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P54504

- RSBRD_BACSU

UniProt

P54504 - RSBRD_BACSU

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Protein

RsbT co-antagonist protein RsbRD

Gene
rsbRD, yqhA, BSU24760
Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

One of 4 functionally non-identical RsbR paralogs, it functions in the environmental signaling branch of the general stress response.2 Publications
Negative regulator of sigma-B activity. Non-phosphorylated RsbS binds to RsbT, preventing its association with RsbU. Requires any one of RsbRA, RsbRB, RsbRC or RsbRD to sequester RsbT. When RsbS and the RsbR paralog(s) are phosphorylated, they release RsbT, which can then bind and activate RsbU.2 Publications

Enzyme and pathway databases

BioCyciBSUB:BSU24760-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RsbT co-antagonist protein RsbRD
Alternative name(s):
Stressosome protein RsbRD
Gene namesi
Name:rsbRD
Synonyms:yqhA
Ordered Locus Names:BSU24760
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU24760. [Micado]

Pathology & Biotechi

Disruption phenotypei

Cells lacking this gene have no visible phenotype is response to salt, ethanol or energy stress. However cells with multiple disruption (RsbRA, RsbRB and RsbRD) have an increased basal level of sigma-B, indicating this protein is a negative regulator of sigma-B.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278RsbT co-antagonist protein RsbRDPRO_0000049817Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei181 – 1811Phosphothreonine1 Publication

Post-translational modificationi

Phosphorylated by RsbT.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP54504.

PTM databases

PhosSiteiP0712194.

Interactioni

Subunit structurei

Probably present in the stressosome with RsbRA, RsbRB, RsbRC and RsbS.1 Publication

Protein-protein interaction databases

STRINGi224308.BSU24760.

Structurei

3D structure databases

ProteinModelPortaliP54504.
SMRiP54504. Positions 162-276.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini160 – 271112STASAdd
BLAST

Sequence similaritiesi

Contains 1 STAS domain.

Phylogenomic databases

eggNOGiCOG1366.
HOGENOMiHOG000008785.
KOiK17763.
OrthoDBiEOG6G4VQG.
PhylomeDBiP54504.

Family and domain databases

Gene3Di3.30.750.24. 1 hit.
InterProiIPR025751. RsbRD_N_dom.
IPR002645. STAS_dom.
[Graphical view]
PfamiPF14361. RsbRD_N. 1 hit.
PF01740. STAS. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 1 hit.
PROSITEiPS50801. STAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54504-1 [UniParc]FASTAAdd to Basket

« Hide

MIALDQHLTE HKKDITQQWL EVCTSNGSWL YSAKDQQKLE QKLKDQHELL    50
VTIVAKSLRK EDVEDELNRW SLQCARDRAV HEVTVTQSVG QFNTFRHIMF 100
EWIHKFSEAS SQDISIQEFY EWSRILNQNI DEIIEVFTEE YHQVTMIQLN 150
AQKEMINELS APIMPITDGI GILPLVGEID THRARTILES VLEQCSALKL 200
SYLFLDISGV PIVDTMVAYQ IFKVIDSTKL LGIETIISGI RPEIAQTVVK 250
LGLDFSNVKT EQSLAKALAN KGFKIKEC 278
Length:278
Mass (Da):31,835
Last modified:July 7, 2009 - v2
Checksum:iB5057DE23E0914D7
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti40 – 401E → G in BAA12530. 1 Publication
Sequence conflicti89 – 891V → F in BAA12530. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D84432 Genomic DNA. Translation: BAA12530.1.
AL009126 Genomic DNA. Translation: CAB14407.2.
PIRiD69958.
RefSeqiNP_390356.2. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB14407; CAB14407; BSU24760.
GeneIDi938513.
KEGGibsu:BSU24760.
PATRICi18976786. VBIBacSub10457_2583.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D84432 Genomic DNA. Translation: BAA12530.1 .
AL009126 Genomic DNA. Translation: CAB14407.2 .
PIRi D69958.
RefSeqi NP_390356.2. NC_000964.3.

3D structure databases

ProteinModelPortali P54504.
SMRi P54504. Positions 162-276.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224308.BSU24760.

PTM databases

PhosSitei P0712194.

Proteomic databases

PaxDbi P54504.

Protocols and materials databases

DNASUi 938513.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB14407 ; CAB14407 ; BSU24760 .
GeneIDi 938513.
KEGGi bsu:BSU24760.
PATRICi 18976786. VBIBacSub10457_2583.

Organism-specific databases

GenoListi BSU24760. [Micado ]

Phylogenomic databases

eggNOGi COG1366.
HOGENOMi HOG000008785.
KOi K17763.
OrthoDBi EOG6G4VQG.
PhylomeDBi P54504.

Enzyme and pathway databases

BioCyci BSUB:BSU24760-MONOMER.

Family and domain databases

Gene3Di 3.30.750.24. 1 hit.
InterProi IPR025751. RsbRD_N_dom.
IPR002645. STAS_dom.
[Graphical view ]
Pfami PF14361. RsbRD_N. 1 hit.
PF01740. STAS. 1 hit.
[Graphical view ]
SUPFAMi SSF52091. SSF52091. 1 hit.
PROSITEi PS50801. STAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the Bacillus subtilis genome containing the skin element and many sporulation genes."
    Mizuno M., Masuda S., Takemaru K., Hosono S., Sato T., Takeuchi M., Kobayashi Y.
    Microbiology 142:3103-3111(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168 / JH642.
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  3. "From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later."
    Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.
    Microbiology 155:1758-1775(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO 40 AND 89.
  4. "New family of regulators in the environmental signaling pathway which activates the general stress transcription factor sigma(B) of Bacillus subtilis."
    Akbar S., Gaidenko T.A., Kang C.M., O'Reilly M., Devine K.M., Price C.W.
    J. Bacteriol. 183:1329-1338(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION BY RSBT, COMPLEX SUGGESTION, DISRUPTION PHENOTYPE.
    Strain: 168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB 3610 / VKM B-501.
  5. "A multicomponent protein complex mediates environmental stress signaling in Bacillus subtilis."
    Kim T.-J., Gaidenko T.A., Price C.W.
    J. Mol. Biol. 341:135-150(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, POSSIBLE SUBUNIT.
    Strain: 168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB 3610 / VKM B-501.
  6. "The serine/threonine/tyrosine phosphoproteome of the model bacterium Bacillus subtilis."
    Macek B., Mijakovic I., Olsen J.V., Gnad F., Kumar C., Jensen P.R., Mann M.
    Mol. Cell. Proteomics 6:697-707(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-181, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: 168.

Entry informationi

Entry nameiRSBRD_BACSU
AccessioniPrimary (citable) accession number: P54504
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 7, 2009
Last modified: July 9, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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