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Protein

Probable elongation factor 1-gamma

Gene

eef-1G

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probably plays a role in anchoring the complex to other cellular components.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-CEL-156842. Eukaryotic Translation Elongation.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable elongation factor 1-gamma
Short name:
EF-1-gamma
Alternative name(s):
eEF-1B gamma
Gene namesi
Name:eef-1GImported
ORF Names:F17C11.9Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF17C11.9a; CE05656; WBGene00008920; eef-1G.
F17C11.9b; CE32385; WBGene00008920; eef-1G.
F17C11.9c; CE39492; WBGene00008920; eef-1G.

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown results in 100% sterility at 25 degrees Celsius.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002088231 – 398Probable elongation factor 1-gammaAdd BLAST398

Proteomic databases

EPDiP54412.
PaxDbiP54412.
PeptideAtlasiP54412.
PRIDEiP54412.

Expressioni

Gene expression databases

BgeeiWBGene00008920.

Interactioni

Subunit structurei

EF-1 is composed of four subunits: alpha, beta, delta, and gamma.Curated

Protein-protein interaction databases

BioGridi44550. 8 interactors.
DIPiDIP-24841N.
IntActiP54412. 5 interactors.
MINTiMINT-1085133.
STRINGi6239.F17C11.9a.

Structurei

3D structure databases

ProteinModelPortaliP54412.
SMRiP54412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 199GST C-terminalAdd BLAST134
Domaini239 – 398EF-1-gamma C-terminalPROSITE-ProRule annotationAdd BLAST160

Phylogenomic databases

eggNOGiKOG0867. Eukaryota.
KOG1627. Eukaryota.
COG0625. LUCA.
GeneTreeiENSGT00390000007552.
HOGENOMiHOG000201196.
InParanoidiP54412.
KOiK03233.
OMAiDGWSLWF.
OrthoDBiEOG091G06QR.
PhylomeDBiP54412.

Family and domain databases

Gene3Di3.30.70.1010. 1 hit.
InterProiView protein in InterPro
IPR010987. Glutathione-S-Trfase_C-like.
IPR004046. GST_C.
IPR001662. Transl_elong_EF1_G_con.
PfamiView protein in Pfam
PF00647. EF1G. 1 hit.
PF00043. GST_C. 1 hit.
SMARTiView protein in SMART
SM01183. EF1G. 1 hit.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF89942. SSF89942. 1 hit.
PROSITEiView protein in PROSITE
PS50040. EF1G_C. 1 hit.
PS50405. GST_CTER. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform aImported (identifier: P54412-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTGKLYGNKD NFRTQKVLIA AKLANKTVTL AGDAAPADKF PLGVTPAFEG
60 70 80 90 100
DALLFGAESI GLHLTGTSAN AETVQWLQFA EGYLLPAVLG YVLPSVSAAN
110 120 130 140 150
FDKKTVEQYK NELNGQLQVL DRVLVKKTYL VGERLSLADV SVALDLLPAF
160 170 180 190 200
QYVLDANARK SIVNVTRWFR TVVNQPAVKE VLGEVSLASS VAQFNQAKFT
210 220 230 240 250
ELSAKVAKSA PKAEKPKKEA KPAAAAAQPE DDEPKEEKSK DPFQDMPKGT
260 270 280 290 300
FVLDNFKRSY SNEDTATKAI PHFWENFDAD NWSIWKCEYK YPEDLTLAFM
310 320 330 340 350
SCNLINGMYQ RLEKLKKNAF ASMILFGTDN NSTISGIWVW KGDKLAFELS
360 370 380 390
PDWQVDYESY TWTKLDAKSD ATKKEVNEYL MWEGDFGGKK FNQGKIFK
Note: No experimental confirmation available.
Length:398
Mass (Da):44,388
Last modified:October 1, 1996 - v1
Checksum:i943174C4CABE96E8
GO
Isoform bImported (identifier: P54412-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: Missing.
     26-44: KTVTLAGDAAPADKFPLGV → MLLQLTSSHLELYVLIYLD

Note: No experimental confirmation available.
Show »
Length:373
Mass (Da):42,004
Checksum:i48CE8B15CB9EA4D2
GO
Isoform cImported (identifier: P54412-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-151: Missing.

Note: No experimental confirmation available.
Show »
Length:365
Mass (Da):40,763
Checksum:iB3120755E7A850BC
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0536531 – 25Missing in isoform b. CuratedAdd BLAST25
Alternative sequenceiVSP_05365426 – 44KTVTL…FPLGV → MLLQLTSSHLELYVLIYLD in isoform b. CuratedAdd BLAST19
Alternative sequenceiVSP_053655119 – 151Missing in isoform c. CuratedAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72507 Genomic DNA. Translation: CAA96631.1.
Z72507 Genomic DNA. Translation: CAD56569.1.
Z72507 Genomic DNA. Translation: CAJ55245.1.
PIRiT21061.
RefSeqiNP_001041100.1. NM_001047635.4. [P54412-3]
NP_505800.1. NM_073399.5. [P54412-1]
NP_872125.1. NM_182325.6. [P54412-2]
UniGeneiCel.9049.

Genome annotation databases

EnsemblMetazoaiF17C11.9a; F17C11.9a; WBGene00008920. [P54412-1]
GeneIDi179522.
KEGGicel:CELE_F17C11.9.
UCSCiF17C11.9a. c. elegans.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72507 Genomic DNA. Translation: CAA96631.1.
Z72507 Genomic DNA. Translation: CAD56569.1.
Z72507 Genomic DNA. Translation: CAJ55245.1.
PIRiT21061.
RefSeqiNP_001041100.1. NM_001047635.4. [P54412-3]
NP_505800.1. NM_073399.5. [P54412-1]
NP_872125.1. NM_182325.6. [P54412-2]
UniGeneiCel.9049.

3D structure databases

ProteinModelPortaliP54412.
SMRiP54412.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi44550. 8 interactors.
DIPiDIP-24841N.
IntActiP54412. 5 interactors.
MINTiMINT-1085133.
STRINGi6239.F17C11.9a.

Proteomic databases

EPDiP54412.
PaxDbiP54412.
PeptideAtlasiP54412.
PRIDEiP54412.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF17C11.9a; F17C11.9a; WBGene00008920. [P54412-1]
GeneIDi179522.
KEGGicel:CELE_F17C11.9.
UCSCiF17C11.9a. c. elegans.

Organism-specific databases

CTDi179522.
WormBaseiF17C11.9a; CE05656; WBGene00008920; eef-1G.
F17C11.9b; CE32385; WBGene00008920; eef-1G.
F17C11.9c; CE39492; WBGene00008920; eef-1G.

Phylogenomic databases

eggNOGiKOG0867. Eukaryota.
KOG1627. Eukaryota.
COG0625. LUCA.
GeneTreeiENSGT00390000007552.
HOGENOMiHOG000201196.
InParanoidiP54412.
KOiK03233.
OMAiDGWSLWF.
OrthoDBiEOG091G06QR.
PhylomeDBiP54412.

Enzyme and pathway databases

ReactomeiR-CEL-156842. Eukaryotic Translation Elongation.

Miscellaneous databases

PROiPR:P54412.

Gene expression databases

BgeeiWBGene00008920.

Family and domain databases

Gene3Di3.30.70.1010. 1 hit.
InterProiView protein in InterPro
IPR010987. Glutathione-S-Trfase_C-like.
IPR004046. GST_C.
IPR001662. Transl_elong_EF1_G_con.
PfamiView protein in Pfam
PF00647. EF1G. 1 hit.
PF00043. GST_C. 1 hit.
SMARTiView protein in SMART
SM01183. EF1G. 1 hit.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF89942. SSF89942. 1 hit.
PROSITEiView protein in PROSITE
PS50040. EF1G_C. 1 hit.
PS50405. GST_CTER. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEF1G_CAEEL
AccessioniPrimary (citable) accession number: P54412
Secondary accession number(s): Q2PJ76, Q8I4K9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 10, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.