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P54422 (GGT_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gamma-glutamyltranspeptidase
EC=2.3.2.2

Cleaved into the following 2 chains:

  1. Gamma-glutamyltranspeptidase large chain
  2. Gamma-glutamyltranspeptidase small chain
Gene names
Name:ggt
Ordered Locus Names:BSU18410
OrganismBacillus subtilis
Taxonomic identifier1423 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length587 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid.

Glutathione + H2O = L-cysteinylglycine + L-glutamate.

Pathway

Sulfur metabolism; glutathione metabolism.

Subunit structure

This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide By similarity.

Subcellular location

Secreted Ref.1.

Developmental stage

Expressed at the end of vegetative growth.

Sequence similarities

Belongs to the gamma-glutamyltransferase family.

Ontologies

Keywords
   Biological processGlutathione biosynthesis
   Cellular componentSecreted
   DomainSignal
   Molecular functionAcyltransferase
Transferase
   PTMZymogen
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological processglutathione biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiongamma-glutamyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Propeptide29 – 357 Potential
PRO_0000011049
Chain36 – 402367Gamma-glutamyltranspeptidase large chain
PRO_0000011050
Chain403 – 587185Gamma-glutamyltranspeptidase small chain
PRO_0000011051

Secondary structure

1 ............................................................................................. 587
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P54422 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 6BF200CBA882C4F6

FASTA58764,189
        10         20         30         40         50         60 
MKRTWNVCLT ALLSVLLVAG SVPFHAEAKK PPKSYDEYKQ VDVGKDGMVA TAHPLASEIG 

        70         80         90        100        110        120 
ADVLKKGGNA IDAAVAIQFA LNVTEPMMSG IGGGGFMMVY DGKTKDTTII DSRERAPAGA 

       130        140        150        160        170        180 
TPDMFLDENG KAIPFSERVT KGTAVGVPGT LKGLEEALDK WGTRSMKQLI TPSIKLAEKG 

       190        200        210        220        230        240 
FPIDSVLAEA ISDYQEKLSR TAAKDVFLPN GEPLKEGDTL IQKDLAKTFK LIRSKGTDAF 

       250        260        270        280        290        300 
YKGKFAKTLS DTVQDFGGSM TEKDLENYDI TIDEPIWGDY QGYQIATTPP PSSGGIFLLQ 

       310        320        330        340        350        360 
MLKILDHFNL SQYDVRSWEK YQLLAETMHL SYADRASYAG DPEFVNVPLK GLLHPDYIKE 

       370        380        390        400        410        420 
RQQLINLDQV NKKPKAGDPW KYQEGSANYK QVEQPKDKVE GQTTHFTVAD RWGNVVSYTT 

       430        440        450        460        470        480 
TIEQLFGTGI MVPDYGVILN NELTDFDAIP GGANEVQPNK RPLSSMTPTI LFKDDKPVLT 

       490        500        510        520        530        540 
VGSPGGATII SSVLQTILYH IEYGMELKAA VEEPRIYTNS MSSYRYEDGV PKDVLSKLNG 

       550        560        570        580 
MGHKFGTSPV DIGNVQSISI DHENGTFKGV ADSSRNGAAI GINLKRK

« Hide

References

« Hide 'large scale' references
[1]"Identification, sequence, and expression of the gene encoding gamma-glutamyltranspeptidase in Bacillus subtilis."
Xu K., Strauch M.A.
J. Bacteriol. 178:4319-4322(1996) [PubMed: 8763966] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION.
Strain: 168 / JH642.
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed: 9384377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U49358 Genomic DNA. Translation: AAC44233.1.
AL009126 Genomic DNA. Translation: CAB13724.1.
PIRF69631.
RefSeqNP_389723.1. NC_000964.3.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2V36X-ray1.85A/C29-402[»]
B/D403-587[»]
3A75X-ray1.95A/C36-402[»]
B/D403-587[»]
ProteinModelPortalP54422.
SMRP54422. Positions 37-395, 403-586.
ModBaseSearch...

Protein family/group databases

MEROPST03.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000004080; EBBACP00000004080; EBBACG00000004072.
GeneID940001.
GenomeReviewsGene locus BSU18410 in contig AL009126_GR.
KEGGbsu:BSU18410.
NMPDRfig|224308.1.peg.1845.
PATRIC18975521. VBIBacSub10457_1951.

Organism-specific databases

GenoListBSU18410. [Micado]

Phylogenomic databases

GeneTreeEBGT00050000001829.
HOGENOMHBG738311.
OMAILNGYNF.
PhylomeDBP54422.
ProtClustDBCLSK887371.

Enzyme and pathway databases

BioCycBSUB:BSU18410-MONOMER.

Family and domain databases

InterProIPR000101. GGT_peptidase.
[Graphical view]
KOK00681.
PANTHERPTHR11686. GGT_peptidase. 1 hit.
PfamPF01019. G_glu_transpept. 1 hit.
[Graphical view]
PRINTSPR01210. GGTRANSPTASE.
TIGRFAMsTIGR00066. G_glut_trans. 1 hit.
PROSITEPS00462. G_GLU_TRANSPEPTIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGGT_BACSU
AccessionPrimary (citable) accession number: P54422
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 25, 2012
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents