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P54424

- GUN1_USTMA

UniProt

P54424 - GUN1_USTMA

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Protein

Endoglucanase 1

Gene
EGL1, UM06332
Organism
Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei34 – 341Nucleophile By similarity
Active sitei152 – 1521Proton donor By similarity

GO - Molecular functioni

  1. cellulase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17192.

Protein family/group databases

CAZyiGH45. Glycoside Hydrolase Family 45.
mycoCLAPiEGL45A_USTMA.

Names & Taxonomyi

Protein namesi
Recommended name:
Endoglucanase 1 (EC:3.2.1.4)
Alternative name(s):
Cellulase 1
Endo-1,4-beta-glucanase 1
Short name:
EG 1
Gene namesi
Name:EGL1
ORF Names:UM06332
OrganismiUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Taxonomic identifieri237631 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago
ProteomesiUP000000561: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed predictionAdd
BLAST
Chaini27 – 393367Endoglucanase 1PRO_0000008025Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi343 – 3431N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

May also be O-glycosylated.

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Hyphal tip.

Developmental stagei

Expressed in filamentous dikaryon.

Interactioni

Protein-protein interaction databases

STRINGi5270.UM06332.1.

Structurei

3D structure databases

ProteinModelPortaliP54424.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi270 – 385116Ala/Gly/Ser-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG140420.
OrthoDBiEOG7712K6.

Family and domain databases

Gene3Di2.40.40.10. 1 hit.
InterProiIPR014733. Barwin-like_endoglucanase.
IPR000334. Glyco_hydro_45.
IPR009009. RlpA-like_DPBB.
[Graphical view]
PfamiPF02015. Glyco_hydro_45. 1 hit.
[Graphical view]
SUPFAMiSSF50685. SSF50685. 1 hit.
PROSITEiPS01140. GLYCOSYL_HYDROL_F45. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54424-1 [UniParc]FASTAAdd to Basket

« Hide

MAFKLNIGLL ALSLSLSLVH LDGVRAGMAT RYWDCCLASA SWEGKAPVYA    50
PVDACKADGV TLIDSKKDPS GQSGCNGGNK FMCSCMQPFD DETDPTLAFG 100
FGAFTTGQES DTDCACFYAE FEHDAQGKAM KRNKLIFQVT NVGGDVQSQN 150
FDFQIPGGGL GAFPKGCPAQ WGVEASLWGD QYGGVKSATE CSKLPKPLQE 200
GCKWRFSEWG DNPVLKGSPK RVKCPKSLID RSGCQRKDDN TISPYSGKVD 250
SANTAAPAQY KRDRSVCLAG GKKGKSAAGG VDGSGDASGG ADASGAGGAA 300
EGSQGQPEGY GQPSGGNDQG SSNGDATTGA GSGSGSDSGS TANGSGSGAP 350
TSGSDGSAVA PPSGGSNPGA AQGGQGGAQP GPSGGHKKCH KKH 393
Length:393
Mass (Da):39,594
Last modified:October 1, 1996 - v1
Checksum:i65C753C610CD6AD3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S81598 Genomic DNA. Translation: AAB36147.1.
AACP01000242 Genomic DNA. Translation: EAK82961.1.
PIRiS59499.
RefSeqiXP_762479.1. XM_757386.1.

Genome annotation databases

EnsemblFungiiUM06332T0; UM06332P0; UM06332.
GeneIDi3634449.
KEGGiuma:UM06332.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S81598 Genomic DNA. Translation: AAB36147.1 .
AACP01000242 Genomic DNA. Translation: EAK82961.1 .
PIRi S59499.
RefSeqi XP_762479.1. XM_757386.1.

3D structure databases

ProteinModelPortali P54424.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5270.UM06332.1.

Protein family/group databases

CAZyi GH45. Glycoside Hydrolase Family 45.
mycoCLAPi EGL45A_USTMA.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii UM06332T0 ; UM06332P0 ; UM06332 .
GeneIDi 3634449.
KEGGi uma:UM06332.1.

Phylogenomic databases

eggNOGi NOG140420.
OrthoDBi EOG7712K6.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-17192.

Family and domain databases

Gene3Di 2.40.40.10. 1 hit.
InterProi IPR014733. Barwin-like_endoglucanase.
IPR000334. Glyco_hydro_45.
IPR009009. RlpA-like_DPBB.
[Graphical view ]
Pfami PF02015. Glyco_hydro_45. 1 hit.
[Graphical view ]
SUPFAMi SSF50685. SSF50685. 1 hit.
PROSITEi PS01140. GLYCOSYL_HYDROL_F45. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Filament-specific expression of a cellulase gene in the dimorphic fungus Ustilago maydis."
    Schauwecker F., Wanner G., Kahmann R.
    Biol. Chem. Hoppe-Seyler 376:617-625(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: FBD11.
  2. "Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis."
    Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J., Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H., Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G., Snetselaar K., McCann M., Perez-Martin J.
    , Feldbruegge M., Basse C.W., Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L., Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L., Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N., Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B., Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J., Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P., Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G., Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A., Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M., Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M., Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E., Birren B.W.
    Nature 444:97-101(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 521 / FGSC 9021.

Entry informationi

Entry nameiGUN1_USTMA
AccessioniPrimary (citable) accession number: P54424
Secondary accession number(s): Q4P0N1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 13, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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