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P54495

- GLK_BACSU

UniProt

P54495 - GLK_BACSU

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Protein

Glucokinase

Gene

glcK

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + D-glucose = ADP + D-glucose 6-phosphate.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glucokinase activity Source: CACAO

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU24850-MONOMER.
MetaCyc:MONOMER-5981.
BRENDAi2.7.1.2. 700.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucokinase (EC:2.7.1.2)
Alternative name(s):
Glucose kinase
Gene namesi
Name:glcK
Synonyms:yqgR
Ordered Locus Names:BSU24850
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU24850. [Micado]

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321GlucokinasePRO_0000095676Add
BLAST

Proteomic databases

PaxDbiP54495.

Interactioni

Protein-protein interaction databases

STRINGi224308.BSU24850.

Structurei

3D structure databases

ProteinModelPortaliP54495.
SMRiP54495. Positions 3-315.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ROK (NagC/XylR) family.Curated

Phylogenomic databases

eggNOGiCOG1940.
HOGENOMiHOG000150087.
InParanoidiP54495.
KOiK00845.
OrthoDBiEOG6CGCDC.
PhylomeDBiP54495.

Family and domain databases

InterProiIPR000600. ROK.
IPR004654. ROK_glcA.
[Graphical view]
PfamiPF00480. ROK. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00744. ROK_glcA_fam. 1 hit.
PROSITEiPS01125. ROK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54495-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDEIWFAGID LGGTTIKLAF INQYGEIQHK WEVPTDKTGD TITVTIAKTI
60 70 80 90 100
DSKLDELQKP KHIIKYIGMG APGPVDMAAG VVYETVNLGW KNYALKNHLE
110 120 130 140 150
TETGIPAVIE NDANIAALGE MWKGAGDGAK DVILVTLGTG VGGGIIANGE
160 170 180 190 200
IVHGINGAGG EIGHICSIPE GGAPCNCGKT GCIETIASAT GIVRIAKEKI
210 220 230 240 250
ANAKKTTRLK ATEQLSARDV FEAAGENDEI ALEVVDYVAK HLGLVLGNLA
260 270 280 290 300
SSLNPSKIVL GGGVSRAGEL LRSKVEKTFR KCAFPRAAQA ADISIAALGN
310 320
DAGVIGGAWI AKNEWLKHQN C
Length:321
Mass (Da):33,604
Last modified:July 7, 2009 - v2
Checksum:iF8162AE8BB49D3CD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti152 – 1521V → L in BAA12521. (PubMed:8969508)Curated
Sequence conflicti198 – 1981E → G in BAA12521. (PubMed:8969508)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84432 Genomic DNA. Translation: BAA12521.1.
AL009126 Genomic DNA. Translation: CAB14416.2.
PIRiB69632.
RefSeqiNP_390365.2. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB14416; CAB14416; BSU24850.
GeneIDi938206.
KEGGibsu:BSU24850.
PATRICi18976806. VBIBacSub10457_2592.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84432 Genomic DNA. Translation: BAA12521.1 .
AL009126 Genomic DNA. Translation: CAB14416.2 .
PIRi B69632.
RefSeqi NP_390365.2. NC_000964.3.

3D structure databases

ProteinModelPortali P54495.
SMRi P54495. Positions 3-315.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224308.BSU24850.

Proteomic databases

PaxDbi P54495.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB14416 ; CAB14416 ; BSU24850 .
GeneIDi 938206.
KEGGi bsu:BSU24850.
PATRICi 18976806. VBIBacSub10457_2592.

Organism-specific databases

GenoListi BSU24850. [Micado ]

Phylogenomic databases

eggNOGi COG1940.
HOGENOMi HOG000150087.
InParanoidi P54495.
KOi K00845.
OrthoDBi EOG6CGCDC.
PhylomeDBi P54495.

Enzyme and pathway databases

BioCyci BSUB:BSU24850-MONOMER.
MetaCyc:MONOMER-5981.
BRENDAi 2.7.1.2. 700.

Family and domain databases

InterProi IPR000600. ROK.
IPR004654. ROK_glcA.
[Graphical view ]
Pfami PF00480. ROK. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00744. ROK_glcA_fam. 1 hit.
PROSITEi PS01125. ROK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the Bacillus subtilis genome containing the skin element and many sporulation genes."
    Mizuno M., Masuda S., Takemaru K., Hosono S., Sato T., Takeuchi M., Kobayashi Y.
    Microbiology 142:3103-3111(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168 / JH642.
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  3. "From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later."
    Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.
    Microbiology 155:1758-1775(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO 152 AND 198.
  4. "The glucose kinase of Bacillus subtilis."
    Skarlatos P., Dahl M.K.
    J. Bacteriol. 180:3222-3226(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiGLK_BACSU
AccessioniPrimary (citable) accession number: P54495
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 7, 2009
Last modified: October 29, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3