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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity).By similarity

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciBSUB:BSU24560-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPA
Synonyms:yqhJ
Ordered Locus Names:BSU24560
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001669611 – 448Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST448

Proteomic databases

PaxDbiP54376
PRIDEiP54376

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100013461

Structurei

3D structure databases

ProteinModelPortaliP54376
SMRiP54376
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107QK8 Bacteria
COG0403 LUCA
HOGENOMiHOG000132025
InParanoidiP54376
KOiK00282
OMAiMYDGASA
PhylomeDBiP54376

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

P54376-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHRYLPATE KDKQEMLATI GVSSIDDLFA DIPENVKYKK EHQIKKAKSE
60 70 80 90 100
TELTRELTKL ASKNRDTVQY ASFLGAGVYD HYQPVIVDHV ISRSEFYTAY
110 120 130 140 150
TPYQPEISQG ELQAIFEFQT MICELTGMDI ANSSMYDGGT ALAEAAMLAS
160 170 180 190 200
GHTKKKKIVV SKTVHPESRE VLKTYAKGQY IDVVEVPAAD GVTDLDALRQ
210 220 230 240 250
TVCENTAAVI VQYPNFFGRI EPLKDIEPIA HQGKSMFIVS ANPLALGLLT
260 270 280 290 300
PPGKFQSDIV VGDAQPFGIP SAYGGPHCGF FAVTKKLMRK VPGRLVGQTE
310 320 330 340 350
DENGKRGFVL TLQAREQHIR RDKATSNICS NQALNALAAS VAMTALGKNG
360 370 380 390 400
VKDIARQNLL KANYAKQEAK KAGLTVMFDG PMFNEFVIKL DEPVRAVNKR
410 420 430 440
LLAKGMIGGY DLGLTYPELD CHMLIAVTEL RTKEEIDALI QELGDRHE
Length:448
Mass (Da):49,429
Last modified:July 7, 2009 - v2
Checksum:i441875530A324E3F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti265 – 266QP → HR in BAA12547 (PubMed:8969508).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84432 Genomic DNA Translation: BAA12547.1
AL009126 Genomic DNA Translation: CAB14387.2
PIRiA69959
RefSeqiNP_390336.2, NC_000964.3
WP_003230207.1, NZ_JNCM01000036.1

Genome annotation databases

EnsemblBacteriaiCAB14387; CAB14387; BSU24560
GeneIDi938546
KEGGibsu:BSU24560
PATRICifig|224308.179.peg.2674

Similar proteinsi

Entry informationi

Entry nameiGCSPA_BACSU
AccessioniPrimary (citable) accession number: P54376
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 7, 2009
Last modified: April 25, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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