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P54512

- MNTR_BACSU

UniProt

P54512 - MNTR_BACSU

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Protein

Transcriptional regulator MntR

Gene

mntR

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Central regulator of manganese homeostasis. In the presence of manganese, it mediates repression of the manganese transporter MntH; under low manganese conditions, it activates the transcription of the mntABCD operon.

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. sequence-specific DNA binding transcription factor activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular manganese ion homeostasis Source: UniProtKB-HAMAP
  2. positive regulation of transcription, DNA-templated Source: UniProtKB-HAMAP
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Manganese

Enzyme and pathway databases

BioCyciBSUB:BSU24520-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulator MntR
Alternative name(s):
Manganese transport regulator
Gene namesi
Name:mntR
Synonyms:yqhN
Ordered Locus Names:BSU24520
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU24520. [Micado]

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 142142Transcriptional regulator MntRPRO_0000201118Add
BLAST

Proteomic databases

PaxDbiP54512.

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

STRINGi224308.BSU24520.

Structurei

Secondary structure

1
142
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 2017Combined sources
Helixi25 – 328Combined sources
Helixi36 – 4813Combined sources
Beta strandi51 – 555Combined sources
Turni56 – 583Combined sources
Beta strandi59 – 624Combined sources
Helixi64 – 8623Combined sources
Helixi91 – 10111Combined sources
Helixi102 – 1043Combined sources
Helixi107 – 12115Combined sources
Helixi124 – 13411Combined sources
Helixi139 – 1413Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ON1X-ray1.75A/B1-142[»]
1ON2X-ray1.61A/B1-142[»]
2EV0X-ray1.65A/B1-142[»]
2EV5X-ray2.00A/B1-142[»]
2EV6X-ray1.70A/B1-142[»]
2F5CX-ray2.40A1-142[»]
2F5DX-ray1.90A/B1-142[»]
2F5EX-ray2.20A/B1-142[»]
2F5FX-ray2.40A/B1-142[»]
2HYFX-ray2.80A/B/C/D1-142[»]
2HYGX-ray2.80D1-142[»]
3R60X-ray1.80A/B2-142[»]
3R61X-ray1.90A/B2-142[»]
4HV5X-ray1.90A/B2-142[»]
4HV6X-ray2.30A/B2-142[»]
4HX4X-ray1.65A/B2-142[»]
4HX7X-ray1.90A/B2-142[»]
4HX8X-ray2.00A/B2-142[»]
ProteinModelPortaliP54512.
SMRiP54512. Positions 4-140.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP54512.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 6363HTH dtxR-typeAdd
BLAST

Domaini

It contains an N-terminal DNA-binding domain and a metal-binding domain.

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1321.
HOGENOMiHOG000040349.
InParanoidiP54512.
OrthoDBiEOG6M9F3P.
PhylomeDBiP54512.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.60.10. 1 hit.
HAMAPiMF_00732. HTH_MntR.
InterProiIPR001367. Fe_dep_repressor.
IPR022689. Fe_dep_repressor_HTH_DtxR.
IPR022687. Fe_dep_repressor_HTH_DtxR_N.
IPR022897. Tscrpt_reg_MntR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF02742. Fe_dep_repr_C. 1 hit.
PF01325. Fe_dep_repress. 1 hit.
[Graphical view]
SMARTiSM00529. HTH_DTXR. 1 hit.
[Graphical view]
SUPFAMiSSF47979. SSF47979. 1 hit.
PROSITEiPS50944. HTH_DTXR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54512-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTPSMEDYI EQIYMLIEEK GYARVSDIAE ALAVHPSSVT KMVQKLDKDE
60 70 80 90 100
YLIYEKYRGL VLTSKGKKIG KRLVYRHELL EQFLRIIGVD EEKIYNDVEG
110 120 130 140
IEHHLSWNSI DRIGDLVQYF EEDDARKKDL KSIQKKTEHH NQ
Length:142
Mass (Da):16,759
Last modified:July 7, 2009 - v2
Checksum:i653BD8E0F4AB9F2C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti81 – 811E → D in BAA12551. (PubMed:8969508)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D84432 Genomic DNA. Translation: BAA12551.1.
AL009126 Genomic DNA. Translation: CAB14383.2.
PIRiE69959.
RefSeqiNP_390332.2. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB14383; CAB14383; BSU24520.
GeneIDi938554.
KEGGibsu:BSU24520.
PATRICi18976738. VBIBacSub10457_2559.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D84432 Genomic DNA. Translation: BAA12551.1 .
AL009126 Genomic DNA. Translation: CAB14383.2 .
PIRi E69959.
RefSeqi NP_390332.2. NC_000964.3.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ON1 X-ray 1.75 A/B 1-142 [» ]
1ON2 X-ray 1.61 A/B 1-142 [» ]
2EV0 X-ray 1.65 A/B 1-142 [» ]
2EV5 X-ray 2.00 A/B 1-142 [» ]
2EV6 X-ray 1.70 A/B 1-142 [» ]
2F5C X-ray 2.40 A 1-142 [» ]
2F5D X-ray 1.90 A/B 1-142 [» ]
2F5E X-ray 2.20 A/B 1-142 [» ]
2F5F X-ray 2.40 A/B 1-142 [» ]
2HYF X-ray 2.80 A/B/C/D 1-142 [» ]
2HYG X-ray 2.80 D 1-142 [» ]
3R60 X-ray 1.80 A/B 2-142 [» ]
3R61 X-ray 1.90 A/B 2-142 [» ]
4HV5 X-ray 1.90 A/B 2-142 [» ]
4HV6 X-ray 2.30 A/B 2-142 [» ]
4HX4 X-ray 1.65 A/B 2-142 [» ]
4HX7 X-ray 1.90 A/B 2-142 [» ]
4HX8 X-ray 2.00 A/B 2-142 [» ]
ProteinModelPortali P54512.
SMRi P54512. Positions 4-140.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224308.BSU24520.

Proteomic databases

PaxDbi P54512.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB14383 ; CAB14383 ; BSU24520 .
GeneIDi 938554.
KEGGi bsu:BSU24520.
PATRICi 18976738. VBIBacSub10457_2559.

Organism-specific databases

GenoListi BSU24520. [Micado ]

Phylogenomic databases

eggNOGi COG1321.
HOGENOMi HOG000040349.
InParanoidi P54512.
OrthoDBi EOG6M9F3P.
PhylomeDBi P54512.

Enzyme and pathway databases

BioCyci BSUB:BSU24520-MONOMER.

Miscellaneous databases

EvolutionaryTracei P54512.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
1.10.60.10. 1 hit.
HAMAPi MF_00732. HTH_MntR.
InterProi IPR001367. Fe_dep_repressor.
IPR022689. Fe_dep_repressor_HTH_DtxR.
IPR022687. Fe_dep_repressor_HTH_DtxR_N.
IPR022897. Tscrpt_reg_MntR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF02742. Fe_dep_repr_C. 1 hit.
PF01325. Fe_dep_repress. 1 hit.
[Graphical view ]
SMARTi SM00529. HTH_DTXR. 1 hit.
[Graphical view ]
SUPFAMi SSF47979. SSF47979. 1 hit.
PROSITEi PS50944. HTH_DTXR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the Bacillus subtilis genome containing the skin element and many sporulation genes."
    Mizuno M., Masuda S., Takemaru K., Hosono S., Sato T., Takeuchi M., Kobayashi Y.
    Microbiology 142:3103-3111(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168 / JH642.
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  3. "From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later."
    Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.
    Microbiology 155:1758-1775(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO 81.
  4. "Manganese homeostasis in Bacillus subtilis is regulated by MntR, a bifunctional regulator related to the diphtheria toxin repressor family of proteins."
    Que Q., Helmann J.D.
    Mol. Microbiol. 35:1454-1468(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
    Strain: 168.

Entry informationi

Entry nameiMNTR_BACSU
AccessioniPrimary (citable) accession number: P54512
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 7, 2009
Last modified: October 29, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3