s):
Manganese transport regulator
Gene namesi
Name:mntR
Synonyms:yqhN
Ordered Locus Names:BSU24520
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002011181 – 142Transcriptional regulator MntRAdd BLAST142

Proteomic databases

PaxDbiP54512
PRIDEiP54512

Interactioni

Subunit structurei

Homodimer.Curated

GO - Molecular functioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100013441

Structurei

Secondary structure

1142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 20Combined sources17
Helixi25 – 32Combined sources8
Helixi36 – 48Combined sources13
Beta strandi51 – 55Combined sources5
Turni56 – 58Combined sources3
Beta strandi59 – 62Combined sources4
Helixi64 – 86Combined sources23
Helixi91 – 101Combined sources11
Helixi102 – 104Combined sources3
Helixi107 – 121Combined sources15
Helixi124 – 134Combined sources11
Helixi139 – 141Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ON1X-ray1.75A/B1-142[»]
1ON2X-ray1.61A/B1-142[»]
2EV0X-ray1.65A/B1-142[»]
2EV5X-ray2.00A/B1-142[»]
2EV6X-ray1.70A/B1-142[»]
2F5CX-ray2.40A1-142[»]
2F5DX-ray1.90A/B1-142[»]
2F5EX-ray2.20A/B1-142[»]
2F5FX-ray2.40A/B1-142[»]
2HYFX-ray2.80A/B/C/D1-142[»]
2HYGX-ray2.80D1-142[»]
3R60X-ray1.80A/B2-142[»]
3R61X-ray1.90A/B2-142[»]
4HV5X-ray1.90A/B2-142[»]
4HV6X-ray2.30A/B2-142[»]
4HX4X-ray1.65A/B2-142[»]
4HX7X-ray1.90A/B2-142[»]
4HX8X-ray2.00A/B2-142[»]
ProteinModelPortaliP54512
SMRiP54512
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP54512

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 63HTH dtxR-typeAdd BLAST63

Domaini

It contains an N-terminal DNA-binding domain and a metal-binding domain.

Phylogenomic databases

eggNOGiENOG4105KST Bacteria
COG1321 LUCA
HOGENOMiHOG000040349
InParanoidiP54512
OMAiCIIERFL
PhylomeDBiP54512

Family and domain databases

Gene3Di1.10.10.10, 1 hit
1.10.60.10, 1 hit
HAMAPiMF_00732 HTH_MntR, 1 hit
InterProiView protein in InterPro
IPR001367 Fe_dep_repressor
IPR036421 Fe_dep_repressor_sf
IPR022687 HTH_DTXR
IPR022689 Iron_dep_repressor
IPR022897 Tscrpt_reg_MntR
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF02742 Fe_dep_repr_C, 1 hit
PF01325 Fe_dep_repress, 1 hit
SMARTiView protein in SMART
SM00529 HTH_DTXR, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF47979 SSF47979, 1 hit
PROSITEiView protein in PROSITE
PS50944 HTH_DTXR, 1 hit

Sequencei

Sequence statusi: Complete.

P54512-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTPSMEDYI EQIYMLIEEK GYARVSDIAE ALAVHPSSVT KMVQKLDKDE
60 70 80 90 100
YLIYEKYRGL VLTSKGKKIG KRLVYRHELL EQFLRIIGVD EEKIYNDVEG
110 120 130 140
IEHHLSWNSI DRIGDLVQYF EEDDARKKDL KSIQKKTEHH NQ
Length:142
Mass (Da):16,759
Last modified:July 7, 2009 - v2
Checksum:i653BD8E0F4AB9F2C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81E → D in BAA12551 (PubMed:8969508).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84432 Genomic DNA Translation: BAA12551.1
AL009126 Genomic DNA Translation: CAB14383.2
PIRiE69959
RefSeqiNP_390332.2, NC_000964.3
WP_003236923.1, NZ_JNCM01000036.1

Genome annotation databases

EnsemblBacteriaiCAB14383; CAB14383; BSU24520
GeneIDi938554
KEGGibsu:BSU24520
PATRICifig|224308.179.peg.2670

Similar proteinsi

Entry informationi

Entry nameiMNTR_BACSU
AccessioniPrimary (citable) accession number: P54512
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 7, 2009
Last modified: May 23, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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