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P54427 (YBXI_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable beta-lactamase YbxI

EC=3.5.2.6
Gene names
Name:ybxI
Synonyms:ybdS
Ordered Locus Names:BSU02090
OrganismBacillus subtilis (strain 168) [Reference proteome] [HAMAP]
Taxonomic identifier224308 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Sequence similarities

Belongs to the class-D beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   DomainSignal
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processantibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

penicillin binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 267244Probable beta-lactamase YbxI
PRO_0000017049

Regions

Region214 – 2163Substrate binding By similarity

Sites

Active site761Acyl-ester intermediate By similarity

Amino acid modifications

Modified residue791N6-carboxylysine By similarity

Experimental info

Sequence conflict129 – 1379YQALARDIG → IISISERYR Ref.3
Sequence conflict1691T → A in CAA63445. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P54427 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: BBE3E698CD46E6ED

FASTA26730,644
        10         20         30         40         50         60 
MKKWIYVVLV LSIAGIGGFS VHAASSAHEK HLNVSKMNVD DEFKDTDGTF ILHDLQKDQT 

        70         80         90        100        110        120 
FVYNRKRANQ RQTPQSTFKV VNALIGLQVK AVRDEYDVKR WDGVKREFES WNRDHTLGSA 

       130        140        150        160        170        180 
MRESAIWYYQ ALARDIGEER MKTWLHTLSY GNEDISGGID QFWLQSSLTI SPLEQETFLE 

       190        200        210        220        230        240 
KLAKEELPFD KPVMKIVKRM MIQEEGDHYT LYGKTGTRLT DMGLGWFVGF IKTEHGSYVF 

       250        260 
VTNVDDSGTK AKNITVDILK KYGLITS 

« Hide

References

« Hide 'large scale' references
[1]"Sequence analysis of the 70kb region between 17 and 23 degree of the Bacillus subtilis chromosome."
Haga K., Liu H., Yasumoto K., Takahashi H., Yoshikawa H.
Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[3]"Characterization of csgA, a new member of the forespore-expressed sigmaG-regulon from Bacillus subtilis."
Shcheptov M., Chyu G., Bagyan I., Cutting S.M.
Gene 184:133-140(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 129-267.
Strain: 168 / PY79.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB006424 Genomic DNA. Translation: BAA33106.1.
AL009126 Genomic DNA. Translation: CAB12003.1.
X92859 Genomic DNA. Translation: CAA63445.1.
PIRB69752.
RefSeqNP_388091.1. NC_000964.3.

3D structure databases

ProteinModelPortalP54427.
SMRP54427. Positions 17-266.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224308.BSU02090.

Proteomic databases

PaxDbP54427.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB12003; CAB12003; BSU02090.
GeneID938466.
KEGGbsu:BSU02090.
PATRIC18971963. VBIBacSub10457_0210.

Organism-specific databases

GenoListBSU02090.

Phylogenomic databases

eggNOGCOG2602.
HOGENOMHOG000296772.
KOK17838.
OMALYAKTGW.
OrthoDBEOG6CVV8V.
ProtClustDBCLSK886603.

Enzyme and pathway databases

BioCycBSUB:BSU02090-MONOMER.

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamPF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMSSF56601. SSF56601. 1 hit.
PROSITEPS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameYBXI_BACSU
AccessionPrimary (citable) accession number: P54427
Secondary accession number(s): O31439
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 30, 2000
Last modified: February 19, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList