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Protein

Superoxide dismutase [Mn]

Gene

sodA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Mn2+1 PublicationNote: Binds 1 Mn2+ ion per subunit.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi27 – 271Manganese
Metal bindingi82 – 821Manganese
Metal bindingi164 – 1641Manganese
Metal bindingi168 – 1681Manganese

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Stress response

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciBSUB:BSU25020-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn] (EC:1.15.1.1)
Alternative name(s):
General stress protein 24
Short name:
GSP24
Gene namesi
Name:sodA
Synonyms:yqgD
Ordered Locus Names:BSU25020
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved2 Publications
Chaini2 – 202201Superoxide dismutase [Mn]PRO_0000160019Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei34 – 341Phosphothreonine1 Publication
Modified residuei70 – 701Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP54375.

PTM databases

iPTMnetiP54375.

Expressioni

Inductioni

By heat shock, salt stress, oxidative stress, glucose limitation and oxygen limitation.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

IntActiP54375. 1 interaction.
MINTiMINT-8366972.
STRINGi224308.Bsubs1_010100013696.

Structurei

Secondary structure

1
202
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni12 – 187Combined sources
Helixi21 – 299Combined sources
Helixi31 – 4212Combined sources
Helixi47 – 504Combined sources
Helixi54 – 596Combined sources
Helixi60 – 634Combined sources
Turni66 – 683Combined sources
Helixi69 – 8719Combined sources
Helixi99 – 10911Combined sources
Helixi112 – 12514Combined sources
Beta strandi128 – 13710Combined sources
Beta strandi140 – 1478Combined sources
Helixi152 – 1554Combined sources
Beta strandi158 – 1647Combined sources
Helixi167 – 1693Combined sources
Helixi171 – 1744Combined sources
Helixi178 – 1858Combined sources
Turni186 – 1883Combined sources
Helixi191 – 20010Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2RCVX-ray1.60A/B/C/D/E/F/G/H1-200[»]
ProteinModelPortaliP54375.
SMRiP54375. Positions 2-200.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP54375.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CK4. Bacteria.
COG0605. LUCA.
HOGENOMiHOG000013583.
InParanoidiP54375.
KOiK04564.
OMAiTFFWEIM.
PhylomeDBiP54375.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54375-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYELPELPY AYDALEPHID KETMTIHHTK HHNTYVTNLN KAVEGNTALA
60 70 80 90 100
NKSVEELVAD LDSVPENIRT AVRNNGGGHA NHKLFWTLLS PNGGGEPTGA
110 120 130 140 150
LAEEINSVFG SFDKFKEQFA AAAAGRFGSG WAWLVVNNGK LEITSTPNQD
160 170 180 190 200
SPLSEGKTPI LGLDVWEHAY YLNYQNRRPD YISAFWNVVN WDEVARLYSE

AK
Length:202
Mass (Da):22,490
Last modified:July 28, 2009 - v5
Checksum:i16BE475DE137A88E
GO

Sequence cautioni

The sequence BAA12507 differs from that shown. Reason: Frameshift at position 200. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti201 – 2011A → R in BAA12507 (PubMed:8969508).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84432 Genomic DNA. Translation: BAA12507.1. Frameshift.
AL009126 Genomic DNA. Translation: CAB14432.3.
PIRiB69709.
RefSeqiNP_390381.3. NC_000964.3.
WP_004398583.1. NZ_JNCM01000036.1.

Genome annotation databases

EnsemblBacteriaiCAB14432; CAB14432; BSU25020.
GeneIDi938052.
KEGGibsu:BSU25020.
PATRICi18976842. VBIBacSub10457_2610.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84432 Genomic DNA. Translation: BAA12507.1. Frameshift.
AL009126 Genomic DNA. Translation: CAB14432.3.
PIRiB69709.
RefSeqiNP_390381.3. NC_000964.3.
WP_004398583.1. NZ_JNCM01000036.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2RCVX-ray1.60A/B/C/D/E/F/G/H1-200[»]
ProteinModelPortaliP54375.
SMRiP54375. Positions 2-200.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP54375. 1 interaction.
MINTiMINT-8366972.
STRINGi224308.Bsubs1_010100013696.

PTM databases

iPTMnetiP54375.

Proteomic databases

PaxDbiP54375.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB14432; CAB14432; BSU25020.
GeneIDi938052.
KEGGibsu:BSU25020.
PATRICi18976842. VBIBacSub10457_2610.

Phylogenomic databases

eggNOGiENOG4105CK4. Bacteria.
COG0605. LUCA.
HOGENOMiHOG000013583.
InParanoidiP54375.
KOiK04564.
OMAiTFFWEIM.
PhylomeDBiP54375.

Enzyme and pathway databases

BioCyciBSUB:BSU25020-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP54375.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSODM_BACSU
AccessioniPrimary (citable) accession number: P54375
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 28, 2009
Last modified: September 7, 2016
This is version 124 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.