SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P54386

- DHE4_SYNY3

UniProt

P54386 - DHE4_SYNY3

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
NADP-specific glutamate dehydrogenase
Gene
gdhA, slr0710
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia By similarity.

Catalytic activityi

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei68 – 681Substrate By similarity
Binding sitei92 – 921Substrate By similarity
Active sitei104 – 1041Proton donor By similarity
Sitei144 – 1441Important for catalysis By similarity
Binding sitei188 – 1881NADP By similarity
Binding sitei219 – 2191NADP By similarity
Binding sitei356 – 3561Substrate By similarity

GO - Molecular functioni

  1. glutamate dehydrogenase (NADP+) activity Source: UniProtKB

GO - Biological processi

  1. glutamate biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
NADP-specific glutamate dehydrogenase (EC:1.4.1.4)
Short name:
NADP-GDH
Gene namesi
Name:gdhA
Ordered Locus Names:slr0710
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428NADP-specific glutamate dehydrogenase
PRO_0000182777Add
BLAST

Proteomic databases

PaxDbiP54386.

Interactioni

Subunit structurei

Homohexamer By similarity.

Protein-protein interaction databases

STRINGi1148.slr0710.

Structurei

3D structure databases

ProteinModelPortaliP54386.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0334.
HOGENOMiHOG000243801.
KOiK00262.
OMAiHGRESAT.
OrthoDBiEOG65XN4D.
PhylomeDBiP54386.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54386-1 [UniParc]FASTAAdd to Basket

« Hide

MAGSLFADAS KRLEKALKYV AISDDAGERL KYPKTSLSVS IPVRMDDGSL    50
KIFPGYRVRY DDTRGPGKGG VRYHPNVTMD EVQSLAFWMT FKCALLNLPF 100
GGAKGGITLN PKELSRAELE RLSRGYIEAI ADFIGPDIDI LAPDVYTNEM 150
MMGWMMDQYS IIRRKISPAV VTGKPVTMGG SQGRNTATGT GAFYIMQGML 200
PKFDQYPENT TVAVQGFGNA GMVVAECLYQ DGYKVVAISD SQGGIYNEQG 250
IDIPAVIDYK QRHRTLAGMY CDQAICDLGE NQQISNAELL ALDVDVLIPA 300
ALENQITRDN ADQVRARYIF EVANGPTTTA ADDILASKGI YVFPDILVNA 350
GGVTVSYFEW VQNRSGLYWS AKEVNDRLKE KMVEEAEHVW NITQELDVNV 400
RTAAYIHALN RLSEAMDAKG TRDYYQDS 428
Length:428
Mass (Da):47,313
Last modified:October 1, 1996 - v1
Checksum:iF966273E8D5AD04E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X77454 Genomic DNA. Translation: CAA54601.1.
BA000022 Genomic DNA. Translation: BAA10756.1.
PIRiS77064.
RefSeqiNP_442685.1. NC_000911.1.
YP_005652746.1. NC_017277.1.
YP_007452561.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA10756; BAA10756; BAA10756.
GeneIDi952177.
KEGGisyn:slr0710.
syy:SYNGTS_2793.
syz:MYO_128190.
PATRICi23843116. VBISynSp132158_3096.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X77454 Genomic DNA. Translation: CAA54601.1 .
BA000022 Genomic DNA. Translation: BAA10756.1 .
PIRi S77064.
RefSeqi NP_442685.1. NC_000911.1.
YP_005652746.1. NC_017277.1.
YP_007452561.1. NC_020286.1.

3D structure databases

ProteinModelPortali P54386.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 1148.slr0710.

Proteomic databases

PaxDbi P54386.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA10756 ; BAA10756 ; BAA10756 .
GeneIDi 952177.
KEGGi syn:slr0710.
syy:SYNGTS_2793.
syz:MYO_128190.
PATRICi 23843116. VBISynSp132158_3096.

Phylogenomic databases

eggNOGi COG0334.
HOGENOMi HOG000243801.
KOi K00262.
OMAi HGRESAT.
OrthoDBi EOG65XN4D.
PhylomeDBi P54386.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000185. Glu_DH. 1 hit.
PRINTSi PR00082. GLFDHDRGNASE.
SMARTi SM00839. ELFV_dehydrog. 1 hit.
[Graphical view ]
PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The NADP-glutamate dehydrogenase of the cyanobacterium Synechocystis 6803: cloning, transcriptional analysis and disruption of the gdhA gene."
    Chavez S., Reyes J.C., Chauvat F., Florencio F.J., Candau P.
    Plant Mol. Biol. 28:173-188(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome."
    Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S.
    DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27184 / PCC 6803 / N-1.
  3. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiDHE4_SYNY3
AccessioniPrimary (citable) accession number: P54386
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

Similar proteinsi