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Protein

Guanine nucleotide-binding protein subunit gamma

Gene

gpc-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  • GTPase activity Source: WormBase
  • signal transducer activity Source: WormBase

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: WormBase
  • sensory perception of taste Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit gamma
Gene namesi
Name:gpc-1
ORF Names:K02A4.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiK02A4.2; CE03458; WBGene00001681; gpc-1.

Subcellular locationi

GO - Cellular componenti

  • heterotrimeric G-protein complex Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5959Guanine nucleotide-binding protein subunit gammaPRO_0000012675Add
BLAST
Propeptidei60 – 623Removed in mature formBy similarityPRO_0000012676

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei59 – 591Cysteine methyl esterBy similarity
Lipidationi59 – 591S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiP54406.
PaxDbiP54406.

Expressioni

Tissue specificityi

Predominantly expressed in the central nervous system.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma (By similarity). Interacts with gpb-1 and gpb-2 (PubMed:11333232).By similarity1 Publication

Protein-protein interaction databases

BioGridi46328. 1 interaction.
DIPiDIP-27168N.
MINTiMINT-1072091.
STRINGi6239.K02A4.2.2.

Structurei

3D structure databases

ProteinModelPortaliP54406.
SMRiP54406. Positions 1-56.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
HOGENOMiHOG000231034.
InParanoidiP54406.
OMAiQHNPFQE.
OrthoDBiEOG7H1JP7.
PhylomeDBiP54406.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54406-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENIKASTEQ LCAEANIQRK KVSEVSKELL DFCEKNKTND MLVSGPTDQH
60
NPFQEKKSCS VL
Length:62
Mass (Da):7,014
Last modified:October 1, 1996 - v1
Checksum:iA85D06EAD34D52C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF291848 mRNA. Translation: AAK55965.1.
Z67883 Genomic DNA. Translation: CAA91806.1.
PIRiT23216.
RefSeqiNP_510145.1. NM_077744.4.
UniGeneiCel.20513.

Genome annotation databases

EnsemblMetazoaiK02A4.2.1; K02A4.2.1; WBGene00001681.
K02A4.2.2; K02A4.2.2; WBGene00001681.
GeneIDi181424.
KEGGicel:CELE_K02A4.2.
UCSCiK02A4.2.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF291848 mRNA. Translation: AAK55965.1.
Z67883 Genomic DNA. Translation: CAA91806.1.
PIRiT23216.
RefSeqiNP_510145.1. NM_077744.4.
UniGeneiCel.20513.

3D structure databases

ProteinModelPortaliP54406.
SMRiP54406. Positions 1-56.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi46328. 1 interaction.
DIPiDIP-27168N.
MINTiMINT-1072091.
STRINGi6239.K02A4.2.2.

Proteomic databases

EPDiP54406.
PaxDbiP54406.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK02A4.2.1; K02A4.2.1; WBGene00001681.
K02A4.2.2; K02A4.2.2; WBGene00001681.
GeneIDi181424.
KEGGicel:CELE_K02A4.2.
UCSCiK02A4.2.2. c. elegans.

Organism-specific databases

CTDi181424.
WormBaseiK02A4.2; CE03458; WBGene00001681; gpc-1.

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
HOGENOMiHOG000231034.
InParanoidiP54406.
OMAiQHNPFQE.
OrthoDBiEOG7H1JP7.
PhylomeDBiP54406.

Miscellaneous databases

PROiP54406.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The G protein beta subunit gpb-2 in Caenorhabditis elegans regulates the G(o)alpha-G(q)alpha signaling network through interactions with the regulator of G protein signaling proteins egl-10 and eat-16."
    van Der Linden A.M., Simmer F., Cuppen E., Plasterk R.H.A.
    Genetics 158:221-235(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH GPB-1 AND GPB-2.
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGBG_CAEEL
AccessioniPrimary (citable) accession number: P54406
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 8, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.