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Protein

Aminomethyltransferase

Gene

gcvT

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The glycine cleavage system catalyzes the degradation of glycine.UniRule annotation

Catalytic activityi

[Protein]-S8-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Enzyme and pathway databases

BioCyciBSUB:BSU24570-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
AminomethyltransferaseUniRule annotation (EC:2.1.2.10UniRule annotation)
Alternative name(s):
Glycine cleavage system T proteinUniRule annotation
Gene namesi
Name:gcvTUniRule annotation
Synonyms:yqhI
Ordered Locus Names:BSU24570
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001225431 – 362AminomethyltransferaseAdd BLAST362

Proteomic databases

PaxDbiP54378

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100013466

Structurei

Secondary structure

1362
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 10Combined sources3
Helixi11 – 14Combined sources4
Beta strandi17 – 21Combined sources5
Beta strandi24 – 31Combined sources8
Helixi33 – 42Combined sources10
Beta strandi43 – 48Combined sources6
Beta strandi52 – 59Combined sources8
Helixi62 – 69Combined sources8
Beta strandi70 – 72Combined sources3
Helixi74 – 76Combined sources3
Beta strandi81 – 88Combined sources8
Beta strandi94 – 104Combined sources11
Beta strandi107 – 112Combined sources6
Helixi114 – 116Combined sources3
Helixi117 – 126Combined sources10
Beta strandi133 – 136Combined sources4
Turni138 – 140Combined sources3
Beta strandi141 – 148Combined sources8
Helixi151 – 156Combined sources6
Beta strandi159 – 161Combined sources3
Helixi163 – 165Combined sources3
Beta strandi170 – 177Combined sources8
Beta strandi180 – 186Combined sources7
Beta strandi189 – 200Combined sources12
Helixi201 – 203Combined sources3
Helixi204 – 215Combined sources12
Helixi216 – 218Combined sources3
Beta strandi220 – 223Combined sources4
Helixi225 – 234Combined sources10
Turni240 – 242Combined sources3
Beta strandi243 – 245Combined sources3
Turni250 – 254Combined sources5
Helixi256 – 258Combined sources3
Helixi270 – 279Combined sources10
Beta strandi282 – 293Combined sources12
Beta strandi301 – 304Combined sources4
Beta strandi307 – 318Combined sources12
Turni319 – 322Combined sources4
Beta strandi323 – 331Combined sources9
Helixi332 – 334Combined sources3
Beta strandi340 – 345Combined sources6
Beta strandi348 – 355Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YX2X-ray2.08A/B1-362[»]
ProteinModelPortaliP54378
SMRiP54378
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP54378

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvT family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D43 Bacteria
COG0404 LUCA
HOGENOMiHOG000239381
InParanoidiP54378
KOiK00605
OMAiMPVQYPA
PhylomeDBiP54378

Family and domain databases

Gene3Di3.30.1360.120, 2 hits
HAMAPiMF_00259 GcvT, 1 hit
InterProiView protein in InterPro
IPR006223 GCS_T
IPR022903 GCS_T_bac
IPR028896 GCST/YgfZ/DmdA
IPR013977 GCV_T_C
IPR006222 GCV_T_N
IPR029043 GcvT/YgfZ_C
IPR027266 TrmE/GcvT_dom1
PfamiView protein in Pfam
PF01571 GCV_T, 1 hit
PF08669 GCV_T_C, 1 hit
PIRSFiPIRSF006487 GcvT, 1 hit
SUPFAMiSSF101790 SSF101790, 1 hit
TIGRFAMsiTIGR00528 gcvT, 1 hit

Sequencei

Sequence statusi: Complete.

P54378-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKRTPLFDL YKEYGGKTID FGGWELPVQF SSIKKEHEAV RTAAGLFDVS
60 70 80 90 100
HMGEVEVSGN DSLSFLQRLM TNDVSALTPG RAQYTAMCYP DGGTVDDLLI
110 120 130 140 150
YQKGENRYLL VINASNIDKD LAWMKEHAAG DVQIDNQSDQ IALLAVQGPK
160 170 180 190 200
AEAILKNLTD ADVSALKPFA FIDEADISGR KALISRTGYT GEDGYEIYCR
210 220 230 240 250
SDDAMHIWKK IIDAGDAYGL IPCGLGARDT LRFEAKLPLY GQELTRDITP
260 270 280 290 300
IEAGIGFAVK HKKESDFFGK SVLSEQKENG AKRKLVGLEM IEKGIPRHGY
310 320 330 340 350
EVFQNGKSVG KVTTGTQSPT LGKNVGLALI DSETSEIGTV VDVEIRKKLV
360
KAKVVKTPFY KR
Length:362
Mass (Da):39,807
Last modified:July 7, 2009 - v2
Checksum:i25D814C97FE94A1B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti236 – 237KL → NV in BAA12546 (PubMed:8969508).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84432 Genomic DNA Translation: BAA12546.1
AL009126 Genomic DNA Translation: CAB14388.2
PIRiH69958
RefSeqiNP_390337.2, NC_000964.3
WP_004398598.1, NZ_JNCM01000036.1

Genome annotation databases

EnsemblBacteriaiCAB14388; CAB14388; BSU24570
GeneIDi938547
KEGGibsu:BSU24570
PATRICifig|224308.179.peg.2675

Similar proteinsi

Entry informationi

Entry nameiGCST_BACSU
AccessioniPrimary (citable) accession number: P54378
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 7, 2009
Last modified: March 28, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health