Reviewed,
UniProtKB/Swiss-Prot P54388 (DHE4_LACBS)
Last modified
September 22, 2009.
Version 47.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: NADP-specific glutamate dehydrogenase Short name=NADP-GDH EC=1.4.1.4 Alternative name(s): NADP-dependent glutamate dehydrogenase | ||||
| Gene names |
| ||||
| Organism | Laccaria bicolor (strain S238N-H82) (Bicoloured deceiver) (Laccaria laccata var. bicolor) | ||||
| Taxonomic identifier | 486041 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Homobasidiomycetes › Agaricomycetidae › Agaricales › Tricholomataceae › Laccaria |
Protein attributes
| Sequence length | 450 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH. |
| Subunit structure | Homohexamer By similarity. |
| Sequence similarities | Belongs to the Glu/Leu/Phe/Val dehydrogenases family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Gene Ontology (GO) | |
| Biological process | cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | binding Inferred from electronic annotation. Source: InterPro glutamate dehydrogenase (NADP+) activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 450 | 450 | NADP-specific glutamate dehydrogenase | PRO_0000182789 | |||||
Sites | |||||||||
| Active site | 111 | 1 | By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 17 | 1 | Q → P in AAA82936. Ref.1 | ||||||
| Sequence conflict | 31 | 1 | E → G in AAA82936. Ref.1 | ||||||
| Sequence conflict | 38 | 1 | Q → P in AAA82936. Ref.1 | ||||||
| Sequence conflict | 49 | 1 | V → I in AAA82936. Ref.1 | ||||||
| Sequence conflict | 231 | 1 | A → G in AAA82936. Ref.1 | ||||||
| Sequence conflict | 349 | 1 | A → E in AAA82936. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning, sequence analysis and expression of a cDNA encoding NADP-glutamate dehydrogenase from the ectomycorrhizal basidiomycete Laccaria bicolor." Lorillou S.S., Martin F.F. Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The genome of Laccaria bicolor provides insights into mycorrhizal symbiosis." Martin F., Aerts A., Ahren D., Brun A., Danchin E.G.J., Duchaussoy F., Gibon J., Kohler A., Lindquist E., Pereda V., Salamov A., Shapiro H.J., Wuyts J., Blaudez D., Buee M., Brokstein P., Canbaeck B., Cohen D. Grigoriev I.V.Nature 452:88-92(2008) [PubMed: 18322534] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| U31369 mRNA. Translation: AAA82936.1. DS547094 Genomic DNA. Translation: EDR12114.1. | |
| RefSeq | XP_001876378.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1AUP based on UniProtKB P24295. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 6072874. |
| KEGG | lbc:LACBIDRAFT_292653. |
Enzyme and pathway databases | |
| BRENDA | 1.4.1.4. 256691. |
Family and domain databases | |
| InterPro | IPR006095. Glu/Leu/Phe/Val_DH. IPR006096. Glu/Leu/Phe/Val_DH_C. IPR006097. Glu/Leu/Phe/Val_DH_dimer. IPR014362. Glu_DH. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| PANTHER | PTHR11606:SF2. GLFV_DH. 1 hit. |
| Pfam | PF00208. ELFV_dehydrog. 1 hit. PF02812. ELFV_dehydrog_N. 1 hit. [Graphical view] |
| PIRSF | PIRSF000185. Glu_DH. 1 hit. |
| PRINTS | PR00082. GLFDHDRGNASE. |
| PROSITE | PS00074. GLFV_DEHYDROGENASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DHE4_LACBS | ||||||||
| Accession | Primary (citable) accession number: P54388 Secondary accession number(s): B0CZ97 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||

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