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Protein

Nicotinate-nucleotide adenylyltransferase

Gene

nadD

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

Catalytic activityi

ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD+.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide.
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate-nucleotide adenylyltransferase (nadD)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, NAD, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU25640-MONOMER.
BRENDAi2.7.7.18. 658.
UniPathwayiUPA00253; UER00332.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate-nucleotide adenylyltransferase (EC:2.7.7.18)
Alternative name(s):
Deamido-NAD(+) diphosphorylase
Deamido-NAD(+) pyrophosphorylase
Nicotinate mononucleotide adenylyltransferase
Short name:
NaMN adenylyltransferase
Gene namesi
Name:nadD
Synonyms:yqeJ
Ordered Locus Names:BSU25640
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189Nicotinate-nucleotide adenylyltransferasePRO_0000181387Add
BLAST

Proteomic databases

PaxDbiP54455.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100014021.

Structurei

Secondary structure

1
189
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 97Combined sources
Helixi16 – 2813Combined sources
Beta strandi32 – 387Combined sources
Beta strandi46 – 483Combined sources
Helixi53 – 6412Combined sources
Beta strandi70 – 723Combined sources
Helixi75 – 773Combined sources
Beta strandi78 – 814Combined sources
Helixi85 – 9511Combined sources
Beta strandi99 – 1068Combined sources
Turni107 – 1126Combined sources
Beta strandi113 – 1164Combined sources
Helixi117 – 1259Combined sources
Beta strandi126 – 1327Combined sources
Beta strandi145 – 1484Combined sources
Helixi156 – 16510Combined sources
Turni170 – 1723Combined sources
Helixi175 – 1839Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KAMX-ray2.10A/B/C/D2-189[»]
1KAQX-ray3.20A/B/C/D/E/F2-189[»]
ProteinModelPortaliP54455.
SMRiP54455. Positions 2-187.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP54455.

Family & Domainsi

Sequence similaritiesi

Belongs to the NadD family.Curated

Phylogenomic databases

eggNOGiENOG4108Z1W. Bacteria.
COG1057. LUCA.
HOGENOMiHOG000262780.
InParanoidiP54455.
KOiK00969.
OMAiHIETPYP.
PhylomeDBiP54455.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00244. NaMN_adenylyltr. 1 hit.
InterProiIPR004821. Cyt_trans-like.
IPR005248. NAMN_adtrnsfrase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR12039. PTHR12039. 1 hit.
PfamiPF01467. CTP_transf_like. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00482. TIGR00482. 1 hit.

Sequencei

Sequence statusi: Complete.

P54455-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKIGIFGGT FDPPHNGHLL MANEVLYQAG LDEIWFMPNQ IPPHKQNEDY
60 70 80 90 100
TDSFHRVEML KLAIQSNPSF KLELVEMERE GPSYTFDTVS LLKQRYPNDQ
110 120 130 140 150
LFFIIGADMI EYLPKWYKLD ELLNLIQFIG VKRPGFHVET PYPLLFADVP
160 170 180
EFEVSSTMIR ERFKSKKPTD YLIPDKVKKY VEENGLYES
Length:189
Mass (Da):22,157
Last modified:October 1, 1996 - v1
Checksum:iE2383AA7F0624B95
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84432 Genomic DNA. Translation: BAA12447.1.
AL009126 Genomic DNA. Translation: CAB14506.1.
PIRiF69951.
RefSeqiNP_390442.1. NC_000964.3.
WP_004398676.1. NZ_JNCM01000036.1.

Genome annotation databases

EnsemblBacteriaiCAB14506; CAB14506; BSU25640.
GeneIDi937818.
KEGGibsu:BSU25640.
PATRICi18976970. VBIBacSub10457_2674.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84432 Genomic DNA. Translation: BAA12447.1.
AL009126 Genomic DNA. Translation: CAB14506.1.
PIRiF69951.
RefSeqiNP_390442.1. NC_000964.3.
WP_004398676.1. NZ_JNCM01000036.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KAMX-ray2.10A/B/C/D2-189[»]
1KAQX-ray3.20A/B/C/D/E/F2-189[»]
ProteinModelPortaliP54455.
SMRiP54455. Positions 2-187.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100014021.

Proteomic databases

PaxDbiP54455.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB14506; CAB14506; BSU25640.
GeneIDi937818.
KEGGibsu:BSU25640.
PATRICi18976970. VBIBacSub10457_2674.

Phylogenomic databases

eggNOGiENOG4108Z1W. Bacteria.
COG1057. LUCA.
HOGENOMiHOG000262780.
InParanoidiP54455.
KOiK00969.
OMAiHIETPYP.
PhylomeDBiP54455.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00332.
BioCyciBSUB:BSU25640-MONOMER.
BRENDAi2.7.7.18. 658.

Miscellaneous databases

EvolutionaryTraceiP54455.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00244. NaMN_adenylyltr. 1 hit.
InterProiIPR004821. Cyt_trans-like.
IPR005248. NAMN_adtrnsfrase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR12039. PTHR12039. 1 hit.
PfamiPF01467. CTP_transf_like. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00482. TIGR00482. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNADD_BACSU
AccessioniPrimary (citable) accession number: P54455
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.