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Protein

Probable elongation factor 1-gamma

Gene

eef-1G

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probably plays a role in anchoring the complex to other cellular components.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

ReactomeiR-CEL-156842. Eukaryotic Translation Elongation.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable elongation factor 1-gamma
Short name:
EF-1-gamma
Alternative name(s):
eEF-1B gamma
Gene namesi
Name:eef-1G
ORF Names:F17C11.9
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF17C11.9a; CE05656; WBGene00008920; eef-1G.
F17C11.9b; CE32385; WBGene00008920; eef-1G.
F17C11.9c; CE39492; WBGene00008920; eef-1G.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Probable elongation factor 1-gammaPRO_0000208823Add
BLAST

Proteomic databases

EPDiP54412.
PaxDbiP54412.
PRIDEiP54412.

Interactioni

Subunit structurei

EF-1 is composed of four subunits: alpha, beta, delta, and gamma.

Protein-protein interaction databases

BioGridi44550. 8 interactions.
DIPiDIP-24841N.
IntActiP54412. 5 interactions.
MINTiMINT-1085133.
STRINGi6239.F17C11.9a.

Structurei

3D structure databases

ProteinModelPortaliP54412.
SMRiP54412. Positions 3-180, 239-398.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini66 – 199134GST C-terminalAdd
BLAST
Domaini239 – 398160EF-1-gamma C-terminalPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 EF-1-gamma C-terminal domain.PROSITE-ProRule annotation
Contains 1 GST C-terminal domain.Curated

Phylogenomic databases

eggNOGiKOG0867. Eukaryota.
KOG1627. Eukaryota.
COG0625. LUCA.
GeneTreeiENSGT00390000007552.
HOGENOMiHOG000201196.
InParanoidiP54412.
KOiK03233.
OMAiDGWSLWF.
PhylomeDBiP54412.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.30.70.1010. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
IPR001662. Transl_elong_EF1_G_con.
[Graphical view]
PfamiPF00647. EF1G. 1 hit.
PF00043. GST_C. 1 hit.
[Graphical view]
SMARTiSM01183. EF1G. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF89942. SSF89942. 1 hit.
PROSITEiPS50040. EF1G_C. 1 hit.
PS50405. GST_CTER. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: P54412-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTGKLYGNKD NFRTQKVLIA AKLANKTVTL AGDAAPADKF PLGVTPAFEG
60 70 80 90 100
DALLFGAESI GLHLTGTSAN AETVQWLQFA EGYLLPAVLG YVLPSVSAAN
110 120 130 140 150
FDKKTVEQYK NELNGQLQVL DRVLVKKTYL VGERLSLADV SVALDLLPAF
160 170 180 190 200
QYVLDANARK SIVNVTRWFR TVVNQPAVKE VLGEVSLASS VAQFNQAKFT
210 220 230 240 250
ELSAKVAKSA PKAEKPKKEA KPAAAAAQPE DDEPKEEKSK DPFQDMPKGT
260 270 280 290 300
FVLDNFKRSY SNEDTATKAI PHFWENFDAD NWSIWKCEYK YPEDLTLAFM
310 320 330 340 350
SCNLINGMYQ RLEKLKKNAF ASMILFGTDN NSTISGIWVW KGDKLAFELS
360 370 380 390
PDWQVDYESY TWTKLDAKSD ATKKEVNEYL MWEGDFGGKK FNQGKIFK
Note: No experimental confirmation available.
Length:398
Mass (Da):44,388
Last modified:October 1, 1996 - v1
Checksum:i943174C4CABE96E8
GO
Isoform b (identifier: P54412-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: Missing.
     26-44: KTVTLAGDAAPADKFPLGV → MLLQLTSSHLELYVLIYLD

Note: No experimental confirmation available.
Show »
Length:373
Mass (Da):42,004
Checksum:i48CE8B15CB9EA4D2
GO
Isoform c (identifier: P54412-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-151: Missing.

Note: No experimental confirmation available.
Show »
Length:365
Mass (Da):40,763
Checksum:iB3120755E7A850BC
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2525Missing in isoform b. CuratedVSP_053653Add
BLAST
Alternative sequencei26 – 4419KTVTL…FPLGV → MLLQLTSSHLELYVLIYLD in isoform b. CuratedVSP_053654Add
BLAST
Alternative sequencei119 – 15133Missing in isoform c. CuratedVSP_053655Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72507 Genomic DNA. Translation: CAA96631.1.
Z72507 Genomic DNA. Translation: CAD56569.1.
Z72507 Genomic DNA. Translation: CAJ55245.1.
PIRiT21061.
RefSeqiNP_001041100.1. NM_001047635.4. [P54412-3]
NP_505800.1. NM_073399.5. [P54412-1]
NP_872125.1. NM_182325.6. [P54412-2]
UniGeneiCel.9049.

Genome annotation databases

EnsemblMetazoaiF17C11.9a; F17C11.9a; WBGene00008920. [P54412-1]
GeneIDi179522.
KEGGicel:CELE_F17C11.9.
UCSCiF17C11.9a. c. elegans. [P54412-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72507 Genomic DNA. Translation: CAA96631.1.
Z72507 Genomic DNA. Translation: CAD56569.1.
Z72507 Genomic DNA. Translation: CAJ55245.1.
PIRiT21061.
RefSeqiNP_001041100.1. NM_001047635.4. [P54412-3]
NP_505800.1. NM_073399.5. [P54412-1]
NP_872125.1. NM_182325.6. [P54412-2]
UniGeneiCel.9049.

3D structure databases

ProteinModelPortaliP54412.
SMRiP54412. Positions 3-180, 239-398.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi44550. 8 interactions.
DIPiDIP-24841N.
IntActiP54412. 5 interactions.
MINTiMINT-1085133.
STRINGi6239.F17C11.9a.

Proteomic databases

EPDiP54412.
PaxDbiP54412.
PRIDEiP54412.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF17C11.9a; F17C11.9a; WBGene00008920. [P54412-1]
GeneIDi179522.
KEGGicel:CELE_F17C11.9.
UCSCiF17C11.9a. c. elegans. [P54412-1]

Organism-specific databases

CTDi179522.
WormBaseiF17C11.9a; CE05656; WBGene00008920; eef-1G.
F17C11.9b; CE32385; WBGene00008920; eef-1G.
F17C11.9c; CE39492; WBGene00008920; eef-1G.

Phylogenomic databases

eggNOGiKOG0867. Eukaryota.
KOG1627. Eukaryota.
COG0625. LUCA.
GeneTreeiENSGT00390000007552.
HOGENOMiHOG000201196.
InParanoidiP54412.
KOiK03233.
OMAiDGWSLWF.
PhylomeDBiP54412.

Enzyme and pathway databases

ReactomeiR-CEL-156842. Eukaryotic Translation Elongation.

Miscellaneous databases

NextBioi905768.
PROiP54412.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.30.70.1010. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
IPR001662. Transl_elong_EF1_G_con.
[Graphical view]
PfamiPF00647. EF1G. 1 hit.
PF00043. GST_C. 1 hit.
[Graphical view]
SMARTiSM01183. EF1G. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF89942. SSF89942. 1 hit.
PROSITEiPS50040. EF1G_C. 1 hit.
PS50405. GST_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.

Entry informationi

Entry nameiEF1G_CAEEL
AccessioniPrimary (citable) accession number: P54412
Secondary accession number(s): Q2PJ76, Q8I4K9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 11, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.