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P54387

- DHE4_AGABI

UniProt

P54387 - DHE4_AGABI

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Protein
NADP-specific glutamate dehydrogenase
Gene
gdhA
Organism
Agaricus bisporus (White button mushroom)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei111 – 1111 By similarity

GO - Molecular functioni

  1. glutamate dehydrogenase (NADP+) activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular amino acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
NADP-specific glutamate dehydrogenase (EC:1.4.1.4)
Short name:
NADP-GDH
Alternative name(s):
NADP-dependent glutamate dehydrogenase
Gene namesi
Name:gdhA
OrganismiAgaricus bisporus (White button mushroom)
Taxonomic identifieri5341 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesAgaricaceaeAgaricus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457NADP-specific glutamate dehydrogenase
PRO_0000182783Add
BLAST

Proteomic databases

PRIDEiP54387.

Interactioni

Subunit structurei

Homohexamer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP54387.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54387-1 [UniParc]FASTAAdd to Basket

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MVLPHEPEFE QALHELETSL QPFLTTNPQY KKALEIIQVP ERVLQFRVTW    50
EDDQGKPQVN RGFRVQYNSA LGPYKGGLRL HPTVNLSILK FLGFEQTFKN 100
ALTGLSMGGG KGGSDFDPKG KSDNEIRRFC VAFMSELFRH IGQDTDVPAG 150
DIGTGAREIG FLFGAYRRLK NEFTGMLTGK GINWGGSFIR PEATGYGLIY 200
YVEHMIAHAC PEYSLDRPST LVAISGSGNV SQFTALKVIE LGATVLSLSD 250
SKGSLISEKG YTKEAIEKIA ELKLKGGALE AIVDDLGAGY TYHAGKRPWT 300
LLPQVHIALP GATQNEVSQE EAEALVKAGT RIVAEGSNMG CTEEAIAIFE 350
NSRRASRAGV WYAPGKASNC GGVAVSGLEM AQNSQRLAWS TQEVDAKLKS 400
IMAECYQICY TAGSRWSGEK VAEGVAEGEA LPSLLSGANL AGFIKVADAM 450
KEQGDWW 457
Length:457
Mass (Da):49,557
Last modified:October 1, 1996 - v1
Checksum:i1BF0E97F67078AC4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X83393 Genomic DNA. Translation: CAA58312.1.
PIRiS63608.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X83393 Genomic DNA. Translation: CAA58312.1 .
PIRi S63608.

3D structure databases

ProteinModelPortali P54387.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P54387.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000185. Glu_DH. 1 hit.
PRINTSi PR00082. GLFDHDRGNASE.
SMARTi SM00839. ELFV_dehydrog. 1 hit.
[Graphical view ]
PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence and expression of the gene encoding NADP+-dependent glutamate dehydrogenase (gdhA) from Agaricus bisporus."
    Schaap P.J., Mueller Y., Baars J.J.P., Op den Camp H.J.M., Sonnenberg A.S.M., van Griensven L.J.L.D., Visser J.
    Mol. Gen. Genet. 250:339-347(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Horst H39.

Entry informationi

Entry nameiDHE4_AGABI
AccessioniPrimary (citable) accession number: P54387
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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