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P54424

- GUN1_USTMA

UniProt

P54424 - GUN1_USTMA

Protein

Endoglucanase 1

Gene

EGL1

Organism
Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei34 – 341NucleophilePROSITE-ProRule annotation
    Active sitei152 – 1521Proton donorBy similarity

    GO - Molecular functioni

    1. cellulase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellulose catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-17192.

    Protein family/group databases

    CAZyiGH45. Glycoside Hydrolase Family 45.
    mycoCLAPiEGL45A_USTMA.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endoglucanase 1 (EC:3.2.1.4)
    Alternative name(s):
    Cellulase 1
    Endo-1,4-beta-glucanase 1
    Short name:
    EG 1
    Gene namesi
    Name:EGL1
    ORF Names:UM06332
    OrganismiUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
    Taxonomic identifieri237631 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago
    ProteomesiUP000000561: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 393367Endoglucanase 1PRO_0000008025Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi343 – 3431N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    May also be O-glycosylated.

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Tissue specificityi

    Hyphal tip.

    Developmental stagei

    Expressed in filamentous dikaryon.

    Interactioni

    Protein-protein interaction databases

    STRINGi5270.UM06332.1.

    Structurei

    3D structure databases

    ProteinModelPortaliP54424.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi270 – 385116Ala/Gly/Ser-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG140420.
    OrthoDBiEOG7712K6.

    Family and domain databases

    Gene3Di2.40.40.10. 1 hit.
    InterProiIPR014733. Barwin-like_endoglucanase.
    IPR000334. Glyco_hydro_45.
    IPR009009. RlpA-like_DPBB.
    [Graphical view]
    PfamiPF02015. Glyco_hydro_45. 1 hit.
    [Graphical view]
    SUPFAMiSSF50685. SSF50685. 1 hit.
    PROSITEiPS01140. GLYCOSYL_HYDROL_F45. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P54424-1 [UniParc]FASTAAdd to Basket

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    MAFKLNIGLL ALSLSLSLVH LDGVRAGMAT RYWDCCLASA SWEGKAPVYA    50
    PVDACKADGV TLIDSKKDPS GQSGCNGGNK FMCSCMQPFD DETDPTLAFG 100
    FGAFTTGQES DTDCACFYAE FEHDAQGKAM KRNKLIFQVT NVGGDVQSQN 150
    FDFQIPGGGL GAFPKGCPAQ WGVEASLWGD QYGGVKSATE CSKLPKPLQE 200
    GCKWRFSEWG DNPVLKGSPK RVKCPKSLID RSGCQRKDDN TISPYSGKVD 250
    SANTAAPAQY KRDRSVCLAG GKKGKSAAGG VDGSGDASGG ADASGAGGAA 300
    EGSQGQPEGY GQPSGGNDQG SSNGDATTGA GSGSGSDSGS TANGSGSGAP 350
    TSGSDGSAVA PPSGGSNPGA AQGGQGGAQP GPSGGHKKCH KKH 393
    Length:393
    Mass (Da):39,594
    Last modified:October 1, 1996 - v1
    Checksum:i65C753C610CD6AD3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S81598 Genomic DNA. Translation: AAB36147.1.
    AACP01000242 Genomic DNA. Translation: EAK82961.1.
    PIRiS59499.
    RefSeqiXP_762479.1. XM_757386.1.

    Genome annotation databases

    EnsemblFungiiUM06332T0; UM06332P0; UM06332.
    GeneIDi3634449.
    KEGGiuma:UM06332.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S81598 Genomic DNA. Translation: AAB36147.1 .
    AACP01000242 Genomic DNA. Translation: EAK82961.1 .
    PIRi S59499.
    RefSeqi XP_762479.1. XM_757386.1.

    3D structure databases

    ProteinModelPortali P54424.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5270.UM06332.1.

    Protein family/group databases

    CAZyi GH45. Glycoside Hydrolase Family 45.
    mycoCLAPi EGL45A_USTMA.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii UM06332T0 ; UM06332P0 ; UM06332 .
    GeneIDi 3634449.
    KEGGi uma:UM06332.1.

    Phylogenomic databases

    eggNOGi NOG140420.
    OrthoDBi EOG7712K6.

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-17192.

    Family and domain databases

    Gene3Di 2.40.40.10. 1 hit.
    InterProi IPR014733. Barwin-like_endoglucanase.
    IPR000334. Glyco_hydro_45.
    IPR009009. RlpA-like_DPBB.
    [Graphical view ]
    Pfami PF02015. Glyco_hydro_45. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50685. SSF50685. 1 hit.
    PROSITEi PS01140. GLYCOSYL_HYDROL_F45. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Filament-specific expression of a cellulase gene in the dimorphic fungus Ustilago maydis."
      Schauwecker F., Wanner G., Kahmann R.
      Biol. Chem. Hoppe-Seyler 376:617-625(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: FBD11.
    2. "Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis."
      Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J., Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H., Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G., Snetselaar K., McCann M., Perez-Martin J.
      , Feldbruegge M., Basse C.W., Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L., Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L., Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N., Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B., Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J., Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P., Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G., Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A., Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M., Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M., Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E., Birren B.W.
      Nature 444:97-101(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 521 / FGSC 9021.

    Entry informationi

    Entry nameiGUN1_USTMA
    AccessioniPrimary (citable) accession number: P54424
    Secondary accession number(s): Q4P0N1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3