P54407 (SODC_DROBS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Superoxide dismutase [Cu-Zn]
EC=1.15.1.1

Gene names

Name:

Sod

Organism

Drosophila busckii (Fruit fly)

Taxonomic identifier

30019 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila

Protein attributes

Sequence length	145 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Catalytic activity	2 superoxide + 2 H+ = O2 + H2O2.
Cofactor	Binds 1 copper ion per subunit By similarity. Binds 1 zinc ion per subunit By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the Cu-Zn superoxide dismutase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Copper Metal-binding Zinc
Molecular function	Antioxidant Oxidoreductase
PTM	Disulfide bond
Gene Ontology (GO)
Biological process	superoxide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW superoxide dismutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 145	›145	Superoxide dismutase [Cu-Zn]		PRO_0000164083
Sites
	Metal binding	37	1	Copper; catalytic By similarity
	Metal binding	39	1	Copper; catalytic By similarity
	Metal binding	54	1	Copper; catalytic By similarity
	Metal binding	54	1	Zinc; structural By similarity
	Metal binding	62	1	Zinc; structural By similarity
	Metal binding	71	1	Zinc; structural By similarity
	Metal binding	74	1	Zinc; structural By similarity
	Metal binding	111	1	Copper; catalytic By similarity
Amino acid modifications
	Disulfide bond	48 ↔ 137		By similarity
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P54407 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 43634D66AA716C04	FASTA	145	14,904
	10 20 30 40 50 60 INGDAKGTVF FEQESEKCPV KVTGEVTGLA KGLHGFHVHE FGDNTNGCMS SGPHFNPQGK 70 80 90 100 110 120 EHGAPTDENR HLGDLGNITA TGDGPTAVDI CDCKITLFGA NSIIGRTVVV HADPDDLGKG 130 140 GHELSKTTGN AGARIGCGVI GIAKI

References

[1]	"Phylogeny of Drosophila and related genera inferred from the nucleotide sequence of the Cu,Zn Sod gene." Kwiatowski J., Skarecky D., Bailey K., Ayala F.J. J. Mol. Evol. 38:443-454(1994) [PubMed: 7545938] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U39445 Genomic DNA. Translation: AAA82059.1.
3D structure databases
ProteinModelPortal	P54407.
SMR	P54407. Positions 7-142.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
FlyBase	FBgn0015074. Dbus\Sod.
Family and domain databases
InterPro	IPR024134. SOD_Cu/Zn_/chaperones. IPR018152. SOD_Cu/Zn_BS. IPR001424. SOD_Cu_Zn_dom. [Graphical view]
Gene3D	G3DSA:2.60.40.200. SOD_Cu_Zn. 1 hit.
PANTHER	PTHR10003. SOD_Cu_Zn. 1 hit.
Pfam	PF00080. Sod_Cu. 1 hit. [Graphical view]
PRINTS	PR00068. CUZNDISMTASE.
SUPFAM	SSF49329. SOD_Cu_Zn. 1 hit.
PROSITE	PS00087. SOD_CU_ZN_1. 1 hit. PS00332. SOD_CU_ZN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SODC_DROBS

Accession

Primary (citable) accession number: P54407

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	July 27, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project