Reviewed, UniProtKB/Swiss-Prot P54415 (CLPP1_SYNE7)

Names and origin

Protein names

Recommended name:
    ATP-dependent Clp protease proteolytic subunit 1
    EC=3.4.21.92
Alternative name(s):
    Endopeptidase Clp 1

Gene names

Name:	clpP1
Ordered Locus Names:	Synpcc7942_1554

Organism

Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2) [Complete proteome] [HAMAP]

Taxonomic identifier

1140 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	197 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity.
Catalytic activity	Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). HAMAP MF_00444
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the peptidase S14 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase Protease Serine protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW serine-type endopeptidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 197	197	ATP-dependent Clp protease proteolytic subunit 1 HAMAP MF_00444		PRO_0000179686
Sites
	Active site	96	1	By similarity
	Active site	121	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P54415-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: FB9B988AE083751D	FASTA	197	21,696
	10 20 30 40 50 60 MIPIVVEESG RGERAFDIYS RLLRERIIFL GEPVTSDVAN RIVAQLLFLE AEDPEKDIYL 70 80 90 100 110 120 YINSPGGSVY DGLGIFDTMN HIRPDVSTVC VGLAASMGAF LLAAGAKGKR TSLAHSRIMI 130 140 150 160 170 180 HQPLGGAQGQ AKDIEIQANE ILYIKQNLNE VLAERTGQPL SRIEDDTDRD FFMSASEAVE 190 YGLIDRVIDR RALKATA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Inactivation of the clpP1 gene for the proteolytic subunit of the ATP-dependent Clp protease in the cyanobacterium Synechococcus limits growth and light acclimation." Clarke A.K., Schelin J., Porankiewicz J. Plant Mol. Biol. 37:791-801(1998) [PubMed: 9678574] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	U16135 Genomic DNA. Translation: AAC67306.1. CP000100 Genomic DNA. Translation: ABB57584.1.
RefSeq	YP_400571.1.
3D structure databases
HSSP	HSSP built from PDB template 1TYF based on UniProtKB P19245.
ModBase	Search...
Protein-protein interaction databases
STRING	P54415.
Protein family/group databases
MEROPS	S14.001.
Genome annotation databases
GeneID	3774978.
GenomeReviews	Gene locus Synpcc7942_1554 in contig CP000100_GR.
KEGG	syf:Synpcc7942_1554.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P54415.
Enzyme and pathway databases
BioCyc	MetaCyc:SYNPCC7942_1554-MON. SELO1140:SYNPCC7942_1554-MON.
BRENDA	3.4.21.92. 2064.
Family and domain databases
HAMAP	MF_00444. [Tree]
InterPro	IPR001907. Pept_S14_ClpP. IPR018215. Pept_S14_ClpP_AS. [Graphical view]
PANTHER	PTHR10381. Pept_S14_ClpP. 1 hit.
Pfam	PF00574. CLP_protease. 1 hit. [Graphical view]
PRINTS	PR00127. CLPPROTEASEP.
TIGRFAMs	TIGR00493. clpP. 1 hit.
PROSITE	PS00382. CLP_PROTEASE_HIS. 1 hit. PS00381. CLP_PROTEASE_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CLPP1_SYNE7

Accession

Primary (citable) accession number: P54415
Secondary accession number(s): Q31MY5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	September 22, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)