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P54448 (YQEC_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative 6-phosphogluconate dehydrogenase YqeC
EC=1.1.1.-
Gene names
Name:yqeC
Ordered Locus Names:BSU25730
OrganismBacillus subtilis
Taxonomic identifier1423 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length297 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

May act as NAD-dependent 6-P-gluconate dehydrogenase. Ref.3

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processpentose-phosphate shunt

Inferred from electronic annotation. Source: InterPro

   Molecular functionNADP binding

Inferred from electronic annotation. Source: InterPro

phosphogluconate dehydrogenase (decarboxylating) activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 297297Putative 6-phosphogluconate dehydrogenase YqeC
PRO_0000090077

Regions

Nucleotide binding7 – 126NAD By similarity
Region120 – 1223Substrate binding By similarity
Region173 – 1742Substrate binding By similarity

Sites

Active site1701Proton acceptor By similarity
Active site1771Proton donor By similarity
Binding site941NAD By similarity
Binding site941Substrate By similarity
Binding site1781Substrate By similarity
Binding site2681Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P54448 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 83607681471AC73C

FASTA29732,769
        10         20         30         40         50         60 
MKIGLIGLGK MGINIGKQFI DRNHQVVGYD VNQAAVDELK AYGAEGTTNL KEFISLLHPP 

        70         80         90        100        110        120 
RILWVMVPHG IVDAVLRDVS PLLSKGDMII EAGNSHYKES IRRYNQMKEA GIHYLDAGTS 

       130        140        150        160        170        180 
GGMEGARHGA CFMVGGDHEA WEIVEPLFRD TAVENGYLYA GEAGSGHFLK MIHNGIEYGM 

       190        200        210        220        230        240 
MAAIGEGFEV LENSQFDFDY EKVARVWNHG SVIRSWLMGL TERAFAKDAK LDQIKGIMHS 

       250        260        270        280        290 
SGEGKWTVET ALDLQTATPV IAMSLMMRYR SLTDDTFTGK VVAALRNEFG GHATEKK

« Hide

References

« Hide 'large scale' references
[1]"Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the Bacillus subtilis genome containing the skin element and many sporulation genes."
Mizuno M., Masuda S., Takemaru K., Hosono S., Sato T., Takeuchi M., Kobayashi Y.
Microbiology 142:3103-3111(1996) [PubMed: 8969508] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168 / JH642.
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed: 9384377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[3]"The Bacillus subtilis yqjI gene encodes the NADP+-dependent 6-P-gluconate dehydrogenase in the pentose phosphate pathway."
Zamboni N., Fischer E., Laudert D., Aymerich S., Hohmann H.P., Sauer U.
J. Bacteriol. 186:4528-4534(2004) [PubMed: 15231785] [Abstract]
Cited for: PROPOSED FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D84432 Genomic DNA. Translation: BAA12439.1.
AL009126 Genomic DNA. Translation: CAB14514.1.
PIRG69950.
RefSeqNP_390450.1. NC_000964.3.

3D structure databases

ProteinModelPortalP54448.
SMRP54448. Positions 2-297.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000000836; EBBACP00000000836; EBBACG00000000834.
GeneID937809.
GenomeReviewsGene locus BSU25730 in contig AL009126_GR.
KEGGbsu:BSU25730.
NMPDRfig|224308.1.peg.2575.
PATRIC18976988. VBIBacSub10457_2683.

Organism-specific databases

GenoListBSU25730.

Phylogenomic databases

GeneTreeEBGT00050000001992.
HOGENOMHBG286913.
OMAGLENGYA.
PhylomeDBP54448.
ProtClustDBPRK09599.

Enzyme and pathway databases

BioCycBSUB:BSU25730-MONOMER.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR004849. 6DGDH-related.
IPR006114. 6PGDH_C.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00872. Gnd_rel. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameYQEC_BACSU
AccessionPrimary (citable) accession number: P54448
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 25, 2012
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

SIMILARITY comments

Index of protein domains and families

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