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P54388

- DHE4_LACBS

UniProt

P54388 - DHE4_LACBS

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Protein

NADP-specific glutamate dehydrogenase

Gene
GDHA, LACBIDRAFT_292653
Organism
Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686) (Bicoloured deceiver) (Laccaria laccata var. bicolor)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei111 – 1111 By similarity

GO - Molecular functioni

  1. glutamate dehydrogenase (NADP+) activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular amino acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
NADP-specific glutamate dehydrogenase (EC:1.4.1.4)
Short name:
NADP-GDH
Alternative name(s):
NADP-dependent glutamate dehydrogenase
Gene namesi
Name:GDHA
ORF Names:LACBIDRAFT_292653
OrganismiLaccaria bicolor (strain S238N-H82 / ATCC MYA-4686) (Bicoloured deceiver) (Laccaria laccata var. bicolor)
Taxonomic identifieri486041 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesTricholomataceaeLaccaria
ProteomesiUP000001194: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450NADP-specific glutamate dehydrogenasePRO_0000182789Add
BLAST

Proteomic databases

PRIDEiP54388.

Interactioni

Subunit structurei

Homohexamer By similarity.

Protein-protein interaction databases

STRINGi29883.JGI292653.

Structurei

3D structure databases

ProteinModelPortaliP54388.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0334.
KOiK00262.
OrthoDBiEOG7XSTPW.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54388-1 [UniParc]FASTAAdd to Basket

« Hide

MVLPVEPEYE QALSELQNSL KPFLAANPDY EKALEIVQIP ERVLQFRVVW    50
EDDQGKAQVN RGFRVQYNSA LGPYKGGLRL HPSVNLSILK FLGFEQTFKN 100
ALTGLSMGGG KGGSDFDPKG KSDGEIRRFC TSFMSELFRH IGQDTDVPAG 150
DIGTGAREIG YLFGAYKKLQ NEFVGMLTGK GLAWGGSFIR PEATGYGLIY 200
YVEHMIAKAA PEYSLSKPET LVAISGSGNV AQFTALKVIE LGATVLSLSD 250
SKGSLIAEKG YTKEFIKEIG QLKLKGGALE SLAQREGYTY HAGKRPWSLL 300
PVVHVALPGA TQNEVSKTEA EDLIKAGVRI VAEGSNMGCT EDAIAVFEAS 350
RKAGAGGVWY APGKASNCGG VAVSGLEMAQ NSQRLAWTTD QVDQKLKKIM 400
AECYEICLSA GTKWSGEEIK DGVLPSLLSG ANVAGFIKVA DAMREHGDWW 450
Length:450
Mass (Da):48,550
Last modified:May 20, 2008 - v2
Checksum:i8FDA699CA3D46945
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171Q → P in AAA82936. 1 Publication
Sequence conflicti31 – 311E → G in AAA82936. 1 Publication
Sequence conflicti38 – 381Q → P in AAA82936. 1 Publication
Sequence conflicti49 – 491V → I in AAA82936. 1 Publication
Sequence conflicti231 – 2311A → G in AAA82936. 1 Publication
Sequence conflicti349 – 3491A → E in AAA82936. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U31369 mRNA. Translation: AAA82936.1.
DS547094 Genomic DNA. Translation: EDR12114.1.
RefSeqiXP_001876378.1. XM_001876343.1.

Genome annotation databases

GeneIDi6072874.
KEGGilbc:LACBIDRAFT_292653.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U31369 mRNA. Translation: AAA82936.1 .
DS547094 Genomic DNA. Translation: EDR12114.1 .
RefSeqi XP_001876378.1. XM_001876343.1.

3D structure databases

ProteinModelPortali P54388.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 29883.JGI292653.

Proteomic databases

PRIDEi P54388.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6072874.
KEGGi lbc:LACBIDRAFT_292653.

Phylogenomic databases

eggNOGi COG0334.
KOi K00262.
OrthoDBi EOG7XSTPW.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000185. Glu_DH. 1 hit.
PRINTSi PR00082. GLFDHDRGNASE.
SMARTi SM00839. ELFV_dehydrog. 1 hit.
[Graphical view ]
PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, sequence analysis and expression of a cDNA encoding NADP-glutamate dehydrogenase from the ectomycorrhizal basidiomycete Laccaria bicolor."
    Lorillou S.S., Martin F.F.
    Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The genome of Laccaria bicolor provides insights into mycorrhizal symbiosis."
    Martin F., Aerts A., Ahren D., Brun A., Danchin E.G.J., Duchaussoy F., Gibon J., Kohler A., Lindquist E., Pereda V., Salamov A., Shapiro H.J., Wuyts J., Blaudez D., Buee M., Brokstein P., Canbaeck B., Cohen D.
    , Courty P.E., Coutinho P.M., Delaruelle C., Detter J.C., Deveau A., DiFazio S., Duplessis S., Fraissinet-Tachet L., Lucic E., Frey-Klett P., Fourrey C., Feussner I., Gay G., Grimwood J., Hoegger P.J., Jain P., Kilaru S., Labbe J., Lin Y.C., Legue V., Le Tacon F., Marmeisse R., Melayah D., Montanini B., Muratet M., Nehls U., Niculita-Hirzel H., Oudot-Le Secq M.P., Peter M., Quesneville H., Rajashekar B., Reich M., Rouhier N., Schmutz J., Yin T., Chalot M., Henrissat B., Kuees U., Lucas S., Van de Peer Y., Podila G.K., Polle A., Pukkila P.J., Richardson P.M., Rouze P., Sanders I.R., Stajich J.E., Tunlid A., Tuskan G., Grigoriev I.V.
    Nature 452:88-92(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S238N-H82 / ATCC MYA-4686.

Entry informationi

Entry nameiDHE4_LACBS
AccessioniPrimary (citable) accession number: P54388
Secondary accession number(s): B0CZ97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 20, 2008
Last modified: November 13, 2013
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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