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Protein

Superoxide dismutase [Mn]

Gene

sodA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Mn2+1 PublicationNote: Binds 1 Mn2+ ion per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi27Manganese1
Metal bindingi82Manganese1
Metal bindingi164Manganese1
Metal bindingi168Manganese1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processStress response
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciBSUB:BSU25020-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn] (EC:1.15.1.1)
Alternative name(s):
General stress protein 24
Short name:
GSP24
Gene namesi
Name:sodA
Synonyms:yqgD
Ordered Locus Names:BSU25020
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001600192 – 202Superoxide dismutase [Mn]Add BLAST201

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34Phosphothreonine1 Publication1
Modified residuei70Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP54375
PRIDEiP54375

PTM databases

iPTMnetiP54375

Expressioni

Inductioni

By heat shock, salt stress, oxidative stress, glucose limitation and oxygen limitation.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

IntActiP54375, 1 interactor
MINTiP54375
STRINGi224308.Bsubs1_010100013696

Structurei

Secondary structure

1202
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni12 – 18Combined sources7
Helixi21 – 29Combined sources9
Helixi31 – 42Combined sources12
Helixi47 – 50Combined sources4
Helixi54 – 59Combined sources6
Helixi60 – 63Combined sources4
Turni66 – 68Combined sources3
Helixi69 – 87Combined sources19
Helixi99 – 109Combined sources11
Helixi112 – 125Combined sources14
Beta strandi128 – 137Combined sources10
Beta strandi140 – 147Combined sources8
Helixi152 – 155Combined sources4
Beta strandi158 – 164Combined sources7
Helixi167 – 169Combined sources3
Helixi171 – 174Combined sources4
Helixi178 – 185Combined sources8
Turni186 – 188Combined sources3
Helixi191 – 200Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RCVX-ray1.60A/B/C/D/E/F/G/H1-200[»]
ProteinModelPortaliP54375
SMRiP54375
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP54375

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CK4 Bacteria
COG0605 LUCA
HOGENOMiHOG000013583
InParanoidiP54375
KOiK04564
OMAiKWGSFDK
PhylomeDBiP54375

Family and domain databases

Gene3Di1.10.287.990, 1 hit
2.40.500.20, 1 hit
InterProiView protein in InterPro
IPR001189 Mn/Fe_SOD
IPR019833 Mn/Fe_SOD_BS
IPR019832 Mn/Fe_SOD_C
IPR019831 Mn/Fe_SOD_N
IPR036324 Mn/Fe_SOD_N_sf
IPR036314 SOD_C_sf
PfamiView protein in Pfam
PF02777 Sod_Fe_C, 1 hit
PF00081 Sod_Fe_N, 1 hit
PIRSFiPIRSF000349 SODismutase, 1 hit
PRINTSiPR01703 MNSODISMTASE
SUPFAMiSSF46609 SSF46609, 1 hit
SSF54719 SSF54719, 1 hit
PROSITEiView protein in PROSITE
PS00088 SOD_MN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54375-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYELPELPY AYDALEPHID KETMTIHHTK HHNTYVTNLN KAVEGNTALA
60 70 80 90 100
NKSVEELVAD LDSVPENIRT AVRNNGGGHA NHKLFWTLLS PNGGGEPTGA
110 120 130 140 150
LAEEINSVFG SFDKFKEQFA AAAAGRFGSG WAWLVVNNGK LEITSTPNQD
160 170 180 190 200
SPLSEGKTPI LGLDVWEHAY YLNYQNRRPD YISAFWNVVN WDEVARLYSE

AK
Length:202
Mass (Da):22,490
Last modified:July 28, 2009 - v5
Checksum:i16BE475DE137A88E
GO

Sequence cautioni

The sequence BAA12507 differs from that shown. Reason: Frameshift at position 200.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti201A → R in BAA12507 (PubMed:8969508).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84432 Genomic DNA Translation: BAA12507.1 Frameshift.
AL009126 Genomic DNA Translation: CAB14432.3
PIRiB69709
RefSeqiNP_390381.3, NC_000964.3
WP_004398583.1, NZ_JNCM01000036.1

Genome annotation databases

EnsemblBacteriaiCAB14432; CAB14432; BSU25020
GeneIDi938052
KEGGibsu:BSU25020
PATRICifig|224308.179.peg.2721

Similar proteinsi

Entry informationi

Entry nameiSODM_BACSU
AccessioniPrimary (citable) accession number: P54375
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 28, 2009
Last modified: March 28, 2018
This is version 131 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health