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Protein

Guanine nucleotide-binding protein subunit gamma

Gene

gpc-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  • GTPase activity Source: WormBase
  • signal transducer activity Source: WormBase

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: WormBase
  • sensory perception of taste Source: WormBase

Keywordsi

Molecular functionTransducer

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit gamma
Gene namesi
Name:gpc-1
ORF Names:K02A4.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiK02A4.2 ; CE03458 ; WBGene00001681 ; gpc-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000126751 – 59Guanine nucleotide-binding protein subunit gammaAdd BLAST59
PropeptideiPRO_000001267660 – 62Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei59Cysteine methyl esterBy similarity1
Lipidationi59S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP54406

Expressioni

Tissue specificityi

Predominantly expressed in the central nervous system.

Gene expression databases

BgeeiWBGene00001681

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma (By similarity). Interacts with gpb-1 and gpb-2 (PubMed:11333232).By similarity1 Publication

Protein-protein interaction databases

BioGridi46328, 1 interactor
DIPiDIP-27168N
IntActiP54406, 1 interactor
STRINGi6239.K02A4.2.2

Structurei

3D structure databases

ProteinModelPortaliP54406
SMRiP54406
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
HOGENOMiHOG000231034
InParanoidiP54406
OMAiSELMNYC
OrthoDBiEOG091G17J0
PhylomeDBiP54406

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54406-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENIKASTEQ LCAEANIQRK KVSEVSKELL DFCEKNKTND MLVSGPTDQH
60
NPFQEKKSCS VL
Length:62
Mass (Da):7,014
Last modified:October 1, 1996 - v1
Checksum:iA85D06EAD34D52C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF291848 mRNA Translation: AAK55965.1
Z67883 Genomic DNA Translation: CAA91806.1
PIRiT23216
RefSeqiNP_510145.1, NM_077744.4
UniGeneiCel.20513

Genome annotation databases

EnsemblMetazoaiK02A4.2.1; K02A4.2.1; WBGene00001681
K02A4.2.2; K02A4.2.2; WBGene00001681
K02A4.2.3; K02A4.2.3; WBGene00001681
GeneIDi181424
KEGGicel:CELE_K02A4.2
UCSCiK02A4.2.2 c. elegans

Similar proteinsi

Entry informationi

Entry nameiGBG_CAEEL
AccessioniPrimary (citable) accession number: P54406
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health