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P54388

- DHE4_LACBS

UniProt

P54388 - DHE4_LACBS

Protein

NADP-specific glutamate dehydrogenase

Gene

GDHA

Organism
Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686) (Bicoloured deceiver) (Laccaria laccata var. bicolor)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 2 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei111 – 1111PROSITE-ProRule annotation

    GO - Molecular functioni

    1. glutamate dehydrogenase (NADP+) activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular amino acid metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADP-specific glutamate dehydrogenase (EC:1.4.1.4)
    Short name:
    NADP-GDH
    Alternative name(s):
    NADP-dependent glutamate dehydrogenase
    Gene namesi
    Name:GDHA
    ORF Names:LACBIDRAFT_292653
    OrganismiLaccaria bicolor (strain S238N-H82 / ATCC MYA-4686) (Bicoloured deceiver) (Laccaria laccata var. bicolor)
    Taxonomic identifieri486041 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesTricholomataceaeLaccaria
    ProteomesiUP000001194: Unassembled WGS sequence

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 450450NADP-specific glutamate dehydrogenasePRO_0000182789Add
    BLAST

    Proteomic databases

    PRIDEiP54388.

    Interactioni

    Subunit structurei

    Homohexamer.By similarity

    Protein-protein interaction databases

    STRINGi29883.JGI292653.

    Structurei

    3D structure databases

    ProteinModelPortaliP54388.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0334.
    KOiK00262.
    OrthoDBiEOG7XSTPW.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR006095. Glu/Leu/Phe/Val_DH.
    IPR006096. Glu/Leu/Phe/Val_DH_C.
    IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
    IPR014362. Glu_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00208. ELFV_dehydrog. 1 hit.
    PF02812. ELFV_dehydrog_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000185. Glu_DH. 1 hit.
    PRINTSiPR00082. GLFDHDRGNASE.
    SMARTiSM00839. ELFV_dehydrog. 1 hit.
    [Graphical view]
    PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P54388-1 [UniParc]FASTAAdd to Basket

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    MVLPVEPEYE QALSELQNSL KPFLAANPDY EKALEIVQIP ERVLQFRVVW    50
    EDDQGKAQVN RGFRVQYNSA LGPYKGGLRL HPSVNLSILK FLGFEQTFKN 100
    ALTGLSMGGG KGGSDFDPKG KSDGEIRRFC TSFMSELFRH IGQDTDVPAG 150
    DIGTGAREIG YLFGAYKKLQ NEFVGMLTGK GLAWGGSFIR PEATGYGLIY 200
    YVEHMIAKAA PEYSLSKPET LVAISGSGNV AQFTALKVIE LGATVLSLSD 250
    SKGSLIAEKG YTKEFIKEIG QLKLKGGALE SLAQREGYTY HAGKRPWSLL 300
    PVVHVALPGA TQNEVSKTEA EDLIKAGVRI VAEGSNMGCT EDAIAVFEAS 350
    RKAGAGGVWY APGKASNCGG VAVSGLEMAQ NSQRLAWTTD QVDQKLKKIM 400
    AECYEICLSA GTKWSGEEIK DGVLPSLLSG ANVAGFIKVA DAMREHGDWW 450
    Length:450
    Mass (Da):48,550
    Last modified:May 20, 2008 - v2
    Checksum:i8FDA699CA3D46945
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti17 – 171Q → P in AAA82936. 1 PublicationCurated
    Sequence conflicti31 – 311E → G in AAA82936. 1 PublicationCurated
    Sequence conflicti38 – 381Q → P in AAA82936. 1 PublicationCurated
    Sequence conflicti49 – 491V → I in AAA82936. 1 PublicationCurated
    Sequence conflicti231 – 2311A → G in AAA82936. 1 PublicationCurated
    Sequence conflicti349 – 3491A → E in AAA82936. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U31369 mRNA. Translation: AAA82936.1.
    DS547094 Genomic DNA. Translation: EDR12114.1.
    RefSeqiXP_001876378.1. XM_001876343.1.

    Genome annotation databases

    GeneIDi6072874.
    KEGGilbc:LACBIDRAFT_292653.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U31369 mRNA. Translation: AAA82936.1 .
    DS547094 Genomic DNA. Translation: EDR12114.1 .
    RefSeqi XP_001876378.1. XM_001876343.1.

    3D structure databases

    ProteinModelPortali P54388.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 29883.JGI292653.

    Proteomic databases

    PRIDEi P54388.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 6072874.
    KEGGi lbc:LACBIDRAFT_292653.

    Phylogenomic databases

    eggNOGi COG0334.
    KOi K00262.
    OrthoDBi EOG7XSTPW.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR006095. Glu/Leu/Phe/Val_DH.
    IPR006096. Glu/Leu/Phe/Val_DH_C.
    IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
    IPR014362. Glu_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00208. ELFV_dehydrog. 1 hit.
    PF02812. ELFV_dehydrog_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000185. Glu_DH. 1 hit.
    PRINTSi PR00082. GLFDHDRGNASE.
    SMARTi SM00839. ELFV_dehydrog. 1 hit.
    [Graphical view ]
    PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, sequence analysis and expression of a cDNA encoding NADP-glutamate dehydrogenase from the ectomycorrhizal basidiomycete Laccaria bicolor."
      Lorillou S.S., Martin F.F.
      Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The genome of Laccaria bicolor provides insights into mycorrhizal symbiosis."
      Martin F., Aerts A., Ahren D., Brun A., Danchin E.G.J., Duchaussoy F., Gibon J., Kohler A., Lindquist E., Pereda V., Salamov A., Shapiro H.J., Wuyts J., Blaudez D., Buee M., Brokstein P., Canbaeck B., Cohen D.
      , Courty P.E., Coutinho P.M., Delaruelle C., Detter J.C., Deveau A., DiFazio S., Duplessis S., Fraissinet-Tachet L., Lucic E., Frey-Klett P., Fourrey C., Feussner I., Gay G., Grimwood J., Hoegger P.J., Jain P., Kilaru S., Labbe J., Lin Y.C., Legue V., Le Tacon F., Marmeisse R., Melayah D., Montanini B., Muratet M., Nehls U., Niculita-Hirzel H., Oudot-Le Secq M.P., Peter M., Quesneville H., Rajashekar B., Reich M., Rouhier N., Schmutz J., Yin T., Chalot M., Henrissat B., Kuees U., Lucas S., Van de Peer Y., Podila G.K., Polle A., Pukkila P.J., Richardson P.M., Rouze P., Sanders I.R., Stajich J.E., Tunlid A., Tuskan G., Grigoriev I.V.
      Nature 452:88-92(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: S238N-H82 / ATCC MYA-4686.

    Entry informationi

    Entry nameiDHE4_LACBS
    AccessioniPrimary (citable) accession number: P54388
    Secondary accession number(s): B0CZ97
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 70 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3