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P54495 (GLK_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucokinase

EC=2.7.1.2
Alternative name(s):
Glucose kinase
Gene names
Name:glcK
Synonyms:yqgR
Ordered Locus Names:BSU24850
OrganismBacillus subtilis (strain 168) [Reference proteome] [HAMAP]
Taxonomic identifier224308 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + D-glucose = ADP + D-glucose 6-phosphate.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the ROK (NagC/XylR) family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glucokinase activity

Inferred from mutant phenotype Ref.4. Source: CACAO

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 321321Glucokinase
PRO_0000095676

Experimental info

Sequence conflict1521V → L in BAA12521. Ref.1
Sequence conflict1981E → G in BAA12521. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P54495 [UniParc].

Last modified July 7, 2009. Version 2.
Checksum: F8162AE8BB49D3CD

FASTA32133,604
        10         20         30         40         50         60 
MDEIWFAGID LGGTTIKLAF INQYGEIQHK WEVPTDKTGD TITVTIAKTI DSKLDELQKP 

        70         80         90        100        110        120 
KHIIKYIGMG APGPVDMAAG VVYETVNLGW KNYALKNHLE TETGIPAVIE NDANIAALGE 

       130        140        150        160        170        180 
MWKGAGDGAK DVILVTLGTG VGGGIIANGE IVHGINGAGG EIGHICSIPE GGAPCNCGKT 

       190        200        210        220        230        240 
GCIETIASAT GIVRIAKEKI ANAKKTTRLK ATEQLSARDV FEAAGENDEI ALEVVDYVAK 

       250        260        270        280        290        300 
HLGLVLGNLA SSLNPSKIVL GGGVSRAGEL LRSKVEKTFR KCAFPRAAQA ADISIAALGN 

       310        320 
DAGVIGGAWI AKNEWLKHQN C 

« Hide

References

« Hide 'large scale' references
[1]"Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the Bacillus subtilis genome containing the skin element and many sporulation genes."
Mizuno M., Masuda S., Takemaru K., Hosono S., Sato T., Takeuchi M., Kobayashi Y.
Microbiology 142:3103-3111(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168 / JH642.
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[3]"From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later."
Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.
Microbiology 155:1758-1775(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION TO 152 AND 198.
[4]"The glucose kinase of Bacillus subtilis."
Skarlatos P., Dahl M.K.
J. Bacteriol. 180:3222-3226(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D84432 Genomic DNA. Translation: BAA12521.1.
AL009126 Genomic DNA. Translation: CAB14416.2.
PIRB69632.
RefSeqNP_390365.2. NC_000964.3.

3D structure databases

ProteinModelPortalP54495.
SMRP54495. Positions 3-315.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224308.BSU24850.

Proteomic databases

PaxDbP54495.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB14416; CAB14416; BSU24850.
GeneID938206.
KEGGbsu:BSU24850.
PATRIC18976806. VBIBacSub10457_2592.

Organism-specific databases

GenoListBSU24850. [Micado]

Phylogenomic databases

eggNOGCOG1940.
HOGENOMHOG000150087.
KOK00845.
OrthoDBEOG6CGCDC.
ProtClustDBCLSK2391277.

Enzyme and pathway databases

BioCycBSUB:BSU24850-MONOMER.
MetaCyc:MONOMER-5981.
BRENDA2.7.1.2. 700.

Family and domain databases

InterProIPR000600. ROK.
IPR004654. ROK_glcA.
[Graphical view]
PfamPF00480. ROK. 1 hit.
[Graphical view]
TIGRFAMsTIGR00744. ROK_glcA_fam. 1 hit.
PROSITEPS01125. ROK. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLK_BACSU
AccessionPrimary (citable) accession number: P54495
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 7, 2009
Last modified: November 13, 2013
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList