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P54427

- YBXI_BACSU

UniProt

P54427 - YBXI_BACSU

Protein

Probable beta-lactamase YbxI

Gene

ybxI

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei76 – 761Acyl-ester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC
    2. penicillin binding Source: InterPro

    GO - Biological processi

    1. antibiotic catabolic process Source: InterPro
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Enzyme and pathway databases

    BioCyciBSUB:BSU02090-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable beta-lactamase YbxI (EC:3.5.2.6)
    Gene namesi
    Name:ybxI
    Synonyms:ybdS
    Ordered Locus Names:BSU02090
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU02090.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 267244Probable beta-lactamase YbxIPRO_0000017049Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei79 – 791N6-carboxylysineBy similarity

    Proteomic databases

    PaxDbiP54427.

    Interactioni

    Protein-protein interaction databases

    STRINGi224308.BSU02090.

    Structurei

    3D structure databases

    ProteinModelPortaliP54427.
    SMRiP54427. Positions 17-266.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni214 – 2163Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the class-D beta-lactamase family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2602.
    HOGENOMiHOG000296772.
    KOiK17838.
    OMAiQEEGDHY.
    OrthoDBiEOG6CVV8V.
    PhylomeDBiP54427.

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR002137. Beta-lactam_class-D_AS.
    IPR001460. PCN-bd_Tpept.
    [Graphical view]
    PfamiPF00905. Transpeptidase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56601. SSF56601. 1 hit.
    PROSITEiPS00337. BETA_LACTAMASE_D. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P54427-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKWIYVVLV LSIAGIGGFS VHAASSAHEK HLNVSKMNVD DEFKDTDGTF    50
    ILHDLQKDQT FVYNRKRANQ RQTPQSTFKV VNALIGLQVK AVRDEYDVKR 100
    WDGVKREFES WNRDHTLGSA MRESAIWYYQ ALARDIGEER MKTWLHTLSY 150
    GNEDISGGID QFWLQSSLTI SPLEQETFLE KLAKEELPFD KPVMKIVKRM 200
    MIQEEGDHYT LYGKTGTRLT DMGLGWFVGF IKTEHGSYVF VTNVDDSGTK 250
    AKNITVDILK KYGLITS 267
    Length:267
    Mass (Da):30,644
    Last modified:May 30, 2000 - v2
    Checksum:iBBE3E698CD46E6ED
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti129 – 1379YQALARDIG → IISISERYR(PubMed:9016963)Curated
    Sequence conflicti169 – 1691T → A in CAA63445. (PubMed:9016963)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB006424 Genomic DNA. Translation: BAA33106.1.
    AL009126 Genomic DNA. Translation: CAB12003.1.
    X92859 Genomic DNA. Translation: CAA63445.1.
    PIRiB69752.
    RefSeqiNP_388091.1. NC_000964.3.

    Genome annotation databases

    EnsemblBacteriaiCAB12003; CAB12003; BSU02090.
    GeneIDi938466.
    KEGGibsu:BSU02090.
    PATRICi18971963. VBIBacSub10457_0210.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB006424 Genomic DNA. Translation: BAA33106.1 .
    AL009126 Genomic DNA. Translation: CAB12003.1 .
    X92859 Genomic DNA. Translation: CAA63445.1 .
    PIRi B69752.
    RefSeqi NP_388091.1. NC_000964.3.

    3D structure databases

    ProteinModelPortali P54427.
    SMRi P54427. Positions 17-266.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224308.BSU02090.

    Proteomic databases

    PaxDbi P54427.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB12003 ; CAB12003 ; BSU02090 .
    GeneIDi 938466.
    KEGGi bsu:BSU02090.
    PATRICi 18971963. VBIBacSub10457_0210.

    Organism-specific databases

    GenoListi BSU02090.

    Phylogenomic databases

    eggNOGi COG2602.
    HOGENOMi HOG000296772.
    KOi K17838.
    OMAi QEEGDHY.
    OrthoDBi EOG6CVV8V.
    PhylomeDBi P54427.

    Enzyme and pathway databases

    BioCyci BSUB:BSU02090-MONOMER.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR002137. Beta-lactam_class-D_AS.
    IPR001460. PCN-bd_Tpept.
    [Graphical view ]
    Pfami PF00905. Transpeptidase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56601. SSF56601. 1 hit.
    PROSITEi PS00337. BETA_LACTAMASE_D. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the 70kb region between 17 and 23 degree of the Bacillus subtilis chromosome."
      Haga K., Liu H., Yasumoto K., Takahashi H., Yoshikawa H.
      Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 168.
    2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.
    3. "Characterization of csgA, a new member of the forespore-expressed sigmaG-regulon from Bacillus subtilis."
      Shcheptov M., Chyu G., Bagyan I., Cutting S.M.
      Gene 184:133-140(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 129-267.
      Strain: 168 / PY79.

    Entry informationi

    Entry nameiYBXI_BACSU
    AccessioniPrimary (citable) accession number: P54427
    Secondary accession number(s): O31439
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3