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Protein

Transcriptional regulator MntR

Gene

mntR

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Central regulator of manganese homeostasis. In the presence of manganese, it mediates repression of the manganese transporter MntH; under low manganese conditions, it activates the transcription of the mntABCD operon.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Manganese

Enzyme and pathway databases

BioCyciBSUB:BSU24520-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulator MntR
Alternative name(s):
Manganese transport regulator
Gene namesi
Name:mntR
Synonyms:yqhN
Ordered Locus Names:BSU24520
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002011181 – 142Transcriptional regulator MntRAdd BLAST142

Proteomic databases

PaxDbiP54512.

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100013441.

Structurei

Secondary structure

1142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 20Combined sources17
Helixi25 – 32Combined sources8
Helixi36 – 48Combined sources13
Beta strandi51 – 55Combined sources5
Turni56 – 58Combined sources3
Beta strandi59 – 62Combined sources4
Helixi64 – 86Combined sources23
Helixi91 – 101Combined sources11
Helixi102 – 104Combined sources3
Helixi107 – 121Combined sources15
Helixi124 – 134Combined sources11
Helixi139 – 141Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ON1X-ray1.75A/B1-142[»]
1ON2X-ray1.61A/B1-142[»]
2EV0X-ray1.65A/B1-142[»]
2EV5X-ray2.00A/B1-142[»]
2EV6X-ray1.70A/B1-142[»]
2F5CX-ray2.40A1-142[»]
2F5DX-ray1.90A/B1-142[»]
2F5EX-ray2.20A/B1-142[»]
2F5FX-ray2.40A/B1-142[»]
2HYFX-ray2.80A/B/C/D1-142[»]
2HYGX-ray2.80D1-142[»]
3R60X-ray1.80A/B2-142[»]
3R61X-ray1.90A/B2-142[»]
4HV5X-ray1.90A/B2-142[»]
4HV6X-ray2.30A/B2-142[»]
4HX4X-ray1.65A/B2-142[»]
4HX7X-ray1.90A/B2-142[»]
4HX8X-ray2.00A/B2-142[»]
ProteinModelPortaliP54512.
SMRiP54512.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP54512.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 63HTH dtxR-typeAdd BLAST63

Domaini

It contains an N-terminal DNA-binding domain and a metal-binding domain.

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105KST. Bacteria.
COG1321. LUCA.
HOGENOMiHOG000040349.
InParanoidiP54512.
OMAiSWDAIDR.
PhylomeDBiP54512.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.60.10. 1 hit.
HAMAPiMF_00732. HTH_MntR. 1 hit.
InterProiIPR001367. Fe_dep_repressor.
IPR022687. HTH_DTXR.
IPR022689. Iron_dep_repressor.
IPR022897. Tscrpt_reg_MntR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF02742. Fe_dep_repr_C. 1 hit.
PF01325. Fe_dep_repress. 1 hit.
[Graphical view]
SMARTiSM00529. HTH_DTXR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF47979. SSF47979. 1 hit.
PROSITEiPS50944. HTH_DTXR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54512-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTPSMEDYI EQIYMLIEEK GYARVSDIAE ALAVHPSSVT KMVQKLDKDE
60 70 80 90 100
YLIYEKYRGL VLTSKGKKIG KRLVYRHELL EQFLRIIGVD EEKIYNDVEG
110 120 130 140
IEHHLSWNSI DRIGDLVQYF EEDDARKKDL KSIQKKTEHH NQ
Length:142
Mass (Da):16,759
Last modified:July 7, 2009 - v2
Checksum:i653BD8E0F4AB9F2C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81E → D in BAA12551 (PubMed:8969508).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84432 Genomic DNA. Translation: BAA12551.1.
AL009126 Genomic DNA. Translation: CAB14383.2.
PIRiE69959.
RefSeqiNP_390332.2. NC_000964.3.
WP_003236923.1. NZ_JNCM01000036.1.

Genome annotation databases

EnsemblBacteriaiCAB14383; CAB14383; BSU24520.
GeneIDi938554.
KEGGibsu:BSU24520.
PATRICi18976738. VBIBacSub10457_2559.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84432 Genomic DNA. Translation: BAA12551.1.
AL009126 Genomic DNA. Translation: CAB14383.2.
PIRiE69959.
RefSeqiNP_390332.2. NC_000964.3.
WP_003236923.1. NZ_JNCM01000036.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ON1X-ray1.75A/B1-142[»]
1ON2X-ray1.61A/B1-142[»]
2EV0X-ray1.65A/B1-142[»]
2EV5X-ray2.00A/B1-142[»]
2EV6X-ray1.70A/B1-142[»]
2F5CX-ray2.40A1-142[»]
2F5DX-ray1.90A/B1-142[»]
2F5EX-ray2.20A/B1-142[»]
2F5FX-ray2.40A/B1-142[»]
2HYFX-ray2.80A/B/C/D1-142[»]
2HYGX-ray2.80D1-142[»]
3R60X-ray1.80A/B2-142[»]
3R61X-ray1.90A/B2-142[»]
4HV5X-ray1.90A/B2-142[»]
4HV6X-ray2.30A/B2-142[»]
4HX4X-ray1.65A/B2-142[»]
4HX7X-ray1.90A/B2-142[»]
4HX8X-ray2.00A/B2-142[»]
ProteinModelPortaliP54512.
SMRiP54512.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100013441.

Proteomic databases

PaxDbiP54512.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB14383; CAB14383; BSU24520.
GeneIDi938554.
KEGGibsu:BSU24520.
PATRICi18976738. VBIBacSub10457_2559.

Phylogenomic databases

eggNOGiENOG4105KST. Bacteria.
COG1321. LUCA.
HOGENOMiHOG000040349.
InParanoidiP54512.
OMAiSWDAIDR.
PhylomeDBiP54512.

Enzyme and pathway databases

BioCyciBSUB:BSU24520-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP54512.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.60.10. 1 hit.
HAMAPiMF_00732. HTH_MntR. 1 hit.
InterProiIPR001367. Fe_dep_repressor.
IPR022687. HTH_DTXR.
IPR022689. Iron_dep_repressor.
IPR022897. Tscrpt_reg_MntR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF02742. Fe_dep_repr_C. 1 hit.
PF01325. Fe_dep_repress. 1 hit.
[Graphical view]
SMARTiSM00529. HTH_DTXR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF47979. SSF47979. 1 hit.
PROSITEiPS50944. HTH_DTXR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMNTR_BACSU
AccessioniPrimary (citable) accession number: P54512
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 7, 2009
Last modified: November 2, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.