Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P54388 (DHE4_LACBS) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADP-specific glutamate dehydrogenase

Short name=NADP-GDH
EC=1.4.1.4
Alternative name(s):
NADP-dependent glutamate dehydrogenase
Gene names
Name:GDHA
ORF Names:LACBIDRAFT_292653
OrganismLaccaria bicolor (strain S238N-H82 / ATCC MYA-4686) (Bicoloured deceiver) (Laccaria laccata var. bicolor) [Complete proteome]
Taxonomic identifier486041 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesTricholomataceaeLaccaria

Protein attributes

Sequence length450 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Subunit structure

Homohexamer By similarity.

Sequence similarities

Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Ontologies

Keywords
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcellular amino acid metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionglutamate dehydrogenase (NADP+) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 450450NADP-specific glutamate dehydrogenase
PRO_0000182789

Sites

Active site1111 By similarity

Experimental info

Sequence conflict171Q → P in AAA82936. Ref.1
Sequence conflict311E → G in AAA82936. Ref.1
Sequence conflict381Q → P in AAA82936. Ref.1
Sequence conflict491V → I in AAA82936. Ref.1
Sequence conflict2311A → G in AAA82936. Ref.1
Sequence conflict3491A → E in AAA82936. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P54388 [UniParc].

Last modified May 20, 2008. Version 2.
Checksum: 8FDA699CA3D46945

FASTA45048,550
        10         20         30         40         50         60 
MVLPVEPEYE QALSELQNSL KPFLAANPDY EKALEIVQIP ERVLQFRVVW EDDQGKAQVN 

        70         80         90        100        110        120 
RGFRVQYNSA LGPYKGGLRL HPSVNLSILK FLGFEQTFKN ALTGLSMGGG KGGSDFDPKG 

       130        140        150        160        170        180 
KSDGEIRRFC TSFMSELFRH IGQDTDVPAG DIGTGAREIG YLFGAYKKLQ NEFVGMLTGK 

       190        200        210        220        230        240 
GLAWGGSFIR PEATGYGLIY YVEHMIAKAA PEYSLSKPET LVAISGSGNV AQFTALKVIE 

       250        260        270        280        290        300 
LGATVLSLSD SKGSLIAEKG YTKEFIKEIG QLKLKGGALE SLAQREGYTY HAGKRPWSLL 

       310        320        330        340        350        360 
PVVHVALPGA TQNEVSKTEA EDLIKAGVRI VAEGSNMGCT EDAIAVFEAS RKAGAGGVWY 

       370        380        390        400        410        420 
APGKASNCGG VAVSGLEMAQ NSQRLAWTTD QVDQKLKKIM AECYEICLSA GTKWSGEEIK 

       430        440        450 
DGVLPSLLSG ANVAGFIKVA DAMREHGDWW 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U31369 mRNA. Translation: AAA82936.1.
DS547094 Genomic DNA. Translation: EDR12114.1.
RefSeqXP_001876378.1. XM_001876343.1.

3D structure databases

ProteinModelPortalP54388.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING29883.JGI292653.

Proteomic databases

PRIDEP54388.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6072874.
KEGGlbc:LACBIDRAFT_292653.

Phylogenomic databases

eggNOGCOG0334.
KOK00262.
OrthoDBEOG7XSTPW.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFPIRSF000185. Glu_DH. 1 hit.
PRINTSPR00082. GLFDHDRGNASE.
SMARTSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHE4_LACBS
AccessionPrimary (citable) accession number: P54388
Secondary accession number(s): B0CZ97
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 20, 2008
Last modified: November 13, 2013
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families